Articles tagged with Warburg Effect
Cancer cells utilize more energy from a less efficient pathway, but researchers found that power-generating waves on the cell membrane could be used to stage cancers and target drugs. Measuring these waves may help stage cancers in a standardized way.
A new strategy enhances pharmaceutical production in Chinese hamster ovary cells by knocking out a gene circuit responsible for producing lactic acid. The approach improves growth rates and significantly increases protein yield, overcoming a decades-old challenge in biomanufacturing.
Researchers discovered that Osteopontin induces mitochondrial biogenesis in deadherent breast tumor cells, which aids metastatic success. The study suggests a possible mechanism and targets for treating cancer metastasis by increasing ATP levels and mitochondrial mass.
Researchers at Massachusetts General Hospital discovered that non-dividing colon cancer cells employ Warburg glycolysis to reduce toxic reactive oxygen species accumulation. This adaptation challenges the long-held dogma of the Warburg effect, highlighting the need for single-cell level analysis tools.
A recent study led by Okayama University scientists found that metformin activates a subset of immune cells called CD8+ T-lymphocytes to attack and kill tumor cells. The study revealed that metformin increases the production of reactive oxygen species in these cells, which activates growth pathways and allows for proliferation.
Researchers at Duke Cancer Institute identified a natural compound, koningic acid, that selectively shuts down the Warburg Effect in cancer cells. This phenomenon, where cancer cells voraciously consume glucose for energy, is controlled by an enzyme called GAPDH.
Arecoline, an analog of nicotine, has been identified as an inhibitor of the enzyme ACAT1, which contributes to the Warburg effect in cancer cells. Researchers found that arecoline steers cells' metabolism away from glycolysis, inhibiting growth in human lung cancer and leukemia cells.
Researchers at SLU developed a drug that targets cancer metabolism, stopping most kinds of cancer by cutting off the energy supply. The drug, SR9243, has shown promising results in cultured cancer cells and human tumor cells grown in animal models.
Researchers discovered signals within exons 9 and 10 of the PK-M gene that determine mutually exclusive splicing, promoting PK-M2 production in cancer cells. This finding has implications for developing therapies to reverse the Warburg effect.
Cancer cells exploit a unique metabolic pathway fueled by sugar consumption to survive. Researchers identified HIF-1 as controlling gene expression in low-oxygen conditions, with PKM2 playing a crucial role in this process.