Articles tagged with Cancer Patients
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Researchers have developed a method to advance undeveloped human eggs to near maturity in laboratory cultures, paving the way for women with cancer to preserve their fertility after treatment. The technique focuses on the follicle and avoids concerns related to freezing ovarian tissue.
Researchers from Northwestern University have successfully grown a woman's immature egg cells, contained in a tiny sac called a follicle, to a healthy and nearly mature egg in the laboratory. This breakthrough could provide a new fertility option for women whose cancer treatments destroy their ability to reproduce.
A new study found that African-American patients with breast, ovarian, and prostate cancer tend to die earlier than patients of other races, even when controlling for medical treatment and socioeconomic factors. The analysis of over 20,000 patient records suggests a potential role for genetic factors in the survival gap.
Researchers have identified a potential therapeutic target for basal breast cancer, an aggressive form of the disease. The Met gene was found to play a critical role in its development, making it a promising drug target for patients with few treatment options.
A study of nearly 20,000 patient records found that African-American breast, ovarian, and prostate cancer patients die earlier than others with similar treatment, suggesting biological or host genetic factors as the cause. The survival gap persists even after controlling for socioeconomic factors.
A commentary in JAMA emphasizes the importance of clarifying patient preferences and values during difficult diagnoses. Doctors can guide patients to use emotions and logical thinking skills together, framing information with multiple perspectives.
The Mayo Clinic Cancer Center has received a $28 million National Cancer Institute (NCI) funding grant for five years. This award extends the center's designation as a comprehensive cancer center, enabling it to continue delivering outstanding care and research programs across its three US sites.
A new study has identified a second gene linked to familial testicular cancer, raising the risk of men with a family history. The PDE11A gene's mutations are found in about one out of every five families studied, and may modify an individual's susceptibility to developing a tumor.
A study published in the World Journal of Gastroenterology found that preoperative biliary drainage significantly reduced wound infection rates in patients undergoing resectional surgery for ampullary carcinoma. The findings suggest that PBD may have a positive impact on surgical outcomes, particularly in terms of infectious morbidity.
A study published in Diabetologia suggests that insulin analogue glargine may increase the risk of cancer in diabetes patients. The analysis found a statistically significant association between glargine use and an increased risk of malignancies, with a dose-dependent relationship observed.
A new protein called Trim24 marks the tumor suppressor p53 for destruction by attaching targeting molecules, leading to increased p53 expression and programmed cell death in cancer cells. The discovery provides a potential therapeutic approach to restoring p53 and killing tumor cells.
A new study from the University of Michigan Comprehensive Cancer Center found that a single round of chemotherapy can identify patients most likely to benefit from preserving their speech. After three years, 78% of T4 study participants were still alive and 58% had an intact larynx.
People with schizophrenia are at a higher risk of dying from all causes, including cancer, due to factors like smoking and delayed diagnosis. Cancer mortality rates among schizophrenic patients are significantly higher than those in the general population, particularly for women.
A large analysis found Caucasians are nine times more likely to be diagnosed with Ewing's sarcoma than African Americans. Additionally, men are more likely to die from the disease than women among Caucasians. The study highlights racial and gender differences in incidence and survival rates.
Patients treated for Hodgkin lymphoma with radiation therapy have a substantially higher risk of stroke. After a median follow-up of almost 18 years, 96 patients developed cerebrovascular disease, with the incidence rate for stroke being 2.2 times that in the general population. Risk factors include radiation to the neck and mediastinum.
A recent study published in PLOS Pathogens has uncovered clues to the development of cancers in AIDS patients, revealing specific miRNA biomarkers that accurately identify stages of tumor progression. The research team also found that certain miRNAs were lost as tumors progressed, accelerating cancer growth.
Researchers found that Stat5a protein has a mixed function in breast cancer development, promoting growth of certain precancerous lesions but also protecting mammary cells from carcinogenic exposure. The study highlights the importance of understanding breast cancer heterogeneity when testing new therapeutic targets.
A study published in the World Journal of Gastroenterology found that females are at a higher risk of developing gastric cancer than males when their mothers have a history of non-gastric cancer. The research analyzed family histories of 2260 patients with gastric cancer and identified key genetic and environmental factors contributing...
A new risk assessment test, CAPRA, has been developed to predict long-term risks and pinpoint high-risk cases in prostate cancer. The test accurately predicted bone metastasis, prostate cancer-specific mortality, and all-cause mortality when localized prostate cancer is first diagnosed.
