Articles tagged with Seizures
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Researchers at UCLA developed brain organoids that mimic human brain structure and function, allowing for the study of neurological disorders like Rett syndrome. The organoids showed organized waves of activity similar to those found in living brains and responded to treatment with an experimental drug.
University of Virginia researchers identified a potential avenue for treating seizure-related brain injuries by harnessing the brain's natural immune response. Microglia cells were found to form pouches that tend to swollen dendrites, suggesting a 'healing' process.
A new dietary supplement, K.Vita, has been shown to reduce seizures in children and adults with drug-resistant epilepsy, with a mean 50% reduction in seizures or paroxysmal events. The study found that the supplement was well-tolerated and palatable, with fewer than 10% of participants producing significant ketones.
A study led by Professor Ivan Rektor found that listening to Mozart's Sonata for Two Pianos K448 reduced epileptiform discharges in epilepsy patients by 32%, while Haydn's music had the opposite effect. The acoustic properties of music were responsible for this anti-epileptic effect.
Researchers at Linköping University have developed new resin acid molecules with antiseizure effects, opening a potassium ion channel that can prevent epileptic seizures. The molecules also show less effect on smooth muscle, reducing undesired side effects.
Researchers used standardized reporting of clinical data to determine the most effective methods for controlling seizures in pediatric epilepsy patients. The study found that using telemedicine had no impact on seizure frequencies and that certain patient demographics were more likely to experience worsening seizures.
A new multicenter study found that continuing antiseizure medication after neonatal seizures stopped did not prevent epilepsy or developmental delays in babies. This contradicts standard practice of extending treatment for months, and highlights the need to reassess standard care for newborns with seizures.
Researchers found that analyzing local networks within brain regions provides superior results to traditional fiber tract connectivity approaches for predicting disease progression and surgery outcomes in epilepsy patients.
Case Western Reserve researchers have identified a potential new approach to controlling epileptic seizures by stabilizing the sodium channel through neddylation. This finding, published in The Journal of Clinical Investigation, offers hope for future research and potential drug development to prevent epilepsy.
New research from the University of Virginia School of Medicine reveals that sleep can increase the risk of sudden death in people with epilepsy. Seizures disrupt the body's natural regulation of sleep-related changes, leading to a slower heart rate and potentially deadly consequences.
New research from the University of Virginia School of Medicine has identified a sequence of events during seizures that can progress to death. The researchers found that breathing disruption, or apnea, occurs during seizures and that artificially stimulating breathing can prevent sudden death after a seizure.
Researchers have discovered that fast brainwave oscillations can pinpoint brain tissues responsible for epileptic seizures. The collaborative research leverages noninvasive EEG technology to automatically identify high-frequency oscillations and epileptiform spikes, which are key links related to epilepsy.
A new study from Massachusetts General Hospital reveals that nonconvulsive seizures in COVID-19 patients are associated with worse outcomes, including higher rates of death and longer hospital stays. Seizures can occur even in patients without prior neurological history, highlighting the need for close monitoring and treatment.
A study found that metformin successfully reduced symptoms associated with tuberous sclerosis complex, including a 44% drop in seizure frequency and a 21% reduction in brain tumour size. Researchers believe this could improve quality of life for TSC patients.
Seizures of methamphetamine and marijuana rose significantly during the pandemic, with quantities of marijuana seized climbing by weight. Investigators found no significant shifts in other drug seizures, but provisional overdose deaths show a further rise through the first half of 2020.
Researchers found sharp decreases in marijuana and methamphetamine seizures during the pandemic's early months, followed by significant increases as restrictions relaxed. The study suggests disruptions in drug supply chains may have contributed to these trends.
Researchers at USC have developed a powerful mathematical model that can predict seizures with high accuracy, providing epilepsy patients with an early warning of up to five minutes. This breakthrough could revolutionize epilepsy management and treatment, allowing patients to take necessary interventions to prevent seizure onset.
Scientists at the University of Exeter made a breakthrough in understanding brain activity during seizures by studying synchronization patterns. The study found that excessive synchronization can lead to epileptic seizures and Parkinson's disease, impairing brain function.
Researchers develop prototype to automate processing of brain data, allowing for accurate identification of epileptic focus; potentially saving up to 90% of time spent reviewing data. The tool has been validated by physicians and is expected to have a clinical impact.
Researchers use mathematical modeling to study synchronization changes during seizure onset, identifying key factors that influence the transition from desynchronization to high levels of synchronization. The study reveals a new phenomenon where amplitude coupling can accelerate or decelerate the domino effect.
