Articles tagged with Seizures
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The study found that selective UBE3A loss from GABAergic brain circuits leads to seizure behaviors and EEG abnormalities typical of AS model mice. Further research into the effects of UBE3A loss in other neuron types may reveal new therapeutic strategies for Angelman syndrome.
Researchers are conducting a nationwide study to find the most effective treatment for established status epilepticus, a life-threatening condition characterized by persistent seizures. The trial, ESETT, will evaluate three commonly used medications to determine which one is most effective at stopping seizures quickly.
Research reveals that genetics play a role in sleep/wake timing of seizures in individuals with epilepsy. The study found that seizures in relatives tend to occur at the same time in the sleep/wake cycle.
Researchers have developed a precise and fast responding tool to measure carbon monoxide (CO) and nitric oxide (NO) levels in the brain during seizure events. The dual sensor probe recorded clearly defined changes in CO/NO levels that changed in accordance with the seizure's phase changes.
Researchers at the University of Bonn have developed a new model that simulates the behavior of neurons in the brain during extreme events, such as epileptic seizures. The model reveals how small-world networks can exhibit spontaneous changes, shedding light on the conditions under which these events develop.
A substantial proportion of stroke survivors (15.3%) develop seizures over an average follow-up period of 3.4 years. The risk is significantly higher than that following traumatic brain injury, even when controlling for age.
The American Epilepsy Society has released a new guideline to help physicians effectively treat patients with prolonged seizures. The guideline recommends a three-phase approach to treatment, prioritizing rapid termination of seizure activity to reduce neurological injuries and deaths.
Penn researchers developed algorithms that can predict where a seizure will originate and which groups of neurons it will likely spread to. These predictions could provide a more objective way of identifying surgical targets, improving the success rate of such interventions.
A study published in the Journal of Feline Medicine and Surgery found that levetiracetam significantly reduced myoclonic seizures in cats with feline audiogenic reflex seizures, improving their quality of life. In contrast, phenobarbital showed limited efficacy and persistent side effects.
A new open-label trial of prescription cannabidiol (CBD) shows significant reduction in seizure frequency and well-tolerated for most children and young adults. The study also found a sufficient safety profile with minimal adverse events, but more research is needed to definitively recommend CBD as a treatment.
Researchers at UT Southwestern Medical Center found that stopping the production of new neurons in the brain following TBI can help reduce epileptic seizures, cognitive decline, and impaired memory. This process, called neurogenesis, is sometimes hyperexcitable, disrupting neural circuits and causing recurring seizures.
Researchers developed algorithms predicting seizure origin and spread based on brain data from 22 epilepsy patients. This could lead to more objective surgical targets and improved treatment outcomes.
Dr. Leon Iasemidis, a renowned expert in nonlinear dynamics and biomedical engineering, has been named a National Academy of Inventors Fellow for his outstanding inventions that have made a tangible impact on quality of life and economic development. He is recognized for his research in seizure prediction and control of epilepsy, with ...
Epilepsy is responsible for more US deaths than sudden infant death syndrome (SIDS) or fires, with over 2,750 cases of sudden unexpected death due to epilepsy annually. The disorder affects individuals over 65 years old, with a significant risk of sudden death and underreporting on death certificates.
Recent studies conclude that people with epilepsy have a 27-fold greater risk of sudden death than those without the disorder. Improved cause-of-death reporting and public education could prevent thousands of deaths annually.
Four studies explore the interplay between epilepsy and aging, revealing unexpected consequences on the brain. Researchers found that uncontrolled epilepsy can lead to accelerated brain aging, while others discovered a link between traumatic brain injury and post-traumatic epilepsy in the elderly population.
A study of 261 children with severe epilepsy found significant seizure reduction after taking pharmaceutical CBD (cannabidiol) in combination with anti-epileptic drugs. The frequency of seizures was reduced by a median of 45% in all participants, with some patients experiencing a 50% or greater reduction.
Research reveals disrupted sleep in people with epilepsy can impede memory formation, impair cognitive performance, and influence daily life. Studies show links between sleep disturbances and seizure control, as well as the impact of nighttime seizures on memory retention.
Researchers have developed personal monitoring devices that can track seizure activity in the home environment, providing advance warning before seizures strike. These devices use biometric recording technology and can operate for seven days on a single charge, revolutionizing epilepsy therapy.
Researchers unveil innovative studies on seizure detection and management, including electrodermal biofeedback and machine learning algorithms. These non-invasive methods offer accessible treatment options for patients with drug-resistant epilepsy.
