Articles tagged with Sepsis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent study found that approximately 40 percent of hospitalizations for severe sepsis can be prevented or treated early to avoid rehospitalization. The most common readmission diagnoses included ambulatory care sensitive conditions such as heart failure and pneumonia.
Researchers found that sildenafil, commonly known as Viagra, induced the liver to produce greater amounts of cyclic GMP, reducing TNF signaling and preventing liver damage. Experiments with human liver cells also showed the protective effects of the drug.
A study in the Journal of Clinical Investigation found that UCP2 induces fatty acid synthesis, activating inflammatory pathways in patients with sepsis. Lack of UCP2 improved survival in a mouse model of sepsis, suggesting UCP2 as a potential therapeutic target.
New research suggests CD39, an enzyme capable of clearing high levels of adenosine triphosphate from the bloodstream, significantly improves survival of mice in severe sepsis. This discovery holds promise for effective treatment and reduction of costs associated with septic patients in intensive care units.
Dr. Felix Ikuomola, a PhD candidate, is searching for natural products from Hawaii's oceans that can block sepsis by inhibiting endothelial cell permeability. His work aims to provide treatment options for the leading cause of death in the US and a major complication of cancer.
Researchers at Massachusetts General Hospital have identified a potential biomarker for sepsis in patients with major burns. By analyzing the movement of white blood cells called neutrophils, they found that changes in their motility patterns may predict the development of sepsis, which is a leading cause of death among burn patients.
A new rapid test developed by University of British Columbia researchers can predict severe sepsis within an hour, allowing timely treatment to begin. The genetic signature associated with the disease has been identified and can be tested as soon as a patient arrives in the emergency ward.
The study developed a prediction tool that uses laboratory and vital-sign data to identify hospital patients at risk for sepsis. The tool resulted in faster sepsis identification, increased orders for diagnostic tests, and more timely administration of antibiotics and intravenous fluids.
Sepsis affects more hospital patients than any other diagnosis, with half of all in-hospital deaths involving the condition. Researchers say a national system is needed to hold hospitals accountable for sepsis diagnosis and care, building on lessons from heart attack treatment.
Researchers at the University of Tokyo have found that PTX3, a protein involved in innate immunity, can reduce mortality from sepsis by protecting endothelial cells from damage. The study's findings suggest that PTX3 may be used to develop a novel therapy for sepsis.
The biospleen device uses magnetic beads coated with genetically engineered MBL proteins to remove pathogens and toxins from the blood. In laboratory tests, it filtered out over 90% of key sepsis pathogens within five hours.
A new app-device can quickly and accurately measure two key signs of sepsis, a leading cause of death worldwide. The device has the potential to save over 6 million children in developing countries, where sepsis accounts for 60-80% of all deaths.
A new study from Penn Medicine found that patients with sepsis who are treated at high-volume hospitals have a 36% increase in their odds of inpatient survival compared to those treated at lower-volume hospitals. The study suggests that regionalized severe sepsis care centers may improve outcomes for critically ill patients.
Researchers found that fibroblastic reticular cells from lymph nodes improved survival in mouse models of sepsis, even when treatment was delayed by up to 16 hours. FRC administration prevented damage to the spleen and death of immune cells, leading to reduced bacterial levels in the bloodstream.
A recent study published in Critical Care Medicine found that heavier patients are more likely to survive sepsis, a life-threatening infection. This obesity paradox challenges conventional wisdom and may improve care for all patients with sepsis and other critical illnesses.
Researchers at USC's Keck School of Medicine have identified a key component of the immune system that is essential for preventing deadly inflammation. Mice lacking this component are completely resistant to sepsis, a potentially fatal complication of infection.
Researchers have created a device using microchannel technology that can remove endotoxins from blood, preventing sepsis. The technology may offer an alternative to antibiotics and could be used as a prophylactic treatment.
A study by Washington University School of Medicine links prolonged sepsis episodes to the reactivation of dormant viruses in the body. The research suggests that drugs to rev up the immune system could be incorporated into treatment for prolonged sepsis, potentially saving lives.
A new study reveals that late-stage sepsis triggers the reactivation of dormant viruses in the body, leading to secondary infections. Researchers found that 43% of sepsis patients had multiple viruses detected in their blood or urine.
A study published in JAMA found that sepsis is a major contributor to hospital mortality, with approximately 1 in 2 to 3 deaths attributed to the condition. Most patients who died from sepsis had the condition present at admission. The study highlights the need for improved standardized care for patients with less severe sepsis.
