Articles tagged with Tissue Damage
A phase 1 study using cells from the nasal septum to repair damaged knee cartilage showed substantial improvements in pain and knee function in 9 of 10 patients two years post operation. However, further studies are needed to assess efficacy and establish its routine clinical use.
Macrophages can differentiate between infections and tissue injury using a single sensor, deploying specific immune responses. This discovery could lead to new targets for treating diseases with extensive tissue damage like arthritis or cancer.
The MDI Biological Laboratory has received a $456,500 NIH grant to study chemotherapy-induced peripheral neuropathy. Dr. Sandra Rieger's research will focus on the molecular mechanisms underlying paclitaxel-induced peripheral neuropathy and its potential applications for other sensory neuropathies.
Scientists at Harvard University have developed a 'bionic' cardiac patch that can monitor and respond to cardiac problems, potentially revolutionizing heart attack treatment. The patch, made of nanoscale electronic scaffolds, can detect arrhythmia and adjust its performance in real-time.
Researchers discovered novel adaptations in hibernating animals that may help protect organs during surgeries and cardiac arrests. By studying Arctic ground squirrels' ability to survive repeated 'cardiac arrests,' scientists identified key mechanisms for metabolic flexibility, which could lead to improved survival rates and recovery.
A national assessment of metal contamination in bats reveals high levels of metals such as lead, copper, and cadmium that can cause toxic effects in bat populations. Around 21% of sampled bats contained residues of at least one metal above toxic thresholds, indicating a significant proportion may be affected by metal exposure.
Researchers are developing a custom-engineered tissue patch using robotic 3-D printing and computer-assisted manufacturing. The patch aims to replace or protect damaged heart muscle after a heart attack, offering new hope for patients with post-infarction left ventricle remodeling and heart failure.
The Environmental Genomics course explores the relationship between genetics and environment, focusing on phenotypic plasticity in organisms like Daphnia pulex. The course aims to provide training in experimental approaches and computational models for studying the effects of environmental challenges on genetics.
Researchers develop hydrogel-based platform to mimic human vocal fold tissue, enabling study of development and disease. The model will facilitate testing of new treatment options for voice disorders, a common condition affecting millions of Americans.
Researchers discovered that heart muscle cell chromosomes rapidly erode after birth, limiting their ability to proliferate and replace damaged heart tissue. Maintaining telomere length may boost regenerative capacity, improving cardiac tissue recovery after a heart attack.
A new method enables the rapid release of intact cell sheets from a culture dish to damaged tissues, revolutionizing tissue repair. The technique leverages Slippery Liquid-Infused Porous Surfaces (SLIPS) to induce slipperiness and detach cell sheets in just five minutes.
Researchers at MDI Biological Laboratory have identified a common mechanism underlying peripheral neuropathy, which causes pain and numbness in the hands and feet. The discovery raises hope for the development of drug therapies to treat this condition, affecting nearly 8 million people in the US.
A team of US doctors successfully reconstructed a severely damaged oesophagus using commercially available FDA-approved stents and skin tissue in a critically ill patient. The patient, who was paralyzed from an earlier car accident, continues to eat a normal diet with no swallowing problems seven years after the procedure.
Researchers have developed a stem cell repair system similar to salamander limb regeneration, capable of regenerating human tissue damaged by injury, disease or ageing. The technique involves reprogramming adult fat cells into induced multipotent stem cells (iMS) that can repair multiple tissue types.
Scientists have successfully directed stem cell-derived neurons to regenerate lost tissue in damaged corticospinal tracts of rats. This breakthrough improves forelimb movements and upends the existing belief that corticospinal neurons lack internal mechanisms for regeneration.
Researchers at the University of Sheffield have developed a novel implantable material that replicates the natural recoil of a healthy pelvic floor. This softer, elastic material is designed to reduce debilitating side-effects associated with current rigid materials used in urinary incontinence surgery.
Researchers at Tel Aviv University have developed a cyborg cardiac patch that combines organic and engineered parts to regulate its own function, monitor vital signs remotely and release medication on demand. The invention has the potential to revolutionize cardiac research and treat heart disease.
Assistant Professor Voot Yin has identified the role of microRNA miR-101a in stimulating heart muscle cell growth and removing scar tissue. This breakthrough research holds promise for developing new drugs to regenerate damaged heart tissue and potentially treating other diseases involving muscle damage.
Researchers at U of T Engineering have developed a new way of growing realistic human tissues outside the body, called AngioChip. The technology uses a three-dimensional structure complete with internal blood vessels and can be used to test drugs on lab-grown human tissues, providing a realistic model at a fraction of the cost.
