Articles tagged with Sepsis
Researchers found that mice lacking fibrin showed dramatically decreased survival and increased bacterial loads during gram-negative sepsis. Fibrin helps protect bodies during infection, and its regulation may hold the key to preventing organ failure in sepsis patients.
A new theory suggests sepsis may be caused by leaking blood vessels, rather than just a symptom. This idea has the potential to lead to novel treatments and improve patient outcomes.
U-M researchers found that attacking specific microRNA molecules can reduce deaths from sepsis. The approach also holds promise for other inflammatory diseases like juvenile rheumatoid arthritis and graft-vs.-host disease.
Researchers have discovered a blueprint to block crucial Matrix Metalloprotease enzymes that activate the fatal inflammatory response in sepsis. Elevated levels of proMMP-1 and active MMP-1 predicted early and late death in human sepsis patients.
Case Western Reserve University researchers found that manipulating Kruppel-like transcription factor 2 can improve survival rates during bacterial infection. The study reveals that boosting immune cells in the early stages of sepsis can cause harm, while curbing the defense system in later stages is crucial to prevent shock and death.
Researchers found that simvastatin significantly reduces lung damage and inflammation in severe abdominal sepsis. The study suggests statins may be of clinical value for patients with severe abdominal infections.
A nationwide study found that group B streptococci are the leading cause of early-onset sepsis in full-term infants, while Escherichia coli is a common pathogen in preterm infants. The study also highlights missed opportunities for prevention due to inadequate screening and electronic medical record linking.
Researchers found that neutralizing C5a protein fragment can prevent cardiomyopathy in patients with sepsis, offering hope for stopping devastating effects of the disease. The study shows promise for developing new treatments to combat heart failure and improve survival rates.
Researchers at the University of California - San Diego discovered a structural basis for how strep protein can trigger toxic shock. The proteins form dense scaffolds that mimic blood clots, leading to widespread inflammation and organ failure. This breakthrough provides new insights into the pathogenesis of strep-induced toxic shock.
A recent study by researchers at Rhode Island Hospital has found that the protein RIP1 plays a dual role in sepsis, promoting both cell death and survival. The study suggests that RIP1 is necessary for survival during septic injury, and its pro-survival trigger may hold key to developing new treatments for sepsis.
Researchers have found that vitamin C can prevent the onset of sepsis and even reverse the disease by restoring blood flow to vital organs. Early and delayed injections of vitamin C have been shown to improve survival rates in mice with sepsis, making it a promising treatment option.
Research found that 60% of hospitalizations for severe sepsis were associated with worsened cognitive and physical function among surviving older adults. Cognitive impairment was 3.3 times higher following an episode of sepsis than for other hospitalizations.
A study published in JAMA found that severe sepsis is associated with significant cognitive impairment and functional disability in older patients. The researchers analyzed data from over 1,000 patients who survived severe sepsis and found a high rate of new functional limitations, including increased caregiver time and mortality.
A high-fat Western diet has been found to exacerbate the inflammatory response to sepsis, a condition of systemic bacterial infection. This increased inflammation can lead to severe outcomes, including higher mortality rates and more morbidity in obese patients.
A predictive model using factors like age, blood pressure, and heart rate accurately predicted the development of critical illness in patients who received out-of-hospital emergency care. The study found that hospitals varying widely in quality of critical care could improve outcomes for critically ill patients by concentrating care at...
Neural stem cells can repair damaged spinal cords by promoting nerve cell generation, restoring hind limb function in mice. Vitamin D may help prevent allergic bronchopulmonary aspergillosis in cystic fibrosis patients.
Researchers found that blocking PD-1 improves survival in a model of severe infection by restoring the host's immune function. The study suggests new drugs to reduce severity of blood infections leading to sepsis.
Researchers found that mesenchymal stem cells can triple survival rates in an experimental model of sepsis, a deadly condition caused by infection. The treatment also reduced inflammation and improved organ function in mice with severe sepsis.
A recent study published in JAMA found that black patients experience a higher rate of severe sepsis compared to white patients. The study attributes this disparity to higher rates of infection and increased risk of acute organ dysfunction, with younger adults being disproportionately affected.
Researchers found that compstatin, a drug that targets the complement system, can reduce blood clotting during dialysis for end-stage kidney disease. In severe sepsis, compstatin also blocks the activation of both complement and coagulation systems, potentially preventing multiple organ failure and death.
