Dr. David Mangelsdorf, chairman of pharmacology at UT Southwestern, was elected to the National Academy of Sciences for his contributions to understanding lipid and bile acid metabolism. His work on nuclear receptors and ligands has led to insights into cholesterol regulation.
Researchers have found a highly efficient inhibitor of botulinum neurotoxin type A, which can block its deadly action. The toxin binds to nerve cell membranes and cleaves proteins, causing muscle paralysis and death.
Patients with mild Alzheimer's disease showed less decline in functional ability after taking 800mg of tarenflurbil twice daily compared to placebo. The treatment also reduced the pace of decline in global function and activities of daily living scale.
A new study published in the Journal of Clinical Endocrinology & Metabolism reveals that anti-Müllerian hormone (AMH) levels can predict a woman's reproductive age and onset of menopause. AMH levels reflect the number of small follicles present in a woman's ovaries, enabling monthly ovulations.
Researchers have found that the ancient human 'Nutcracker Man' did not eat nuts, contrary to previous assumptions. The study used microscopy and fractal analysis to examine marks on the teeth of Paranthropus boisei, suggesting that dietary preferences were based on scarcity rather than a regular diet.
A study found that consumers have misconceptions about restaurant inspection frequency and scores. While most respondents believed restaurants were inspected regularly, many overestimated the frequency and importance of inspections. The industry must work with public health departments to improve understanding of inspection scores and ...
A study by researchers at Baylor College of Medicine found that conventional chemotherapy often fails to eliminate breast cancer stem cells, leading to potential relapse. Treatment with lapatinib and other drugs appears to kill both tumor cells and stem cells, reducing the risk of recurrence in patients with HER2-positive tumors.
Arizona State University professors Edward Prescott and Luc Anselin have been elected to the National Academy of Sciences for their groundbreaking work in macroeconomics and spatial econometrics. Their election recognizes the institution's commitment to advancing knowledge in these fields.
Researchers found that administration of triflusal increased insulin secretion significantly in relation to dose size, but did not improve insulin sensitivity. The study's findings suggest salicylates may have a therapeutic benefit in the fight against type 2 diabetes in obese individuals.
A new study published in the Journal of the National Cancer Institute estimates that Medicare costs for elderly cancer patients will top $21.1 billion over a 5-year period. The estimated cost varies widely depending on tumor type, stage at diagnosis, and phase of care.
Researchers found that bats emit exceptionally loud sounds of up to 140 dB SPL to detect small insects in air using echolocation. The study's results showed that the high frequencies emitted by the bats serve as a countermeasure to attenuation, allowing them to effectively hunt despite the limitations of ultrasonic frequencies.
Scientists from the University of New Hampshire and University of Maine are heading to Denali National Park on an ice core expedition to gather climate records from glaciers in the Alaska wilderness. The mission aims to provide a comprehensive picture of regional climate variability in the Arctic, spanning 2,000 years.
Researchers from Conservation International discovered 14 new species in the Cerrado, a biodiversity hotspot threatened by deforestation and urbanization. The finds include a legless lizard and a tiny woodpecker, highlighting the urgent need for conservation efforts in this region.
Researchers have identified a role for hydrogen sulphide in regulating blood pressure, which works by relaxing vascular tissue and improving blood flow. A slow-releasing H2S donor molecule has been synthesised to study the effects of naturally produced H2S in the body.
A mathematical model suggests that women with wild-type CYP2D6 genotype may derive as much benefit from tamoxifen as from aromatase inhibitors, potentially leading to personalized therapy approaches. Additionally, a study finds that cancer stem cells resistant to standard chemotherapy are responsive to targeted therapy.
Researchers developed a novel 3-D screening method for analyzing cell-material interactions, cutting initial search times in half. The technique enables rapid assessment of biomaterials' biocompatibility and properties, with applications in tissue and organ repair.
Researchers found that synesthetes share specific grapheme-color combinations and that these pairings are influenced by language use. The study also discovered a relationship between color saturation and linguistic frequency.
A new study published in PLOS ONE reveals that mice and humans exhibit similar behavioral patterns, with no differences in statistics between resting periods and activity durations. This discovery has implications for the development of new treatments for depression and challenges current models of human-specific disorders.
Researchers found that Paranthropus boisei's teeth showed little pitting indicative of eating hard foods, suggesting a more general diet than previously thought. This challenges the idea that their anatomy was specialized for a specific diet.
Researchers develop a system that transmits unprocessed medical images via cellular phones, enabling sophisticated radiological diagnoses and treatment in remote areas. The technology uses electrical impedance tomography and reduces costs by simplifying the apparatus at patient sites.
Researchers at NIST have demonstrated that nanoimprint lithography can accurately stamp delicate insulating structures on advanced microchips without damaging them. The process also increases the population of small pores, improving performance and reducing the risk of short circuits.
New research using atomic force microscopy reveals that liquids can respond to environmental changes by adjusting their viscosity. When confined to a nanometer-sized space and shaken, these liquids exhibit structural and mechanical properties similar to those in thicker layers.
Cancer survivors who practice healthy habits such as avoiding tobacco, eating more fruits and vegetables, and getting adequate exercise tend to have higher health-related quality of life scores. However, many survivors are not meeting physical activity recommendations or the '5-A-Day' fruit and vegetable consumption recommendation.
Scientists investigate impacts of demographic change on European cities, finding parallels between Poland, Czech Republic, and Germany. Empty properties are often the result of redevelopment needs rather than oversupply, while urban planning adaptations are crucial for elderly populations.
