Articles tagged with Blood Flow
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Researchers at Cincinnati Children's Hospital Medical Center discovered that blocking cyclophilin D protects the heart from injury due to loss of blood flow. A class of drugs already exists that blocks cyclophilin D and has been shown to protect against stroke in animal models.
Orqis Medical's Cancion CRS therapy has shown promising results in improving cardiac index and pulmonary capillary wedge pressure in patients with severe heart failure. The therapy provides continuous aortic flow augmentation, enabling progressive hemodynamic improvement without taking over the heart's function.
A study found that laughter increased beneficial blood vessel relaxation by 22%, while mental stress caused a 35% decrease. Laughter offsets the negative impact of mental stress on the endothelium, which regulates blood flow and cardiovascular health.
A recent study by the American Academy of Neurology found that marijuana use impacts brain blood flow, even after a month of abstinence. The research involved 54 marijuana users and 18 control subjects, who underwent transcranial Doppler sonography to measure blood flow velocity and pulsatility index.
Researchers at Children's Hospital of Philadelphia studied 25 newborns born with congenital heart defects and found significantly lower cerebral blood flow, associated with periventricular leukomalacia, a condition linked to cognitive problems. The study suggests that abnormal neurological conditions may play a role even before surgery.
Brett Wong's research identifies histamine receptors as contributing to increased blood flow during heat stress, which can help improve survival rates among elderly and those with conditions like diabetes and heart disease.
Researchers have found that astrocytes play a key role in regulating blood flow within the brain, and may hold promise as a target for new therapies to treat strokes. The study, funded by CIHR and Canadian Stroke Network, could lead to new treatments within 5-10 years.
Researchers have developed a novel gene therapy that combines a therapeutic gene with a genetic sensor to protect the heart from damage caused by reduced blood flow. The therapy, which was tested in rats, showed a significant reduction in tissue death and damage compared to untreated animals.
Research reveals that humans can't pump enough blood to meet the demand of highly trained muscles during exercise, leading to hypotension. This finding has implications for understanding reduced exercise tolerance in pathologic conditions and may guide new therapeutic approaches.
Perfusion CT scans can reveal how much blood is present in the brain and how quickly it's moving, helping doctors decide on treatments such as surgery or clotbuster drugs. The technique has shown promise in assessing patients with stroke or carotid artery issues, potentially improving treatment outcomes.
Researchers developed a new fluid mechanical model system that simulates the active nature of the arterial system, providing insights into why stenting in forked regions has low success rates. The study suggests stenting only the main branch for optimal healing and maintenance of open vasculature.
Researchers at UT Southwestern Medical Center have identified a characteristic sign of Alzheimer's disease that can distinguish it from frontotemporal diseases, which are the second-leading cause of dementia in the elderly. SPECT testing measures brain blood flow and shows significant reductions in the posterior cingulate cortex, indic...
Researchers at University of Texas Southwestern Medical Center developed a new SPECT imaging test that can accurately diagnose Alzheimer's disease in its early stages. The test identifies reduced blood flow in the posterior cingulate cortex, allowing doctors to identify AD patients significantly sooner than current methods.
A new corkscrew-shaped retrieval system has been shown to restore blood flow and reverse paralysis in 61 of 114 patients with ischemic strokes. The device, MERCI Retrieval System, was able to dissolve clots and open blood vessels in patients who were not eligible for standard tPA therapy within three hours.
Researchers developed a device called NeuroFlo that increases blood flow to the brain by diverting it from lower extremities. The study tested its safety and effectiveness on 17 patients with ischemic strokes, resulting in improved treatment outcomes for 10 out of 15 conscious patients.
Researchers have discovered a link between the ratio of two energy-compounds and increased blood flow in brain cells. By modulating this ratio, scientists can better understand how blood circulation is activated in the brain, potentially leading to new treatments for diseases like Alzheimer's and diabetes.
Researchers discovered that nitrite in saliva significantly increases gastric mucosal blood flow and mucus thickness, suggesting a potential link between bad breath and gastric ulcers. This finding also has implications for conditions like sickle cell anemia.
Researchers found that blocking blood flow to the brain, like mini-strokes, can impair mental function by reducing nerve cell fibers that use acetylcholine. This study provides insight into the effects of cerebral blood flow disruption on cognitive decline in dementia, highlighting the importance of maintaining healthy blood vessels.
A recent Stanford Medicine study shows that an automatic CPR device, AutoPulse, can restore blood flow and pressure more effectively than manual compressions. The device restored blood flow and returned hearts to normal condition in 73% of treated animals.
Researchers found decreased tumor blood flow correlated significantly with survival in patients treated with neoadjuvant chemotherapy. The study suggests tumor biology should be an important factor in considering patient response to treatment.