Two studies unveil neural networks that produce and propagate seizure activity, providing information to refine surgical interventions. A third study describes a device capable of detecting and diminishing seizure activity through brief electrical stimulation.
Studies investigate biological factors behind memory decline in people with epilepsy, particularly those with temporal lobe epilepsy. Loss of neurons from the hippocampus is a common cause of impaired memory. Researchers also explore effects of seizures on signaling pathways and brain activity.
A new study identified three main brain regions where abnormalities are common to all types of focal epilepsy. The findings, published in Brain Connectivity, provide valuable insights into the neural networks underlying this neurological condition.
A new review of 45 years of medical literature found relatively few cases of meperidine-associated seizures, with coexisting conditions often contributing to the increased risk. The study concludes that meperidine's role as an effective anti-shivering agent should continue to be explored.
Scientists have developed a technique using optogenetics to suppress nervous system activity in genetically-altered fruit fly embryos, showing promise in preventing the onset of epilepsy symptoms when treated early enough.
A team of researchers has decoded a signaling pathway involved in the onset of seizure disorders, discovering that a central switch called MTF1 plays a key role. By inhibiting this switch, they were able to reduce seizures in epileptic mice, offering new potential for diagnosis and treatment.
A study of 74 children with TSC found that more extensive surgery, including the entire epileptogenic zone, yields better seizure control. The study suggests that simply resecting the tuber may not be enough, and that a larger area of surrounding tissue must also be removed to achieve optimal results.
A young adult developed clonic seizures while trying to solve Sudoku puzzles after being exposed to oxygen deficiency during an avalanche. The patient stopped solving the puzzle and has been seizure-free for over five years.
Researchers at Duke University have discovered a potential new class of drugs that may prevent the development of temporal lobe epilepsy. A small-protein drug called pY816 was found to reduce both the likelihood and severity of epilepsy in mice after an episode of prolonged seizures.
Children with TSC who undergo more extensive surgery have improved seizure control, whereas resecting just the tuber may not be enough. The study suggests that 'the malformed cortex surrounding the tuber may contribute more to epileptogenicity as opposed to the tuber itself'.
Researchers at Emory and Georgia Tech have developed inhibitory luminopsins that can modulate neuronal firing in culture and in vivo, enabling the study of ways to halt or prevent seizure activity. The tools use a glowing protein from coral as a light source, offering a cleaner alternative to traditional optogenetics.
Researchers at University of California, Irvine discovered that valproic acid preserves the M-current during seizures, which contributes to neuronal hyperexcitability. This finding points to new drug discovery approaches with fewer side effects.
Seizures are a common occurrence in childhood brain tumor survivors, affecting 24% at the start and 14% on an ongoing basis. Certain factors such as tumor type and extent of surgery contribute to seizure risk, impacting treatment management.
Seizures in neonates after cardiac surgery are common and linked to higher mortality rates, according to a new study. The study found that seizures were not uncommon and would not have been detected without continuous EEG monitoring.
A new study by the National Institutes of Health found no significant differences in birth complications between fetal ECG monitoring and traditional heart rate monitoring during labor. Infants in ECG-monitored groups were slightly more likely to have low Apgar scores, but overall outcomes remained unchanged.
Researchers found that people with epilepsy exhibit synchronized brainwave activity when listening to music, particularly in the temporal lobe region. This phenomenon may lead to novel therapies to prevent seizures in individuals with epilepsy.
A study by University of Iowa researchers has identified areas of the brain controlled by breathing, providing an important insight into SUDEP. Breathing loss was recorded when the amygdala was stimulated in human subjects, even if they were aware and awake.
The EpSMon app analyzes risk factors and provides personalized advice, helping users take actions to lower their risks. With around 600,000 people in the UK affected by epilepsy, this innovative tool aims to fill the information gap left by NHS funding cuts for GP monitoring.
Scientists confirm neuroprotective function of PrPC against epilepsy using four animal models, revealing its crucial role in preventing seizures. The study's precision and collaboration between international institutes make it a significant reference point in the field.
A team led by Professor Jozef Gecz has identified a gene mutation responsible for female-only epilepsy and found a treatment using synthetic allopregnanolone, promising to delay seizure onset and reduce autism and intellectual disability effects.
Researchers developed mobile applications to aid in everyday care for patients with epilepsy. These apps include seizure diaries, medication trackers, and alarm systems that detect epileptic seizures. Continuous EEG monitoring could also be made possible through special sensors integrated into smartphones.
