Articles tagged with Tissue Damage
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Researchers have developed a dye-free method to visualize blood flow in the brain, allowing for detailed mapping of small capillaries and assessing blood flow rates. The technique has potential applications in understanding cardiovascular diseases, tumor growth, and targeted drug delivery.
Scientists create a cell culture system where blood vessels can grow within a framework made of synthetic materials. The team investigates material properties that promote blood vessel formation and refines the model to improve its performance, paving the way for growing implantable tissues.
A University at Buffalo-led study found that photobiomodulation therapy sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein controlling cell growth and division. The findings may improve therapeutic treatments for burn injuries worldwide.
Researchers use X-rays to activate opsins in neurons, allowing for remote control of neural function and behavior. Scintillators emit visible light in response to X-ray irradiation, enabling the technique without tissue damage.
BioAesthetics Corp., a Tulane University spin-out company, has received a $256,000 grant to develop a novel graft for treating pelvic organ prolapse (POP). The graft, strengthened with biodegradable polymers, will be tested in Kristin Miller's lab to compare its elasticity and strength to normal tissue.
Neutrophils use an internal start-stop system to balance search and destroy phases for efficient pathogen elimination. This system helps prevent excessive inflammation and tissue damage. The study provides new insights into neutrophil biology, essential for immune host defense against bacteria.
Researchers at the University of Illinois Chicago have developed a microgel coating that can optimize cell-based therapy for pulmonary fibrosis. The coating boosts the therapeutic potential of donor cells by degrading scar tissue and promoting healthy lung tissue regeneration.
A Yale-led study discovered that children with multi-system inflammatory response (MIS-C) exhibit unique immune system signatures, including elevated alarmins and adaptive immune responses. These findings may aid in diagnosis and early treatment of the condition, which can be fatal if left untreated.
Researchers developed a hyaluronic acid hydrogel system to stabilize damaged cartilage, pausing its degeneration and promoting the formation of a protective barrier. The therapy was shown to enhance healing and restore regular activity to chondrocytes in lab tests.
Researchers at Ohio State University developed a technology called tissue nanotransfection (TNT) that reprograms skin cells into vascular cells to repair damaged brain tissue. In a mouse study, cells treated with this innovative cell therapy regained 90% of their motor function, showing promise for treating stroke patients.
A new study reveals that the behavior of p53, a key tumor-suppressor protein, over time determines whether tissues can survive radiation exposure. In vulnerable tissues, p53 levels remain high, leading to cell death, while in more radioresistant tissues, p53 levels oscillate, allowing cells to survive.
A study found that surgery to repair an inflamed gut may trigger a second immune system attack, which could lead to pouchitis. Researchers analyzed tissue samples and gene activity in patients who developed pouchitis after J-pouch surgery.
Engineers at MIT designed a bioadhesive patch inspired by origami that can seal internal wounds and tissues. The patch, made from three layers, resists contamination and biodegrades over time.
Researchers have developed a safe and efficient stem cell therapy to regenerate cardiac function in pediatric patients with dilated cardiomyopathy. The therapy, using cardio sphere-derived cells, has shown promising results in small human trials, reversing damage and improving heart function.
A study by UC Santa Cruz professor Terrie Williams explores how marine mammals' physiological adaptations can help understand the effects of COVID-19. Marine mammals have evolved mechanisms to protect critical organs during low-oxygen conditions, which may inform strategies for humans to mitigate long-term damage from oxygen deprivation.
A study by Radboud University Medical Center found that most lung tissue recovers well after COVID-19, with limited residual damage. Patients who were referred to the aftercare clinic showed poorer recovery rates compared to those admitted to the ICU.
Researchers have identified two key factors involved in cellular recovery from extreme stress, which may provide new strategies for treating cancers. The study reveals that apoptosis is a more nuanced process than previously known, and sometimes cells survive the executioner caspase via anastasis.
Researchers at KIST developed a new material that changes color when damaged, improving sensitivity by 850% compared to existing materials. The innovative process allows for easy application to various materials, making it suitable for wearable sensors and artificial skin.
A collaborative team developed an organs-on-a-chip system to monitor heart toxicity from breast cancer drugs. The dual-organ system closely mimics bodily tissues and provides evidence that the interplay between the heart and breast cancer tissues influences cell function and disease progression.
A new study reveals that brain cell dysfunction in low oxygen is caused by the body's protective response system, which ultimately impairs brain cell function. Researchers have identified a class of drugs that can overcome this damage and restore brain-stem cell function.