Researchers confirm ancient sunflower domestication in Mexico dating back 4,000 years, contrary to previously believed eastern North American origin. This discovery highlights the importance of sunflower as a major oil seed crop and its potential for modern crop-breeding purposes.
A recent assessment by the Wildlife Conservation Society and other groups suggests that bison can thrive again in large areas from Alaska to Mexico within the next 100 years. The study identified prime locations across Canada and the US, as well as parts of Mexico, where ecological restoration could take place.
A University of Minnesota study found that online interventions can help reduce HIV risk among young men who have sex with men. The research showed that meeting partners both online and offline increases the number of sexual partners and engagement in unprotected anal intercourse.
Researchers at NIST and Max Planck Institute plan to measure the Rydberg constant with unprecedented accuracy by boosting an electron to a high-flying orbit. This could reveal anomalies in quantum electrodynamics and improve element identification in stars, environmental pollutants, and more.
Research from Cardiff University finds that a third of Down's syndrome children who wear bifocals can switch to ordinary glasses within two years. The study, led by Dr Maggie Woodhouse, reveals that bifocals may be 'teaching' children with the condition to use their own focusing ability.
Researchers at USC Information Sciences Institute have developed a method to manufacture miniscule closed containers for precise drug delivery. The new technique uses micro-origami to fold up small shapes, which can be used to create 'voxels' - tiny volume-enclosing structures.
A moral philosopher is investigating the ethics of medicated memory manipulation, particularly in the context of post-traumatic stress disorder (PTSD). The use of beta-blockers to dampen emotional responses to traumatic events may undermine an individual's understanding of their moral responsibility.
The READ-2 study, a collaboration between JDRF, Johns Hopkins, and Genentech, found that ranibizumab injections significantly improved visual acuity and reduced excess retinal thickness in patients with diabetic macular edema. The treatment resulted in a 56% reduction in retinal thickness compared to laser photocoagulation therapy.
Researchers have found evidence of mesenchymal stem cells in the periosteum of deer pedicles, which are responsible for antler regeneration. The study suggests that understanding this unique process could have significant implications for regenerative medicine.
Researchers from University of Copenhagen conducted a study to identify the most effective diet to help adults stop regaining weight. After a successful initial weight loss, participants followed different diets, including high or low protein and glycemic index foods, for six months, with some receiving additional support.
Researchers confirm that farmers domesticated sunflowers in Mexico by 2600 B.C., contradicting the theory that they were introduced from eastern North America. The study's findings are based on physical evidence of early domesticated remains and linguistic traditions.
Astronomers find nine young, compact galaxies with masses of 200 billion times the Sun's, each only 5,000 light-years across. These ultra-dense galaxies formed 11 billion years ago and are thought to be building blocks for today's largest galaxies.
A new study reveals that absinthe's supposed mind-altering effects were caused by its high alcohol content, not thujone. The researchers analyzed pre-ban absinthe and found relatively small concentrations of thujone, which was insufficient to explain the drink's reputation.
Researchers at UC Berkeley developed a system that uses cell phones for medical imaging, reducing costs and increasing accessibility. The system consists of a data acquisition device connected to a central server where the image is processed, making it possible to view images on a cell phone screen.
A recent study from University College London suggests that investors' emotional states play a significant role in the stock market's behavior. The researchers argue that 'emotional inflation' - the unchecked enthusiasm and wishful thinking that can lead to excessive risk-taking - is a major contributor to market crashes.
A body image program called the Body Project has been shown to reduce the risk of onset of eating disorders by 61% and obesity by 55% in young women. The program, which consists of four one-hour weekly sessions, helps participants challenge negative body ideals and adopt healthier attitudes towards food and exercise.
Researchers at UC San Diego report improved resuscitation with a radically different approach combining hypertonic saline with viscosity enhancers that thicken blood. Dramatic increases in healthy blood flow through tissues and organs were observed in hamsters with severe blood loss.
Researchers have found that silver nanoparticles destroy benign bacteria used to remove ammonia from wastewater treatment systems. The presence of these particles can hinder the reproduction activity of good bacteria, potentially harming soil and food crops.
Researchers at USC School of Dentistry have found a connection between bisphosphonate drugs and jaw infections, with biofilms playing a key role in the deterioration of jaw tissue. The study aims to develop effective treatments or prevention methods for osteonecrosis of the jaw.
Research highlights diacetyl's acute toxicity and respiratory harm when inhaled by humans. Studies have found that diacetyl can injure lungs, particularly among workers making microwave popcorn and flavoring chemicals.
Scientists at Yale University propose a new explanation for cancer metastasis, suggesting that the fusion of a cancer cell with a white blood cell is the key to its spread. This theory has been validated in mouse studies and could lead to new therapeutic approaches.
Researchers identified four additional factors, including birth weight, gender, and antenatal steroid use, that can predict the outcome for extremely low-birth-weight infants. The study found that older gestational age, female sex, singleton births, and higher birth weight enhanced survival chances without disability.
Researchers discovered that viral agents can kick-start the body's immune response in the moist nasal lining, leading to inflammation and symptoms like sneezing and congestion. This understanding may lead to new therapies to block the triggering reactions for sinusitis and asthma.
Researchers at Arizona State University have developed a synthetic analog of DNA, called Glycerol Nucleic Acid (GNA), with unique properties that can be used to create nanostructures. The team, led by John Chaput, has successfully synthesized self-assembled nanostructures composed entirely of GNA.
A nationwide study found that regular cervical cancer screening reduces incidence rates in all ages, particularly among younger women. However, imperfect population coverage and inadequate follow-up programs remain major risk factors, highlighting the need for improved screening programs.