Articles tagged with Blood Flow
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A Johns Hopkins study suggests that a commonly used bypass surgery technique may impair the brain's ability to regulate blood flow, increasing the risk of stroke. Researchers found that seven patients experienced strokes after cooling and rewarming, highlighting the need for improved monitoring to prevent such incidents.
Researchers found that ischemic preconditioning increases arterial blood flow while portal vein flow remains unaffected, suggesting a new strategy to reduce I/R injury. The study also suggests temporary occlusion of the portal vein may help avoid complications during liver surgery.
Researchers discover mechanism underlying female sexual arousal, finding that stimulating pelvic nerve increases blood flow and enhances effects of prototype drug UK-414,495. This breakthrough could lead to development of treatments for female sexual arousal disorder (FSAD), a condition affecting up to 40% of women.
Researchers developed a new test that uses CT scans to measure blood flow in the lungs, identifying smokers most at risk of emphysema. The study found subtle differences in blood flow patterns between smokers with normal lung function and those with early signs of emphysema.
Researchers at UMass Chan Medical School have identified a novel microRNA-mediated genetic pathway responsible for triggering vascular growth in zebrafish embryos. This discovery provides new insights into how vascular systems develop and may offer a potential therapeutic target for limiting blood vessel formation in solid cancers.
A new study aims to investigate whether erectile dysfunction drugs can improve muscle blood flow and reduce fatigue in muscular dystrophy patients. The research, led by Ronald G. Victor, will test the effects of tadalafil on muscle blood flow during exercise in adult males with Becker muscular dystrophy.
New transcatheter valve replacements reduce surgical risks for elderly patients with severe aortic stenosis. The procedure benefits 3% of the population over 75 years old and may treat lower-risk patients in the future.
A recent study discovered that blood flow force triggers a chain reaction protecting arteries from dangerous clogs. The reaction involves the structural change of an enzyme, histone deacetylase 5 (HDAC5), influencing key genes involved in reversing atherosclerosis.
A new Cochrane Systematic Review suggests that Doppler ultrasound can reduce infant deaths and caesarean sections in high-risk pregnancies by monitoring fetal health. However, the quality of the included studies is questionable, and more research is needed to confirm these findings.
Researchers at Duke University Medical Center found that adding ethyl nitrite to carbon dioxide gas used in laparoscopy preserves normal blood flow and organ function. The use of ENO could improve outcomes and reduce recovery time by increasing nitric oxide bioactivity.
Researchers at Johns Hopkins have developed therapies using gene therapy and stem cells to increase blood flow, improve movement, and decrease tissue death. The findings hold promise for developing clinical therapies to save limbs from amputation.
Researchers at UCSD and Stanford University developed a computational tool to simulate blood flow on computers, optimizing surgical designs for the Fontan surgery. This tool allows doctors to test plans and evaluate blood flow patterns before operating, potentially reducing risks associated with the procedure.
Red blood cells can deform into an asymmetrical slipper shape when flowing through arteries, a phenomenon that affects blood flow. Simulations suggest this deformation helps the cells catch up with fluid, leading to more efficient blood flow.
Researchers at Ohio State University have found that giving supplemental oxygen to animals during a stroke can reduce damage to brain tissue surrounding the clot. The timing of delivery is critical to achieving this benefit, and using pure oxygen delivered by mask was also effective.
Researchers found that stimulation of inner ear balance organs affects brain blood flow in opposition to changes in blood pressure. The study may lead to new treatment options for conditions such as aging-related vestibular loss and orthostatic intolerance.
A study found that measuring ankle circulation using a blood pressure cuff can identify asymptomatic peripheral artery disease in stroke and TIA survivors, who are at higher risk of subsequent cerebrovascular events. The test, called ABI measurement, is easily performed in under 15 minutes and detected PAD in 26% of survivors.
Researchers have developed a new approach to treat ischemic pathologies by activating the protein HIF, which stimulates revascularization and organ repair. This strategy aims to address cardiovascular diseases that cause millions of deaths worldwide, by over-producing HIF in response to ischemia.
Elevated levels of ECE-2 enzyme are linked to reduced blood flow in the brain, a hallmark of Alzheimer's disease. The findings suggest that drugs blocking endothelin-1 may also benefit Alzheimer's patients.
A Monash-led research team has discovered a new link between disturbed blood flow and blood clotting, which is identified as the precise mechanism by which these changes activate the clotting process. This discovery may explain the lack of effectiveness of commonly used anti-clotting therapies.
A study found that bone marrow cell injection significantly improved myocardial perfusion and left ventricular function in patients with chronic ischemia. The treatment also showed greater improvement in exercise capacity and quality-of-life scores, suggesting potential benefits for patients with ischemic heart disease.
