Articles tagged with Seizures
A CHOP study demonstrates that remote continuous EEG monitoring can detect seizures in at-risk neonates, impacting clinical care and guiding treatment decisions. The study showed that seizures occurred in about one-quarter of the records, with CEEG impacting outcomes in three-quarters of cases.
Researchers at George Washington University discovered that GABAergic interneurons in the hippocampus are excitatory during development, rather than suppressive. This finding could lead to more targeted therapies for infantile seizure disorders.
A study published in Epilepsia journal found that 8% of individuals with a history of seizures report hallucinations, which are associated with a higher risk of mental health disorders and suicidal behavior. The study highlights the importance of assessing hallucinations in epilepsy clinics to identify high-risk patients.
A recent clinical research study found that listening to Mozart's Sonata for Two Pianos in D Major, K. 448 daily reduced seizure frequency in adult individuals with epilepsy. The study suggests this as a supplemental therapeutic option for those who do not respond well to anti-seizure medications.
A study published in Lancet Psychiatry found that adding cognitive behavioral therapy (CBT) to standardised medical care significantly reduced the frequency of dissociative seizures, improved functioning, and enhanced quality of life. Researchers recommend incorporating CBT into specialist care for patients with dissociative seizures.
Adding CBT to standard medical care gives patients with dissociative seizures longer periods of seizure freedom and a greater quality of life. This study suggests that CBT combined with specialist care can improve symptoms and satisfaction for those affected by this condition.
Researchers found that naked mole-rats require high levels of carbon dioxide to function, unlike other mammals. The genetic mutation in the KCC2 gene leads to impaired brain inhibition, which is compensated by increased carbon dioxide levels.
Researchers found that advancing glioma cells desynchronize neuronal activity and blood flow changes, affecting neurovascular coupling and potentially leading to seizures. The study provides promising targets for disrupting tumor growth and offers insights into diagnosis and surgical guidance.
University of Iowa scientists have identified a specific area of the brain involved in seizure-induced loss of breathing, which could help predict and prevent sudden unexpected death due to epilepsy. The Amygdala Inhibition of Respiration (AIR) site was found to be critical in children with epilepsy.
Researchers have discovered a potential new treatment for drug-resistant epilepsy using compounds derived from magnolia trees. The study found that extracts from the bark of Magnolia officinalis reduced seizure-like behavior in both zebrafish and mice, providing a promising lead for the development of new treatments.
A preliminary study by the American Academy of Neurology found that children and teens with epilepsy who were treated with pharmaceutical cannabidiol (CBD) had better seizure control compared to those treated with artisanal CBD. Pharmaceutical CBD was found to have a 39% reduction in seizures, while artisanal CBD resulted in a 70% incr...
Researchers found that developing seizures after a severe ischemic stroke increases the risk of death and disability. The study identified several risk factors for post-stroke seizures, including age, severity of stroke, and previous heart conditions.
Researchers have developed sensitive and specific potassium nanosensors that can monitor dynamic changes of potassium ions in the brain during epileptic seizures. These nanosensors enable the accurate sensing of potassium levels in different parts of the brain, facilitating the diagnosis and therapy of epilepsy.
Researchers developed an algorithm using deep convolutional neural networks to analyze myoclonus severity from video footage. The method successfully quantified myoclonic jerks in EPM1 patients, correlating well with clinical evaluations and detecting small-amplitude and high-frequency jerks.
A recent study published in Seizure found that over 40% of status epilepticus patients suffer from adverse outcomes, including a 9% risk of death. The researchers developed two prognostic scores, STESS and EMSE, which can accurately predict mortality risk in the emergency room.
Researchers at Duke-NUS Medical School and NNI discovered that misregulated potassium ion channel activity causes seizures in AS patients. Suppressing this activity could potentially resolve seizures, benefiting people with autism as well.
Researchers found that implanted neurostimulators can record brain data during anxiety attacks, guiding therapy changes to reduce negative symptoms caused by seizures. Five patients with epilepsy showed improvements in treating neuropsychiatric comorbidities through data analysis and counseling.
A randomized controlled trial found that fenfluramine reduced convulsive seizures by 62% in patients with Dravet Syndrome. Low-dose fenfluramine also showed significant reductions in seizure frequency, while side effects were manageable.
Researchers found that fenfluramine significantly reduced convulsive seizures in Dravet syndrome patients, with a 62% decrease in seizures per month. The study also showed improvements in seizure-free intervals and parental assessments of child improvement.
Scientists at Georgetown University Medical Center have discovered that a specific set of neurons in the brain can be targeted to stop seizure activity. The study's findings provide new hope for treating epilepsy, an incurable condition affecting millions worldwide.