A team of Virginia Tech scientists has identified a new link between seizures and connexin 36 deficiency in zebrafish models. The study found that connexin 36 deficiency altered the susceptibility to neuronal hyperactivity, which may contribute to the onset of subsequent seizures.
A large-scale electronic health record study found that functional seizures are prevalent and often misdiagnosed as epileptic seizures. The study also discovered novel associations between functional seizures and cerebrovascular disease, including stroke, as well as psychiatric disorders such as PTSD and depression.
Researchers identified a pathway involving astrocytes that sheds light on why seizures occur in some MS patients. The study found altered expression of EAAT2 and AQP4 proteins, leading to increased seizure activity.
Researchers at Université de Genève have developed a technique that can predict epileptic seizure periods between one and several days in advance. By recording neuronal activity over six months, they can detect individual cycles of epileptic activity and provide information about the probability of a future seizure.
Researchers have made breakthroughs in predicting epilepsy seizures using brain implant data, identifying weekly-to-monthly cycles of 'brain irritability' that predict higher likelihood of seizures. The study's findings could enable patients to plan their lives around high or low seizure risk, avoiding potentially dangerous situations.
Researchers found that microglial surveillance helps maintain normal neuronal activity levels by preventing overactive neurons. This discovery opens new avenues for treating neurological disorders such as Alzheimer's disease, epilepsy, and autism.
A highly unusual case of a right-handed patient performing unconscious 'mirror-writing' with her left hand while in the midst of having epileptic seizures was reported by doctors. The study, published at Euroanaesthesia, suggests that mirror writing may occur in patients with epilepsy affecting one limb.
A new study finds that focal epilepsy, affecting one in 26 American adults, is often overlooked due to subtle symptoms. Early diagnosis can lead to fewer car accidents, with the researchers estimating 1,816 preventable accidents annually worldwide.
Researchers have found that an amino acid called D-serine could prevent a type of epileptic seizure by blocking receptors in the brain. The study, published in Nature Communications, suggests that D-serine levels are depleted in patients with temporal lobe epilepsy, leading to neuronal death and loss of function.
Scientists from the University of Copenhagen have identified specific neurons most affected by epilepsy, which could lead to personalized medicine-based treatments. The study analyzed over 117,000 neurons and found thousands of genes changing their expression in epilepsy.
A Rutgers University study found that patients with generalized epilepsy are at a higher risk of developing obstructive sleep apnea compared to those with focal epilepsy. Treatment of OSA may improve seizure control and overall health for these patients.
Researchers pinpoint a specific protein and brain region responsible for dissociation, a phenomenon affecting up to 10% of the population. This discovery could lead to targeted therapies for conditions like PTSD and borderline personality disorder.
A new analysis confirms that listening to Mozart's piano music can significantly reduce the frequency of epileptic seizures. The study, which evaluated 147 research articles, found that daily Mozart listening sessions resulted in a 31-66% reduction in epilepsy attacks.
Researchers found that deleting AMPK from astrocyte brain cells disrupts glucose and lactate metabolism in neurons, leading to spontaneous seizures. The study suggests that metformin, an antidiabetic drug, may mitigate epileptic seizures by targeting AMPK.
A new generation of long-term brain monitoring technologies records neural activity to provide a reliable alternative to subjective seizure diaries. These devices, such as the Wyss Center's Epios system, offer flexible configurations and could enable optimized and personalized treatment for each patient.
Women with catamenial epilepsy experience nearly four times more frequent seizures during menstrual cycle and are more likely to have drug-resistant epilepsy. The study may lead to tailored treatments for this group.
Researchers discovered abnormalities in communication between brain cells and molecular changes affecting protein production due to dysfunctional CASK gene. The study also suggests an unexpected role for CASK in regulating energy production in cells, which may explain diminished brain size and dysregulated function.
Researchers at the Medical University of South Carolina have developed a vitamin K-based compound that eliminates medication-resistant epileptic seizures in mice. The compound works by increasing brain cells' ability to produce energy and protects mitochondrial health, making it a promising new treatment option for those with epilepsy.
A new study published in Neurology found no difference in developmental and behavioral outcomes for children who had febrile seizures after vaccination, compared to those with febrile seizures not associated with vaccination or never having a seizure. This reassuring news supports the safety of vaccines.
Researchers discovered a novel potassium channel activator, GiGA1, that selectively opens GIRK channels and reduces neuronal excitability. Systemic administration of GiGA1 exhibits anti-seizure properties in an acute epilepsy animal model.
