Articles tagged with Human Immunodeficiency Virus
A study proposes a framework for complementary prevention by targeting specific subgroups with tailored interventions. The research finds that 'treatment as prevention' needs to consider the full range of HIV-risk behaviors.
The Scripps Research Institute has been awarded a grant to develop a vaccine against HIV and the disease it causes, AIDS. The Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery (CHAVI-ID) will conduct multidisciplinary research into immune responses that prevent infection or control the virus in infected individuals.
A study found that liver stiffness measured by transient elastography is an independent predictor of liver failure, hepatocellular carcinoma, and mortality in cirrhotic patients coinfected with HIV/HCV. The measurement also predicts potential recovery and survival in patients with cirrhosis.
A collection of articles investigates the impact of antiretroviral treatment on new HIV infections, exploring its potential epidemiological impact and affordability. The studies assess the utility of mathematical models and evaluate their consistency with real-world data.
Lauren Sciences LLC has received a grant from The Campbell Foundation to develop a V-Smart therapeutic for neuro-HIV. The treatment aims to deliver tenofovir across the blood brain barrier to treat viral reservoirs in the central nervous system.
A study by Columbia University's Mailman School of Public Health found that PEPFAR-funded HIV programs are associated with more deliveries at health facilities, suggesting a positive impact on maternal health services. This is likely due to the expansion of HIV treatment and infrastructure investments supporting other health services.
Researchers have developed a new monitoring approach to track HIV-positive ex-offenders' access to community-based HIV care after release. The system uses encrypted data from the Ryan White HIV/AIDS Program and corrections release data to identify barriers to care and guide future strategies.
A study by San Francisco State University suggests that gay dads' lifestyles may change in ways that protect them from risky sexual behavior after becoming parents. Many couples reported a decrease in sex frequency but found this acceptable, while others remained committed to their monogamous relationships.
A study by UCSF found that bacterial vaginosis increases female-to-male HIV transmission risk threefold. Women with the condition are more likely to transmit HIV to their male partners, highlighting the need for better understanding and treatment of the disorder.
A recent NIH study found that HIV-positive young men are more likely to experience low bone mass than their peers. Regular monitoring, exercise, and sufficient vitamin D intake can help prevent future fracture risk. The study's findings highlight the importance of addressing bone health in this vulnerable population.
Scientists at Scripps Research Institute developed a new chemical-screening method to find anti-HIV compounds targeting the nucleocapsid protein. The method yielded two effective and safe inhibitors with demonstrated anti-HIV activity in cell culture tests, offering hope for the development of new HIV treatments.
A study published in PLoS Medicine found that a nevirapine-based treatment regimen was as effective as lopinavir/ritonavir in suppressing the HIV virus, but had a higher stop-treatment rate due to adverse health effects. The researchers emphasize the need for better-tolerated regimes and improved access to effective treatments.
A study of 700 people living with HIV in Russia found that approximately half reported not disclosing their status to all partners. The findings suggest that risky alcohol use is common, but does not contribute to nondisclosure, emphasizing the importance of counseling and encouraging disclosure to prevent further HIV spread
A new study suggests that HIV superinfection rates are equivalent to primary HIV infections among a general heterosexual population. Researchers used ultra-deep sequencing to detect even the lowest levels of circulating HIV strains and found 7 cases of superinfection out of 149 tested individuals.
A new study in Uganda found that HIV superinfection may be more common than previously thought, occurring at a rate comparable to the annual incidence of new HIV infections. The research suggests that post-test counseling should emphasize the risk of superinfection and its implications for public health strategies.
A UBC-developed oral drug delivery system of Amphotericin B shows promise in 'flushing' HIV from reservoirs and boosting effectiveness of existing therapies. The $1.1-million funding supports its clinical development as a treatment for HIV patients, offering new hope for the quest to find a cure.
Scientists have discovered the detailed structure of the shell surrounding genetic material in retroviruses like HIV at a crucial stage. This finding may lead to the development of new anti-retroviral therapies by targeting the immature virus shell.
Researchers at Penn State have developed a biochip-based device that can rapidly screen cells for leukemia or HIV. The device uses microfluidic drifting technology to focus particles or cells in a single stream, eliminating the need for bulky lenses and mirrors, and potentially reducing costs to $1,000 from current prices of $100,000.
A new study found significant decreases in hospital mortality rates among severely ill HIV-positive patients nationwide, primarily due to a decrease in opportunistic infections. However, the study also revealed an increase in chronic diseases and bloodstream infections among this population.
Researchers from Microbicide Trials Network reformulated tenofovir gel to reduce glycerin content, making it safer and more effective for rectal use. The new formulation is three times less likely to cause cells to release water and equally effective against HIV as the original vaginal formulation.
