Articles tagged with Seizures
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Researchers found that fenfluramine significantly reduced convulsive seizures in Dravet syndrome patients, with a 62% decrease in seizures per month. The study also showed improvements in seizure-free intervals and parental assessments of child improvement.
Scientists at Georgetown University Medical Center have discovered that a specific set of neurons in the brain can be targeted to stop seizure activity. The study's findings provide new hope for treating epilepsy, an incurable condition affecting millions worldwide.
Researchers have discovered that drugs targeting brain inflammation can reverse cognitive decline in aged mice by reducing the 'fog' of inflammatory load. This breakthrough offers a potential new treatment for dementia and age-related diseases, with two biomarkers identified to flag people with blood-brain barrier problems.
A new statistical tool has been validated for assessing epilepsy seizure risk, allowing for more accurate treatment decisions. The Epilepsy Seizure Assessment Tool (EpiSAT) correctly identified changes in seizure risk in over 87% of cases.
A new study found that intravenous levetiracetam, fosphenytoin, and valproate are equally effective in stopping status epilepticus seizures, with each drug working about 45% of the time. The results suggest a major change in clinical practice, recommending increased dosing of commonly used levetiracetam.
A new study reveals that levetiracetam, fosphenytoin, and valproate are equally safe and effective in treating patients with refractory status epilepticus, a life-threatening condition characterized by prolonged seizures. The three drugs stopped seizures and improved responsiveness in approximately half of the study participants.
A new study has found that levetiracetam, fosphenytoin, and valproate are equally safe and effective in treating patients with refractory status epilepticus. The three drugs were tested on over 380 children and adults, showing similar benefits in stopping seizures and improving responsiveness.
Cenobamate reduces seizures by 55% in patients with treatment-resistant epilepsy, offering new hope for those who have limited success with traditional medications. The study, led by Johns Hopkins lead investigator Gregory Krauss, involved 437 participants across 16 countries and found significant improvements in seizure control.
A new study published in the British Journal of Clinical Pharmacology found that cannabidiol may not have a significant antiepileptic effect on seizure frequency in patients with Lennox-Gastaut syndrome. However, the interaction between cannabidiol and clobazam could be responsible for the reduction in seizures.
A new gene therapy has shown promise in suppressing epileptic seizures in animal models and human tissue samples. The treatment delivers a specific gene that produces dynorphin, modulating neural activity and dampening seizure spread.
New research by UVA neonatologist Jennifer Burnsed suggests that seizures caused by inadequate oxygen and blood flow can lead to behavioral issues and learning disabilities later in life. Mapping brain activity during infant seizures may help predict outcomes and inform treatment options.
Researchers identified a new neurological syndrome caused by IQSEC1 gene mutations, affecting five patients from consanguineous families in Pakistan and Saudi Arabia. The study used fruit flies and mice to demonstrate that defective IQSEC1 proteins contribute to intellectual disability and neural development defects.
A Stanford University School of Medicine study found that even people with well-controlled epilepsy often experience cognitive deficits due to abnormal brain electrical activity called high-frequency oscillations. The research suggests that certain medications or implantable devices could be improved to alleviate these deficits.
Researchers found that the endoplasmic reticulum stress response helps reduce brain activity during seizures, potentially leading to more effective epilepsy therapies. The study's findings may also provide insights into other neurological disorders caused by seizures.
A study published in Annals of Neurology found that the spread of seizures through the brain can be suppressed by a
Researchers found that CBD substantially lessened seizure severity in mice and restored normal brain rhythms in Angelman syndrome models. The study suggests CBD could benefit kids and adults with this serious condition, characterized by intellectual disability and epilepsy.
A systematic review and meta-analysis suggests that people with drug-resistant epilepsy have better prospects of being seizure-free if they undergo surgical treatment at an earlier stage. The study found a 15-21% higher probability of attack freedom for those who underwent surgery early compared to later stages.
Researchers have developed a new machine learning algorithm that can detect the seizure onset zone in just 10-20 minutes, eliminating the need for prolonged monitoring and reducing risks. This breakthrough could lead to a new treatment approach for epilepsy patients, particularly those with drug-resistant forms of the disease.
Researchers found that higher serotonin levels after a seizure are associated with less breathing dysfunction, particularly in people who do not temporarily stop breathing during seizures. This study provides new insights into the possible link between serotonin levels and breathing during and after seizures.
Researchers found that glial cells, which make up 80% of brain cells, contribute to seizures by releasing glutamate, a chemical that transmits signals between neurons. The study suggests that targeting glial cells may lead to new treatments for epilepsy.