Research found that Andean women's uterine artery blood flow and oxygen delivery are higher than European counterparts at high altitude, resulting in larger babies. The study suggests genetic adaptation allows Andean mothers to adapt to the high-altitude environment, protecting their fetuses from reduced growth.
A Queen's University research team challenges the common belief that massage after exercise improves circulation to the muscle and removes lactic acid. Their study reveals that massage actually impairs blood flow to the muscle after exercise, resulting in impaired removal of lactic acid.
Researchers studied brain electrical activity and blood flow during caffeine withdrawal, finding increased brain blood flow and changes in EEG that relate to common withdrawal symptoms. The study also showed no net beneficial effects of chronic caffeine administration.
A noninvasive finger sensor test is highly predictive of major cardiac events for people at low or moderate risk. The EndoPAT test measures blood flow and identifies endothelial dysfunction, a condition that can lead to atherosclerosis and cardiovascular problems.
Researchers have developed a new way to detect early stages of diabetic retinopathy using beams of light to measure blood flow in the back of the eye. This technique may provide a more quantitative and less invasive method for diagnosing the condition, potentially cutting costs.
A University of Pennsylvania team has successfully demonstrated a noninvasive optical device to monitor cerebral blood flow in acute stroke patients. The technology uses diffuse correlation spectroscopy to detect physiological changes, providing continuous bedside monitoring of brain blood flow and metabolism.
The FAME study found that stents placed using fractional flow reserve (FFR) had a 28% lower incidence of major adverse cardiac events compared to conventional angiography. This technique can distinguish between hemodynamically relevant and irrelevant stenoses, allowing for more targeted interventions.
Researchers discovered that small arteries at the brain's surface redirect and widen to maintain a constant blood supply after a stroke. The mesh-like vascular network enables the arteries to compensate for reduced blood cell velocity by increasing diameter, ensuring steady delivery of oxygen and nutrients.
Researchers investigated the mechanisms behind reduced gastric mucosal blood flow caused by H. pylori extracts, finding a nerve- and iNOS-mediated pathway involved. The study revealed that H. pylori extracts decrease gastric mucosal blood flow by approximately 30% in mice.
A new diagnostic tool can help doctors determine whether stenting is necessary for patients with coronary artery disease. The study found that using this tool resulted in a significant reduction in cardiac events, including death, heart attack, and repeat stenting or bypass surgery.
A recent study published in Neurobiology of Aging found that being physically fit significantly improves blood flow to the brain, leading to enhanced cognitive abilities. The research, conducted by Marc Poulin and his team, involved comparing two groups of women aged 65, one who was active and the other who was inactive.
A new study by Yale University researchers identifies a mechanism behind stroke in patients with sleep apnea, revealing impaired cerebral autoregulation and increased risk of death. Symptoms of sleep apnea include loud snoring, pauses in breathing and excessive daytime fatigue.
A new study suggests that brain starvation as we age can lead to the production of amyloid plaques, a hallmark of Alzheimer's disease. Regular exercise, managing cholesterol and hypertension, and improving blood flow to the brain may help prevent or treat the disease.
Researchers discovered a new mechanism by which temporarily cutting off blood flow to arteries before a heart attack reduces damage caused. The study suggests that boosting the effect of this natural response, possibly through administering nitro-linoleic acid (LNO2) beforehand, may reduce heart attack damage in the future.
Researchers found that exercise increased cerebral blood flow and the number of small blood vessels in the brain of older adults. The study suggests that regular physical activity may help prevent age-related cognitive decline by improving brain health.
Researchers at the University of Maryland School of Medicine discovered that joyful music can promote heart health by dilating blood vessels, similar to laughter. The study showed a significant increase in blood vessel diameter after listening to joyful music, while anxious music caused narrowing.
Research on sildenafil use in cirrhosis patients found that it does not induce profound changes in splanchnic blood flow and portal hypertension. The study suggests phosphodiesterase type-5 inhibition is not a useful therapeutic agent for alleviating portal hypertension in end-stage liver disease.
A new University of Georgia study found that even occasional cigarette smoking can decrease arterial responsiveness by up to 36% in young, healthy adults. Repeated bouts of smoking further impaired flow-mediated dilation, indicating a potential long-term risk for cardiovascular disease.
Researchers at the University of Maryland Medical Center developed a minimally invasive procedure to bypass narrowed aortic valves in high-risk elderly patients. The study showed that this procedure can be performed safely without stopping the heart and offers effective treatment for those who were previously considered too frail for s...
Researchers at Indiana University have discovered a molecule that could lead to new treatments for heart attacks and protect hearts during open heart surgery. The compound, Alda-1, was found to activate an enzyme that reduces cell death caused by lack of blood flow to the heart.
