Articles tagged with Seizures
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A new study found temperature-sensitive L-type calcium channels play a key role in febrile seizures. Nimodipine, a commonly available drug, dramatically reduced the incidence and duration of febrile seizures in animal models.
A new study found that children and adolescents with seizures involving the temporal lobe are at risk for clinically significant behavioral problems and psychiatric illness, especially depression. Routine psychiatric evaluation is crucial before epilepsy surgery to improve quality of life.
A new imaging technique developed by Jean Gotman and his colleagues combines electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) to more precisely localize the areas generating epileptic seizures. This allows neurosurgeons to better understand the optimal ways of intervention for patients with epilepsy.
Researchers at the University of Arizona used a state-of-the-art DNA sequencing technique to determine the genetic mutations causing severe epilepsies in seven out of ten previously undiagnosed children. The study found 15 mutations in nine children, seven of which are known or likely to cause epilepsy.
Researchers have developed a new, more precise form of electroconvulsive therapy (ECT) called FEAST, which shows promising results in reducing depressive symptoms with minimal adverse cognitive effects. In a feasibility study, patients experienced significant improvements after just 10 sessions over four weeks.
Researchers at UCSF controlled seizures in epileptic mice with a one-time transplantation of MGE cells, which inhibit signaling in overactive nerve circuits. The treatment showed promising results, eliminating seizures in half of the treated mice and reducing spontaneous seizures in the rest.
Researchers at the University of California at San Francisco have made a breakthrough in treating epilepsy by transplanting new inhibitory nerve cells into the brains of adult mice. This innovative approach has shown promising results in reducing seizure occurrence and reversing associated learning and memory problems.
A world-first study led by Professor Mark Cook has accurately predicted epilepsy seizures in humans using a device implanted between the skull and brain surface. The system correctly predicted seizures with a high warning rate of 65% of the time, offering new management strategies for epilepsy.
Researchers developed an implantable device that detects abnormal brain activity and predicts seizures with a high accuracy rate. The technology has the potential to improve management strategies and potentially allow patients to avoid dangerous situations.
Researchers report success with Sirolimus treatment, minimizing seizures and improving language function in Pretzel syndrome children. The study's findings have implications for related neurodevelopmental disorders like tuberous sclerosis complex.
A study by W. Curt LaFrance Jr., M.D., M.P.H. found that TBI significantly increases the odds of major depression, personality impulsivity, and PTSD in patients with psychogenic nonepileptic seizures (PNES). Patients with PNES and TBI had higher rates of disability, unemployment, and poorer functioning.
Researchers found that prolonged seizures in children are associated with developmental delays and impairments within six weeks of the event, which persist at one year. The study suggests that seizures may have a long-lasting impact on future development through reorganization of functional brain networks.
A retrospective study found that nearly 80% of patients with in-hospital EEG had abnormal findings, including diffuse slowing and seizures. The study highlights the value of EEG in identifying treatable causes of impaired consciousness in non-critical hospitalized patients.
A study by UCSF researchers found that EEGs can identify seizures in up to 7.4% of hospitalized patients, highlighting the underutilization of this diagnostic tool. Seizures are treatable with FDA-approved anticonvulsants, and prompt diagnosis can lead to shorter hospital stays and improved patient outcomes.
A new study by Michigan State University found that young people with epilepsy experienced significant reductions in stigmatization after participating in regular peer support groups. The research, published in Epilepsy and Behavior, suggests a potential solution to the debilitating stigma surrounding epilepsy in developing countries.
A new study in rats indicates that gentle brain cooling after injury may prevent seizures in humans, a finding that could lead to a safe and relatively simple way to treat patients with head injuries.
A consortium of top researchers has made significant progress in understanding and treating Rasmussen encephalitis, a rare neurological disease. The RE Children's Project has raised funds to study the disease tissue and search for genetic links.
A Michigan State University research team begins a groundbreaking clinical drug trial to control seizures caused by cerebral malaria, which affects brain function in three million children. The trial aims to improve seizure control and potentially prevent epilepsy.
Researchers at Emory University School of Medicine have discovered a potential lead compound that can reduce mortality when given to mice after drug-induced seizures. The compound, TG6-10-1, blocks signals from prostaglandin E2, which is involved in the toxic inflammation in the brain arising after status epilepticus.
Researchers tracked 73 subjects with intracerebral hemorrhage (ICH) to find that about 60% of newborns had visible seizures at the time of stroke, while 43% of older children did. Within two years, 13% of study subjects developed epilepsy, and patients with elevated brain pressure were more likely to experience later seizures.