Researchers identified a gene in fruit flies that helps prevent seizures triggered by environmental stress. In humans, mutations in the gene may be linked to seizures associated with Long QT Syndrome, suggesting a potential connection between brain and heart function.
Mutations of a gene implicated in long QT syndrome trigger seizures due to its direct effects on neurons and glia, independent from heart function. This discovery challenges the assumption that seizures are secondary outcomes of cardiovascular disease.
Researchers at UTSA have successfully removed new neurons that developed after a brain injury to reduce seizures in mice. The study found a 65% reduction in seizures, but the effect was not permanent and may be due to underlying factors such as chronic inflammation or reactive astrocytes.
Researchers uncovered the molecular action of cilantro as a potent KCNQ channel activator, reducing seizure activity and opening potassium channels in the brain. This discovery may lead to more effective use of cilantro as an anticonvulsant or development of safer and more effective anticonvulsant drugs.
Researchers at UT Health San Antonio have discovered a novel therapy that reduces brain damage after traumatic brain injury (TBI) in mice, preventing seizures and reducing inflammation. The study aims to develop a simple and effective treatment for TBI patients.
Researchers found that removing new neurons born after a brain injury reduced seizures in mice, with a 65% decrease observed. This approach may potentially prevent post-injury epilepsy if implemented within a specific time frame.
A study by the University of Saskatchewan found that medicinal cannabis oil containing CBD and THC can reduce or end seizures in children with severe, drug-resistant epilepsy. The research team tested a dosage regimen that showed significant improvements in quality of life for the children, with some experiencing complete seizure freedom.
The UAB clinic has achieved rapid accessibility and improved seizure control for patients with drug-resistant epilepsy. Vagal nerve stimulation (VNS) and responsive neurostimulation (RNS) therapies have shown promise, with 12-11 out of 27-16 patients experiencing a 60% reduction in seizures.
A new study found that stimulating the brain's dorsal anterior insula triggers an ecstatic aura in epileptic patients. This region is proposed to be a key area for elicit symptoms of altered consciousness and ecstasy-like experiences. The findings provide additional support for its role in human consciousness.
Researchers discovered a genetic basis for sudden unexpected death in epilepsy (SUDEP), suggesting that a specific gene mutation can disrupt brainstem cells controlling breathing. The study used mice with the mutation to test its effects, finding disordered breathing patterns and reduced inhibitory cell activity.
A new study found that even people with well-controlled epilepsy are at risk of sudden unexpected death in epilepsy (SUDEP). Researchers analyzed cases referred to the North American SUDEP Registry and found that sleep deprivation, skipping medication, and lack of seizure activity were common factors contributing to SUDEP.
A new study found that inducing seizures in epilepsy patients can determine the brain region where seizures originate, reducing hospital stays from two weeks to 48 or 72 hours. This method is as effective as relying on spontaneous seizures and could lead to cost savings for hospitals.
Research suggests that strobe lighting at electronic dance music festivals triples the risk of epileptic fits in susceptible individuals. Organisers are advised to issue warnings and provide preventive measures for those with photosensitive epilepsy.
Researchers at FutureNeuro have discovered molecules in the blood that are higher in people with epilepsy before a seizure happens. These molecules are fragments of transfer RNAs (tRNAs), which could serve as an early warning system for predicting seizures.
A synthetic, non-intoxicating analogue of cannabidiol (CBD) has been found to be effective in treating seizures in rats, reducing both frequency and severity with equal efficacy to herbal CBD. This breakthrough offers a safer and more accessible alternative for epilepsy treatment, potentially paving the way for clinical trials.
A pilot study led by Dr. Stephanie McGrath found that 89% of dogs who received CBD had a reduction in seizure frequency. The research suggests a correlation between CBD concentration and seizure reduction, leading to potential alternative treatments for canine epilepsy.
Researchers found that successful epilepsy surgery can restore brain networks, leading to improved quality of life for patients with temporal lobe epilepsy. The study showed significant improvements in brain network activity after surgery compared to healthy subjects.
Researchers have identified a small organic compound called gluconate that acts as an anticonvulsant, inhibiting seizures by targeting chloride ion channels. The study found that gluconate suppresses seizure activity more effectively in neonatal animals than adults.
A new tool developed by Queen Mary University researchers can accurately predict the risk of seizures during pregnancy and up to six weeks after delivery. The EMPiRE tool uses routinely collected data to inform care and close monitoring, potentially reducing maternal and fetal mortality.
Researchers at MIT's Picower Institute found that excess calcium in glia cells causes them to hyper-activate a molecular pathway leading to seizures. They identified calcineurin and sandman proteins as key players in the process, suggesting a promising avenue for future drug development.