In a groundbreaking clinical trial, OHSU doctors used the Onyx Liquid Embolic System to repair aneurysms in patients with promising results. The new procedure uses a catheter to inject a liquid that solidifies into a spongy mass, sealing off the defect and preventing future ruptures.
Researchers found that people with high blood pressure have reduced blood flow to the brain compared to those with normal blood pressure, leading to slightly worse scores on memory tests. This vascular remodeling may explain why some individuals experience subtle differences in mental tasks.
A study found that diuretic amiloride improved cerebral blood flow in cocaine-dependent subjects, reversing cognitive impairments and depressive symptoms. The medication's ability to dilate arteries in the brain may be responsible for this improvement.
Researchers tested 'reverse CPR' on critically ill patients in intensive care units, improving average systolic and arterial blood pressure. The new approach could lead to better treatment outcomes in the community setting.
The Georgia Tech research aims to develop advanced Computational Fluid Dynamics (CFD) techniques to study blood flow turbulence in heart valves. The team will create a virtual environment that accurately models the turbulent flow environment, which could lead to better design and reduced thromboembolic complications.
Researchers found a genetic connection between blood flow patterns and cardiovascular disease, with oscillatory shear stress leading to increased expression of the protein BMP4. This finding may help explain why physical inactivity promotes heart disease and could lead to new diagnostic tests or gene-based therapies.
Researchers from the University of Virginia measured microvascular diameters in response to static magnetic field exposure in skeletal muscle. The study found a restorative, biphasic effect on microvascular tone acting to normalize tone following exposure, with primary mediation by smaller resistance arterioles.
Using adaptive optics, researchers can now clearly see features such as blood flow in the retina, enabling early diagnosis of diseases. This technology will help eye doctors track changes in patients with conditions like diabetes and glaucoma.
Researchers at the University of Pennsylvania School of Medicine found that increased blood flow can cause cells to produce their own anti-inflammatory response. This effect is triggered by shear stress, which activates glucocorticoid receptors and leads to the production of genes that combat inflammation.
Researchers found increased vascular resistance in paralyzed legs of humans with long-term spinal cord injuries. However, a short period of training led to a marked decrease in vascular resistance, suggesting that deconditioning is the primary cause of the increase in vascular resistance.
Studies show that the left hemisphere processes meaningful semantic content automatically, while the right hemisphere is involved in processing emotional prosody. Researchers used Transcranial Doppler Ultrasonography to measure blood flow velocity in the brain's middle cerebral arteries when participants identified emotions conveyed th...
Researchers found that providing reliable warning cues enhances vigilance performance, maintaining attention and efficiency over time. The study's results have practical implications for designing operational cueing systems to reduce brain strain and improve safety in various applications.
A recent study conducted by Dr. Tim McCulley at Stanford University found that high doses of Viagra preserved the thickness of the eye's choroids layer, supplying blood to the eyeball, with minimal change in blood vessels or flow. However, some individuals with underlying vascular diseases may experience changes in vision due to small ...
Researchers found that switching from traditional cannulation in the aorta to the axillary artery significantly reduced the risk of stroke and brain damage during bypass surgery. This innovative approach deflected debris away from the brain, markedly limiting postoperative neurological complications.
A new chest compression device has been shown to restore blood flow four times better than manual compressions, potentially saving more lives. Researchers tested the device on 20 pigs in cardiac arrest and found it restored vital organs with improved oxygenation.
A new study published by the American Heart Association found that MRI stress tests can predict fatal and nonfatal heart attacks in patients with certain conditions. The study used MRI stress tests on 279 men and women referred for further testing after initial ultrasound screenings were inconclusive.
A new study investigates blood flow in toads' pelvic skin while absorbing water, finding a significant increase in red cell velocity prior to water exposure and a seven-fold increase within one minute. The results support the initial hypothesis that increased blood flow is associated with water absorption behavior.
A recent study, TRAFFIC, found that intra-arterial infusions of recombinant fibroblast growth factor-2 (rFGF-2) improved exercise capacity in patients with moderate-to-severe intermittent claudication. Peak walking time increased by 1.77 minutes with single-dose rFGF-2 and 1.54 minutes with double-dose rFGF-2.
A Swedish registry study found that early revascularisation significantly reduces mortality risk by up to 50% within a year after a heart attack. This suggests improved success rates for bypass surgery and balloon angioplasty over time, as well as the inclusion of sicker patients in previous studies.
Pooled data from two randomised trials show that off-pump surgery substantially reduced in-hospital complications compared to on-pump surgery. The need for blood transfusions was significantly lower, with a reduction of 33%.
