Articles tagged with Seizures
Exposure to commonly prescribed antiseizure medications during pregnancy does not negatively impact neurodevelopmental outcomes in young children. The MONEAD study found that lamotrigine and levetiracetam pose low risks for cognitive effects, with some caution needed for high dosages of levetiracetam.
A University of Ottawa study reveals that a diverse brain's ecosystem is key to maintaining normal function while responding to changes. This concept is inspired by Charles Darwin's idea that biodiversity is crucial for survival, suggesting cell-to-cell diversity helps prevent failures in brain circuits.
A new study by investigators from the Brigham and Women’s Hospital found that lesions associated with epilepsy are connected to a common brain network, suggesting the brain connections disrupted by the lesions are key. This discovery may have clinical implications for predicting epilepsy risk and targeting treatments.
Researchers at Tel Aviv University have developed an innovative gene therapy that shows promise in treating Dravet syndrome, a severe developmental epilepsy affecting children. The treatment was found to be effective in improving epilepsy, protecting against early death, and enhancing cognitive abilities.
The Hotchkiss Brain Institute will recruit and train emerging neuroscience research leaders to improve brain and mental health globally. Dr. Deepika Dogra's innovative method screens anti-seizure drugs for children using cerebral organoids.
A new study published in Neurology found that people with focal epilepsy experience seizures while driving at a rate of 5%, with significant risks for themselves and others on the road. Early diagnosis is crucial to prevent these seizures, which can lead to accidents and hospitalizations.
Researchers have developed a simple blood test that can diagnose De Vivo disease, a rare and disabling neurological disorder. The test, called METAglut1, has a high sensitivity and specificity, allowing for accurate diagnosis in a short amount of time.
Researchers from Tel Aviv University and UCLA developed a method to improve memory consolidation by inducing deep-brain stimulation during sleep. The study found that precise timing of electrical stimulation enhances synchronization between the hippocampus and frontal cortex, leading to improved accuracy in recalling memories.
A significant increase in illicit ketamine seizures in the US has raised concerns about the risks of non-medical and recreational use, as well as the presence of fentanyl. The study found a 349% rise in seizures from 2017 to 2022, with the highest numbers reported in Tennessee, Florida, and California.
Researchers at UVA Health System have made a breakthrough discovery about the role of microglia in seizure disorders. The study suggests that enhancing microglial activity could be a promising approach to preventing and managing seizures, offering new hope for patients who don't respond to existing treatments.
Researchers have identified 11 somatic mutations in the RAS/MAPK pathway that contribute to treatment-resistant adult epilepsy, suggesting the potential for repurposed anti-cancer agents as new treatments. This study provides insight into the genetic mechanisms underlying this form of epilepsy and opens up new avenues for targeted ther...
A new study published in PNAS reports surge of gamma activation in dying brains of humans and animals post-cardiac arrest, hinting at conscious-like activity.
Researchers developed a machine learning model that predicts strokes more accurately than current systems, using data available at hospital arrival. The model achieved high precision and sensitivity, outperforming existing scales.
A study published in Brain found that disconnecting nerve pathways in the brain can lead to improved seizure freedom in patients with frontal lobe epilepsy. The research, involving 47 patients, revealed that cutting these connections resulted in 88% of patients being seizure-free after three years.
A new study identifies several cytokine markers associated with poor prognosis in New-Onset Refractory Status Epilepticus (NORSE) patients. The researchers found that the concentration of these inflammatory proteins was higher in NORSE patients than controls, and their increase was correlated with short-term and long-term neurological ...
Researchers from CHOP developed a prediction model that determines which newborn babies are likely to experience seizures in the NICU. The model, built using machine learning methods, can predict seizures with over 90% accuracy, particularly in newborns with hypoxic-ischemic encephalopathy.
Researchers have discovered that altered neuronal avalanches in epilepsy patients' brains are tied to cognitive performance. The study found that even during rest, the brain's network dynamics are altered, which can be used for a new diagnostic method.
A new study by Tufts University researchers has identified a small molecule, Compound 350, that may help treat people with epilepsy whose condition has become resistant to traditional anti-seizure drugs. The compound was found to reduce seizure activity in rodents with drug-resistant seizures and lower brain cell death.
Researchers have discovered higher levels of immune proteins in the blood before and after epileptic seizures. The study suggests a potential biomarker for epilepsy, which could be identified using a simple blood test. This finding may help distinguish epilepsy from other conditions, such as psychogenic non-epileptic seizures.