A recent study has linked leptin action in the brain to sepsis survival. Researchers found that leptin mediates actions in the central nervous system, improving the host response to a standard model of sepsis.
A new study identifies a protein pathway that protects blood vessels from hyper-inflammatory response to infection, reducing mortality rates in mouse models of avian flu and sepsis by up to 50%. The researchers found that activating the Robo4 pathway stabilizes blood vessels, preventing leakage and tissue damage.
Neonatal sepsis is a major public health concern worldwide, particularly in developing countries where high fatality rates are common. The World Health Organization estimates that 1 million deaths per year are due to neonatal sepsis, with disparities in care across countries. In addition, adolescent binge drinking is a significant glob...
Researchers found that chlorhexidine-soaked wipes did not reduce neonatal sepsis or vertical transmission of group B streptococcus. The study suggests that other interventions are needed to target child mortality and achieve the Millennium Development Goal of reducing childhood mortality.
A randomized trial found that milk protein lactoferrin supplementation alone or in combination with a probiotic reduced the incidence of late-onset sepsis in very low birth-weight infants. The supplement exhibited antimicrobial activity and was well-tolerated, making it a promising prevention strategy.
A mathematical model suggests that improved community-based access to life-saving drugs like misoprostol and antibiotics can prevent up to 59,000 maternal deaths across sub-Saharan Africa per year. The study found that the poorest women would benefit most from these interventions.
Researchers discovered how resveratrol controls inflammation by inhibiting two molecules that trigger inflammatory responses. The findings suggest resveratrol may be used to treat inflammatory diseases and lead to new resveratrol-based drugs.
A randomised controlled trial shows ketamine is a safe alternative to etomidate for intubating critically ill patients, reducing adrenal insufficiency risk. The study's results suggest pharmacological knowledge may be crucial for successful emergency intubation.
The new system detects sepsis in real-time, alerting doctors to potential cases. The team also plans to add an automated decision support system to guide physicians through sepsis treatment.
Research found black Americans are nearly twice as likely to develop acute lung injury compared to white Americans, with a higher burden of immune-compromising conditions and greater severity of illness at admission. Despite this, in-hospital mortality rates among patients with ALI did not vary meaningfully by race.
A team of scientists at Emory University School of Medicine identified a direct link between oxidative stress and inflammatory signals in the blood. They found that supplementing the diet with cysteine can reduce inflammation by blunting the impact of sepsis-like inflammation.
Scientists have identified platelets as a contributor to organ failure in patients with sepsis. The study found that granzyme B production in platelets can cause cell death, leading to organ failure. Researchers hope this discovery will lead to better treatments and potentially even prevention of organ failure.
Researchers found that diabetic patients are less likely to develop acute respiratory failure during severe sepsis. They discovered that people with diabetes and sepsis were more likely to develop acute renal failure than those without diabetes.
Yale researchers identified proteins associated with early onset neonatal sepsis, a stealthy bacterial infection linked to premature birth and death. The biomarkers found have diagnostic value for infection and inflammation, allowing for earlier identification of babies at risk.
A new study found that administering GM-CSF to premature babies did not reduce the risk of sepsis or improve survival rates. The trial, which studied 280 babies, showed that while white blood cell counts rose with GM-CSF treatment, there was no significant difference in infection-free survival between the two groups.
New computer-based models describe how bacteria act within blood vessels and can be filtered out, offering insights into treatment options for bacteremia and sepsis. The models validate laboratory experiments in mice and have implications for developing new treatments for deadly bacterial infections.
Stapled hemorrhoidopexy is a safe and effective procedure but can lead to life-threatening complications. Pelvic sepsis after stapled hemorrhoidopexy has a high mortality rate due to the lack of established treatment protocols, emphasizing the need for further research to identify optimal management strategies.
Researchers identified a new anatomical path through which the brain and spleen communicate, enabling the immune system to respond to disease. The study suggests that stimulating the vagus nerve can suppress inflammation-producing molecules in the spleen, potentially leading to new treatments for sepsis.
Researchers discovered the Ashwell receptor's essential role in reducing coagulation abnormalities during infection and sepsis, significantly improving survival. The receptor triggers a protective response, limiting lethal side effects by removing pro-coagulation factors from circulation.
Recent research finds that blacks are nearly twice as likely to develop severe sepsis as whites, with a significantly higher mortality rate. After controlling for poverty and geography, black race remained independently associated with higher severe sepsis incidence.