Researchers at UniSA have identified a new biomarker for osteoarthritis using mass spectrometry imaging, which may improve early diagnosis and treatment. The study found specific sugars associated with damaged tissue compared to healthy tissue, potentially helping slow the progression of the disease.
Researchers at La Jolla Institute for Immunology report that protein TL1A drives fibrosis in several mouse models, triggering tissue remodeling and making it harder for lungs and airways to function normally. This discovery suggests potential targets for therapeutics aimed at reducing fibrosis and tissue remodeling.
A Rutgers-led team has created a smart drug delivery system to reduce inflammation and promote tissue repair in damaged nervous tissues. The system, which uses ultrathin biomaterials, aims to improve the treatment of spinal cord injuries and other neurological disorders.
Researchers at UC Davis Health have made a breakthrough in using stem cell treatments for heart disease. By blocking an enzyme linked with inflammation, they were able to increase the survival of transplanted stem cells and improve cardiac function. This discovery could lead to a cellular-based treatment for heart failure.
Researchers at Scripps Research have identified a new class of compounds that can restart cellular production of VEGF-A, a key factor in rebuilding blood vessels and muscle in damaged heart tissue. The discovery has the potential to revolutionize the treatment of heart failure and other cardiovascular diseases.
Researchers have developed coatings that can help integrate electronics with human tissues, enabling new diagnostics and potential applications in merging humans and AI. The coatings improve signal quality and battery lifetime, making them suitable for medical implants.
Researchers used computational models to study the effects of thinner biological tissues on transcatheter aortic valve replacement. The findings indicate that thinner tissues can lead to high levels of 'flutter energy', causing blood damage and accelerating leaflet deterioration.
Researchers are developing biomaterials to boost the body's natural healing process, with two approaches: incorporating cells or designing materials to stimulate cellular response. This can lead to improved success rates in tissue regeneration, reducing regulatory barriers and increasing available options.
Researchers at MIT developed a double-sided adhesive that can quickly and firmly stick to wet surfaces like biological tissues. The new design allows for detachability without tissue damage by applying a liquid solution, making it easier for surgeons to close internal wounds.
Researchers have discovered a way to soften a cell's nucleus, allowing it to move through dense connective tissues and promote injury repair. This breakthrough could lead to new therapeutics for healing dense connective tissues with poor natural repair capacity.
Researchers developed a novel dietary silicon-based antioxidant agent that suppressed the development and progression of kidney failure and Parkinson's disease in rodents. The agent enabled the continuous production of an OH-eliminating molecule, significantly lowering oxidative stress and inflammation.
Researchers at Terasaki Institute developed a minimally invasive approach using 'Detachable Microneedle Depots' to deliver MSCs into damaged tissues, accelerating wound healing in mouse models. The technique targets damaged areas with high spatial precision, utilizing microneedles to deploy therapeutic cells and promote healing.
Researchers discovered that M2-type macrophages are more susceptible to ferroptosis and may exacerbate chronic inflammation. A mathematical model was developed to describe the stability of macrophages under different conditions.
Researchers have developed a textile approach to tissue engineering using woven human tissue threads, which can create any shape and display excellent mechanical properties without synthetic materials. This innovative approach has the potential to aid in repairing damaged blood vessels, skin, nerve injuries, and other tissues and organs.
Researchers develop combined technique to restore damaged intervertebral discs, improving hydration and structural integrity of the nucleus pulposus. The method also repairs damaged annulus fibrosus tissue, suggesting a potential strategy for improving outcomes in discectomy patients.
Researchers found that social isolation is associated with increased inflammation in the body, particularly in males. Inflammation can lead to various health issues, including cardiovascular disease.
Scientists at Inserm have cultivated human cells in the lab to produce extracellular matrix deposits high in collagen, which can be woven into yarn to replace damaged blood vessels. This biologically derived material is expected to be well-accepted by the body and could lead to clinical trials.
Researchers at CNIC discovered a 'disarmament' mechanism in neutrophils that reduces their toxic capacity to prevent damage to healthy tissues. This innate system, driven by CXCR2 and circadian rhythms, helps regulate the immune response and could have implications for treating conditions like myocardial infarction and stroke.
A new study reveals that caspase-8 controls multiple cell death mechanisms, including pyroptosis, apoptosis, and necroptosis. The research found that the enzymatic activity of caspase-8 is required to inhibit pyroptosis, while inactive caspase-8 induces pyroptosis when necroptosis is blocked.
Scientists have developed a new material that controls cell immune response, using inhibitors placed directly in the material. The polycaprolactone scaffolds are biodegradable and release the inhibitors gradually, which can reduce negative consequences after heart attacks and strokes.