Researchers have discovered that drugs targeting brain inflammation can reverse cognitive decline in aged mice by reducing the 'fog' of inflammatory load. This breakthrough offers a potential new treatment for dementia and age-related diseases, with two biomarkers identified to flag people with blood-brain barrier problems.
A new statistical tool has been validated for assessing epilepsy seizure risk, allowing for more accurate treatment decisions. The Epilepsy Seizure Assessment Tool (EpiSAT) correctly identified changes in seizure risk in over 87% of cases.
A new study found that intravenous levetiracetam, fosphenytoin, and valproate are equally effective in stopping status epilepticus seizures, with each drug working about 45% of the time. The results suggest a major change in clinical practice, recommending increased dosing of commonly used levetiracetam.
A new study reveals that levetiracetam, fosphenytoin, and valproate are equally safe and effective in treating patients with refractory status epilepticus, a life-threatening condition characterized by prolonged seizures. The three drugs stopped seizures and improved responsiveness in approximately half of the study participants.
A new study has found that levetiracetam, fosphenytoin, and valproate are equally safe and effective in treating patients with refractory status epilepticus. The three drugs were tested on over 380 children and adults, showing similar benefits in stopping seizures and improving responsiveness.
Cenobamate reduces seizures by 55% in patients with treatment-resistant epilepsy, offering new hope for those who have limited success with traditional medications. The study, led by Johns Hopkins lead investigator Gregory Krauss, involved 437 participants across 16 countries and found significant improvements in seizure control.
A new study published in the British Journal of Clinical Pharmacology found that cannabidiol may not have a significant antiepileptic effect on seizure frequency in patients with Lennox-Gastaut syndrome. However, the interaction between cannabidiol and clobazam could be responsible for the reduction in seizures.
New research by UVA neonatologist Jennifer Burnsed suggests that seizures caused by inadequate oxygen and blood flow can lead to behavioral issues and learning disabilities later in life. Mapping brain activity during infant seizures may help predict outcomes and inform treatment options.
A new gene therapy has shown promise in suppressing epileptic seizures in animal models and human tissue samples. The treatment delivers a specific gene that produces dynorphin, modulating neural activity and dampening seizure spread.
Researchers identified a new neurological syndrome caused by IQSEC1 gene mutations, affecting five patients from consanguineous families in Pakistan and Saudi Arabia. The study used fruit flies and mice to demonstrate that defective IQSEC1 proteins contribute to intellectual disability and neural development defects.
A Stanford University School of Medicine study found that even people with well-controlled epilepsy often experience cognitive deficits due to abnormal brain electrical activity called high-frequency oscillations. The research suggests that certain medications or implantable devices could be improved to alleviate these deficits.
Researchers found that the endoplasmic reticulum stress response helps reduce brain activity during seizures, potentially leading to more effective epilepsy therapies. The study's findings may also provide insights into other neurological disorders caused by seizures.
A study published in Annals of Neurology found that the spread of seizures through the brain can be suppressed by a
Researchers found that CBD substantially lessened seizure severity in mice and restored normal brain rhythms in Angelman syndrome models. The study suggests CBD could benefit kids and adults with this serious condition, characterized by intellectual disability and epilepsy.
A systematic review and meta-analysis suggests that people with drug-resistant epilepsy have better prospects of being seizure-free if they undergo surgical treatment at an earlier stage. The study found a 15-21% higher probability of attack freedom for those who underwent surgery early compared to later stages.
Researchers have developed a new machine learning algorithm that can detect the seizure onset zone in just 10-20 minutes, eliminating the need for prolonged monitoring and reducing risks. This breakthrough could lead to a new treatment approach for epilepsy patients, particularly those with drug-resistant forms of the disease.
Researchers found that higher serotonin levels after a seizure are associated with less breathing dysfunction, particularly in people who do not temporarily stop breathing during seizures. This study provides new insights into the possible link between serotonin levels and breathing during and after seizures.
Researchers found that glial cells, which make up 80% of brain cells, contribute to seizures by releasing glutamate, a chemical that transmits signals between neurons. The study suggests that targeting glial cells may lead to new treatments for epilepsy.
Researchers identified a gene in fruit flies that helps prevent seizures triggered by environmental stress. In humans, mutations in the gene may be linked to seizures associated with Long QT Syndrome, suggesting a potential connection between brain and heart function.
Mutations of a gene implicated in long QT syndrome trigger seizures due to its direct effects on neurons and glia, independent from heart function. This discovery challenges the assumption that seizures are secondary outcomes of cardiovascular disease.
