Articles tagged with Human Immunodeficiency Virus
Researchers discovered that a protein called SAMHD1 protects resting T helper cells from HIV replication by degrading genetic information. The study provides new insights into the immunodeficiency syndrome AIDS and could lead to new treatments for HIV.
Same-sex contact and inconsistent condom use were major risk factors for HIV infection among US Navy and Marines personnel. The study highlights opportunities for targeted prevention efforts, particularly promoting condom use after the 'Don't Ask, Don't Tell' repeal.
Research reveals that preferentially transmitted HIV strains in heterosexuals are often similar to the strain initially infecting the partner, indicating an evolutionary advantage. This finding may help advance HIV prevention efforts and develop an effective vaccine.
The Scripps Research Institute has received a $20 million grant to research HIV drug resistance and develop new anti-HIV treatments. The HIVE Center will investigate the structure and function of HIV, including how it responds to drugs used in AIDS therapy.
Researchers discovered a HIV mutation that makes certain strains more susceptible to treatment. This knowledge will help doctors improve drug regimens for HIV-infected individuals by targeting the 172K polymorphism.
Jon Cohen, a contributing correspondent for Science magazine, has won the Victor Cohn Prize for his exceptional coverage of biomedical topics and chronicling of the global HIV/AIDS epidemic. He will receive the prize at an awards ceremony on October 27 in Raleigh, North Carolina.
Scientists at Gladstone Institutes have developed a method to precisely track the life cycle of individual cells infected with HIV, targeting 'HIV latency'. This breakthrough could help advance the discovery of a cure for AIDS by understanding and interrupting the dormant virus.
A new study shows that integrating on-site rapid HIV testing into drug treatment programs is cost-effective, with a beneficial cost-effectiveness ratio of $60,300 per QALY. This approach provides better value than off-site referral and can help identify more people infected with HIV.
A vaginal ring releasing an anti-HIV drug has been shown to prevent the transmission of SHIV in macaques, providing strong potential for its success in women. The study found that the rings provided highly significant protection when inserted 2 weeks or 24 hours before virus exposure.
Between 2000-2008, the proportion of HIV-infected patients in the US receiving effective treatment increased from 54% to 83%, leading to reduced infectiousness and healthier immune systems. This trend was observed across all age groups, regardless of treatment adherence.
The National Institute of Allergy and Infectious Diseases has awarded 14 grants totaling $7.8 million to focus on basic research for designing a safe and effective HIV vaccine. Recent discoveries about HIV biology are guiding the development of new vaccine strategies.
A recent study published in the journal AIDS and Behavior found that HIV home testing kits are a cost-effective and acceptable tool for preventing HIV transmission among men who have sex with men. The kits were found to be particularly effective in encouraging individuals to disclose their HIV status, leading to reduced risk of transmi...
Researchers discovered that catechins, found in green tea and cocoa, can protect neurons from damage and increase brain-derived neurotrophic factor (BDNF) levels. This could lead to new hope for patients with HIV-associated cognitive impairment.
A new study published in The Lancet shows that nurse-centred care of HIV patients can be just as safe and effective as care delivered by doctors. The research found significant improvements in detection of tuberculosis, white blood cell count, weight, and treatment adherence.
African American couples affected by HIV will benefit from a new intervention program, Eban, which aims to reduce HIV transmission and promote healthier living. The program's effectiveness was previously tested in a four-city study with 535 serodiscordant couples.
A recent study published in The Lancet found that black gay men are 15 times more likely to have HIV than their counterparts. Social inequalities play a major role, with stigma, poverty, and inadequate healthcare access contributing to the disparities.
Researchers discovered HIV exploits immune system by using infected T cells to travel and infect other CD4 T cells. The study used a humanized mouse model and found that infected cells carry virus to remote locations, supporting the development of new treatment strategies.
Researchers from UNC Chapel Hill found that adults with mild HIV infections can work longer hours per week and have their children enroll in school at higher rates. The study suggests that early treatment could lead to greater earning potential for those affected by HIV.
A study in Swaziland found the national rate of new HIV infections to be 2.38%, comparable to the 2009 estimate of 2.66%. The country's high HIV prevalence may have begun to level off, with prevention and treatment programs taking effect.
A computer program calibrated to model accurately HIV spread in NYC predicts significant reduction in infection rate with comprehensive intervention strategies. The model simulates individual behavior and transmission networks, providing detailed examination of how interventions affect the epidemic.
A new study found that many heterosexual men with HIV in Canada feel existing programs and services don't meet their needs, due to stigma and lack of support. The study emphasizes the need for more inclusive health care and service initiatives specifically tailored to these men's unique experiences.
