Articles tagged with Sepsis
Researchers found altered gut microbiota in sepsis patients, leading to more severe liver damage in mice. The study suggests that transplantation of healthy feces may help treat sepsis in intensive care units.
Researchers investigated metabolic changes across organs in a large animal model of sepsis, identifying common and organ-specific alterations that could inform new therapeutic approaches. The study, published in The American Journal of Pathology, has the potential to reduce mortality and morbidity associated with sepsis.
Researchers at University of California San Diego School of Medicine found that removing the enzyme PHLPP1 improves outcomes in a mouse model of sepsis. The study introduces the possibility of inhibiting PHLPP1 as a new treatment for sepsis.
Sepsis survivors are at higher risk for major health problems and death due to persistent inflammation, according to a study published in JAMA Network Open. The researchers found that nearly all patients with sepsis have increased inflammation during hospitalization, but this inflammation often persists long after discharge.
A national study found that combining early home health nursing with at least one outpatient physician visit after hospital discharge reduces the risk of 30-day hospital readmission for sepsis patients. The intervention facilitates coordinated care planning and early surveillance, resulting in improved outcomes.
Scientists at WashU Medicine have found a set of genes that help cells survive exposure to cytokines, which can trigger a deadly cytokine storm. Targeting these genes may lead to new treatments for sepsis, a life-threatening condition that claims 15% of patients despite prompt medical care.
A study led by University of Pittsburgh researchers found that implementing a state-mandated sepsis regulation in New York resulted in a significant drop in death rates from sepsis, with a 4.3% decrease compared to control states. The policy requires hospitals to quickly implement certain protocols when sepsis is suspected.
State-mandated protocols for sepsis care in New York have been associated with significant improvements in patient outcomes, including a reduced risk of death. The study analyzed hospital discharge data and found that these regulations led to better management of sepsis cases, resulting in improved survival rates.
A new study found that while the New York Sepsis Initiative improved overall sepsis care, hospitals treating mainly white patients saw greater increases in protocol compliance than those serving more black patients. This disparity raises concerns about the potential exacerbation of racial disparities in healthcare.
A multicentre study analyzed over 1.9 million pediatric emergency department visits and found no significant association between overcrowding and death within 14 days or hospital admission within 7 days. However, the study saw an increase in admissions among sicker children and return visits from less sick kids with increasing crowding.
A new study found that delayed antibiotic delivery for sepsis patients is associated with lower ER triage scores, particularly among those assigned mid-range scores. This delay can result in longer door-to-antibiotic times of up to 32 minutes, impacting patient survival.
Researchers used big data to identify four distinct subtypes of sepsis, each with unique clinical characteristics and treatment needs. These findings could lead to the development of precision medicine approaches for sepsis treatment, potentially improving patient outcomes.
Researchers have discovered a biochemical compound responsible for the rapid decline in blood pressure during sepsis. The compound, cis-WOOH, is formed by an enzyme and plays a signaling role in vasodilation, potentially leading to organ failure and death.
Scientists have discovered that bacterial proteins and endotoxin activate the inflammasome, leading to pyroptosis and the release of tissue factor, which initiates blood clotting. This understanding may lead to new treatments for sepsis by targeting inflammatory responses.
A KAIST research team visualized pulmonary microcirculation in vivo using a custom-built 3D intravital microscope imaging system. They found that neutrophils aggregate inside capillaries during sepsis-induced acute lung injury, leading to tissue hypoxia and damage.
A new computer-aided model developed in the UK can predict sepsis risk using routinely collected data. The cNEWS score can trigger screening within 30 minutes of admission and support clinical judgment.
The Society for Maternal-Fetal Medicine has released new guidelines for diagnosing and treating sepsis in pregnancy, emphasizing the importance of early recognition and management. The recommendations are designed to improve care and prevent organ damage caused by sepsis, with a focus on increasing maternal survival rates.
Researchers will compare DNA from sepsis patients who died and survived to isolate signals and identify future drug targets. The study, funded by Sepsis Research, aims to better understand how genes govern sepsis recovery.
A study published in JAMA Network Open found that sepsis was present in over 50% of terminal hospitalizations and accounted for 35% of all deaths. However, only one in twenty-five sepsis-associated deaths were considered moderately or highly likely preventable.
A pre-clinical trial of InnovoSep has demonstrated potential to stop sepsis-causing bacteria from triggering organ damage. The drug also showed effectiveness in preventing sepsis progression and treating advanced sepsis.