Researchers at Johns Hopkins Medicine identified a potent seizure inhibitor in mice using D-leucine, an amino acid found in many foods and certain bacteria. The amino acid interrupts prolonged seizures effectively without sedative side effects, paving the way for new treatments for drug-resistant epilepsy.
A study using DNA from ivory samples identifies two major areas of elephant poaching in Africa, with over 85% of seized ivory tracing back to these regions. This research could help combat ivory trafficking at its source and inform law enforcement efforts.
Researchers used genetic tools to trace illegal ivory back to its source, identifying two primary poaching hotspots in Africa since 2006. The study found that most savanna and forest elephant tusks originated from Tanzania, Mozambique, Gabon, and the Central African Republic.
A multidisciplinary team of Loyola University Medical Center physicians report a case of a 12-year-old boy with refractory seizures due to an arteriovenous malformation (AVM) in the brain. The case highlights the challenge in distinguishing different lesions based on imaging, emphasizing the importance of carefully analyzing available ...
Recurrent febrile seizures warrant urgent assessment and consideration of antiepileptic drugs. The new report provides expert opinion-based recommendations until further studies consolidate higher evidence-based data.
Research finds EU tobacco agreements with major companies have failed to stop cigarette smuggling and recoup lost tax revenues. The agreements contain many loopholes that the industry can easily exploit, making them ineffective deterrents.
The task force recommends avoiding valproate in pregnant women due to high risks of malformations, while ensuring those with uncontrolled seizures receive effective treatment. The guidelines prioritize shared decision-making between clinicians and patients, balancing treatment benefits and risks.
A new study has found that high-pitched sounds can cause seizures in older cats, with certain breeds and triggers identified. The study, published in the Journal of Feline Medicine and Surgery, reveals that audiogenic reflex seizures (FARS) occur in pedigree and non-pedigree cats, often triggered by loud noises such as crinkling tin fo...
Benjamin Tolchin, a Massachusetts researcher, will receive a $130,000 award to investigate psychogenic non-epileptic seizures (PNES) and develop new treatment approaches. His research aims to identify ways to increase the number of patients who successfully complete therapy and eliminate their PNES.
A new guideline from the American Academy of Neurology and the American Epilepsy Society aims to help doctors treat the millions of people who experience their first seizure each year. The guideline found that taking epilepsy drugs immediately after a first seizure may reduce the risk of having another seizure.
A new guideline recommends administering an antiepileptic medication immediately after a first seizure to reduce the risk of another seizure within two years. The risk is highest for those with a previous brain injury or significant abnormality on imaging tests.
The new guidelines emphasize the importance of discussing treatment options with patients after a first seizure, weighing individual risks and benefits. Immediate treatment with an epilepsy drug may reduce recurrent seizures within two years, but its effectiveness decreases after three years.
A study found that cannabidiol, a non-psychoactive component of marijuana, significantly reduced seizures in children with severe epilepsy. The drug was shown to decrease seizures by an average of 54 percent and improve convulsive seizure activity. However, side effects were reported in 6% of participants.
Researchers have identified a genetic mutation in salt-inducible kinase 1 (SIK1) that regulates myocyte-specific enhancer factor 2C (MEF2C), contributing to severe seizures. The finding may lead to better treatment options for individuals with developmental epilepsy.
A novel deuterium-containing sigma-1 agonist, C-10068, demonstrated anti-seizure and anti-inflammatory effects in a preclinical model of traumatic brain injury (TBI). It affected multiple neurochemical pathways, including sigma-1 receptors, which play a widespread modulatory role in the central nervous system.
Researchers at KAIST identify brain somatic mutations in the MTOR gene as the cause of intractable epilepsy. These mutations are specific to the brain and can lead to permanent disabilities and death. A targeted therapy using rapamycin may offer a solution, suppressing mTOR kinase activation to lessen epileptic seizures.
A 10-year-old boy developed seizures and hypertension after consuming excessive licorice sweets. The case study highlights the dangers of overconsumption of glycyrrhizic acid in licorice, a risk particularly high for children with low body weight. Manufacturers are urged to state recommended daily limits as a safety measure.
A seven-year study found that responsive direct cortical stimulation significantly reduced seizures by up to 60% and improved quality of life. The Long-Term Treatment Study showed that 84% of participants experienced some improvement, with 16% being seizure-free for at least three months.
Researchers found that Broca's area is active early in forming sentences and ends its work before a word is spoken, suggesting it plays a key role in organizing the string of sounds that express ideas. The study could benefit the treatment of language impairments due to stroke, epilepsy, and brain injuries.