Cats and humans share a similar form of epilepsy caused by an autoimmune response targeting nerve cell proteins. Researchers have discovered antibodies reacting to these proteins in the blood of affected cats, which is consistent with a similar human condition.
Researchers created an EEG-based computer system that activates optical fibers in the brain to arrest seizure activity and reduce severe 'tonic-clonic' events. The approach shows promise for treating severe manifestations of epilepsy with minimal side effects.
A new study from MIT researchers suggests that some epileptic seizures may originate in non-neuronal glial cells. Mutations in a gene called zydeco, which influences glial-cell communication with neurons, appear to make neurons more excitable and prone to seizures.
Researchers at LA BioMed identified a potential new target for medications to halt status epilepticus, a life-threatening condition causing brain damage. The study found that NMDA receptor activity increases during persistent seizures, leading to increased medication effectiveness with NMDA antagonists.
Scientists have identified a gene expression that initiates a protective electrical response after seizures, which could prevent recurrent seizures and the onset of devastating epilepsy. This discovery also has implications for relief from chronic pains, cardiovascular disease, and recovery from mood disorders.
A study by neurologists at Henry Ford Hospital found that brain surgery for refractory localization-related epilepsy can lead to significant long-term benefits, with 73% achieving favorable seizure outcomes and 28% experiencing seizure freedom. The researchers tracked 470 patients over 15 years after surgery.
A small Johns Hopkins Children's Center study found that children on the ketogenic diet experienced reduced seizures after incorporating periodic fasting. The results suggest that fasting does not intensify but rather changes the metabolism of children with epilepsy.
A new study by Emory researchers has proven successful in preventing depression in people with epilepsy, reducing seizures and improving quality of life. The web-based method, called Project UPLIFT, provides patients with depression prevention and stress management skills, increasing knowledge and skills to replace negative feelings.
A Loyola University Medical Center neurologist reports a higher-than-expected rate of patients with non-epileptic seizures who also experience epileptic seizures during the same hospital stay. This finding is significant because it highlights the need for more accurate diagnosis and treatment of these conditions.
Researchers identified a molecular mechanism underlying antifibrinolytic drug-induced seizures. Antifibrinolytics inhibit glycine receptors, leading to seizures, but isoflurane treatment prevents this effect.
Researchers found that drugs like TXA and EACA associated with a four-to-six-fold increase in post-operative seizures. Adjusting these drug doses and maintaining sedation levels can help reduce the risk of seizure.
Researchers found that bariatric surgery techniques produce similar outcomes, with weight loss itself being the primary factor responsible for improved metabolic responses. In another study, antifibrinolytic drugs were linked to seizures due to their inhibition of glycine receptors in the brain. A companion commentary reviews the conne...
Researchers created a new fruit fly model of inherited epilepsy that shows the link between temperature-dependent seizures and flawed sodium channels. The study establishes a platform to develop therapies for febrile seizure disorders, such as GEFS+, which can persist beyond childhood and often develop seizures in the absence of fever.
Scientists developed a genetically engineered fruit fly model to study temperature-dependent seizures. The model reveals that disease-causing mutations lead to breakdowns in brain regulation, causing excessive electrical activity. Researchers hope this discovery will lead to the development of new treatments for febrile seizures.
A study by Rhode Island Hospital researcher W. Curt LaFrance Jr. compared diagnosis and treatment practices for PNES in the US and Chile. Increasing access to video-EEG is crucial for accurate diagnosis and effective treatment of PNES, which are often misdiagnosed as epilepsy.
Researchers at Cincinnati Children's Hospital Medical Center discovered a biological mechanism that causes brain seizures in mice with molecular disruptions in small neurons called granule cells. Treating epileptic mice with a drug that blocks the mTOR pathway stopped seizures, solidifying the link to the PTEN-mTOR pathway.
Researchers found that nerve cells in the posterior medial cortex (PMC) are strongly activated during recall tasks but suppressed when performing mathematical calculations. This study provides new insights into the brain's introspective activities and highlights the importance of the PMC region.
Researchers at University of Minnesota develop new non-invasive brain scan technique to study seizures immediately after they occur. The method could lead to breakthroughs in identifying the brain regions responsible for seizures and finding effective treatments.
Researchers developed a method to determine the origin of seized ivory using mitochondrial DNA sequences from elephant samples. The technique identified unique sequences linked to specific locations and countries, providing valuable information for conservationists to prevent poaching.
Researchers at Newcastle University have identified a unique brain wave pattern, called glissando, that can predict epileptic seizures. The study found that this pattern is highly indicative of human epilepsy and cannot be easily reproduced in non-epileptic brain tissue.
