Articles tagged with Blood Samples
A new international study has discovered epigenetic marks in Finnish twin pairs discordant for Alzheimer's disease, which were also found in brain samples of patients. These marks are influenced by environmental factors, age, gender, and APOE genotype, and have potential diagnostic applications.
Researchers have developed a new cytometry platform to detect rare cells in blood with high throughput and low cost. The technique uses magnetic bead labelling and alternating magnetic fields to enrich and detect target cells, achieving a limit of detection of 10 cells per millilitre.
Researchers at the University of Strathclyde are working on a system to measure blood chemistry levels in premature and sick babies through their skin, which could replace invasive blood tests. The technology aims to collect glucose and lactate levels using a wireless patch sensor that can be placed on the baby's stomach.
A new test measures protein albumin proportions in blood plasma and serum samples to establish their integrity, addressing concerns about degraded samples producing spurious results. The study highlights the importance of proper sample handling and storage conditions to maintain reliability in medical research.
Researchers developed SILVER-seq to detect extracellular RNA in 5-7-microliter droplets of blood serum. The assay distinguishes between biopsies from patients with breast cancer and control samples, suggesting its potential use in diagnostic trials.
A novel open-source computational framework promotes affordable and routine NIPT applications in clinics, detecting fetal trisomies and parental chromosome origin from maternal blood samples. The framework incorporates machine learning methods to estimate euploidy or trisomy for each studied chromosome.
The All of Us Research Program has made strong progress in advancing precision medicine by collecting diverse participant data. The program aims to include 1 million or more people from diverse communities, with over 230,000 participants enrolled and 80% from underrepresented groups.
Researchers developed a novel method to directly detect circulating tumor cells in blood samples without enrichment, using lanthanide ions released from nanoparticles. The technique was tested on cancer patients' blood samples, correctly identifying 14 out of 15 cases with strong correlation to cancer stage.
Researchers at Massachusetts General Hospital have identified markers that can distinguish between major subtypes of lung cancer and accurately predict lung cancer stage. The study's findings could help physicians decide whether an individual patient with lung cancer benefits from standard treatment or needs more aggressive therapy.
Researchers analyzed blood samples from cognitively normal participants who developed Alzheimer's and found an association between neuronal-enriched extracellular vesicles and the disease. The study suggests these biomarkers may play a role in Alzheimer's progression, potentially serving as diagnostic or monitoring tools.
Scientists at the Francis Crick Institute created a comprehensive database of gene activity in mice with ten diseases, allowing researchers to study immune responses without needing actual mice. The database uses next-generation sequencing technology and shows the activity of over 45,000 genes across different diseases.
Women with severe morning sickness during pregnancy are invited to join the largest European study of hyperemesis gravidarum, a condition that can lead to weight loss, dehydration, and malnutrition. The study aims to build a database of information about the genetic basis for the condition and potentially find new ways to treat it.
Researchers at the University of Georgia have developed a microfluidic device that captures nearly every circulating tumor cell (CTC) in a blood sample, over 99%. This technology has the potential to provide key information on CTCs and aid in the early detection of cancer relapse and disease progression.
Researchers have developed a new micro-device that enables the study of blood cells and tiny particles as if they were inside the human body. The device uses a mini-vortex to spin cells, allowing for tailored experiments in drug development and disease research.
Researchers developed an AI-powered platform that rapidly diagnoses genetic diseases in critically ill infants, matching expert interpretation in 95 cases. The platform correctly diagnosed three of seven ICU patients with 100% sensitivity and precision, affecting treatment outcomes.
Researchers discovered high concentrations of toxic heavy metals in blood samples from Great white sharks in South Africa. The study found no adverse effects on the sharks' immune system despite the presence of these toxins.
A team of researchers detected the Zika virus in feces of nonhuman primates in South America, revealing potential reservoirs. The study used a novel method to collect and test fecal samples, overcoming previous limitations in testing for the virus in other bodily fluids.
Researchers at Ohio State University have developed a blood test that can reliably detect fibromyalgia by identifying unique biomarkers in the blood. The discovery has the potential to improve diagnosis and treatment outcomes for patients with this often-misdiagnosed disease, which affects millions of Americans.
A global team of scientists has mapped a newborn's life development in unprecedented detail, revealing thousands of changes over the first week. This breakthrough study could transform our understanding of health and disease in babies, and inform the development of optimized protective measures, including vaccines.
A new study reveals that certain children with strep throat are more susceptible to repeated tonsil infections due to smaller germinal centers in their tonsils and lower antibody levels against a key bacterial toxin. Genetic variations have also been identified as a risk factor for the disease.
