Articles tagged with Sepsis
Researchers at Temple University Health System have identified a potential target for treating sepsis: the STIM1 protein. By blocking its activity, they halted a cascade of cellular events that lead to out-of-control inflammation and protected lungs from severe damage. The findings may lead to new treatment strategies against sepsis.
Scientists have identified an 'immune system kill switch' that triggers the destruction of blood stem cells in response to severe stress, such as chemotherapy or systemic infections. Blocking this internal signal could prevent death after chemotherapy and boost recovery from infection.
Researchers have identified early liver function changes as a potential indicator of severe sepsis. The study found that these changes occur hours before conventional markers and are linked to clinical outcomes. This breakthrough has significant implications for diagnosing and treating patients with critical illness.
Researchers at The Feinstein Institute for Medical Research have discovered that extract from mung bean can reduce the release of HMGB1, thereby increasing survival rates in mice. This finding has promise for the treatment of sepsis in humans.
A recent study by Henry Ford Health found that women are more than twice as likely to suffer infections related to kidney stones and other urinary blockages. The study also showed significantly higher rates of complications following urgent treatments for the condition.
Researchers at Boston Children's Hospital have created a model to study sepsis in newborns, identifying diagnostic markers and potential treatments. The model has shown that even at the earliest hours of life, newborns can mount a robust inflammatory response to bacterial challenge.
Cefazolin outperforms vancomycin in preventing hospitalizations and deaths from specific bloodstream infections, a study reveals. The antibiotic was found to be 48% more effective at preventing sepsis.
A University of Michigan study reveals that spouses of severe sepsis patients are nearly four times more likely to experience substantial depressive symptoms. Greater mental health screenings may be necessary for these individuals to support their loved ones' rehabilitation and decision-making.
A new study examines real-life usage of Xigris over ten years and concludes that its efficacy is comparable to the original PROWESS trial. The study found a significant reduction in hospital death risk for patients with severe sepsis.
Researchers at Brigham and Women's Hospital have identified a microRNA called miR-181b that can reduce the inflammatory response responsible for diseases like sepsis. The findings suggest that higher levels of miR-181b may be protective against sepsis and other inflammatory diseases.
Researchers have designed and tested molecules that can block or enhance aspects of the immune system's activity, offering a potential new treatment for inflammatory diseases. The breakthrough, published in Journal of Medicinal Chemistry, uses a novel optimization-based approach to design peptides with unprecedented potency and precision.
Researchers found excess protein in urine dipstick tests predicted renal failure in 55% of sepsis patients. The test is widely available and inexpensive, providing early diagnosis of renal failure.
A new biohybrid device can reprogram the inflammatory response at the whole-organism level, offering a foundational concept for genetically modified cells and tailored clinical applications. This innovation holds potential to prevent sepsis and other life-threatening complications associated with acute inflammation.
Recent studies suggest a decline in pneumonia hospitalizations and inpatient deaths in the US. However, analysis of data from the Nationwide Inpatient Sample reveals that trends in diagnostic coding, such as increased use of sepsis and respiratory failure codes, may be driving these declines.
A new study found that inhibiting necroptosis protects mice from lethal sepsis by blocking a specific cell death pathway. The research may lead to new therapeutic interventions for fatal inflammatory conditions.
A recent study by researchers at Boston University School of Medicine found that severe sepsis and new-onset atrial fibrillation are associated with a higher risk of hospital stroke and death. Patients diagnosed with these conditions during hospitalization had three times the risk of stroke and a seven percent increased risk of mortality.
Earthquakes result in massive death tolls due to trauma, crush injuries, and disruptions to medical services. Many victims succumb to complications, sepsis, or organ failure, while others experience mental health problems like depression and post-traumatic stress disorder.
Researchers aim to determine optimal Vitamin C dosing schedule and test therapy in septic patients to moderate organ dysfunction and improve outcomes. A potential new treatment for sepsis may be on the horizon thanks to a significant grant.
Researchers found that mice lacking fibrin showed dramatically decreased survival and increased bacterial loads during gram-negative sepsis. Fibrin helps protect bodies during infection, and its regulation may hold the key to preventing organ failure in sepsis patients.
A new theory suggests sepsis may be caused by leaking blood vessels, rather than just a symptom. This idea has the potential to lead to novel treatments and improve patient outcomes.
