Articles tagged with Tissue Damage
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Researchers have discovered that macrophage activity is lowered when they sit in tissue between cells, even with pro-inflammatory stimuli present. This mechanism helps prevent unnecessary inflammatory responses in healthy tissues.
A new study by CNIC researchers reveals that immune cells like neutrophils help maintain normal function of healthy tissues, performing roles unrelated to immunity. The findings suggest that the immune system is essential for day-to-day health, with potential benefits in some tissues and risks in others.
Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have discovered a new mechanism that controls tissue infiltration by neutrophils, which are tasked with eliminating the source of infection or inflammation. This regulation prevents excessive tissue injury and is essential to understanding immune system balance.
Brigham and Women's Hospital researchers have developed a method to bioprint complex tubular structures that mimic native vessels and ducts in the body. The 3D bioprinting technique allows for fine-tuning of printed tissues' properties, enabling potentially viable replacements for damaged tissue.
Researchers have engineered yeast microbreweries within disposable badges to detect low doses of radiation, potentially reducing cancer risk. The technology uses yeast's response to radiation to measure electrical conductivity, providing an instant reading of radiation exposure.
Researchers found that diabetes medications controlling macrophage metabolism can reduce inflammation and promote wound healing. By regulating energy sources for immune cells, these medications may inhibit the progression of diseases such as obesity and diabetes.
Researchers discovered seal blood serum has anti-inflammatory properties, protecting against damage to pulmonary tissues and inflammation. This unique adaptation allows elephant seals and Weddell seals to safely dive deep without lung damage or inflammation.
A study published in PLOS Biology found that mice can stimulate local growth while suppressing overall growth, enabling damaged tissues to recover and achieve symmetrical adult form. The placenta plays a crucial role in regulating overall growth rate and body proportions during development.
Russian scientists have developed a new method of bioprinting that allows creating 3D-biological objects without the use of layer-by-layer approach. This technology was made possible by magnetic levitation experiments in microgravity conditions, enabling the creation of radiation-sensitive biological constructs and repair of damaged ti...
A new study from MIT and Harvard University introduces the 'Therepi' device, which attaches directly to damaged heart tissue to deliver multiple therapies. The device addresses issues with current drug delivery methods, providing a non-invasive solution for treating heart disease.
Scientists have successfully programmed cells to self-organize into multi-layered structures reminiscent of simple organisms or embryonic development. These complex cellular assemblies can repair themselves and form complex tissue-like structures, opening doors for wound repair and organ regeneration.
Researchers at Columbia University have developed a new non-invasive approach to permanently correct vision. The technique uses a low-powered ultrafast laser to alter biochemical and biomechanical properties of collagenous tissue, resulting in changes in corneal curvature and refractive power.
Researchers have developed a non-invasive technique to measure the hardness of living tissues, which can influence organ formation during development. The method combines physical modeling and statistical estimation to estimate tissue hardness based on cell population deformation and mechanical forces applied to the tissue.
The UK Regenerative Medicine Platform aims to develop novel therapies that mimic the environment where stem cells grow in the body. Researchers will use their findings to stimulate repair mechanisms in damaged tissues, funded by £4 million.
Researchers at Goethe University Frankfurt found that single cells in the innermost layer of blood vessels proliferate after injury and contribute to the formation of new vessels. This process, known as clonal expansion, is thought to play a significant role in tissue damage repair, such as in diabetes or heart attacks.
A study published in Developmental Cell found that a signal from the tumor necrosis factor (TNF) signaling molecule Eiger reduces tension in tissue barrier cells, allowing immune cells like macrophages to pass through more easily. This mechanism was previously unknown and has potential importance beyond fruitflies to vertebrates.
Mammary stem cells from dairy cows may help heal damaged tissue and combat bacterial infections, potentially reducing antibiotic use and improving milk quality. The secreted factors of these cells have been shown to promote tissue regeneration, form new blood vessels, and protect epithelial cells from damage.
Researchers at UAB identified a therapeutic target to prevent or delay heart failure by blocking early infiltration of macrophages into the heart. Macrophage targeting may also reduce inflammation and T-cell expansion in patients with pressure-overload hypertrophy.
Researchers have developed high-density stretchable electrode grids for long-term stable neural recording, overcoming challenges in biocompatibility and mechanical properties. The breakthrough enables crucial applications in biomedical engineering, including diagnosing and treating neurological disorders such as epilepsy.
Researchers created biodegradable bandages with antibacterial properties, accelerating tissue regeneration twice as quickly as usual. The bandages also prevent scarring and promote normal skin covering tissue regeneration.