Researchers at Karolinska Institute have identified a new source of dopamine cells that provided marked benefit when transplanted into mice with Parkinson's-like disease. Wnt5a-treated neural stem cells may be an efficient and safe source for DA cell replacement therapy in individuals with PD.
A new study found that green tea's EGCG ingredient can rescue mice from lethal sepsis, paving the way for clinical trials. The substance works by preventing HMGB1 from being released and activating immune cells.
Researchers have found that the vagus nerve directly communicates with the immune system, controlling inflammation. This discovery is leading to novel treatments for diseases such as sepsis and autoimmune conditions.
A recent study published in Critical Care found that children under four are highly susceptible to sepsis, which can lead to severe disease states and death. The study analyzed data from nearly 300 children with sepsis and purpura between 1988 and 2006, revealing that younger age is a critical factor in determining survival rates.
Researchers found that sepsis's inflammatory response is highly variable across patients, extending past outward symptoms. The study aims to inform future treatment and prevention strategies by providing a better understanding of the disease.
A new mathematical model of sepsis can predict patient outcomes, including deaths, discharges, and disease progression. The model was developed using data from over 1,800 patients with pneumonia-related sepsis and showed high accuracy in predicting these outcomes.
A new treatment, micafungin, has been shown to be equally effective as existing treatments in treating Candida-related infections. With fewer side effects, micafungin is a promising alternative for first-line therapy of candidemia and invasive candidosis.
Researchers at Johns Hopkins found that statins significantly reduce the risk of sepsis in patients undergoing kidney dialysis. The study, published in JAMA, followed 1041 patients for 10 years and found a 41-case risk in the statin group compared to 110 cases in the non-statin group.
Biosite has identified a combination of three biomarkers that performed better in assessing risk of sepsis progression. The sepsis biomarker panel may aid in the rapid assessment of patients presenting to the emergency department with signs and symptoms of sepsis.
A blood marker, procalcitonin, helps identify patients at increased risk of organ failure and death due to abdominal infections. Procalcitonin levels can predict multi-organ dysfunction syndrome and overall prognosis in patients with secondary peritonitis.
Researchers at the University of Virginia Health System have developed a non-invasive, real-time monitoring system to predict sepsis in neonates. This technology analyzes heartbeat signals to identify characteristic patterns that indicate an impending infection. By detecting these patterns early, clinicians can initiate treatment soone...
Researchers used gene chips to analyze patterns of gene expression in mice and found a 94% accuracy rate in distinguishing sepsis from non-infectious inflammation. The technology could lead to a rapid bedside blood test that speeds diagnosis and treatment, especially in intensive care units.
Researchers at UTMB discovered that blocking aldose reductase can short-circuit sepsis, protecting heart function and reducing deaths. The compound is similar to an existing diabetes drug in stage three clinical trials.
Researchers discovered that phosphatase and tensin homolog (PTEN) regulates the proliferative capabilities of naturally occurring CD4+CD25+ Tregs but not their suppressive function. This finding provides a potential solution to harnessing the therapeutic potential of Tregs in autoimmune diseases.
A handheld radio wand scanning device was tested on eight surgery patients and detected all tagged sponges with 100% accuracy. The device improved patient safety by reducing the risk of retained foreign objects, but human error remains a concern.
Severe sepsis is a significant health problem causing death and ill-health in UK hospitals. Reliable data tracking is needed to plan resources and campaigns to improve outcomes.
A new study found that vascular endothelial growth factor (VEGF) plays a key role in the onset of sepsis, a leading cause of organ failure and ICU hospitalizations. The study's findings suggest that VEGF could be a novel therapeutic agent for managing this deadly disease.
The HealthGrades study reveals a significant increase in hospital incidents, with Medicare patients experiencing one-in-four chance of dying during hospitalization. Top-performing hospitals and states like Minnesota show progress in patient safety, with potential cost savings of $2.45 billion.
Researchers found that HIV's Vpr protein disables host immunity by interacting with PARP-1 through the glucocorticoid receptor. This discovery provides potential novel approaches for designing new drugs to combat AIDS and inflammatory disorders.
A study found that corticosteroids in the trauma intensive care unit are associated with a higher risk of pneumonia, bloodstream infections, urinary tract infections, prolonged ICU stays, and increased mortality rates. The use of corticosteroids for conditions not widely studied also resulted in significant additional costs.