U-M researchers found that attacking specific microRNA molecules can reduce deaths from sepsis. The approach also holds promise for other inflammatory diseases like juvenile rheumatoid arthritis and graft-vs.-host disease.
Researchers have discovered a blueprint to block crucial Matrix Metalloprotease enzymes that activate the fatal inflammatory response in sepsis. Elevated levels of proMMP-1 and active MMP-1 predicted early and late death in human sepsis patients.
Case Western Reserve University researchers found that manipulating Kruppel-like transcription factor 2 can improve survival rates during bacterial infection. The study reveals that boosting immune cells in the early stages of sepsis can cause harm, while curbing the defense system in later stages is crucial to prevent shock and death.
Researchers found that simvastatin significantly reduces lung damage and inflammation in severe abdominal sepsis. The study suggests statins may be of clinical value for patients with severe abdominal infections.
A nationwide study found that group B streptococci are the leading cause of early-onset sepsis in full-term infants, while Escherichia coli is a common pathogen in preterm infants. The study also highlights missed opportunities for prevention due to inadequate screening and electronic medical record linking.
Researchers found that neutralizing C5a protein fragment can prevent cardiomyopathy in patients with sepsis, offering hope for stopping devastating effects of the disease. The study shows promise for developing new treatments to combat heart failure and improve survival rates.
Researchers at the University of California - San Diego discovered a structural basis for how strep protein can trigger toxic shock. The proteins form dense scaffolds that mimic blood clots, leading to widespread inflammation and organ failure. This breakthrough provides new insights into the pathogenesis of strep-induced toxic shock.
A recent study by researchers at Rhode Island Hospital has found that the protein RIP1 plays a dual role in sepsis, promoting both cell death and survival. The study suggests that RIP1 is necessary for survival during septic injury, and its pro-survival trigger may hold key to developing new treatments for sepsis.
Researchers have found that vitamin C can prevent the onset of sepsis and even reverse the disease by restoring blood flow to vital organs. Early and delayed injections of vitamin C have been shown to improve survival rates in mice with sepsis, making it a promising treatment option.
A study published in JAMA found that severe sepsis is associated with significant cognitive impairment and functional disability in older patients. The researchers analyzed data from over 1,000 patients who survived severe sepsis and found a high rate of new functional limitations, including increased caregiver time and mortality.
Research found that 60% of hospitalizations for severe sepsis were associated with worsened cognitive and physical function among surviving older adults. Cognitive impairment was 3.3 times higher following an episode of sepsis than for other hospitalizations.
A high-fat Western diet has been found to exacerbate the inflammatory response to sepsis, a condition of systemic bacterial infection. This increased inflammation can lead to severe outcomes, including higher mortality rates and more morbidity in obese patients.
A predictive model using factors like age, blood pressure, and heart rate accurately predicted the development of critical illness in patients who received out-of-hospital emergency care. The study found that hospitals varying widely in quality of critical care could improve outcomes for critically ill patients by concentrating care at...
Neural stem cells can repair damaged spinal cords by promoting nerve cell generation, restoring hind limb function in mice. Vitamin D may help prevent allergic bronchopulmonary aspergillosis in cystic fibrosis patients.
Researchers found that blocking PD-1 improves survival in a model of severe infection by restoring the host's immune function. The study suggests new drugs to reduce severity of blood infections leading to sepsis.
Researchers found that mesenchymal stem cells can triple survival rates in an experimental model of sepsis, a deadly condition caused by infection. The treatment also reduced inflammation and improved organ function in mice with severe sepsis.
A recent study published in JAMA found that black patients experience a higher rate of severe sepsis compared to white patients. The study attributes this disparity to higher rates of infection and increased risk of acute organ dysfunction, with younger adults being disproportionately affected.
Researchers found that compstatin, a drug that targets the complement system, can reduce blood clotting during dialysis for end-stage kidney disease. In severe sepsis, compstatin also blocks the activation of both complement and coagulation systems, potentially preventing multiple organ failure and death.
A recent study has linked leptin action in the brain to sepsis survival. Researchers found that leptin mediates actions in the central nervous system, improving the host response to a standard model of sepsis.
A new study identifies a protein pathway that protects blood vessels from hyper-inflammatory response to infection, reducing mortality rates in mouse models of avian flu and sepsis by up to 50%. The researchers found that activating the Robo4 pathway stabilizes blood vessels, preventing leakage and tissue damage.