A Brazilian woman infected with Zika virus had a stillborn baby with severe tissue swelling and central nervous system defects, suggesting the virus may cause damage outside the CNS. The case raises concerns about the risk of stillbirths and other adverse outcomes in pregnant women exposed to the virus.
Researchers have discovered that neutrophils promote cardiac repair by producing a factor that stimulates the differentiation of macrophages, which accelerate tissue repair. This finding challenges previous views on neutrophils' role in inflammation and suggests a potential therapeutic approach to boost repair processes.
Researchers developed a muscle-on-a-chip model that demonstrates how cardiac stem cell therapies can fail due to inefficient force transmission between new and old heart cells. The study suggests that mechanical forces are not transmitted properly, leading to the formation of cellular adhesions that dissipate force to surrounding tissues.
Researchers have developed new mathematical approaches to understand stem cell function, nutrient signaling, and brain development. The models provide insights into the complex interactions between stem cells and neural tissues, shedding light on phenomena such as differentiation and cortical formation.
FAU researchers have found a way for cells to digest dead neighbors before they become toxic, which could lead to new therapies for eye diseases like cataracts. The discovery challenges the long-held belief that specialized immune cells are responsible for removing dead cells.
Researchers develop a bioengineered collagen patch loaded with Fstl1 protein to regenerate heart tissue after damage. The treatment restored function and allowed for progressive recovery in animal models.
Engineers at the University of Toronto have developed a biocompatible scaffold that allows sheets of beating heart cells to snap together like Velcro. This technology enables the creation of layered tissues with varying configurations, including tiny checkerboards, and could be used to repair damaged hearts.
Aging is shown to cripple the production of new immune cells, decreasing the immune response. Antioxidants in the diet may slow this process, suggesting a key role for antioxidants in mitigating age-related immune decline.
Scientists propose using embryonic stem cells to repair damaged lung tissue, with successful results in mouse models. The study overcomes a major obstacle by harvesting stem cells from the ideal time frame for lung regeneration.
Researchers found that very small brain lesions noted on imaging are associated with a heightened risk of stroke and death. The discovery may help physicians identify people at risk for stroke before they have symptoms, even in middle age.
Researchers utilized ultrasound imaging to treat patients with chronic, refractory plantar fasciopathy, achieving over 90% symptom improvement at six months. The treatment allows for permanent removal of diseased tissue, enabling healthy regrowth and restored normal function.
Researchers have developed a technology that mimics the cellular environment to restore organ function and promote tissue regeneration. The bioengineered miniature structures can release biologically active peptides to protect and repair damaged heart muscle cells.
Researchers found that A1M stops the oxidation of blood fats and repairs damaged molecules, protecting against atherosclerosis. The protein can also clean and reduce oxidised blood fats from LDL and take care of dangerous substances from MPO.
Researchers at Queen Mary University of London have developed microcapsules that can deliver C-type natriuretic peptide (CNP), an anti-inflammatory protein, to damaged cartilage in osteoarthritis patients. The microcapsules could potentially slow the progression of osteoarthritis and repair damaged tissue.
Researchers found that administering stem cell factor directly into damaged heart muscle after a heart attack can help repair and regenerate injured tissue. The study showed improved cardiac function, reduced cell death, and increased regeneration of heart tissue blood vessels.
Researchers at Houston Methodist develop a new approach to regrow damaged blood vessels using trans-differentiated fibroblasts, improving blood flow and oxygenation. The technique shows promise for treating cardiovascular damage and injuries with minimal risk of chromosome damage.
Researchers at the University of Washington have developed a way to use high-intensity sound waves to create cellular scaffolding, a unique approach that could help overcome one of regenerative medicine's significant obstacles. The technique involves using boiling histotripsy to decellularize tissues, leaving behind a fibrous network t...
A study found that excessive myofibroblast activity during wound healing leads to increased ECM organization, promoting the release of active TGF-β1. This activation then induces further myofibroblast activity and fibrosis.
Researchers at Brigham and Women's Hospital have discovered that NAD+, a natural molecule found in living cells, can regulate autoimmune diseases by altering the immune response and turning destructive cells into protective ones. The study showed significant delayed onset of disease and reduced severity in mice receiving NAD+ treatment.
Researchers at Tel Aviv University developed a hybrid cardiac patch using biomaterial from patients and gold nanoparticles. The patch can improve heart function after heart attacks without triggering an immune response.