A phase 3 study found that taking pharmaceutical cannabidiol cut seizures nearly in half for children with Dravet syndrome. The treatment showed significant efficacy even among those who had tried multiple other medications without success.
A new study found that rapid whole genome sequencing can identify etiology and direct therapy in neonates with unexplained seizures. The analysis revealed six molecular diagnoses out of 19 patients, leading to changes in management for four patients, including targeted seizure medications and dietary supplements.
Adult mouse models of SYNGAP1 disorder show improvement in measures of seizure and memory after gene repair, suggesting potential for treatment at any stage of life. The study offers a path to measure the effectiveness of potential medications or therapies.
A study of 1,022 children found febrile seizures following vaccinations have the same severity as those from other causes. Most seizures are short-lived and self-resolving, with only 6% requiring hospital treatment. The research also identified a link between infections and longer hospital stays in vaccinated children.
A New Zealand-Australian study has found that using two anti-convulsant medications one after the other can increase the success rate of stopping prolonged seizures in children by up to 75%. This breakthrough treatment may halve the number of children ventilated and sent to intensive care, improving their chances of recovery.
Researchers at the University of Pittsburgh School of Medicine have found that responsive neurostimulation can remodel the brain to be less susceptible to seizures. By analyzing individual brain activity recordings over time, the study shows that stimulation changes brain networks, making it harder for seizures to spread.
A new study published in JAMA Neurology reveals that a minimally invasive procedure can help identify patients with drug-resistant epilepsy who are suitable for brain surgery. The procedure produces more favorable outcomes among patients, including reduced complications and increased likelihood of seizure freedom.
Scientists at UT Southwestern Medical Center have developed a method to predict epileptic seizures at least four minutes in advance using EEG monitoring. The study shows that delivering an edible acid called acetate can prevent seizures if detected early, providing new potential therapy options.
The Vilcek Foundation awards $250,000 Prizes to immigrant scientists Angelika Amon, Amit Choudhary, Jeanne T. Paz, and Mikhail G. Shapiro for their pioneering work in human biology and disease research. Their discoveries have significant implications for understanding cell growth, cancer, and neurological disorders.
The study found that benzodiazepine prescriptions for anxiety increased from 3.8% to 7.4% over the 12-year period, with primary care physicians accounting for half of all visits. The growing use of benzodiazepines has led to an increase in overdose deaths, prompting a need for addressing prescribing patterns.
Researchers have identified a cellular response to repeated concussions that may contribute to seizures in mice. A unique population of astrocytes responded to these injuries, leading to spontaneous recurrent seizures in some mice within one month. This study establishes a new animal model for post-traumatic epilepsy research.
A protein-secreting device implanted into the hippocampus of epileptic rats reduced seizures by 93% in three months, improving anxiety-like symptoms and cognitive performance. The effects persisted even after device removal, indicating a possible modification of disease progression.
A new study found that ketogenic supplements can delay tonic-clonic seizures caused by high levels of oxygen, even in a normal diet. The supplements increased blood ketone levels, providing therapeutic ketosis and resistance to seizures.
Researchers identified a key factor leading to epileptic seizures by analyzing changes in the temporal lobe cortex of a rat brain. The study found that excessive excitation of neurons, triggered by calcium-permeable AMPA receptors, increases the risk of convulsive discharges.
A new neurostimulator, WAND, can stimulate and record electric current in the brain simultaneously, potentially delivering fine-tuned treatments to patients with diseases like epilepsy and Parkinson's. This closed-loop system allows for real-time adjustments, enabling improved outcomes and accessibility.
Researchers at Texas A&M University have made a breakthrough in treating epilepsy by using stem cell-derived neurons to stop seizures and improve cognitive function. The study showed that transplanted human GABAergic neurons formed synapses with host excitatory neurons and were directly involved in controlling seizures.
Researchers have discovered a potential treatment for chronic epilepsy using human induced pluripotent stem cells. The study found that grafting these cells into the hippocampus can alleviate symptoms of chronic epilepsy, including reduced seizure frequency and improved cognitive function.
A recent study found a higher than anticipated number of seizures in infant patients monitored with continuous EEG. The research identified conditions associated with seizures and suggests cEEG monitoring may be valuable for diagnosing neurological problems in patients under 14 months old.
A recent analysis of published studies suggests that cannabidiol, a non-psychoactive cannabinoid, can reduce seizures in children with severe forms of epilepsy. The median frequency of monthly seizures decreased with cannabidiol treatment, with many participants experiencing a 50% or greater reduction.
People with epilepsy living in high-crime Chicago neighborhoods have three times as many seizures as those in low-crime areas, a new study finds. The researchers used data from 63 participants and found that those in high-crime neighborhoods experienced an average of seven seizures over 90 days.