The Madariaga virus has been identified in eight children in Haiti, with symptoms resembling dengue fever infection. Researchers suggest the virus was introduced to Haiti from Panama between 2012 and 2015, raising concerns about its potential spread to other Caribbean or North American regions.
The study found that over half (55.3%) of the 365 victims had consumed alcohol or drugs shortly before their death, with a high prevalence of cocaine and cannabis use. This correlation suggests a significant link between substance use and violent deaths in São Paulo City.
A water T2 biomarker discovered by Texas Tech University Health Sciences Center El Paso researcher David P. Cistola can detect individuals at risk of developing Type 2 diabetes, allowing for potential disease prevention through lifestyle modifications or therapies.
A Duke University research team has found a way to detect autologous blood transfusions, a method used by athletes to boost oxygen-carrying capacity. By analyzing RNA changes, researchers can identify stored red blood cells and detect self-transfusions.
A large prospective cohort study found that higher levels of prolactin in women are associated with a lower risk of developing type 2 diabetes. Women with the highest 25% of prolactin levels were 27% less likely to develop T2D than those in the lowest 25%. The association was similar regardless of menopausal status and other risk factors.
Researchers have created a see-through microfluidic device that minimizes biological sample destruction and allows for clear observation of inner workings. Thin hafnium oxide layers enable biocompatibility and transparency, reducing unwanted side effects like cell lysis.
A new pilot clinical trial found that consuming crickets can help support the growth of beneficial gut bacteria and reduce inflammation in the body. The study showed an increase in beneficial gut bacteria like Bifidobacterium animalis and a decrease in inflammatory proteins.
A new nano-sized trap device has been developed by McGill University scientists to detect disease-causing bacteria quickly and accurately. The device can analyze very small volumes of culture media containing bacteria such as E. coli and S. aureus in just minutes.
Researchers found that patients with severe depression have decreased levels of acetyl-L-carnitine in their blood, which may indicate a specific subtype of depression. The study suggests that LAC screening could be used as an effective biomarker for diagnosing treatment-resistant depression.
Researchers identified cytotoxic T cell responses to Ebola-specific proteins in 26 Sierra Leonean survivors, suggesting a vaccine targeting both viral nucleoprotein and glycoprotein could elicit cell-mediated immunity. The study provides insights into the immune response of Ebola survivors and potential strategies for vaccine development.
A study suggests that abnormal metabolism of three essential amino acids may contribute to the development of type 2 diabetes in women who have a history of gestational diabetes. Women with a history of gestational diabetes had higher levels of branched-chain amino acids in their blood, regardless of their dietary intake.
The initiative aims to enrich the world's largest health database with comprehensive metabolic biomarker profiles from 500,000 blood samples. Nightingale Health's technology will measure over 200 metabolic biomarkers in a single blood test.
Researchers at Johns Hopkins Bloomberg School of Public Health have developed a method to determine diet adherence from a blood sample. By analyzing small molecules called 'metabolites' in the blood, they found that levels differed significantly between participants following a prescribed diet and those not adhering to it.
Researchers found that positive results for glucose and HbA1c in one blood sample are a highly accurate predictor of diabetes and major complications. The study suggests a single blood sample may be sufficient to diagnose diabetes, potentially reducing the need for repeat tests.
Researchers at Rockefeller University have devised an improved method for isolating and identifying tiny fragments of RNA in human blood products, establishing extracellular RNA as a potentially reliable class of biomarkers. The new approach has been successfully tested on 312 blood samples from healthy subjects, confirming the stabili...
Researchers found that triclosan causes colon inflammation and worsens colon cancer in mice, raising concerns about its safety for human consumption. The study suggests that individuals with inflammatory bowel disease or colon cancer may be more vulnerable to the chemical's adverse effects.
A new blood test can detect liver damage in 30-45 minutes, distinguishing between healthy and damaged individuals. The test could lead to earlier treatment and potentially save millions of lives.
A new prototype for a portable instrument capable of early-stage malaria detection has been developed by researchers at the University of Southern California. The device uses magnetic properties of a parasite byproduct to detect all malaria strains, making it suitable for low-resource environments.
The MIT researchers developed modular blocks that can be assembled to produce diagnostic devices for diseases such as cancer, Zika virus, and tuberculosis. These 'plug-and-play' devices are inexpensive, easy to use, and can perform multiple biochemical functions, potentially improving access to medical technology in developing countries.
Research published in Occupational & Environmental Medicine found that adults living closer to farms had lower rates of allergic sensitization, with proximity to pigs and cattle being particularly significant. Long-term exposure to farm environments was also associated with reduced allergy risk.