A recent grant will allow researcher Wendy Walker to study immune cell contributions to sepsis, a life-threatening disorder with a high mortality rate. Her goal is to manipulate these cells to improve clinical outcomes and potentially cure the disease.
Researchers found that delaying or withholding antibiotics for older adults with urinary tract infections increases the risk of bloodstream infections and death. Immediate antibiotic treatment is recommended for this vulnerable group due to their increased susceptibility to sepsis following UTI.
Researchers found that early antibiotic treatment for elderly patients with urinary tract infections (UTIs) reduces the risk of sepsis and death compared to delayed or no treatment. The study suggests that immediate antibiotics should be prescribed for elderly patients with UTIs, especially older men and those living in deprived areas.
Scientists at the University of British Columbia have discovered a new protein 'switch' that can stop the progression of sepsis, a life-threatening disease. This discovery could lead to new treatments for chronic and acute inflammatory diseases.
Sepsis-associated deaths occurred in over half of hospitalizations, with most deaths attributed to complex patients with severe coexisting conditions. Further innovations in prevention and care of underlying conditions may be necessary to reduce sepsis deaths
A study from the University of Virginia Health System suggests that an antidepressant drug could stop deadly sepsis by regulating inflammation. The researchers tested the drug in a mouse model and found it to be effective, paving the way for potential human trials.
A Western diet characterized by low fiber and high fat and sugar content can lead to increased chronic inflammation, higher mortality rates, and more severe sepsis severity in mice. The study identifies molecular markers that could predict patients at high risk for severe sepsis or require aggressive treatment.
Researchers have successfully engineered a protein that balances an overreaction of the immune system, making it a promising candidate for sepsis therapy. By understanding how interleukins mediate communication between immune cells, scientists can now modulate their reaction in a targeted manner.
A synthetic compound derived from flaxseed has been shown to reverse cardiovascular dysfunction and improve heart function in mice with sepsis. Treatment with the antioxidant LGM2605 significantly reduced oxidative stress and restored energy production in heart cells.
Basophils, a rare type of white blood cell, have been found to play a crucial role in preventing sepsis. By releasing protein tumor necrosis factor (TNF), basophils trigger an immune response that helps protect against infection and prevents the progression to sepsis.
A large clinical study in Australia and New Zealand aims to better understand sepsis treatment practices and evaluate the effectiveness of a reduced fluid approach. The study, funded by the Emergency Medicine Foundation, will investigate how intravenous fluids are used to treat sepsis patients.
In a breakthrough study, researchers successfully delivered a microRNA called miR-126 via a nanocarrier to improve survival rates in a preclinical model of sepsis. The treatment resulted in over 67% of mice being alive at seven days compared to just 25% of untreated mice.
A study reveals that current screening tools can miss severe infections in pregnant women, highlighting the need for better identification and timely interventions. Simple measures such as frequent vital sign reassessment and prompt antibiotic administration within an hour of diagnosis can significantly reduce maternal deaths.
Researchers have developed a new method for administering the antibiotic ceftriaxone through rectal delivery, which could save thousands of newborn lives annually. The approach builds upon earlier work and has been shown to be effective in treating critically ill patients with sepsis.
Researchers developed an AI Clinician system that predicts and recommends optimal treatment strategies for patients with sepsis, showing a higher chance of survival compared to human doctors. The system analyzed 100,000 hospital records and made more reliable treatment decisions than humans.
Researchers at Kazan Federal University investigated the virulence factors of Klebsiella pneumoniae in neonates with sepsis and urinary tract infections. They found that rmpA gene-containing strains were associated with more severe diseases, revealing a higher prevalence of virulent K. pneumoniae strains than previously thought.
A new report in the American Journal of Pathology demonstrates a link between prenatal inflammation and postnatal immune status and organ function in preterm pigs. Prenatal exposure to bacterial endotoxin induced acute fetal lung and gut immune responses, followed by systemic inflammation after birth.
A new study found increasing infection rates for urinary tract infections, sepsis, and skin infections among people with diabetes in the USA. Rates of infection-related hospitalisations increased by 52% between 2010 and 2015 compared to the general population.
The article discusses clinical early warning scores as new clinical tools to predict future clinical deterioration, particularly related to sepsis. It provides a critical review of the state-of-the-art in early warning algorithms and suggests further research initiatives.
A large Taiwanese study found that patients with sepsis are at increased risk of cardiovascular events, including stroke and heart attack, within the first 4 weeks after hospital discharge. Younger patients with sepsis aged 20 to 45 years were particularly at higher risk.