Researchers at UTSA have successfully removed new neurons that developed after a brain injury to reduce seizures in mice. The study found a 65% reduction in seizures, but the effect was not permanent and may be due to underlying factors such as chronic inflammation or reactive astrocytes.
Researchers uncovered the molecular action of cilantro as a potent KCNQ channel activator, reducing seizure activity and opening potassium channels in the brain. This discovery may lead to more effective use of cilantro as an anticonvulsant or development of safer and more effective anticonvulsant drugs.
Researchers at UT Health San Antonio have discovered a novel therapy that reduces brain damage after traumatic brain injury (TBI) in mice, preventing seizures and reducing inflammation. The study aims to develop a simple and effective treatment for TBI patients.
Researchers found that removing new neurons born after a brain injury reduced seizures in mice, with a 65% decrease observed. This approach may potentially prevent post-injury epilepsy if implemented within a specific time frame.
A study by the University of Saskatchewan found that medicinal cannabis oil containing CBD and THC can reduce or end seizures in children with severe, drug-resistant epilepsy. The research team tested a dosage regimen that showed significant improvements in quality of life for the children, with some experiencing complete seizure freedom.
The UAB clinic has achieved rapid accessibility and improved seizure control for patients with drug-resistant epilepsy. Vagal nerve stimulation (VNS) and responsive neurostimulation (RNS) therapies have shown promise, with 12-11 out of 27-16 patients experiencing a 60% reduction in seizures.
A new study found that stimulating the brain's dorsal anterior insula triggers an ecstatic aura in epileptic patients. This region is proposed to be a key area for elicit symptoms of altered consciousness and ecstasy-like experiences. The findings provide additional support for its role in human consciousness.
Researchers discovered a genetic basis for sudden unexpected death in epilepsy (SUDEP), suggesting that a specific gene mutation can disrupt brainstem cells controlling breathing. The study used mice with the mutation to test its effects, finding disordered breathing patterns and reduced inhibitory cell activity.
A new study found that even people with well-controlled epilepsy are at risk of sudden unexpected death in epilepsy (SUDEP). Researchers analyzed cases referred to the North American SUDEP Registry and found that sleep deprivation, skipping medication, and lack of seizure activity were common factors contributing to SUDEP.
A new study found that inducing seizures in epilepsy patients can determine the brain region where seizures originate, reducing hospital stays from two weeks to 48 or 72 hours. This method is as effective as relying on spontaneous seizures and could lead to cost savings for hospitals.
Research suggests that strobe lighting at electronic dance music festivals triples the risk of epileptic fits in susceptible individuals. Organisers are advised to issue warnings and provide preventive measures for those with photosensitive epilepsy.
Researchers at FutureNeuro have discovered molecules in the blood that are higher in people with epilepsy before a seizure happens. These molecules are fragments of transfer RNAs (tRNAs), which could serve as an early warning system for predicting seizures.
A synthetic, non-intoxicating analogue of cannabidiol (CBD) has been found to be effective in treating seizures in rats, reducing both frequency and severity with equal efficacy to herbal CBD. This breakthrough offers a safer and more accessible alternative for epilepsy treatment, potentially paving the way for clinical trials.
A pilot study led by Dr. Stephanie McGrath found that 89% of dogs who received CBD had a reduction in seizure frequency. The research suggests a correlation between CBD concentration and seizure reduction, leading to potential alternative treatments for canine epilepsy.
Researchers found that successful epilepsy surgery can restore brain networks, leading to improved quality of life for patients with temporal lobe epilepsy. The study showed significant improvements in brain network activity after surgery compared to healthy subjects.
Researchers have identified a small organic compound called gluconate that acts as an anticonvulsant, inhibiting seizures by targeting chloride ion channels. The study found that gluconate suppresses seizure activity more effectively in neonatal animals than adults.
A new tool developed by Queen Mary University researchers can accurately predict the risk of seizures during pregnancy and up to six weeks after delivery. The EMPiRE tool uses routinely collected data to inform care and close monitoring, potentially reducing maternal and fetal mortality.
A phase 3 study found that taking pharmaceutical cannabidiol cut seizures nearly in half for children with Dravet syndrome. The treatment showed significant efficacy even among those who had tried multiple other medications without success.
Researchers at MIT's Picower Institute found that excess calcium in glia cells causes them to hyper-activate a molecular pathway leading to seizures. They identified calcineurin and sandman proteins as key players in the process, suggesting a promising avenue for future drug development.
A new study found that rapid whole genome sequencing can identify etiology and direct therapy in neonates with unexplained seizures. The analysis revealed six molecular diagnoses out of 19 patients, leading to changes in management for four patients, including targeted seizure medications and dietary supplements.