Researchers developed a new method to detect and locate seizures in real-time using artificial intelligence and systems theory. By treating the brain as a network, they extracted meaningful data from electroencephalograph (EEG) signals, improving seizure detection accuracy.
Researchers identified microRNAs associated with epilepsy and designed drug-like molecules to target them, finding three that stopped seizures in preclinical tests. The study aims to develop novel treatments for people whose seizures cannot be controlled by current medications.
A CHOP study demonstrates that remote continuous EEG monitoring can detect seizures in at-risk neonates, impacting clinical care and guiding treatment decisions. The study showed that seizures occurred in about one-quarter of the records, with CEEG impacting outcomes in three-quarters of cases.
Researchers at George Washington University discovered that GABAergic interneurons in the hippocampus are excitatory during development, rather than suppressive. This finding could lead to more targeted therapies for infantile seizure disorders.
A study published in Epilepsia journal found that 8% of individuals with a history of seizures report hallucinations, which are associated with a higher risk of mental health disorders and suicidal behavior. The study highlights the importance of assessing hallucinations in epilepsy clinics to identify high-risk patients.
A recent clinical research study found that listening to Mozart's Sonata for Two Pianos in D Major, K. 448 daily reduced seizure frequency in adult individuals with epilepsy. The study suggests this as a supplemental therapeutic option for those who do not respond well to anti-seizure medications.
A study published in Lancet Psychiatry found that adding cognitive behavioral therapy (CBT) to standardised medical care significantly reduced the frequency of dissociative seizures, improved functioning, and enhanced quality of life. Researchers recommend incorporating CBT into specialist care for patients with dissociative seizures.
Adding CBT to standard medical care gives patients with dissociative seizures longer periods of seizure freedom and a greater quality of life. This study suggests that CBT combined with specialist care can improve symptoms and satisfaction for those affected by this condition.
Researchers found that naked mole-rats require high levels of carbon dioxide to function, unlike other mammals. The genetic mutation in the KCC2 gene leads to impaired brain inhibition, which is compensated by increased carbon dioxide levels.
Researchers found that advancing glioma cells desynchronize neuronal activity and blood flow changes, affecting neurovascular coupling and potentially leading to seizures. The study provides promising targets for disrupting tumor growth and offers insights into diagnosis and surgical guidance.
University of Iowa scientists have identified a specific area of the brain involved in seizure-induced loss of breathing, which could help predict and prevent sudden unexpected death due to epilepsy. The Amygdala Inhibition of Respiration (AIR) site was found to be critical in children with epilepsy.
Researchers have discovered a potential new treatment for drug-resistant epilepsy using compounds derived from magnolia trees. The study found that extracts from the bark of Magnolia officinalis reduced seizure-like behavior in both zebrafish and mice, providing a promising lead for the development of new treatments.
A preliminary study by the American Academy of Neurology found that children and teens with epilepsy who were treated with pharmaceutical cannabidiol (CBD) had better seizure control compared to those treated with artisanal CBD. Pharmaceutical CBD was found to have a 39% reduction in seizures, while artisanal CBD resulted in a 70% incr...
Researchers found that developing seizures after a severe ischemic stroke increases the risk of death and disability. The study identified several risk factors for post-stroke seizures, including age, severity of stroke, and previous heart conditions.
Researchers have developed sensitive and specific potassium nanosensors that can monitor dynamic changes of potassium ions in the brain during epileptic seizures. These nanosensors enable the accurate sensing of potassium levels in different parts of the brain, facilitating the diagnosis and therapy of epilepsy.
Researchers developed an algorithm using deep convolutional neural networks to analyze myoclonus severity from video footage. The method successfully quantified myoclonic jerks in EPM1 patients, correlating well with clinical evaluations and detecting small-amplitude and high-frequency jerks.
A recent study published in Seizure found that over 40% of status epilepticus patients suffer from adverse outcomes, including a 9% risk of death. The researchers developed two prognostic scores, STESS and EMSE, which can accurately predict mortality risk in the emergency room.
Researchers at Duke-NUS Medical School and NNI discovered that misregulated potassium ion channel activity causes seizures in AS patients. Suppressing this activity could potentially resolve seizures, benefiting people with autism as well.
Researchers found that implanted neurostimulators can record brain data during anxiety attacks, guiding therapy changes to reduce negative symptoms caused by seizures. Five patients with epilepsy showed improvements in treating neuropsychiatric comorbidities through data analysis and counseling.
Researchers found that fenfluramine significantly reduced convulsive seizures in Dravet syndrome patients, with a 62% decrease in seizures per month. The study also showed improvements in seizure-free intervals and parental assessments of child improvement.