Articles tagged with Seizures
The American Academy of Neurology has issued an updated guideline outlining the best treatments for infantile spasms. The hormone therapy adrenocorticotropic hormone (ACTH) may be effective for treatment, with low-dose ACTH showing similar effectiveness to high-dose and potentially lower risk of side effects.
A 25-year follow-up study found that 68% of juvenile myoclonic epilepsy patients became seizure-free, with nearly 30% no longer needing antiepileptic drug treatment. AED polytherapy and generalized tonic-clonic seizures preceding bilateral myoclonic seizures predicted poor long-term seizure outcomes.
Researchers have found an imbalance between neuronal excitation and inhibition in individuals with Angelman syndrome, a neurodevelopmental disorder characterized by seizures, cognitive delay, and severe intellectual disability. This imbalance may underlie the high seizure activity observed in AS patients.
Researchers discovered a link between a protein called BAD and glucose metabolism in the brain, finding that modifications to this protein reduced seizure susceptibility. The study suggests that targeting BAD could lead to new treatments for epilepsy.
A protein called BAD modifies cellular metabolism in the brain, resisting epileptic seizures and providing a potential treatment option. Researchers discovered that altering BAD's function can reduce seizures without dietary therapy.
A study published in Epilepsia found that pediatric epilepsy severely affects both child and parental sleep patterns. Parents of children with epilepsy reported decreased sleep quality when sharing a room or co-sleeping with their child, while children experienced greater sleep disturbance and daytime sleepiness.
A Georgetown University Medical Center study found that phenobarbital stunts neuronal growth, leading to cognitive abnormalities in rats. The researchers suggest that anti-epilepsy drugs may not be as benign as thought and could have long-lasting impacts on brain function.
A new study found that how well people respond to their first drug treatment for newly diagnosed epilepsy can predict their likelihood of having more seizures. The study showed that 50% of participants were seizure-free after the first drug, while only 4% remained seizure-free after the third drug regimen.
A study published in Neurology found that the response to initial treatment can predict future seizure risk. The research followed 1,098 people with newly diagnosed epilepsy for up to 26 years and found that 50% were seizure-free after the first drug tried, while 4% became seizure-free after the third.
Michigan State University researchers are leading a clinical trial in Malawi to test the safety and feasibility of levetiracetam, an anti-seizure medication, to control seizures in children with cerebral malaria. The trial aims to improve neurologic outcomes for survivors, who often develop epilepsy or other neurologic disorders.
Researchers at MIT and two Boston hospitals have developed a simple wrist sensor that can measure the severity of epileptic seizures with high accuracy, potentially allowing patients to monitor their condition at home. The device could also predict seizure onset, enabling early intervention.
A new study from UCSF found that brain surgery for epilepsy has not increased in the decade since a landmark clinical trial demonstrated its effectiveness. Despite this, thousands of Americans suffer from uncontrolled seizures each year, highlighting disparities by race and insurance status.
The American Academy of Neurology issues new guidelines for preventing migraine, recommending several treatments including prescription drugs and over-the-counter options. These guidelines aim to address the underrecognition and undertreatment of migraine, with potential benefits in reducing attack frequency and severity.
Researchers have identified a protein called SUMO that regulates information transfer between nerve cells in the brain. The discovery could lead to new therapies for stroke and epilepsy.
Researchers at Johns Hopkins Medicine have developed a new medication, perampanel, that selectively targets proteins in the brain to control excitability and significantly reduce seizure frequency. The study, involving over 700 participants, found that roughly one-third of patients experienced a more than 50% reduction in seizures.
Patients with pseudo-seizures, also known as psychogenic non-epileptic seizures (PNES), often misdiagnosed due to stress-triggered symptoms. Research suggests that these patients lack effective coping mechanisms and are more distressed by stressful events than those with epilepsy or healthy individuals.
Researchers have developed new seizure detection software that significantly reduces false alarms, offering promise for improved epilepsy treatment. The system uses algorithms to detect imminent seizures and has been tested on real-time brain activity recordings from four patients with drug-resistant epilepsy.
A study by Kaiser Permanente found no increased risk of febrile seizures among 4-6 year olds after measles-containing vaccine administration. The research analyzed over 86,750 children and found that separate MMR plus V vaccines also did not increase the risk of febrile seizures in this age group.
A study published in Archives of Neurology found that early-initiated immunotherapy is associated with improved seizure outcomes among patients with autoimmune epilepsy. In a cohort of 32 patients, 81% reported improvement after immunotherapy and 44% were seizure-free within 12 weeks.
Researchers will study new methods to detect impending seizures using real-time EEG data, aiming to prevent seizures through fast-acting drug therapies. The goal is reliable seizure forecasting and timely intervention for both canine and human epilepsy.