Case Western Reserve University scientists have engineered natural windpipe replacement structures using patient cells and self-assembling modules. This approach overcomes challenges in current tissue-engineering methods, enabling the creation of functional living tracheas that can be implanted into patients with damaged airways.
Newborn naked mole rats display developmental senescence in various tissues, including hair follicles, nail beds, and skin dermis. Oncogene-induced and DNA damage-induced senescence occur in embryonic and skin fibroblasts, suggesting cellular senescence is not eliminated with evolution.
Researchers have developed a new technique using optical coherence elastography to measure the mechanical properties of heart tissue after a heart attack. The method reveals differences in tissue mechanics between healthy and scarred tissue, providing insights into developing therapies to regenerate damaged heart tissue.
Researchers at Binghamton University have developed a self-healing fungi concrete that can repair cracks in aging concrete permanently. The fungus, Trichoderma reesei, is mixed with concrete and germinates when water and oxygen enter the crack, producing calcium carbonate to heal the damage.
Researchers developed a therapeutic complex based on multi-layer polymer nano-structures of superoxide dismutase (SOD) to effectively rehabilitate patients after acute spinal injuries, strokes, and heart attacks. The substance can neutralize free radicals and reduce swelling, promoting faster recovery.
Researchers created an injectable dye that illuminates molecules with near infrared light, making it easier to track disease progression and study biological processes. The novel Washington Red dye has potential applications in various medical fields.
Scientists show that transplanted muscle cells loaded with magnetic nanoparticles engraft better onto the existing tissue, leading to improved heart function. The technology could potentially be used to revitalize damaged heart tissue and has shown promising results in mice.
Researchers at Tel Aviv University and Weizmann Institute successfully transformed mature cells from various parts of the body into melanocytes, responsible for producing skin pigment. This breakthrough enables the potential for curing deafness and developing novel transplants.
Researchers found that Rapamycin significantly reduces heterotopic ossification (HO) in rats, mimicking blast-related limb injury, and decreases progenitor cells and gene expression associated with abnormal bone formation. The treatment has potential as a prophylactic strategy to prevent HO in combat casualties and civilians.
Researchers at the University of Birmingham have discovered a novel approach to tissue regeneration, utilizing extracellular vesicles to stimulate cell production and facilitate tissue repair. The study shows promise in treating bone fractures, osteoporosis, and cartilage damage, with potential applications for widespread use.
Researchers at Johns Hopkins Medicine discovered that inflammation is required for olfactory tissue regeneration in a mouse study. Suppressing inflammation with steroids slowed stem cell proliferation, highlighting the complex relationship between inflammation and healing.
Id genes have been linked to heart development for the first time, revealing a new tool to create large numbers of cardiac cells to regenerate damaged heart tissue. The study uses CRISPR-Cas9 gene editing and high-throughput microRNA screening to identify the role Id genes play in heart development.
Researchers found that aged stem cells reprogram their circadian functions to focus on tissue repair and stress response, rather than maintenance. A low-calorie diet also preserves the rhythmic functions of stem cells.
Researchers have created a new gadolinium-based probe for noninvasive monitoring of lung fibrogenesis, which can lead to scarring. The probe targets allysine, an amino acid indicative of active collagen cross-linking, and displays high target selectivity in both test tube and real mouse models.
Scientists successfully merged heart tissues from different species and ages, demonstrating the potential for artificial heart patches to function with host cardiac tissue. The study overcomes a major hurdle in regenerative medicine by proving electrical coupling between cells of different origins.
Scientists have discovered two molecules that enhance tissue repair in vital organs, potentially leading to new treatments for diseases like asthma and fibrosis. The study found specific signals in the lungs and liver can regulate the immune response, aiding in damage repair.
Phagocytosis not only eliminates useless cells, but also 'educates' macrophages, the immune cells that carry it out. This process helps maintain tissues in a clean and healthy state. Researchers identified specific molecular toolkits for eliminating unwanted cells in each tissue.
A recent study has discovered that macrophages are essential for the normal functioning of the heart, helping conduct electric signals that coordinate heartbeat. The findings suggest that changes in macrophage numbers or properties may contribute to heart rhythm abnormalities.
Scientists discovered that naked mole-rats can survive up to 18 minutes without oxygen by converting fructose to fuel in their vital tissues. This process allows them to avoid tissue damage associated with heart disease and stroke in humans.
Researchers at the University of Utah have discovered that collagen can get unraveled at a molecular level before complete failure of connective tissues, leading to common injuries such as ligament and tendon tears. This breakthrough allows for early detection and potential treatment using the CHP probe.