Researchers at UTHealth Houston received $15 million in NIH BRAIN grants to study brain processes related to speech, epilepsy, and reading. A new minimally invasive device will be developed to record brain activity during speech, while another project aims to disrupt seizures using neuromodulation.
A study published in NEJM Evidence found that seizures can be predicted at least 35 minutes before onset in patients with temporal lobe epilepsy. This breakthrough discovery has significant implications for developing more effective therapies for this common seizure disorder, which affects over 50 million people globally.
Researchers identify duplicated gene as cause of social deficits and seizures in autism type, finding that reducing PRRT2 levels can restore normal brain activity and behavior. This discovery could lead to novel therapies for neurodevelopmental disorders with brain over-activation.
A Chinese Medical Journal study analyzed the temporal and spatial distribution of epilepsy across China, finding significant increases in incidence and prevalence rates between 1990 and 2019. The study also showed a general decrease in age-standardized DALY rates with increasing socio-demographic index.
A team of researchers at Baylor College of Medicine found that glioma-related epilepsy is driven by IGSF3-mediated potassium dysregulation. This disruption leads to seizure activity, which favors disease progression. The study used human patients and animal models to confirm the findings.
A study reveals how CBD reduces seizures in pediatric epilepsy by blocking signals carried by lysophosphatidylinositol (LPI), a molecule that can amplify nerve signals and promote seizures. The research provides new insights into the mechanisms behind seizures and suggests potential targets for future drugs.
A group of researchers from Chung-Ang University have summarized the applications based on anomaly detection in multivariate time series. They evaluated the current state-of-the-art anomaly detection techniques and addressed the challenges associated with them, providing a thorough overview of the applications for anomaly detection in ...
A new study found that a medication previously used to treat seizures can reprogram donor hearts to boost the production of beneficial enzymes, increasing storage time and improving post-transplant function. This technology could lead to a paradigm shift in extending heart storage and reducing primary graft dysfunction.
A new study found that Black and Hispanic stroke survivors in the US are less likely to receive treatment for common complications, despite improved overall stroke survival rates. Researchers analyzed electronic health records from 2002 to 2022 and matched patients based on 41 factors to minimize biases.
NeuralTree is a closed-loop neuromodulation system-on-chip that can detect and classify biomarkers from real patient data and animal models of disease in-vivo, leading to high accuracy in symptom prediction. The system boasts 256 input channels, making it highly versatile and scalable.
A personalized brain modeling approach is being tested in a large-scale clinical trial for drug-resistant epilepsy, aiming to improve surgery preparation and patient specificity. The technique uses virtual models of patients' brains to simulate abnormal activity during seizures, helping clinicians identify target areas more effectively.
A nationwide registry of AVM patients from 52 hospitals in mainland China investigated the efficacy of different treatments on patient groups. The study found that categorizing treatment strategies based on disease severity is an ideal approach, and a multidisciplinary comprehensive assessment promotes individualized treatment protocols.
Researchers developed an innovative deep learning-based approach to classify epileptic seizures in near real-time, overcoming clinical limitations. The system uses action recognition with intelligent 3D cropping to distinguish between frontal and temporal lobes seizures or non-epileptic events.
Researchers at Johns Hopkins University have developed two new models that can identify where seizures originate in the brain, potentially leading to more effective surgeries and improved patient outcomes. The models use machine learning and calculus to analyze brain activity patterns, predicting seizure onset with 79% accuracy.
A research team led by City University of Hong Kong neuroscientist Dr. Geoffrey Lau Chun-yue identified a new drug candidate, D4, that selectively blocks connexin hemichannels to suppress neuroinflammation and curbs TLE seizures in a mouse model. The findings suggest a promising new treatment strategy for epilepsy.
A new study finds that children with severe forms of epilepsy, such as Dravet syndrome, are at high risk of seizures triggered by the flu. The seasonal influenza vaccine is recommended for these children to protect them from complications and prolong their survival.
A three-year research project led by Aston University aims to prevent epileptic seizures in children. The team will explore how epilepsy becomes established in the brain and test new drugs using living tissue samples.
A new study led by Rice University and UCSF researchers found that seizure cycles are linked to age and common triggers, such as illness and menstrual cycles. The study used data from over 1,000 patients aged 2 months to 80 years to develop a statistical model that captures the effect of these factors on seizure risk.
Researchers have developed a new gene therapy that selectively targets overactive brain cells, reducing excitability and suppressing seizures in mice. The treatment shows promise for treating neurological disorders such as epilepsy, Parkinson's disease, schizophrenia, and pain disorders.
