12 new epilepsy drugs usher in 'era of abundance'
A dozen new epilepsy drugs are now available, offering more treatment options for patients. However, this increased choice also complicates treatment decisions for clinicians.
Seizures
Articles tagged with Seizures
Life Sciences
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
447,757
articles
2542
topics
Health and Medicine
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
431,843
articles
751
topics
Social Sciences
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
260,756
articles
745
topics
Physical Sciences
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
257,913
articles
1552
topics
Applied Sciences and Engineering
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
225,386
articles
998
topics
Scientific Community
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
193,043
articles
157
topics
Space Sciences
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
29,662
articles
175
topics
Research Methods
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
21,889
articles
139
topics
Mathematics
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
3,023
articles
113
topics
Researchers find possible biomarker to identify seizure-related stress
A study published in Neurology found decreased levels of BDNF in patients with psychogenic non-epileptic seizures (PNES) and epileptic seizures, potentially identifying a biomarker for PNES. The study also suggests that stress may be a common underlying factor in both conditions.
Adjunctive rufinamide reduces refractory partial-onset seizures
Researchers found that rufinamide significantly reduced total partial seizure frequency compared to placebo, with a notable 50% reduction in responder rate and total partial seizure frequency. The study also showed efficacy for complex partial seizures, simple partial seizures, and secondarily generalized partial seizures.
Higher incidence of seizures seen in children with H1N1 virus compared to seasonal flu
A recent study found that the 2009 pandemic influenza A (H1N1) caused a higher rate of neurological complications in children than the seasonal flu. The most common complications observed were seizures and encephalopathy.
Epileptic seizures may be linked to an ancient gene family
Researchers identify an ancient gene family regulating nerve excitability in the brain, which may contribute to epileptic seizures. Studies on mice suggest that activating this potassium channel can block seizures, opening up potential new drug targets with fewer side effects.
Soldiers with brain injuries at higher risk of epilepsy decades later
Researchers found that 44% of veterans with a traumatic brain injury developed post-traumatic epilepsy, and in some cases, seizures didn't appear until over 14 years after the injury. The study strongly suggests that veterans with brain injuries will require long-term neurology care.
New data for Vimpat (lacosamide) C-V showed sustained efficacy for up to 5 years
New data demonstrate Vimpat (lacosamide) C-V's sustained efficacy in reducing seizure frequency and improving responder rates when added to a broad range of antiepileptic drugs. Long-term results show improved seizure control for up to 5 years, with median percent reductions in seizure frequency ranging from 45.5% to 71.8%.
Combination MMRV vaccine linked with 2-fold risk of seizures
A Kaiser Permanente study found the MMRV vaccine doubles the risk of febrile seizures in 1- to 2-year-old children compared to separate MMR and varicella vaccines. The study analyzed 459,000 children and recommended that families without a preference for MMRV receive separate vaccinations.
New oral solution formulation of antiepileptic drug Vimpat (lacosamide) (C-V)
UCB has announced an oral solution formulation of Vimpat (lacosamide) C-V, expanding treatment options for people with epilepsy. The new formulation is available in three forms, including oral solution and IV injection, allowing patients to maintain consistent treatment across various clinical settings.
Improved management of severe epilepsy may reduce treatment costs
A new study found that improved treatment of severe epilepsy could significantly reduce the overall cost of the condition. The study analyzed data from 9,163 epilepsy patients and found that non-AED related costs increased disproportionately with disease severity, while AED-related costs remained stable.
Study looks at major advances in pediatric epilepsy surgery at UCLA over 2 decades
A new study from UCLA's Pediatric Epilepsy Surgery Program found significant improvements in surgical outcomes for pediatric epilepsy patients over the past two decades. The researchers attribute the success to advancements in diagnostic technology and experience in selection and operations.
High-fat ketogenic diet effectively treats persistent childhood seizures
A Johns Hopkins study found that nearly 40% of children with infantile spasms became seizure-free after being on the high-fat ketogenic diet for at least six months. The diet, which is rich in fat and low in carbohydrates, works by triggering biochemical changes that eliminate seizure-causing short circuits in the brain.
Vaccination linked with early onset of seizures in Dravet syndrome but clinical outlook unaffected
A retrospective study found that vaccination is associated with earlier onset of seizures in children with Dravet syndrome, but does not affect the clinical outcome. The study analyzed 40 patients and found no difference in intellectual outcome or subsequent seizure type between vaccinated and unvaccinated groups.
Ginkgo herbal medicines may increase seizures in people with epilepsy
A new report concludes that Ginkgo herbal medicines can increase the risk of seizures in people with epilepsy and reduce the effectiveness of anti-seizure drugs. The herb's potentially toxic material, ginkgotoxin, may alter a chemical signaling pathway that triggers epileptic seizures.
