Hutchinson-Gilford progeria syndrome affects 1 in 8 million newborns worldwide and is characterized by accelerated aging. The researchers identified a single-letter misspelling in the LMNA gene as the cause of this disorder.
SourceNIH/National Human Genome Research Institute·JournalNature·DateApr 16, 2003
Researchers have identified the Progeria gene, which may lead to answers about natural aging and cardiovascular disease. The discovery gives hope to children with Progeria, who die at an average age of 13 due to complications from accelerated aging.
SourceNIH/National Human Genome Research Institute·JournalNature·DateApr 16, 2003
Researchers found progeria cells have low catalase and glutathione peroxidase activity, making it hard to remove toxic peroxides. Reintroducing these enzymes could halt or reverse the problem using adenovirus gene transfers.
SourceUniversity of Iowa·JournalBiochemical and Biophysical Research Communications·DateMay 21, 1999