A new paper by Brown University researchers finds that African-American clergy are willing to join the fight against HIV by promoting testing, treatment, and social justice. The study highlights the importance of engaging clergy in HIV prevention efforts, particularly in addressing racial disparities in infection rates.
A study found that African countries with more intense PEPFAR assistance experienced lower all-cause adult mortality rates, with an estimated 740,914 deaths averted. The initiative also showed significant reductions in HIV-specific deaths.
Researchers conducted a 10-year retrospective study on HIV patients in San Francisco, finding that they suffered sudden cardiac death at a rate four times higher than the general population. The study suggests that HIV changes the electrophysiology of the heart, increasing the risk of conduction abnormalities and sudden death.
Funding for non-custodial alternatives, community service, and legal representation are essential to reduce overcrowding and HIV/TB transmission. African governments have a responsibility to address life-threatening prison conditions contrary to international law.
A new study from the University of California - Davis Health found that flash-heating breastmilk can reduce the risk of HIV transmission to infants in sub-Saharan Africa. The technique involves heating breastmilk to a high temperature without destroying its nutritional properties, making it safe for babies beyond six months.
A University of Michigan study found African-Americans with HIV have lower adherence rates to antiretroviral therapy compared to other patients. Untreated depression also hinders adherence in low-income HIV-infected patients regardless of race, but antidepressant treatment nearly doubles optimal ART adherence.
Researchers from the University of Pennsylvania report that genetically modified T cells remain healthy up to 11 years after initial therapy in a decade-long study of HIV patients. The approach provides a framework for gene therapy as a powerful weapon in treating HIV, cancer, and other diseases.
Researchers at UC Davis Health System demonstrated the safety and efficacy of transplanting anti-HIV stem cells into mice, replicating a functioning human immune system. The technique protects and expands HIV-resistant immune cells, maintaining normal CD4 levels.
A new study published in PLOS ONE found that addressing subsistence needs is crucial for improving the health of HIV-infected individuals living in poverty. The research, conducted by UCSF scientists, revealed that unmet basic needs like housing and food significantly undermine the benefits of HIV medication delivery.
A groundbreaking study found that effective HIV treatment and transmission reduction are thwarted by patients' unmet basic living needs such as housing, food, and hygiene. The research suggests that addressing these subsistence needs is crucial to improving public health outcomes.
A large-scale randomized study found that daily antiretroviral drugs given to HIV-infected mothers or their breastfeeding babies for 28 weeks significantly reduced HIV transmission through breast milk. However, early weaning was found to be of little protective value against HIV transmission and may even increase infant mortality.
Preliminary data suggests that neem compounds target the HIV protease, a protein essential for virus replication. Researchers hope that further studies will validate these findings and lead to new HIV-AIDS therapies.
Researchers examined how vaginal gel formulation affects user experience, finding specific sensations and experiences reported by women. This information can help develop better microbicides that women will use consistently, reducing the impact of HIV on vulnerable populations.
The Clinical Research Forum announced Top 10 Clinical Research Achievement Awards for outstanding projects tackling difficult health problems, including disease prevention, cystic fibrosis, leukemia, and cardiovascular disease. The top prize was awarded for HIV transmission prevention through early treatment.
A recent study in Brazil found that severe food insecurity is associated with increased symptoms of sexually transmitted infection and decreased condom use among women. The authors argue that addressing food insecurity could have beneficial implications for HIV prevention by reducing risk avoidance behaviors.
Researchers at Simon Fraser University have received a $2.7 million funding boost to enhance the effectiveness of their DNA-based HIV/AIDS vaccine. The team aims to strengthen a vaccine targeting the MPER region, a highly prized site for antibody production.
Researchers found that HIV in semen persists among sexually active HIV-infected MSM on HAART, posing a transmission risk. Detection of HIV in semen was strongly associated with high-risk behavior and genital inflammation.
A cost-utility analysis shows the DC Female Condom program prevented significant HIV infections and saved over $8 million in future medical care costs. The program's success suggests promoting female condoms as an effective HIV prevention intervention for women at high risk.
Research from UCSF and Harvard Medical School finds that trauma significantly contributes to the HIV epidemic among women. Women with HIV are exposed to trauma at higher rates than the general population, leading to post-traumatic stress disorder (PTSD) and poor treatment outcomes.
A new study suggests that even with a small initial virus population, HIV rapidly evolves to evade immune defenses and treatments due to mutation, recombination, and random genetic changes. This findings sheds light on the difficulty in developing an HIV cure and highlights the need for novel strategies to control the virus.