The study provides detailed pictures of NMDA receptors, which mediate essential signals between neurons. The findings have significant implications for treating schizophrenia, depression, and other neuropsychiatric conditions.
Researchers found that structural racism and insurance barriers limit access to advanced epilepsy care for minority groups in New Jersey. Black patients with private insurance and Medicaid had the lowest EMU admission rates relative to emergency room visits.
A study finds that functional seizures, a type of non-epileptic seizure, are associated with structural changes in the brain, including thinning in the superior temporal cortex and thickness in the left occipital cortex. These differences can be detected using MRI scans.
Researchers aim to shift policing focus from law enforcement to building strong communities through situational policing. The approach considers connections within the community and collaboratively builds resources.
Researchers developed an algorithm to decode brain scans and identify epilepsy types based on electrical signal patterns. The Cumulative Sharp Count and areas under spike and sharp curves were used as parameters to detect epilepsy, with high accuracy rates in blind validation studies.
A new study published in Cell Reports has identified the molecular pathways responsible for reduced seizures during fasting. The researchers found that amino acid sensing plays a critical role in the beneficial effects of fasting on seizures, suggesting targeted dietary strategies may be effective for patients without DEPDC5 mutations.
A review of evidence found that 2-3% of monkeypox patients experienced severe complications such as seizure or encephalitis. Mood disorders like depression and anxiety were also common among infected individuals.
A recent study by Florida Atlantic University and Nova Southeastern University has linked the use of herbicide Roundup to convulsions in soil-dwelling roundworms, suggesting that glyphosate targets GABA-A receptors. The study found that even low concentrations of glyphosate had concerning effects on the nervous system.
Researchers developed a peptide that can be administered through nasal spray to reduce seizure activity and protect neurons in both Alzheimer's and epilepsy. The A1R-CT peptide inhibits neurabin, a protein that prevents the overactivation of neurons, allowing for increased action by adenosine receptors.
A new AI algorithm has been developed to detect subtle brain abnormalities causing epileptic seizures. The Multicentre Epilepsy Lesion Detection project used over 1,000 patient MRI scans to train the algorithm, which was able to detect focal cortical dysplasia (FCD) in 67% of cases. This could lead to more patients being considered for...
Astrocytes in the thalamus play a key role in susceptibility to seizures after brain injuries. Targeting a specific protein, GAT3, in these cells may prevent long-term damage.
A study of nearly 4.5 million children found a potential association between prenatal exposure to antiseizure medications and increased risk of neurodevelopmental disorders. The research suggests that further investigation is needed to confirm these findings.
Researchers discovered a previously unknown mutation in a child with epilepsy that affects the functioning of ion channels, which are crucial for brain function. The mutation has been found to decrease the function of normal proteins as well, highlighting the importance of studying genetic mutations.
A recent study in CMAJ found that nearly half of Canadian drownings were caused by pre-existing medical conditions, with seizure disorders posing a significant risk. Young women aged 20-34 with seizure disorders were particularly vulnerable, facing a risk 23 times higher than the general population.
Researchers tracked brain cell activity in zebrafish during seizures, finding that seizures arise from an excess of excitatory over inhibitory neuron activity in confined regions. The findings suggest a nuanced role for both excitation and inhibition in seizure origins.
Researchers have identified a potential method of preventing damaging seizure activity by restoring the integrity of blood vessels in the brain. This breakthrough could hold promise for treating patients who are currently non-responsive to anti-seizure medications.
Researchers discovered newborn neurons and immature astroglia in patients with epilepsy, which could lead to new anti-seizure medications. The study suggests that targeting immature astroglia may be an effective approach to controlling seizures without aggressive brain surgery.
A new study by researchers at the University of Chicago Medicine has identified a set of sporadic genetic mutations that make it more likely a person will develop cavernous angiomas, which can lead to stroke and seizures. Understanding these underlying causes is key to identifying patients at risk and finding effective treatments.
A research team found that limiting energy in neurons increases hyperexcitability and severity of seizures in mice. The ketogenic diet restored mitochondrial function and reduced seizure intensity.
Researchers created cortical organoids from patients' skin cells, mimicking focal cortical dysplasia and identifying mechanisms involved in its emergence. The model can be used to screen existing medications for patients with severe epilepsy.
Researchers discovered that epilepsy patients' social media activity increased before their sudden deaths from SUDEP. The study found significant alterations in the patients' digital behavior, including changes in the number of words written and drastic sentiment shifts in their posts.
When the eyes land on a face, certain cells in the amygdala react and trigger memory-making activity. Theta wave activity is also reset or restarted, preparing the hippocampus to receive new socially relevant information.