A study suggests that kinking in the iliac arteries is a common cause of blood flow restriction in endurance athletes, particularly cyclists and speed skaters. Surgical release of these kinks can improve performance and enable athletes to return to competition, with 87% successfully returning to their desired level.
Researchers have successfully treated five patients with severe chest pain with injections of their own bone marrow cells, showing increased blood flow in treated areas. The treatment appears safe and relatively inexpensive with no reported side effects.
A study published by Harvard University Medical School found that during a woman's menstrual cycle, estrogen levels may shield them from cocaine's brain-altering effects. The findings suggest progesterone and testosterone enhance cocaine-induced vasoconstriction, while estrogen may blunt its vascular effects.
Researchers found that new collateral blood flow pathways were created in the brain after a minor stroke. This suggests that the brain can recover some blood flow after a small stroke, potentially reducing damage and improving long-term recovery.
Women with chronic constipation exhibit reduced rectal blood flow, indicative of altered nerve function. This association is also seen with symptoms of anxiety, depression, and feelings of 'unfemininity',
Research by Penn State specialist Dr. W. Larry Kenney highlights the strain on older hearts when exercising in heat stress, increasing mortality rates among those over 65. Regular exercise and hydration countermeasures can mitigate effects, but individual factors like fitness level and medication impact thermoregulation.
A UCSF study finds that eptifibatide helps preserve microvasculature and blood flow into the heart muscle, improving oxygen supply to patients undergoing angioplasty. The drug improves large artery blood flow by 39% and microvascular blood flow by 84%, potentially reducing irreversible heart injury.
A study by Mayo Clinic researchers reveals a possible cause of sudden deaths among men using Viagra, highlighting the need for safe use guidelines. The interaction between Viagra and nitrates can reduce blood flow through critically narrowed coronary arteries, leading to a life-threatening drop in oxygen supply.
University of Iowa researchers found that injecting angioblasts, precursor cells for endothelial cells, accelerates blood flow restoration in diabetic mice. This breakthrough has implications for treating diabetes-related circulatory problems and improving limb health.
A new medical imaging approach using 3D color Doppler ultrasound shows promise for better cancer detection and recognition in breast cancer patients. The technique uses sound waves and computerized equipment to visualize blood flow in the vessels around suspicious areas, distinguishing between tumors and benign masses.
Recent UI studies found that frequent marijuana users have substantially lower blood flow to certain parts of their brains, indicating altered brain function. However, smoking the illicit drug does not affect brain size or structure, contradicting previous claims.
A study published in Circulation found that a timed-release capsule of basic fibroblast growth factor improved blood supply and heart function in heart bypass patients. The treatment, which promotes angiogenesis, showed no serious adverse effects in a small but promising clinical trial.
Heart cells secrete substances to regulate oxygen-rich blood flow, triggering vessel constriction or dilation as needed. Research reveals an optimal oxygen concentration of 6%, with narrow permissible windows above or below this level.
Research by Penn State engineers shows mechanical forces exert equivalent roles in some aspects of cardiovascular health and disease as bio-regulators like cholesterol and dietary fat. The study found a one-to-one correspondence between effects of shear stress and growth factor VEGF on blood vessel health.
A recent study published in the New England Journal of Medicine found that abciximab, a blood-thinner, can help prevent heart attacks in patients with unstable angina who have high troponin T levels. The treatment reduced heart attack risk by 44% in these patients compared to those without elevated troponin T levels.
Researchers found that tumor oxygen levels and blood flow are not predictable, which could hinder radiation therapy and drug delivery. The study's findings challenge previous assumptions and highlight the importance of measuring tumor oxygenation and blood flow in human tumors.
Researchers at UB's Toshiba Stroke Research Center have developed a new dual contrast injection method, enabling neurosurgeons to characterize and treat arteriovenous malformations (AVMs) more effectively. The technique allows for precise measurement of blood flow rate, facilitating the accurate administration of a glue-like substance ...
A new study finds that Enhanced External Counterpulsation (EECP) is effective in reducing angina in individuals with coronary artery disease. EECP, a non-invasive therapy, has been proven to improve exercise tolerance and reduce angina attacks, offering relief for patients who suffer from this condition.
Researchers found that combining abciximab with two low-dose boluses of reteplase provided complete blood flow to up to 35% more patients than using abciximab alone or in combination with a single dose of reteplase. This new strategy may represent an exciting new step in treating most heart attacks.
Case Western Reserve University researchers are developing a new method to study blood flow through artificial heart components by mimicking the behavior of coal water slurries. This approach has revealed the importance of particle distribution and velocity in preventing blood clots, which can lead to stroke and death.