A new study published in Epilepsia found that human herpesviruses (HHV)-6B and HHV-7 are associated with febrile status epilepticus (FSE) cases, accounting for one-third of FSE cases. The study suggests a possible link between these viruses and the development of epilepsy, particularly temporal lobe epilepsy.
A study has determined that human herpesvirus-6B (HHV-6B) is linked to mesial temporal lobe epilepsy in infants and children. HHV-6B can cause limbic encephalitis, a condition that frequently progresses to epilepsy.
The American Academy of Neurology has issued an updated guideline outlining the best treatments for infantile spasms. The hormone therapy adrenocorticotropic hormone (ACTH) may be effective for treatment, with low-dose ACTH showing similar effectiveness to high-dose and potentially lower risk of side effects.
Researchers have found an imbalance between neuronal excitation and inhibition in individuals with Angelman syndrome, a neurodevelopmental disorder characterized by seizures, cognitive delay, and severe intellectual disability. This imbalance may underlie the high seizure activity observed in AS patients.
A 25-year follow-up study found that 68% of juvenile myoclonic epilepsy patients became seizure-free, with nearly 30% no longer needing antiepileptic drug treatment. AED polytherapy and generalized tonic-clonic seizures preceding bilateral myoclonic seizures predicted poor long-term seizure outcomes.
Researchers discovered a link between a protein called BAD and glucose metabolism in the brain, finding that modifications to this protein reduced seizure susceptibility. The study suggests that targeting BAD could lead to new treatments for epilepsy.
A protein called BAD modifies cellular metabolism in the brain, resisting epileptic seizures and providing a potential treatment option. Researchers discovered that altering BAD's function can reduce seizures without dietary therapy.
A study published in Epilepsia found that pediatric epilepsy severely affects both child and parental sleep patterns. Parents of children with epilepsy reported decreased sleep quality when sharing a room or co-sleeping with their child, while children experienced greater sleep disturbance and daytime sleepiness.
A Georgetown University Medical Center study found that phenobarbital stunts neuronal growth, leading to cognitive abnormalities in rats. The researchers suggest that anti-epilepsy drugs may not be as benign as thought and could have long-lasting impacts on brain function.
A study published in Neurology found that the response to initial treatment can predict future seizure risk. The research followed 1,098 people with newly diagnosed epilepsy for up to 26 years and found that 50% were seizure-free after the first drug tried, while 4% became seizure-free after the third.
A new study found that how well people respond to their first drug treatment for newly diagnosed epilepsy can predict their likelihood of having more seizures. The study showed that 50% of participants were seizure-free after the first drug, while only 4% remained seizure-free after the third drug regimen.
Michigan State University researchers are leading a clinical trial in Malawi to test the safety and feasibility of levetiracetam, an anti-seizure medication, to control seizures in children with cerebral malaria. The trial aims to improve neurologic outcomes for survivors, who often develop epilepsy or other neurologic disorders.
Researchers at MIT and two Boston hospitals have developed a simple wrist sensor that can measure the severity of epileptic seizures with high accuracy, potentially allowing patients to monitor their condition at home. The device could also predict seizure onset, enabling early intervention.
The American Academy of Neurology issues new guidelines for preventing migraine, recommending several treatments including prescription drugs and over-the-counter options. These guidelines aim to address the underrecognition and undertreatment of migraine, with potential benefits in reducing attack frequency and severity.
A new study from UCSF found that brain surgery for epilepsy has not increased in the decade since a landmark clinical trial demonstrated its effectiveness. Despite this, thousands of Americans suffer from uncontrolled seizures each year, highlighting disparities by race and insurance status.
Researchers have identified a protein called SUMO that regulates information transfer between nerve cells in the brain. The discovery could lead to new therapies for stroke and epilepsy.
Researchers at Johns Hopkins Medicine have developed a new medication, perampanel, that selectively targets proteins in the brain to control excitability and significantly reduce seizure frequency. The study, involving over 700 participants, found that roughly one-third of patients experienced a more than 50% reduction in seizures.
Patients with pseudo-seizures, also known as psychogenic non-epileptic seizures (PNES), often misdiagnosed due to stress-triggered symptoms. Research suggests that these patients lack effective coping mechanisms and are more distressed by stressful events than those with epilepsy or healthy individuals.
Researchers have developed new seizure detection software that significantly reduces false alarms, offering promise for improved epilepsy treatment. The system uses algorithms to detect imminent seizures and has been tested on real-time brain activity recordings from four patients with drug-resistant epilepsy.
A study by Kaiser Permanente found no increased risk of febrile seizures among 4-6 year olds after measles-containing vaccine administration. The research analyzed over 86,750 children and found that separate MMR plus V vaccines also did not increase the risk of febrile seizures in this age group.