Researchers have discovered a way to curb chronic pain by modulating genes that reduce tissue- and cell-damaging inflammation. This technique uses the CRISPR system to protect cells from inflammation, preventing tissue degeneration and pain.
Researchers found that acute kidney injury causes a buildup of indoxyl sulfate in the blood and lungs, leading to damage. Oral treatment with AST-120 decreases IS levels and improves lung function in animal models.
Dying cells must be detached from their neighbors to avoid causing further damage to surrounding healthy tissue. The study reveals a carefully choreographed sequence of molecular events that revolve around an interplay between cell adhesions and protein-based contractile cables.
A team of researchers from the University of Basel has clarified the role of the enzyme MPO in fighting infections. They found that MPO produces a highly aggressive acid that kills pathogens without damaging surrounding tissue, providing new approaches for immunity strengthening therapies.
Researchers evaluated the effects of laser tissue welding on simulated spina bifida repair in rabbits, finding that it did not cause damage to spinal cord or skin tissue. The study suggests a potential breakthrough in fetal surgical repair procedures, offering a possible solution for reducing complications and improving outcomes.
Researchers at Tufts University School of Dental Medicine have successfully regenerated dental pulp-like tissues in animal model experiments using a collagen-based biomaterial to deliver stem cells. The approach shows promise in restoring normal tooth function and may offer an alternative to traditional endodontic treatments.
Professor Ari Waisman receives prestigious Sobek Prize for groundbreaking multiple sclerosis research, enabling deeper insight into inflammatory cell role and regulation in the brain.
Researchers at CNIO found that tissue damage enables cells to adopt embryonic features through the OSKM gene system, mediated by proinflammatory molecule IL-6. This discovery could improve regenerative medicine and treatment of degenerative diseases.
A new technique for real-time temperature monitoring during cryotherapy procedures has been reported, using red blood cells as temperature sensors to convert optoacoustic images to temperature maps. This approach potentially prevents noncancerous tissue from being destroyed or damaged during cryotherapy.
Researchers at UNC School of Medicine have found the Rabep2 gene plays a major role in forming collateral vessels that protect tissues from stroke damage. Variants of this gene may explain individual differences in survival rates after artery blockages.
A phase 1 study using cells from the nasal septum to repair damaged knee cartilage showed substantial improvements in pain and knee function in 9 of 10 patients two years post operation. However, further studies are needed to assess efficacy and establish its routine clinical use.
Macrophages can differentiate between infections and tissue injury using a single sensor, deploying specific immune responses. This discovery could lead to new targets for treating diseases with extensive tissue damage like arthritis or cancer.
The MDI Biological Laboratory has received a $456,500 NIH grant to study chemotherapy-induced peripheral neuropathy. Dr. Sandra Rieger's research will focus on the molecular mechanisms underlying paclitaxel-induced peripheral neuropathy and its potential applications for other sensory neuropathies.
Scientists at Harvard University have developed a 'bionic' cardiac patch that can monitor and respond to cardiac problems, potentially revolutionizing heart attack treatment. The patch, made of nanoscale electronic scaffolds, can detect arrhythmia and adjust its performance in real-time.
Researchers discovered novel adaptations in hibernating animals that may help protect organs during surgeries and cardiac arrests. By studying Arctic ground squirrels' ability to survive repeated 'cardiac arrests,' scientists identified key mechanisms for metabolic flexibility, which could lead to improved survival rates and recovery.
A national assessment of metal contamination in bats reveals high levels of metals such as lead, copper, and cadmium that can cause toxic effects in bat populations. Around 21% of sampled bats contained residues of at least one metal above toxic thresholds, indicating a significant proportion may be affected by metal exposure.
The Environmental Genomics course explores the relationship between genetics and environment, focusing on phenotypic plasticity in organisms like Daphnia pulex. The course aims to provide training in experimental approaches and computational models for studying the effects of environmental challenges on genetics.
Researchers are developing a custom-engineered tissue patch using robotic 3-D printing and computer-assisted manufacturing. The patch aims to replace or protect damaged heart muscle after a heart attack, offering new hope for patients with post-infarction left ventricle remodeling and heart failure.
Researchers develop hydrogel-based platform to mimic human vocal fold tissue, enabling study of development and disease. The model will facilitate testing of new treatment options for voice disorders, a common condition affecting millions of Americans.
Researchers discovered that heart muscle cell chromosomes rapidly erode after birth, limiting their ability to proliferate and replace damaged heart tissue. Maintaining telomere length may boost regenerative capacity, improving cardiac tissue recovery after a heart attack.