A commentary suggests using smart technology and artificial intelligence to improve the detection of sepsis in children in Canada. The authors propose automating data combinations of sepsis symptoms and other relevant information to create more accurate and low-cost trigger tools.
A team of researchers from Case Western Reserve University discovered a way to stop immune cell death associated with multiple diseases, including sepsis, IBD, and arthritis. They identified a chemical, necrosulfonamide, that potently inhibits inflammatory cell death by preventing pyroptosis, a type of cell suicide.
A £2 million project, ARCS, aims to tackle sepsis in Africa by creating sustainable partnerships between research, clinical, and government organizations. The initiative focuses on delivering high-quality training, establishing care quality indicators, and testing innovative interventions.
Researchers at UCalgary discovered the key target of a toxin that worsens sepsis caused by Staphylococcus aureus. The findings suggest an antibody targeting this toxin could prevent platelet aggregation and organ failure, offering new hope for patients in intensive care.
A new analysis shows that completing a sepsis protocol within an hour of detection significantly increases survival rates in children, with completion of all elements required to reduce mortality. The study supports New York's Rory's Regulations mandate and encourages expansion to other states.
Researchers at Columbia University Irving Medical Center found a potential link between microRNAs and sepsis, identifying two molecules that silence inflammatory gene expression. These biomarkers could help diagnose patients at risk of organ failure and death, allowing for faster treatment and potentially saving lives.
The Massachusetts Medical Device Development Center has received a $500,000 grant from BARDA to help startups develop cures for pandemic flu and sepsis. Two startups already working with M2D2 plan to join the new network.
A new study reveals children's immune systems can control infections and prevent sepsis, a disease responsible for more UK deaths than cancer combined. The research identifies key responses in children's cells that help them ward off severe infections.
Researchers have discovered a novel treatment that reduces the deadly immune response triggered by trauma, which can lead to systemic inflammatory response syndrome and sepsis. The drug, deformylase, neutralizes N-formyl peptides released from damaged mitochondria, improving survival rates in animal models.
Immunocompromised patients with sepsis are more likely to die if treated in a hospital caring for a relatively small number of these patients. Hospitals that treat large numbers of immunosuppressed patients with sepsis may improve outcomes, study results suggest.
Researchers at Intermountain Medical Center found that about 16 percent of sepsis patients diagnosed in emergency departments are treated and released for outpatient management. Despite this, these patients have fairly good outcomes, including a similar chance of dying in the following 30 days as admitted patients.
A recent study analyzing over 3.7 million hospital admissions found that overweight and obese patients had a lower risk of dying from sepsis compared to those with normal weight. The study also showed improved survival and reduced readmission rates for these groups.
A recent awareness and management programme for sepsis has led to increased E. coli blood stream infection cases, raising questions about the effectiveness of existing targets. The programme's success in sepsis detection suggests considering alternative measures, such as positive-to-negative sample ratios or urine analysis.
Researchers at Massachusetts General Hospital developed a microfluidic device that measures neutrophil motility to accurately diagnose sepsis. The device achieved more than 95% accuracy in distinguishing patients with sepsis from those without, offering a promising new approach to timely treatment.
Researchers discovered that gut bacteria play a role in brain impairment after sepsis, with certain strains associated with neuroinflammation and cognitive difficulties. The study suggests treating gut bacteria may help reduce long-term effects of critical illness.
Researchers discovered that gut bacteria stimulate serum IgA responses that offer protection against bacterial sepsis. The study found mice with Proteobacteria-rich microbiota survived longer after sepsis, while those without IgA antibodies died quickly.
Scientists used a computational model to show that sepsis treatment needs multiple-step targeting for effective therapy. The study suggests 'precision medicine' is necessary due to the complexity of individual patient responses.
Researchers at Saint Louis University have discovered a link between elevated chlorinated lipids and severe outcomes in sepsis patients. The study found that high levels of these lipids can predict acute respiratory distress syndrome and death within 30 days, suggesting they may serve as an early warning sign of the condition.
Scientists at NUST MISIS have developed a new rapid-test that can accurately diagnose acute myocardial infarction and identify sepsis in just 10 minutes. The test uses immunochromatography principles and detects disease markers in blood, allowing for early treatment intervention.
A recent study found that sepsis kills an alarming 55.7% of ICU patients, with Brazilian ICUs facing low bed availability and inadequate care contributing to the high mortality rate. Vaccination and simple hospital infection-control measures can prevent community- and healthcare-acquired sepsis.