A meta-analysis of 102 studies found that female sex workers in low-income and middle-income countries have an overall HIV prevalence of 12%, with a 14 times increased risk of infection compared to the general female population. The region with the highest risk was Asia, where the risk was 29 times increased.
A two-year Duke University study found that over half of patients had experienced sexual or physical abuse in their lifetime, leading to worse medical outcomes and poorer health-related behaviors. Childhood trauma was also associated with instances of unprotected sex, missing antiretroviral medications, and recent emergency room visits.
A new study by ICAP at Columbia University's Mailman School of Public Health found that HIV infection rates among black women in US hot spots are 5 times higher than the national estimate. The study highlights the need for tailored prevention efforts in these communities.
A recent study using advanced gene-sequencing technologies tracked viral evolution in HIV-infected patients. The research found that early mutations can evade the host's immune response, making it challenging to control the infection. This understanding may lead to the development of vaccines targeting specific regions of the virus.
A recent study has successfully flushed latent HIV infection from hiding using a drug used to treat certain types of lymphoma. The results show that targeting the biological mechanism that keeps the HIV virus hidden can be effective in providing a cure.
A new study reveals that HIV incidence rate for US black women is five times higher than the overall estimated rate for black adolescent and adult women. The study found an HIV incidence of 0.24% among 2,099 women, comparable to rates in sub-Saharan Africa.
The Swaziland HIV Incidence Measurement Survey found that HIV prevalence has stabilized over the past five years, with current prevalence peaking at 54% for women ages 30-34 and 48% for men ages 35-39. The survey also indicates declines in HIV prevalence among young adults, which may suggest a reduction in new HIV infections.
A clinical trial shows that interferon-alpha can control HIV replication in patients who stop antiretroviral therapy, reducing integrated HIV DNA levels and decreasing reservoirs. The study provides hope for a functional cure and opens the way to further research on HIV eradication.
A recent US study found that only about 75% of HIV/AIDS patients in the United States remain in consistent care, with long gaps between appointments common. Patients with certain characteristics, such as women, white patients, and those with low CD4 counts, are more likely to stay in care.
The International Association of Physicians in AIDS Care published new evidence-based guidelines to overcome barriers to optimal HIV care. The guidelines address key areas such as entry into care, monitoring adherence, and education, with a focus on special populations like children and adolescents.
A study has revealed that eight new diseases, including herpes zoster and certain forms of cancer, can serve as indicators for undiagnosed HIV. The findings highlight the importance of earlier testing and diagnosis to improve survival rates and quality of life among infected individuals.
A study of patients infected with both HIV and hepatitis shows how interferon boosts the human body's natural immunity to fight the virus. The drug, once used to alleviate symptoms, works by mediating the action of restriction factors that combat HIV.
Researchers at SFU have discovered a benign bacterium, Rhizobium radiobacter, with sugar molecules resembling those on the surface of HIV. This resemblance could trigger an immediate immune response against the virus, potentially leading to the development of a preventative vaccine.
A Scripps Florida team has been awarded nearly $1.5 million to identify and develop novel potent inhibitors of the human immunodeficiency virus (HIV). The research targets the capsid protein, a critical component of HIV, with the goal of creating new treatments for HIV-infected patients.
Researchers have identified a promising strategy for HIV vaccine design using mathematical techniques also used in quantum physics and stock market analyses. They found high-order evolutionary constraints in the Gag region of HIV, which could be targeted by vaccines.
The discovery highlights a mechanism for regulatory T-cell accumulation in lymphoid tissue, which could lead to a treatment strategy that slows the production of this type of T cell. Regulatory T cells normally tamp down immune-system attacks, but high numbers might prevent an immune response against HIV.
Researchers at the University of Texas at Austin have developed a molecule that can bind to DNA for up to 16 days, making it a promising step towards creating drugs that can target rogue DNA. This breakthrough could lead to new treatments for genetic diseases, cancer, and retroviruses like HIV.
The authors argue that HAART roll-out's cost-effectiveness has been significantly understated, as economic analyses fail to account for its role in preventing HIV transmission. This oversight highlights the need for expanded 'Seek, Test, Treat and Retain' programs to control HIV and AIDS-related morbidity, mortality, and transmission.
Research published in Neurology finds that people with HIV who have a larger waistline are more likely to experience impaired mental functions such as poor memory and concentration. The study also notes that certain anti-HIV drugs can cause weight gain in the center of the body, which may contribute to these issues.
A researcher at Indiana University has discovered a compound that could counteract HIV's ability to hijack the immune system's protection mechanism. The compound, which binds to the CD59 protein, enables antibodies and complement proteins to attack infected cells instead of just viral particles.