A recent study published in JAMA found that patients with epilepsy who underwent brain surgery soon after failing to respond to drug treatment had a lower risk of seizures during the 2nd year of follow-up. The study showed that 73% of participants in the surgical group were seizure-free, compared to 0% in the medical group.
The research aims to use real-time EEG data to detect impending seizures and develop fast-acting drug therapies to prevent them. The technology has the potential to improve epilepsy management for both canine and human patients.
A study found that 73% of patients with mesial temporal lobe epilepsy who underwent surgery were seizure-free after two years. The procedure, called anteromesial temporal resection, also improved quality of life for those patients. Early diagnosis and referral to specialized centers are crucial for optimal treatment outcomes.
Researchers found that early surgical intervention followed by antiepileptic drugs stopped seizures and improved quality of life for patients with medically intractable temporal lobe epilepsy. The study suggests that surgery should not be viewed as a last resort for these patients.
A recent study published in Epilepsy & Behavior found that 41% of seizure-related tweets were derogatory, perpetuating negative attitudes towards epilepsy. The study highlights the need for improved epilepsy education to combat these stereotypes and promote positive change.
A new report from Michigan State University criminologists found that local police were involved in nearly half of the identified product counterfeiting cases related to Michigan, highlighting their crucial role in combating this growing crime. The study also revealed alarming statistics, including a $3 million fine for an individual c...
A new study has found that an autoinjector pen is a faster and more effective way to treat serious seizures, with 73% of patients becoming seizure-free upon arrival at the hospital. The treatment involves delivering medication directly into the thigh muscle via intramuscular injection, reducing precious time for paramedics.
A new study by Wayne State University reveals that an autoinjector delivering midazolam can effectively stop prolonged seizures in patients, with 73% of participants seizure-free upon hospital arrival. This method is faster and more reliable than traditional intravenous treatment.
A nationwide study has shown that injecting anticonvulsant medication into the thigh muscle using an autoinjector is as safe and more effective than traditional intravenous administration. The method resulted in 73% of patients being seizure-free upon arrival at the hospital, compared to 63% for those receiving IV treatment.
A study sponsored by NIH found that intramuscular injection of anticonvulsant drugs, like midazolam, is as safe and effective as giving medicine directly into a vein. This method may be faster and more reliable, especially for patients having convulsions, reducing the risk of severe consequences if seizures are not stopped quickly.
A national trial has shown that autoinjectors are quicker and more effective in stopping seizures than traditional IV line treatment. The study found that patients who received midazolam via an autoinjector were 73% seizure-free upon arrival at the hospital, compared to 63% of those receiving IV lorazepam.
Researchers discovered Substance P causes seizures in patients with neurocysticercosis (NCC), a parasitic tapeworm infection of the brain. Blocking Substance P receptors may prove effective in treating and preventing seizures in affected individuals.
Researchers found that selective serotonin reuptake inhibitors (SSRIs) like fluoxetine can prevent sudden death in epilepsy patients by enhancing respiratory function. The study provides hope for developing treatments to lessen SUDEP risk, but further studies are needed to confirm its effectiveness in humans.
Researchers found Substance P, a pain transmitter, causes seizures in brain-infected patients; blocking its receptor may provide treatment relief. The study suggests a new approach for managing seizures in these patients.
A 26-year study found that nearly half of epilepsy surgery patients were free of disabling seizures, while 80% reported better quality of life. The study suggests increased use of surgical intervention could offer patients long-term seizure control and improved lives.
A new study by Brown University researchers found that exposure to a common cosmetic chemical, methylisothiazolinone (MIT), can disrupt the fine wiring of the nervous system in tadpoles, even at very low concentrations. The study suggests that lower concentrations of MIT may be detrimental to brain development.
A new guideline issued by the American Academy of Neurology recommends caution when selecting seizure medications for individuals with HIV/AIDS due to the risk of adverse interactions. The guideline aims to minimize the impact of these drug combinations, particularly in developing countries where treatment options are limited.
Researchers have developed a flexible brain implant that could pinpoint seizure start points and shut them down. The device conforms to the brain's surface, allowing for unprecedented brain activity observation.
Sudden unexpected death in epilepsy (SUDEP) affects 2.7 million Americans, with a high risk associated with chronic and severe cases. Increased awareness, improved prevention, and better treatments can help reduce SUDEP rates through devices that detect seizures and understanding its mechanisms.
A first-of-its-kind study found that brain stimulation significantly reduced 'medically refractory' epileptic seizures in adults. The NeuroPace Responsive Neurostimulation System delivered electrical pulses to stop seizures, providing a new treatment option for patients who have tried multiple medications and surgery without success.