Acetic acid irrigation after button battery removal may prevent continued tissue injury and long-term complications in children. A recent study found that irrigation with dilute sterile vinegar, 0.25% acetic acid, improved mucosal appearance and prevented esophageal complications.
Frostbite can be prevented by wearing proper clothing, avoiding wind-chill, and addressing pre-existing conditions that may affect circulation. Early treatment with thrombolytic therapies like iloprost can help prevent tissue loss and promote recovery.
Researchers develop a high-resolution printing method to create complex tissue shapes in a biocompatible hydrogel containing stem cells. The resulting tissue can be vascularized by adding endothelial cells, enabling the creation of functional bioprinted organs with unprecedented speed and design freedom.
Researchers at the University of Bristol have made a world-first discovery by hijacking bacteria's homing ability to guide stem cells to cardiac tissue. The breakthrough could improve treatment for cardiovascular disease, which causes over a quarter of all deaths in the UK.
Purdue University researchers have created a 3D mapping technology to monitor and track the behavior of engineered cells and tissues. The technology offers diverse options for sensing and works in moist internal body environments, providing complete isolation from electronic instruments.
A new scaffold derived from a pig's meniscus has shown promise in repairing torn meniscus tissue. In lab tests, repairs aided by the scaffold resulted in stronger meniscus repairs after four weeks compared to natural healing.
Researchers identified a potential new therapeutic target for sepsis by uncovering a pathway involving Lipopolysaccharide (LPS) that could suppress the inflammatory response. This discovery offers a promising approach to treating sepsis, which can lead to organ failure and death if not recognized early.
Researchers from Boston University School of Medicine have discovered a previously unknown role of Serum Amyloid A (SAA) in rapidly removing lipid debris from damaged cells. This process is crucial for tissue healing and survival during acute events such as injury, infection, or inflammation.
High-intensity focused ultrasound waves can penetrate biological tissue and trigger chemical reactions on demand. The technology, developed by an interdisciplinary team, addresses challenges of noninvasive access to deep tissue for therapeutic purposes.
Researchers at UBC Okanagan have created an automated encapsulation device that encases cells in microgels, protecting them from physical damage and the immune system. The device enables over 85% of cells to survive and can be scaled up for rapid production of cell-encapsulated microgels.
Researchers have developed a water-based hydrogel material that can be placed directly on the heart to prevent stretching of the heart muscle, a common problem after a heart attack. The patch outperformed existing patches and showed promising results in reducing post-heart attack damage.
A new study from Thomas Jefferson University reveals that decreased oxygen supply to tendons leads to a loss of flexibility and an increase in fibrocartilage-like cells. This knowledge could help develop better treatments for tendinosis and regrow damaged tissue, which is common in older individuals.
Researchers created biocompatible structures on the basis of chitin obtained from crab shells through mechanochemical synthesis. The resulting structures can be used to replace damaged soft tissues in the human body, and have been shown to be biodegradable and non-toxic.
The University of Texas at San Antonio's Biomedical Engineering Research for Active military and Veterans (BRAVe) program aims to engage and retain undergraduate students in research projects, including tissue regeneration and non-invasive recovery. The program, funded by a $352,414 NSF award, will pair participants with faculty mentor...
Scientists at the University of British Columbia have discovered a new protein 'switch' that can stop the progression of sepsis, a life-threatening disease. This discovery could lead to new treatments for chronic and acute inflammatory diseases.
A recent study by MIT researchers found that overactive DNA-repair enzymes can lead to cell death and severe tissue damage in photoreceptor cells, a condition that may be linked to retinal blindness. The enzyme Aag glycosylase plays a key role in this process, promoting an inflammatory response that produces toxic intermediates.
Bioactive compounds 5 and others were found to be potent inhibitors of ROS and NO. Most active compounds showed good anti-inflammatory potential without toxicity on NIH-3T3 cells.
Researchers discovered activated PMN exosomes cause destruction in COPD lungs, harboring protease enzymes like NE that degrade collagen. These tiny entities, similar to those found in human COPD patients, can also cause damage when instilled into healthy mice.
Researchers at Imperial College London have developed a new molecule called TrAPs that interact with the body's natural repair systems to drive healing. The technique mimics nature and can be tailored to release specific therapeutic proteins based on cell type, offering new hope for patients with difficult-to-heal wounds.
Researchers at EPFL have developed a biocompatible hydrogel that naturally adheres to cartilage and the meniscus, eliminating the need for special membranes and sutures. The composite double-network hydrogel has shown superior adhesive properties and is poised to revolutionize treatment for soft tissue injuries.