Despite improvements in supportive care, the mortality rate remains high due to sepsis. Statin therapy showed no significant difference in outcomes for patients with sepsis and ARDS, highlighting the need for further research into alternative treatments.
A review by Kevin J. Tracey, MD, and Clifford S. Deutschman argues that treatment for sepsis is nonspecific and limited to organ support, with no approved drugs targeting the condition. Instead, a new approach focusing on immunometabolic and neurophysiological mechanisms may be needed.
Researchers characterized the gut bacteria of premature infants who developed sepsis, suggesting a new approach to early detection and prevention. Genetic matches were found between bacteria in stool samples and those in blood samples, indicating that gut bacteria are responsible for these infections.
Researchers at Washington University School of Medicine found three types of potentially harmful gut microbes in preterm babies who developed late-onset sepsis: E. coli, group B strep, and S. marcescens. These findings suggest new strategies to detect and prevent severe bloodstream infections in neonatal intensive care units (NICUs).
A Rutgers-led study finds acupuncture can reduce inflammation and organ injury in septic mice, with half surviving for at least a week. The treatment also triggers increased levels of dopamine, which may help alleviate other inflammatory diseases like arthritis and Crohn's disease.
A Japanese study found that sarcopenia, a loss of skeletal muscle mass, increases the risk of sepsis and mortality in patients undergoing live donor liver transplantation. Early nutritional support with enteral nutrition reduced sepsis rates in these patients. Treating malnutrition may reduce mortality risk following transplantation.
A recent study led by Boston University School of Medicine found that hospitals caring for more sepsis patients have significantly lower mortality rates than those with lower volumes. The superior outcomes were achieved at similar costs, suggesting improved processes of care for patients with severe sepsis.
A new receptor, similar to those for endorphins or morphine, has been discovered to play a crucial role in the body's response to sepsis. Blocking this receptor may help reduce inflammation and improve outcomes for critically ill patients suffering from sepsis.
A new study by UCSB's Jamey Marth reveals a protective mechanism against lethal blood coagulation and thrombosis in sepsis. By pre-activating the Ashwell-Morell receptor, survival rates can be increased twofold.
A recent study from Boston University School of Medicine and Boston Medical Center found that severe sepsis mortality rates decreased significantly between 1991-1995 (47%) and 2006-2009 (29%). The decline occurred without the development of new pharmacological treatments for severe sepsis.
Researchers have identified a biomarker for sepsis in the blood that can be screened for at a patient's bedside, enabling rapid diagnosis and treatment. This breakthrough has the potential to save thousands of lives by reducing diagnosis time from up to two days to just two hours.
Researchers at The Feinstein Institute for Medical Research identified the cold-inducible RNA-binding protein (CIRP) as a key player in triggering inflammation during hemorrhagic shock and sepsis. Blocking CIRP activity may improve patient survival rates, according to preclinical studies.
Severe sepsis increased by about 10% per year, affecting about 1 in 11,000 women; many cases occur in women with no known risk factors, highlighting the need for improved detection of sepsis.
A new test uses a plastic bottle with an 'artificial nose' to detect eight common disease-causing bacteria, producing results in 24 hours. This faster method reduces the toll of sepsis in developing countries and medically underserved areas.
Scientists at Helmholtz Centre for Infection Research discovered natural killer cells have optimal immune response balance, having less active NK cells during early stages of infection improves survival. The overproduction of interferon IFN-γ can block recruitment of neutrophilic granulocytes, leading to fatal sepsis.
Researchers discovered that severe trauma injuries or burns lead to defective neutrophils, which contribute to septic complications. Measuring neutrophil motility could become a biomarker for predicting risk of septic complications and personalizing treatments.
Researchers created a US map pinpointing areas with higher rates of infection and sepsis-related deaths, including clusters in the Midwest, mid-Atlantic, and South. The analysis highlights the need for targeted interventions to improve public health resources.
Researchers discovered zinc's role in preventing excessive inflammation by interacting with the NF-κB pathway. Zinc deficiency can lead to poor outcomes in sepsis and common colds, but supplementation may help. The study sheds light on how zinc balances the immune response.
Researchers at Temple University Health System have identified a potential target for treating sepsis: the STIM1 protein. By blocking its activity, they halted a cascade of cellular events that lead to out-of-control inflammation and protected lungs from severe damage. The findings may lead to new treatment strategies against sepsis.