Neonatal sepsis is a major public health concern worldwide, particularly in developing countries where high fatality rates are common. The World Health Organization estimates that 1 million deaths per year are due to neonatal sepsis, with disparities in care across countries. In addition, adolescent binge drinking is a significant glob...
Researchers found that chlorhexidine-soaked wipes did not reduce neonatal sepsis or vertical transmission of group B streptococcus. The study suggests that other interventions are needed to target child mortality and achieve the Millennium Development Goal of reducing childhood mortality.
A randomized trial found that milk protein lactoferrin supplementation alone or in combination with a probiotic reduced the incidence of late-onset sepsis in very low birth-weight infants. The supplement exhibited antimicrobial activity and was well-tolerated, making it a promising prevention strategy.
A mathematical model suggests that improved community-based access to life-saving drugs like misoprostol and antibiotics can prevent up to 59,000 maternal deaths across sub-Saharan Africa per year. The study found that the poorest women would benefit most from these interventions.
Researchers discovered how resveratrol controls inflammation by inhibiting two molecules that trigger inflammatory responses. The findings suggest resveratrol may be used to treat inflammatory diseases and lead to new resveratrol-based drugs.
A randomised controlled trial shows ketamine is a safe alternative to etomidate for intubating critically ill patients, reducing adrenal insufficiency risk. The study's results suggest pharmacological knowledge may be crucial for successful emergency intubation.
The new system detects sepsis in real-time, alerting doctors to potential cases. The team also plans to add an automated decision support system to guide physicians through sepsis treatment.
Research found black Americans are nearly twice as likely to develop acute lung injury compared to white Americans, with a higher burden of immune-compromising conditions and greater severity of illness at admission. Despite this, in-hospital mortality rates among patients with ALI did not vary meaningfully by race.
A team of scientists at Emory University School of Medicine identified a direct link between oxidative stress and inflammatory signals in the blood. They found that supplementing the diet with cysteine can reduce inflammation by blunting the impact of sepsis-like inflammation.
Scientists have identified platelets as a contributor to organ failure in patients with sepsis. The study found that granzyme B production in platelets can cause cell death, leading to organ failure. Researchers hope this discovery will lead to better treatments and potentially even prevention of organ failure.
Researchers found that diabetic patients are less likely to develop acute respiratory failure during severe sepsis. They discovered that people with diabetes and sepsis were more likely to develop acute renal failure than those without diabetes.
Yale researchers identified proteins associated with early onset neonatal sepsis, a stealthy bacterial infection linked to premature birth and death. The biomarkers found have diagnostic value for infection and inflammation, allowing for earlier identification of babies at risk.
A new study found that administering GM-CSF to premature babies did not reduce the risk of sepsis or improve survival rates. The trial, which studied 280 babies, showed that while white blood cell counts rose with GM-CSF treatment, there was no significant difference in infection-free survival between the two groups.
New computer-based models describe how bacteria act within blood vessels and can be filtered out, offering insights into treatment options for bacteremia and sepsis. The models validate laboratory experiments in mice and have implications for developing new treatments for deadly bacterial infections.
Stapled hemorrhoidopexy is a safe and effective procedure but can lead to life-threatening complications. Pelvic sepsis after stapled hemorrhoidopexy has a high mortality rate due to the lack of established treatment protocols, emphasizing the need for further research to identify optimal management strategies.
Researchers identified a new anatomical path through which the brain and spleen communicate, enabling the immune system to respond to disease. The study suggests that stimulating the vagus nerve can suppress inflammation-producing molecules in the spleen, potentially leading to new treatments for sepsis.
Researchers discovered the Ashwell receptor's essential role in reducing coagulation abnormalities during infection and sepsis, significantly improving survival. The receptor triggers a protective response, limiting lethal side effects by removing pro-coagulation factors from circulation.
Recent research finds that blacks are nearly twice as likely to develop severe sepsis as whites, with a significantly higher mortality rate. After controlling for poverty and geography, black race remained independently associated with higher severe sepsis incidence.
Researchers at Karolinska Institute have identified a new source of dopamine cells that provided marked benefit when transplanted into mice with Parkinson's-like disease. Wnt5a-treated neural stem cells may be an efficient and safe source for DA cell replacement therapy in individuals with PD.
A new study found that green tea's EGCG ingredient can rescue mice from lethal sepsis, paving the way for clinical trials. The substance works by preventing HMGB1 from being released and activating immune cells.