Researchers at UC San Diego used mesh-free simulation to analyze skeletal muscle tissue, finding loss of force exceeds loss of volume with aging. The method cuts back on processing time and can be applied to study injuries from extreme events.
Researchers developed a technique using high-frequency pulsed electric fields to open the blood-brain-barrier, allowing effective treatment of brain cancer and neurological disorders. The technology, called VEIN pulses, can be applied without causing muscle contractions, enabling potential treatments under conscious sedation.
Scientists analyzed horse tendons to understand aging mechanisms, revealing protein differences between young and old horses. They found that certain proteins alter with age, slowing healing processes. This research could lead to better treatment strategies for human tendon injuries.
Preconditioning stem cells prior to transplantation is crucial for improving their survival and therapeutic function. Current methods include exposing stem cells to microenvironments, creating three-dimensional aggregates, or using hydrogels to prepare them for the environment found in damaged tissue.
Researchers found that H. pylori bacteria can rapidly detect minor injuries in the stomach and navigate toward them. The study shows how H. pylori causes disease by interfering with healing at these injury sites.
Researchers at PTB have developed an experiment to measure the stopping power of tissue for carbon ions, which will improve dosing for cancer therapy. The study found that carbon ions are less strongly stopped in liquid water than in water vapour.
Researchers at NIST gather data on human skin's spectral signatures to develop calibration standards for hyperspectral imaging. The technology can detect oxygen levels and other factors in tissues, enabling non-invasive wound healing assessments.
Researchers discovered that salamanders can regenerate their hearts within six weeks by activating stem cells from the blood. This finding raises hope for new treatments for people with damaged tissue, potentially paving the way for clinical trials and improved therapies.
Researchers isolated very small embryonic-like stem cells from human adult tissues and demonstrated their ability to differentiate into multiple cell types, including bone, neurons, and connective tissue. The study provides evidence that these multipotent stem cells could be used for regenerative therapies.
Researchers at Harvard University's Wyss Institute have developed a bioprinting method to create intricately patterned 3D tissue constructs with multiple cell types and tiny blood vessels. The breakthrough enables the creation of thicker, functional tissues that can be used for drug testing and potentially replaced damaged human tissue.
Researchers created a computer simulation to accurately predict blood vessel growth in the laboratory. By studying real blood vessels from rats, they found that denser extracellular matrix impairs vessel formation. This breakthrough aims to develop new treatments for diseases related to blood flow and cancer metastasis.
Researchers have created a novel scaffold for growing cardiac muscle cells using carbon nanofibers, which can conduct electricity and promote better metabolic activity. This breakthrough aims to repair damaged hearts through tissue engineering.
Patients with celiac disease who experience persistent villous atrophy have a heightened risk of hip fractures, according to research. A gluten-free diet may help minimize tissue damage and reduce the risk of complications.
A new MRI method using CEST technology measures creatine levels in the heart, providing higher resolution than traditional methods and potentially spotting heart problems earlier. This technique could lead to improved clinical decision-making and earlier detection of heart disorders.
Two studies examine the effects of spaceflight on mouse eyes, revealing oxidative stress as a key mechanism behind eye damage. Researchers found genes involved in response to oxidative stress and potential indicators of optic nerve damage, highlighting the need for countermeasures to protect astronauts' vision.
Researchers at Penn have found that the optimal amount of strain for a beating heart depends on the stiffness of its collagen framework. The study showed that as the embryo develops, the stiffening of collagen leads to an increase in myosin motor proteins to maintain the optimal heartbeat.
Researchers have gained new insights into tissue cryo-injury mechanisms, revealing that gap junctions are not the primary pathway for ice crystal propagation between cells. Intercellular connections also play a significant role in cell crystallization during freezing.
Associate Professor David Tarlinton will receive $1 million funding to study immune cells causing lupus. He aims to develop treatments that prevent or reverse the disease by inhibiting harmful antibody production.
A collaborative study between Spain and the Icahn School of Medicine at Mount Sinai found that administering beta-blocker medication to heart attack patients while in transit can significantly reduce heart damage. The study showed metoprolol therapy resulted in smaller infarcts and improved heart contractility.
Researchers at Tel Aviv University have developed spring-like fibers to engineer cardiac tissue that can pump more like the real thing. The new fibers show improved elasticity and contraction force compared to straight fibers, holding promise for repairing damaged heart tissue.
Scientists at Case Western Reserve University have developed a method to create three-dimensional gradients of signals that guide stem cell behavior. The system can help discern recipes for tissue and organ repair and replacements by controlling the spatial presentation of growth factors, physical triggers, and adhesion ligands.