What causes seizure in focal epilepsy?
A study reveals that early activation of astroglia in focal epilepsy drives neurons to generate epileptic discharges. This neuron-astrocyte interaction may represent a novel target for controlling epilepsy.
Tapeworm brain infection 'serious health concern'
Neurocysticercosis, a tapeworm brain infection, is increasing in Mexico and bordering southwestern US states, affecting up to 10% of the population. The infection can cause severe symptoms like seizures, headaches, and encephalitis, highlighting the need for proper evaluation and management.
Fetal alcohol spectrum disorder linked to high prevalence of epilepsy, Queen's study
A national study by Queen's University researchers has found a strong correlation between Fetal Alcohol Spectrum Disorder (FASD) and a high prevalence of epilepsy. Six percent of participants had epilepsy, while twelve percent experienced one or more seizures in their lifetimes.
Fetal alcohol spectrum disorder linked to high prevalence of epilepsy
Children with fetal alcohol spectrum disorder (FASD) are at a high risk of developing epilepsy or seizure history, according to a new study. Researchers found that six percent of individuals with FASD developed epilepsy and 12 percent had one or more seizures in their life.
Deep brain stimulation reduces epileptic seizures in patients with refractory partial and secondarily generalized seizures
A recent study found that deep brain stimulation significantly reduced seizure frequency in patients with refractory partial and secondarily generalized seizures, with a 56% reduction in seizure frequency by 2 years. The benefits of stimulation persisted long-term, with improved responder rates.
Study reinforces role of AED Vimpat (lacosamide) (C-V) as add-on treatment for POS
A Phase III clinical study published online in Epilepsia found that Vimpat (lacosamide) demonstrated significantly fewer partial-onset seizures versus placebo in adults living with epilepsy. The study showed that patients taking Vimpat had greater reductions in seizure frequency and a higher 50% responder rate compared to placebo.
Lacosamide validated as promising therapy for uncontrolled partial-onset seizures
Researchers found that lacosamide 400 mg/day provides good efficacy and tolerability for patients with uncontrolled partial-onset seizures, while higher doses may provide additional benefits. The study confirms the safety and effectiveness of adjunctive lacosamide treatment in reducing seizure frequency and severity.
Dolphins' health shed light on human and ocean health
Dolphins' health is shedding light on human and ocean health. Researchers have discovered that diseases found in dolphins are similar to human diseases, providing clues into how human health might be affected by contaminated coastal water or seafood. High levels of PCBs in dolphins may be suppressing their immune function.
Study supports alternative anti-seizure medication following acute brain injury
A study by researchers at the University of Cincinnati Neuroscience Institute supports the use of Keppra as an alternative to Dilantin for preventing seizures in patients after a brain injury. Patients treated with Keppra had fewer side effects and better long-term outcomes compared to those receiving Dilantin.
High-fat ketogenic diet to control seizures is safe over long term
A recent study at Johns Hopkins Children's Center found that a high-fat ketogenic diet is both effective and safe for controlling seizures in the long term. The diet, which consists of high-fat foods and very few carbohydrates, has been shown to reduce seizure frequency by nearly 80% in patients treated for a minimum of 16 months.
Drama or reality TV: Do medical shows depict proper first aid for seizures?
A study found that medical dramas and reality TV shows responded inappropriately to seizures nearly half the time, with improper practices occurring in 25 cases. The American Academy of Neurology urges the TV industry to adhere to seizure management guidelines.
Noninvasive testing, earlier surgery can stop seizures in tuberous sclerosis complex
Researchers at UCLA's Pediatric Epilepsy Surgery Program have found that a non-invasive approach to pre-surgical testing, combined with earlier consideration for surgery, is associated with the best seizure-free surgical outcome in patients with TSC. Approximately two-thirds of TSC patients became seizure-free after surgery.
More than fish bait: Worms unlock secrets to new epilepsy treatments
Researchers identify key molecular switches controlling GABA transport, which could prevent seizure onset. The study uses C. elegans worms to reveal genetic factors contributing to epilepsy susceptibility.
Pivotal trial data demonstrate Neuropace RNS system reduced seizures in people with epilepsy
The pivotal trial data demonstrate that the RNS System significantly reduced seizure frequency among people with medically intractable partial onset epilepsy. The device delivered brief and mild electrical stimulations to suppress seizures, with a mean percentage reduction of 29% in disabling seizures.