Two men with longstanding HIV infections have no detectable traces of HIV after bone marrow transplants, suggesting protection under anti-retroviral therapy. Researchers plan to study additional HIV-positive patients and explore tracing HIV in tissues.
The HPTN 052 study found that early antiretroviral therapy significantly delayed the time to both AIDS and non-AIDS primary events and reduced the overall incidence of clinical events. Immediate ART also decreased the incidence of clinical events likely due to reversal of immune suppression.
Researchers have discovered a new strategy to directly attack and eradicate latent HIV infection using the deacetylase inhibitor vorinostat. The study showed that vorinostat was able to unmask hidden virus in patients receiving treatment for HIV, increasing active HIV levels by an average of 4.5-fold.
A rural Ugandan parish experienced a substantial decrease in HIV virus levels within one year following two community health campaigns that provided free counseling, testing, and treatment. The SEARCH study found that 55% of HIV-positive individuals had undetectable viral loads, compared to an estimated 20-30% in the US.
Researchers have discovered a human peptide that effectively blocks HIV entry into cells by targeting specific targets on both the virus and the cells. The peptide, human neutrophil peptide 1, prevents early and late stages of HIV-cell fusion and inhibits viral uptake without compromising cell function.
A new study reveals disturbingly high HIV infection rates among young black gay and bisexual men in the US, with a 2.8% annual rate of new infections nearly 50% higher than among white MSM. The study also found that poverty and untreated sexually transmitted infections were associated with HIV infection in this population.
A community health campaign in Uganda tested 4,343 people for HIV and offered testing, treatment, and prevention services for malaria, tuberculosis, diabetes, and hypertension. The campaign demonstrated the feasibility of rapid testing and linkage to care in resource-poor settings.
A new analysis by UCSF/SFGH researchers suggests the recommended dose adjustment of efavirenz may not be necessary, especially in non-Caucasian populations. The study found no significant difference in efavirenz levels between patients weighing more than 50 kg and those weighing less than 50 kg.
A recent HPTN study found significantly higher rates of new HIV infections among young black gay and bisexual men in the US compared to white MSM. The study's findings highlight the need for urgent action to stem the spread of HIV among this population.
A study conducted in India found that non-disclosure of HIV serostatus to sex partners is a significant issue among female sex workers and their clients, with rates ranging from 17-86%. The study suggests that improving basic HIV knowledge, reducing alcohol consumption, and increasing awareness about partner status can help increase di...
A recent study published in JAMA found that HIV patients taking antiretroviral drugs experienced improved viral suppression rates, with a 60% increase over the past decade. However, the percentage of patients in tightly controlled HIV infection remains lower than previously estimated.
Black gay couples tend to practice safe sex and discuss their safety habits, while white gay couples are more likely to discuss risks but less likely to use condoms. The study suggests that being in a relationship isn't a risk factor for black men, but rather other factors need to be explored.
A study by Massachusetts General Hospital found that HIV-infected individuals have comparable levels of arterial inflammation as those with established cardiovascular disease, despite being at lower risk. The researchers suggest that targeting monocyte activation may be a unique strategy to reduce arterial inflammation in these patients.
A clinical study in rural Uganda found that nearly all patients with high CD4+ T cell counts were eager to take antiretroviral drugs, citing health, work, and family reasons. The results suggest a significant demand for early HIV treatment among African patients.
A study by Johns Hopkins and University of Pennsylvania found that HIV suppression rates are lower than previously thought, with younger adults, blacks, injection drug users, and uninsured individuals more likely to have uncontrolled disease. The study reviewed over 100,000 individual blood test results from 32,483 infected adults.
The new guidelines recommend that all adults with HIV infection be treated, with no CD4 cell count threshold for initiating therapy. Initial regimens include a combination of nucleoside reverse transcriptase inhibitors and nonnucleoside reverse transcriptase inhibitors.
A new study assessing HIV drug resistance shows rising rates in some areas of Africa since antiretroviral therapy roll-out. The prevalence of drug resistance has increased significantly, mainly driven by non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance in East and Southern Africa.
The FDA Antiviral Advisory Committee discusses the pros and cons of Truvada approval for pre-exposure prophylaxis (PrEP). Dr. Judith Feinberg votes in favor of approval, citing good outcomes and tolerability, while Dr. Lauren V. Wood expresses concerns about inconsistent evidence, adherence issues, and safety concerns. Primary care phy...
A study of HIV-positive persons born outside the US finds they are more likely to be Hispanic or Asian and have higher rates of heterosexual contact. The researchers also found that these individuals face challenges accessing medical care due to language and cultural barriers.