Researchers at Broad Institute of MIT and Harvard have developed a new tool that enables clinicians to quickly diagnose patient samples and track epidemics using CRISPR-based SHERLOCK. The platform can detect viruses directly in bodily fluids, eliminating the need for lab equipment and trained personnel.
A portable test has been developed to identify populations at risk of measles and rubella infections in remote areas. The new technology can rapidly test multiple blood samples and is a potentially useful tool for addressing vaccine-preventable diseases in developing countries.
Researchers discovered malaria parasites in 21% of white-tailed fawns in Florida, with infected deer more likely to die during the first year. The study's findings suggest that young animals are particularly vulnerable to these parasites.
Research found that infected children produce distinctive chemical fingerprints in their skin odors, making them more attractive to malaria mosquitoes. The study identified key volatile chemicals, including aldehydes, which are detected by mosquitoes and increase attractiveness.
Researchers at Massachusetts General Hospital developed a microfluidic device that measures neutrophil motility to accurately diagnose sepsis. The device achieved more than 95% accuracy in distinguishing patients with sepsis from those without, offering a promising new approach to timely treatment.
A new test developed by chemists can screen for synthetic opioids and cannabinoids in just under five minutes, helping medical staff identify the cause of an overdose. The device uses a small cartridge to extract and analyze drugs from blood samples, providing a potential solution to the growing crisis of opioid overdoses.
A study from Umea University found that people who use moist snuff have significantly higher levels of protein cornulin in their blood. Lifestyle factors can influence background levels, and the researchers hope to find disease-detecting proteins in the future.
Researchers at Washington University developed a novel, low-cost technique to preserve blood and urine samples without refrigeration. The method uses nanoporous materials to protect protein biomarkers, maintaining 95% purity and enabling efficient transportation and analysis.
Scientists have developed a new sample storage method that uses tiny metal-organic hybrid structures to encapsulate and protect disease indicators from blood and urine samples. This technique has been shown to retain more than 85% of biomarkers for kidney damage, comparable to refrigeration.
A new telomere length test has been shown to alter treatment decisions for patients with certain types of bone marrow failure. The test can help identify people at increased risk for developing diseases associated with short telomeres, such as lung scarring and other cancers.
Researchers at University of Waterloo develop coated blade-spray mass spectrometry for rapid on-site screening of athletes' blood and urine samples, reducing analysis time to 55 seconds and cost to a few dollars per sample. The technology aims to prevent cheating by providing continuous monitoring.
A new study has identified protein biomarkers that can help monitor the progression and treatment of Hutchinson-Gilford progeria syndrome (HGPS) in children. The research found levels of more than 40% of proteins to be significantly different in HGPS samples compared to non-HGPS control samples.
A new blood stabilization method developed at Massachusetts General Hospital significantly prolongs the lifespan of circulating tumor cells (CTCs) in whole blood samples. This approach allows for the preservation of high-quality RNA suitable for demanding molecular assays, opening up potential for personalized drug testing and expandin...
A new DNA marker discovered by University College London researchers can detect fatal breast cancer up to a year before symptoms appear. The EFC#93 DNA methylation marker in blood serum correctly identified 43% of women who went on to be diagnosed with fatal breast cancer within three to six months.
Researchers at the University of Huddersfield have developed a method to quickly detect signs of multiple sclerosis using blood samples. The discovery identifies two natural biomarker compounds, sphingosine and dihydrosphingosine, which are found to be at significantly lower concentrations in patients with MS.
Researchers developed a point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings. The device, using disposable lateral flow cards, measures total serum bilirubin levels with high accuracy, suggesting a potential solution for resource-limited settings.
Scientists have identified two biomarkers that accurately predict patient survival in Ebola cases. The study analyzed blood samples from survivors and fatal cases, revealing distinct metabolic responses and immune-related molecules. These findings could improve treatment allocation and patient outcomes.
A research team led by the University of Wisconsin-Madison has identified 11 biomarkers that distinguish fatal Ebola infections from nonfatal ones. These biomarkers may aid in future treatment efforts and help clinicians prioritize scarce resources for the sickest patients.
Researchers at Tufts University will develop devices to improve the collection, storage and transport of blood samples in field settings, enhancing sample reliability for disease surveillance and diagnostics.
A new study by University of Pennsylvania researchers has found that the 'push-pull' blood sampling technique is as accurate as venipuncture, but requires no presample to be discarded and minimizes contamination risk. The method uses a catheter's dead space to collect samples, reducing needle pricks and pain for patients.