Epilepsy patients caught in treatment gap are not getting state-of-the-art care
A global consensus definition of refractory epilepsy has been developed to aid better care for patients caught in the treatment gap. The definition highlights the need for state-of-the-art care for millions of people with epilepsy worldwide, who are currently not receiving adequate treatment.
Current cigarette smokers at increased risk of seizures
A recent study published in Epilepsia found that current cigarette smokers are at a significant risk of seizure. The study analyzed data from over 116,000 female nurses and found that long-term moderate caffeine or alcohol use is not associated with an increased risk of seizures or epilepsy.
A new understanding of why seizures occur with alcohol withdrawal
Researchers found that increased calcium current density occurs before seizure onset, and remains elevated during seizure susceptibility periods.
Gene mutation causes severe epilepsy, febrile seizures in thousands of infants worldwide
Researchers at the University of Utah Health have discovered a gene mutation that causes severe epilepsy and febrile seizures in some infants. The SCN9A gene mutation can alter sodium channel function in the brain, leading to seizures, and may be responsible for up to 5% of febrile syndrome patients.
MassGeneral Hospital for Children study explains some mysteries of neonatal seizures
A study by MassGeneral Hospital for Children reveals that newborn seizures often do not produce visible convulsions due to the brain's immature response to GABA. Treatment with a new medication, bumetanide, successfully suppressed seizure activity in both cortical and subcortical regions.
Researchers restore missing protein in rare genetic brain disorder
UCSF researchers have successfully restored the missing protein calpain degrades LIS1 protein to near-normal levels in mice with the mouse-model of this defect. The team gave daily injections of a calpain inhibitor to pregnant mice whose fetuses had the mouse-model, resulting in more normal brains and no sign of mental retardation.
Dead ahead: Similar early warning signals of change in climate
Researchers found that similar symptoms occur in many systems as they approach a critical state of transition, indicating 'tipping points' for abrupt changes. These early-warning signals are observed in ecosystems, financial markets, and human physiology, highlighting the potential for catastrophic bifurcations.
Children with newly diagnosed epilepsy at risk for cognitive problems
A study published in Neurology found that children with normal IQs before a first seizure may experience language, memory, learning and other cognitive skills problems. Children who took epilepsy drugs had difficulties in processing speed, verbal memory, and learning.
Seizures during pregnancy associated with risk of pre-term and small babies
A study found that women with epilepsy who experience seizures during pregnancy are more likely to give birth to pre-term and small babies than those without epilepsy. The study analyzed data from over 1,000 women with epilepsy and found a significant association between seizure activity and adverse pregnancy outcomes.
Epilepsy halted in mice
Researchers at the University of Leeds have successfully prevented epilepsy in mice by identifying a faulty gene as the cause. The study, published in PNAS, offers irrefutable proof that a defective version of the Atp1a3 gene is responsible for causing epileptic seizures in mice.
Daily potassium citrate wards off kidney stones in seizure patients on high-fat diet
A daily supplement of potassium citrate has been found to prevent kidney stones in children on the high-fat ketogenic diet, a common treatment for epilepsy. The study, published in Pediatrics, showed that those who received potassium citrate twice daily were seven times less likely to develop kidney stones.
Duke, UNC scientists create entirely new way to study brain function
Researchers have devised a chemical technique to discover brain function and provide clues for treating brain diseases. The technique allows neuroscientists to noninvasively activate entire populations of neurons in an animal brain, promoting understanding of brain function and disease treatment.
Study pinpoints drugs that prevent epilepsy, seizures after severe brain injury
Researchers discovered a drug that blocks transforming growth factor-beta (TGF-beta) receptors can prevent brain changes associated with epilepsy in rats. This treatment halts hyper-excitability and prevents gene expression changes, offering hope for preventing epilepsy in humans after severe brain injury.
CU-Boulder study shows brain's immune system may cause chronic seizures
A CU-Boulder study found that chemicals released by the brain's immune system can cause chronic seizures in people who have suffered a traumatic head injury. The research suggests that temporarily shutting down the immune response could prevent the development of acquired epilepsy.
New findings encourage more vigilant monitoring of seizure activity among intensive care patients
Researchers found subtle seizures may prolong recovery and worsen outcome among ICU patients, emphasizing the importance of continuous EEG monitoring. The studies suggest treating clinically silent seizures with anti-seizure medications may help prevent neuronal damage and improve patient outcomes.
Rutgers research tackles childhood epilepsy
Researchers at Rutgers University have discovered a potential new treatment for childhood epilepsy, using the therapeutic drug rapamycin to suppress epileptic seizures in mice. The study, published in Disease Models and Mechanisms, shows promise for treating cortical dysplasia, a common cause of childhood epilepsy.