Researchers at Scripps Research have identified a natural compound, Cortistatin A, that effectively reduces HIV replication by 99.7 percent in infected cells. The compound works by inhibiting the viral protein Tat, making it a promising potential treatment for the ongoing pandemic.
Researchers created a model by transplanting human immune elements into an immunodeficient mouse, allowing it to mount human-like immune responses against HIV. The study successfully replicates critical host-pathogen interactions and provides a promising tool for accelerating HIV vaccine development.
A novel approach using a gift card incentive is being tested in a new HIV study. Patients who adhere to HIV treatment regularly can receive rewards and motivation through the program, which aims to improve patient engagement and viral suppression.
Researchers at Stanford University have created a collection of compounds called bryologs that can activate latent HIV reservoirs with equal or greater potency than the original substance. The discovery holds promise as a practical way to flush out dormant viruses, offering hope for a cure for AIDS patients.
A new study published in PLOS Medicine suggests that non-inferiority trials, which involve switching HIV patients to a new antiretroviral therapy, may not be beneficial to participants. The authors argue that these trials often enroll patients who cannot benefit from the switch and do not capture or report all potential risks.
Duke University has been awarded a seven-year, $186 million grant to develop an HIV vaccine by inducing precise immune factors. The program will focus on designing immunogens capable of preventing HIV transmission and protecting people worldwide.
The Scripps Research Institute has been awarded a grant to develop a vaccine against HIV and the disease it causes, AIDS. The Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery (CHAVI-ID) will conduct multidisciplinary research into immune responses that prevent infection or control the virus in infected individuals.
A study proposes a framework for complementary prevention by targeting specific subgroups with tailored interventions. The research finds that 'treatment as prevention' needs to consider the full range of HIV-risk behaviors.
Lauren Sciences LLC has received a grant from The Campbell Foundation to develop a V-Smart therapeutic for neuro-HIV. The treatment aims to deliver tenofovir across the blood brain barrier to treat viral reservoirs in the central nervous system.
A study found that liver stiffness measured by transient elastography is an independent predictor of liver failure, hepatocellular carcinoma, and mortality in cirrhotic patients coinfected with HIV/HCV. The measurement also predicts potential recovery and survival in patients with cirrhosis.
A collection of articles investigates the impact of antiretroviral treatment on new HIV infections, exploring its potential epidemiological impact and affordability. The studies assess the utility of mathematical models and evaluate their consistency with real-world data.
Researchers have developed a new monitoring approach to track HIV-positive ex-offenders' access to community-based HIV care after release. The system uses encrypted data from the Ryan White HIV/AIDS Program and corrections release data to identify barriers to care and guide future strategies.
A study by Columbia University's Mailman School of Public Health found that PEPFAR-funded HIV programs are associated with more deliveries at health facilities, suggesting a positive impact on maternal health services. This is likely due to the expansion of HIV treatment and infrastructure investments supporting other health services.
A study by San Francisco State University suggests that gay dads' lifestyles may change in ways that protect them from risky sexual behavior after becoming parents. Many couples reported a decrease in sex frequency but found this acceptable, while others remained committed to their monogamous relationships.
A study by UCSF found that bacterial vaginosis increases female-to-male HIV transmission risk threefold. Women with the condition are more likely to transmit HIV to their male partners, highlighting the need for better understanding and treatment of the disorder.
A recent NIH study found that HIV-positive young men are more likely to experience low bone mass than their peers. Regular monitoring, exercise, and sufficient vitamin D intake can help prevent future fracture risk. The study's findings highlight the importance of addressing bone health in this vulnerable population.
Scientists at Scripps Research Institute developed a new chemical-screening method to find anti-HIV compounds targeting the nucleocapsid protein. The method yielded two effective and safe inhibitors with demonstrated anti-HIV activity in cell culture tests, offering hope for the development of new HIV treatments.
A study published in PLoS Medicine found that a nevirapine-based treatment regimen was as effective as lopinavir/ritonavir in suppressing the HIV virus, but had a higher stop-treatment rate due to adverse health effects. The researchers emphasize the need for better-tolerated regimes and improved access to effective treatments.
A study of 700 people living with HIV in Russia found that approximately half reported not disclosing their status to all partners. The findings suggest that risky alcohol use is common, but does not contribute to nondisclosure, emphasizing the importance of counseling and encouraging disclosure to prevent further HIV spread
A new study in Uganda found that HIV superinfection may be more common than previously thought, occurring at a rate comparable to the annual incidence of new HIV infections. The research suggests that post-test counseling should emphasize the risk of superinfection and its implications for public health strategies.