The AAN has released an updated guideline for treating essential tremor, recommending the use of medications such as propranolol and primidone to improve shaking in people with the disorder. The guideline also suggests that brain surgery may be a viable option for those who do not benefit from drug treatment.
Around half of adults undergoing surgery for epilepsy are seizure-free after 10 years, with improved outcomes seen for those with anterior temporal resections. The study highlights the need for further improvements in presurgical assessment and surgical treatment to increase success rates.
A study funded by the Department of Defense aims to understand the long-term effects of traumatic brain injury on soldiers. The researchers hope to develop better treatments for post-traumatic epilepsy and headache, two conditions often occurring together after TBI.
A new study found that epilepsy patients who receive additional treatment with antiepileptic drugs have a seven times lower risk of dying from a sudden unexpected death. The study suggests that the reduction in seizure frequency is the most likely explanation for this finding.
Researchers found respiratory alkalosis in children with febrile seizures and metabolic acidosis in pediatric patients admitted for gastroenteritis. The study suggests that applying 5% carbon dioxide to breathing air could be a possible treatment for febrile seizures.
Human gliomas implanted in mice were found to release excess levels of glutamate, overstimulating neurons and triggering seizures. Sulfasalazine, an anti-inflammatory drug, was shown to reduce seizures by inhibiting glutamate release from the tumor.
A new study published in Neurology found that psychogenic non-epileptic seizures may be misdiagnosed for up to five years in veterans compared to one year in civilians. The delay is largely due to limited access to epilepsy monitoring units, which can lead to delayed diagnosis and treatment.
A study of 17 cats with epilepsy revealed that early treatment can lead to improved outcomes and a better quality of life for affected animals. The researchers found changes in the hippocampus similar to those seen in human MTLE-HS, but without structural brain damage.
Rasmussen Encephalitis is a rare neurological disease causing seizures, cognitive deficits and paralysis of half the body. Researchers at UCLA aim to narrow down the cause(s) of the disease using animal models and collaboration between experts in brain immunology and neuropathology.
Researchers at U of M Medical School used advanced MRI technology to develop a better approach to diagnosing epilepsy. The study revealed highly detailed images of brain tissue, allowing doctors to accurately locate scar tissue associated with the condition.
Research confirms fast ripples as a reliable marker for the brain region responsible for seizure activity in children. Resection of brain regions with fast ripples and seizure-onset zones may lead to better seizure outcomes, suggesting a new surgical approach to improve treatment.
Researchers have identified a new gene, LGI2, linked to human benign childhood epilepsies characterized by seizure remission. The discovery provides new insights into the development of a child's brain and the mechanisms of childhood epilepsy.
A new UCSF study reveals that brain surgery can completely cure two-thirds of people with severe and untreatable epilepsy, highlighting the importance of accurate brain mapping in achieving successful outcomes. The study's findings also underscore the need for further research into developing new methods to pinpoint seizure sources.
A recent study found that women with generalized tonic-clonic seizures had a greater number of seizures during anovulatory cycles than in ovulatory cycles. This suggests that reproductive steroids, such as estradiol and progesterone, may contribute to the occurrence of tonic-clonic seizures.
Research highlights the importance of controlling seizures through effective drug treatment and good compliance in protecting against SUDEP. The study also recommends modifying risk factors such as polytherapy and non-adherence to prescribed medications.
Researchers have identified a central switch responsible for transforming healthy brain cells into epileptic ones. The discovery marks a dramatic change in understanding how temporal lobe epilepsy (TLE) develops, revealing the role of epigenetic mechanisms and a master switch-like protein called NRSF.
Researchers at UC Riverside have made a breakthrough discovery in understanding epileptic seizures by developing a computational model that simulates the cortical network. The model shows that restricting chloride increase can lead to faster seizure termination and even make seizures impossible, offering new hope for treating epilepsy.
A recent study found that preschool children with epilepsy exhibit significant cognitive impairment, particularly those with early-onset seizures. The study suggests that age at seizure onset is a crucial factor in determining cognitive function, with higher IQ scores associated with later seizure onset.
Researchers found that antiepileptic drugs reduce seizures but worsen sleep and communication issues, while non-antiepileptic drugs improve symptoms without reducing seizure frequency. Non-traditional diets like ketogenic and gluten-free diets showed promise in lessening seizure severity.
Researchers have developed a novel technology to precisely modulate individual neurons, allowing for unprecedented insight into cellular mechanisms of neuronal networks. The technology enables real-time monitoring of brain activity, detection or prediction of seizure onset, and simultaneous treatment with anti-convulsive drugs.