Findings in epilepsy gene in animals may guide treatment directions for infants
Researchers developed genetically engineered mice that experience seizures resembling those in patients with infantile spasms. The discovery provides a new opportunity to test treatments that may benefit children with this difficult-to-treat form of childhood epilepsy.
Drug's epilepsy-prevention effect may be widely applicable
Researchers found that rapamycin blocks brain changes believed to cause seizures in rats and reduces spontaneous seizures in mice with a genetic condition. The drug may also help prevent common forms of epilepsy caused by brain injury, offering new hope for patients.
Bull's-eye electrode helps interpret thoughts, deliver stimulus to aid paralyzed, epileptic patients
Researchers have developed a unique bulls-eye electrode that can interpret brain signals, allowing paralyzed patients to control their environment. The device is also being studied as a means of delivering a stimulus to control epileptic seizures, with potential applications in treating status epilepticus, a life-threatening condition.
U of Minnesota researcher develops brain-scanning process that holds promise for epilepsy treatments
A new brain-scanning process developed by University of Minnesota researcher Bin He holds promise for epilepsy treatment advancements. The technique uses functional neuroimaging to identify seizure foci and aid surgeons in pinpointing the brain network affected by seizures.
Camphor-containing products may cause seizures in children
A new study by Albert Einstein College of Medicine found that camphor-containing products can cause seizures in children, particularly those from Hispanic communities. The cases highlight the importance of proper labeling and education about the hazards of camphor usage.
Drug prevents seizure progression in model of epilepsy
Researchers identified a new anticonvulsant compound that eliminates seizures in a model of epilepsy by inhibiting ion channels associated with the disease. The study found that blocking these channels can prevent subsequent seizures, offering a promising treatment for epilepsy.
Guidelines: Pregnancy safe with epilepsy, but valproate should be avoided
New American Academy of Neurology and American Epilepsy Society guidelines suggest pregnant women with epilepsy consider avoiding valproate, a drug linked to increased fetal malformations and decreased thinking skills. The guidelines recommend regular blood testing to adjust medication doses.
Researchers discover that gene switches on during development of epilepsy
A study published in the Journal of Neuroscience found that a specific gene can be 'switched on' in animals without a genetic predisposition to epilepsy, leading to changes in calcium channels and brain activity. This discovery may reveal a new mechanism for how epilepsy develops in some individuals.
Study finds cognitive behavioral therapy can alleviate nonepileptic seizures
Researchers found that cognitive behavioral therapy can reduce the frequency of seizures in patients with PNES, improving their overall quality of life. The study also showed significant improvement in depression, anxiety, and psychosocial functioning.
Surgery safe for babies and toddlers suffering from seizures
A new study published in Epilepsia reveals that surgery for babies and toddlers suffering from epilepsy is relatively safe and effective in controlling seizures. Early surgery may also have a positive impact on brain development.
Search for blood pressure secrets reveals a surprising new syndrome
Researchers at Yale University have discovered a previously undescribed syndrome associated with seizures, developmental delay, and hearing loss. The syndrome, named SeSAME, is caused by mutations in the KCNJ10 gene, which affects potassium channels in the brain, inner ear, and kidney.
Stun guns may cause seizures
A new case report suggests stun guns can cause seizures, particularly when shots are fired at the head. The study analyzed an incident where a police officer was mistakenly hit by a taser and experienced severe symptoms, including mild traumatic brain injury.
Veterinary college, Luna Innovations partner on nationally funded nerve gas program
Researchers at Virginia Tech will explore the development of novel methods for delivering chemical antidotes that can mitigate the devastating effect of organophosphate-based neurotoxicants. The team aims to use nanoparticles called fullerenes to enhance their water solubility and catalytic properties, which could potentially protect a...
First gene discovered for most common form of epilepsy
Researchers have identified a new gene, ELP4, linked to Rolandic epilepsy, a common form of childhood epilepsy. The discovery supports a new theory about the causes of epilepsy and offers insights into other cognitive and behavioral disorders such as ADHD, speech dyspraxia, and DCD.
Study: Adding Vimpat significantly reduces partial-onset seizures in adults with epilepsy
A Phase III clinical study published online in Epilepsia found that Vimpat significantly reduced seizure frequency per 28 days from baseline compared to placebo. The study demonstrated efficacy in patients with uncontrolled partial-onset seizures, with higher rates of seizure reduction and complete seizure freedom among those receiving...
BUSM researcher solves mystery of 9-month-old
A 9-month-old breast-fed infant was diagnosed with rickets caused by vitamin D deficiency after presenting with seizures and a bulging soft spot. The case study published in the New England Journal of Medicine highlights the importance of considering nutritional deficiencies in infants, particularly those who are solely breast-fed.