A multi-center study led by UIC aims to assess blood flow and stroke risk in patients with first-time symptoms caused by 50% or greater blockage of the arteries leading to the back of the brain. The study will compare blood flow of patients who had a stroke since their initial symptoms with those who did not have a stroke.
Researchers found that steady blood flow creates frictional force and stretching force that protect blood vessels from atherosclerosis. The study identified proteins involved in this process, including PECAM-1 and Fyn, which could lead to the development of new therapies.
Researchers at OHSU have devised an ultrasound imaging technique that picks up subtle early evidence of PAD, which current conventional tests miss. The test could lead to early treatments that head off serious complications like gangrene and death.
Researchers at Harvard University have identified a key mechanism by which neural activity increases blood flow to the brain. Astrocytes play a crucial role in this process, releasing neurotransmitters that bind to and elevate intracellular calcium levels, leading to blood vessel dilation.
A recent study published in Circulation has uncovered the mechanisms by which low blood flow contributes to vascular disease. The research found that cyclophilin A plays a dual role in promoting inflammation and pathogenic growth, highlighting its potential as a target for developing new treatments against atherosclerosis.
Researchers at MIT's Picower Institute for Learning and Memory have shown that star-shaped brain cells called astrocytes make noninvasive brain scans possible by regulating local blood flow. Astrocytes respond exquisitely to sensory drive, influencing neuronal responses and complex computations.
Researchers at Thomas Jefferson University have developed a new ultrasound technique that targets areas of increased blood flow in the prostate gland, significantly reducing the number of unnecessary biopsies. The study found that targeted biopsies were twice as likely to detect cancer compared to conventional methods.
Researchers at UC San Diego report improved resuscitation with a radically different approach combining hypertonic saline with viscosity enhancers that thicken blood. Dramatic increases in healthy blood flow through tissues and organs were observed in hamsters with severe blood loss.
Biologists at UC San Diego have found that mouse skin responds to low oxygen levels by regulating EPO production, a hormone that stimulates red blood cell creation. This discovery could revolutionize treatment for anemia and improve endurance athlete performance.
Researchers identify gene variation associated with mental stress-induced ischemia, a condition that increases the risk of heart attack and sudden death. About two-thirds of patients with coronary artery disease experience detectable mental stress-induced reductions in blood flow to the heart.
A recent study found that contrast-enhanced MRI significantly outperforms 16 slice multidetector CT in detecting endoleaks after endovascular repair of abdominal aortic aneurisms. The study detected 21 endoleaks in 18 patients with 100% sensitivity and accuracy on MRI, while MDCT had lower detection rates.
A recent study found that even light loads of 26 pounds can decrease upper extremity blood flow, contributing to shoulder fatigue. Backpack straps typically compress the axillary vein, causing abnormally high blood pressure and subsequent decreased blood flow in the shoulders and arms.
Researchers discovered that diabetes drives inflammation and slows blood flow, accelerating atherosclerosis through interference with ERK5 signaling. The study identifies advanced glycation end products (AGEs) as key molecules sabotaging this protective mechanism.
Researchers at Duke University Medical Center discovered a genetic mutation linked to peripheral artery disease (PAD), which affects blood flow in the legs. The study found that one strain of mice with surgically-induced PAD-like injury showed greater tissue loss and poor recovery, while another strain recovered well.
A study published in Circulation Research reveals that flexing muscles send biochemical signals through nearby matrix proteins, increasing blood flow and potentially reversing poor circulation and healing chronic wounds. The discovery sheds light on the role of extracellular matrix proteins like fibronectin in controlling bodily function.
A recent study by Weill Cornell Medical College reveals that the brain contains its own store of tissue plasminogen activator (tPA), a powerful enzyme that boosts blood flow to brain cells via nitric oxide synthase. This finding has significant implications for understanding stroke and Alzheimer's disease, and may lead to new treatments.
Researchers found that brief periods of blocked blood flow activate a protective molecular pathway in the heart, protecting it from damage caused by restored blood flow. The study suggests that these 'mini stress tests' may help precondition and protect the heart from future attacks.
Researchers found vasopressin significantly reduces blood flow to vital organs like the liver and pancreas, but not the heart. The study used pigs to test vasopressin's effects on sepsis and found severe disturbances in blood flow.
Prelox, a patented blend of Pycnogenol and L-Arginine, shows significant improvement in men with ED after just one day, increasing nitric oxide production for enhanced blood flow. The study achieved almost 100% increase in orgasmic function, sexual desire, and overall satisfaction.
Researchers at Ohio State University Medical Center found that the mitochondria send a death signal to cardiac cells when blood flow is restored, leading to cell damage and weakening heart function. The study identifies a specific enzyme, mitochondrial nitric oxide synthase, as a potential therapeutic target to stop this process.