Scientists have identified an 'immune system kill switch' that triggers the destruction of blood stem cells in response to severe stress, such as chemotherapy or systemic infections. Blocking this internal signal could prevent death after chemotherapy and boost recovery from infection.
Researchers have identified early liver function changes as a potential indicator of severe sepsis. The study found that these changes occur hours before conventional markers and are linked to clinical outcomes. This breakthrough has significant implications for diagnosing and treating patients with critical illness.
Researchers at The Feinstein Institute for Medical Research have discovered that extract from mung bean can reduce the release of HMGB1, thereby increasing survival rates in mice. This finding has promise for the treatment of sepsis in humans.
A recent study by Henry Ford Health found that women are more than twice as likely to suffer infections related to kidney stones and other urinary blockages. The study also showed significantly higher rates of complications following urgent treatments for the condition.
Researchers at Boston Children's Hospital have created a model to study sepsis in newborns, identifying diagnostic markers and potential treatments. The model has shown that even at the earliest hours of life, newborns can mount a robust inflammatory response to bacterial challenge.
Cefazolin outperforms vancomycin in preventing hospitalizations and deaths from specific bloodstream infections, a study reveals. The antibiotic was found to be 48% more effective at preventing sepsis.
A University of Michigan study reveals that spouses of severe sepsis patients are nearly four times more likely to experience substantial depressive symptoms. Greater mental health screenings may be necessary for these individuals to support their loved ones' rehabilitation and decision-making.
A new study examines real-life usage of Xigris over ten years and concludes that its efficacy is comparable to the original PROWESS trial. The study found a significant reduction in hospital death risk for patients with severe sepsis.
Researchers at Brigham and Women's Hospital have identified a microRNA called miR-181b that can reduce the inflammatory response responsible for diseases like sepsis. The findings suggest that higher levels of miR-181b may be protective against sepsis and other inflammatory diseases.
A new biohybrid device can reprogram the inflammatory response at the whole-organism level, offering a foundational concept for genetically modified cells and tailored clinical applications. This innovation holds potential to prevent sepsis and other life-threatening complications associated with acute inflammation.
Researchers have designed and tested molecules that can block or enhance aspects of the immune system's activity, offering a potential new treatment for inflammatory diseases. The breakthrough, published in Journal of Medicinal Chemistry, uses a novel optimization-based approach to design peptides with unprecedented potency and precision.
Researchers found excess protein in urine dipstick tests predicted renal failure in 55% of sepsis patients. The test is widely available and inexpensive, providing early diagnosis of renal failure.
Recent studies suggest a decline in pneumonia hospitalizations and inpatient deaths in the US. However, analysis of data from the Nationwide Inpatient Sample reveals that trends in diagnostic coding, such as increased use of sepsis and respiratory failure codes, may be driving these declines.
A new study found that inhibiting necroptosis protects mice from lethal sepsis by blocking a specific cell death pathway. The research may lead to new therapeutic interventions for fatal inflammatory conditions.
A recent study by researchers at Boston University School of Medicine found that severe sepsis and new-onset atrial fibrillation are associated with a higher risk of hospital stroke and death. Patients diagnosed with these conditions during hospitalization had three times the risk of stroke and a seven percent increased risk of mortality.
Earthquakes result in massive death tolls due to trauma, crush injuries, and disruptions to medical services. Many victims succumb to complications, sepsis, or organ failure, while others experience mental health problems like depression and post-traumatic stress disorder.
Researchers aim to determine optimal Vitamin C dosing schedule and test therapy in septic patients to moderate organ dysfunction and improve outcomes. A potential new treatment for sepsis may be on the horizon thanks to a significant grant.
Researchers found that mice lacking fibrin showed dramatically decreased survival and increased bacterial loads during gram-negative sepsis. Fibrin helps protect bodies during infection, and its regulation may hold the key to preventing organ failure in sepsis patients.
A new theory suggests sepsis may be caused by leaking blood vessels, rather than just a symptom. This idea has the potential to lead to novel treatments and improve patient outcomes.
U-M researchers found that attacking specific microRNA molecules can reduce deaths from sepsis. The approach also holds promise for other inflammatory diseases like juvenile rheumatoid arthritis and graft-vs.-host disease.
Researchers have discovered a blueprint to block crucial Matrix Metalloprotease enzymes that activate the fatal inflammatory response in sepsis. Elevated levels of proMMP-1 and active MMP-1 predicted early and late death in human sepsis patients.