Researchers discovered a correlation between CHFR silencing and microsatellite alteration in gastric cancer, leading to mitotic checkpoint disruption and increased cell survival. This study provides new information on the genetic mechanisms underlying gastric carcinogenesis.
Two studies found that patients with cancer aged 65+ experience a significant decline in physical and mental health, leading to lower overall quality of life. The impact on HRQOL was quantified by analyzing changes in patients' well-being before and after diagnosis.
A four-year UCLA study found significant impacts on quality of life for prostate cancer patients treated with radical prostatectomy, seed implants, or external beam radiation. The study developed 'probability plots' to predict when side effects will return to normal or if a patient will fully recover.
A new review of cancer clinical trials reveals that women make up only 38.8% of patients enrolled, with a lower proportion in treatment-focused studies. Studies funded by government vs. private funds show a higher percentage of female participants.
The I-SPY trial offers critical insights into locally advanced breast cancer, emphasizing the importance of not ignoring growing breast masses. The study found that most interval cancers are discovered between routine mammogram exams, suggesting a need for better screening strategies.
A phase I trial found a two-drug combination of temsirolimus and bryostatin to be safe and active in patients with metastatic kidney cancer. The combination showed sustained responses in some patients, particularly those with rare forms of renal cell carcinoma that don't respond well to standard therapies.
A new study by Memorial Sloan Kettering Cancer Center found that most patients with stage IV colorectal cancer do not require surgery to remove the primary tumor. Chemotherapy is an effective treatment option for these patients, allowing them to avoid surgical complications and start treatment sooner. The retrospective study analyzed 2...
A Phase III trial found that vandetanib significantly improved progression-free survival compared to chemotherapy alone. The therapy, which targets both EGFR and VEGFR, also showed reduced side effects, particularly nausea and vomiting.
The study found that those who received the vaccine had a significant response rate of 22.1% and progression-free survival of 2.9 months compared to 9.7% and 1.6 months respectively in those that did not. The median overall survival for those receiving vaccine trended positive at 17.6 months.
A new study found that combining erlotinib and bevacizumab delays disease progression in advanced non-small cell lung cancer patients by 29% compared to those receiving bevacizumab alone. The combination also prolongs median progression-free survival from 3.7 months to 4.8 months.
The shift towards oral chemotherapy agents poses risks of non-adherence, which can lead to increased healthcare costs and reduced efficacy. Studies show that non-adherence is often linked to financial constraints, education issues, and side effects, highlighting the need for innovative strategies to improve patient compliance.
A national survey reveals that nearly all oncologists and ID specialists are highly concerned about the negative impact of infection on treatment outcomes in chemotherapy patients. Infections among chemotherapy patients are common, with one in four patients experiencing an infection in the last 12 months.
Researchers found that the level of physical activity and cancer treatment do not affect a person's cardiovascular fitness. A new test, three-minute step test, can help determine a patient's current fitness level.
A $18 million grant will support a three-year investigation into new approaches to treating pancreatic cancer, the fourth leading cause of cancer death in the US. The project aims to develop tests that determine what nutrients fuel pancreatic cancer cell growth and survival.
Five multi-disciplinary research teams will pursue innovative cancer treatments, combining laboratory scientists and physicians with a focus on rapid progress and collaboration. The funding model aims to eliminate barriers to creativity and collaboration, enabling diverse experts from institutions across the US to work together.
V. Craig Jordan, a renowned breast cancer scientist, has assembled a team of top researchers to tackle the complexities of breast cancer through a $73.7 million grant from Stand Up To Cancer. The 'Dream Team' aims to accelerate cancer treatment within three years by understanding the molecular diversity of human breast cancer.
A new study found that childhood cancer survivors have a significantly increased risk of developing second primary cancers throughout their lives. The research, published in the Journal of the National Cancer Institute, analyzed data from 47,697 people diagnosed with cancer before age 20 and found a higher incidence rate of new primary...
Researchers at Fred Hutchinson Cancer Center identified two proteins associated with chronic inflammation linked to long-term survival in breast cancer patients. Elevated levels of C-reactive protein and serum amyloid A are associated with reduced overall survival, regardless of patient age or tumor stage.
Cancer care's high costs are impacting patients' welfare and society as a whole. The economic burden is too great to ignore, with rising costs threatening personalized medicine's promise.
Researchers used PET scanning to assess estrogen receptor positive breast cancer patients' response to standard aromatase inhibitor therapy after just two weeks. The results showed significant declines in glucose analogue FDG values, similar to earlier studies using needle biopsies.
A US citizen with head and neck cancer treated with capecitabine experienced a mild case of hand-foot syndrome, leading to fingerprint loss. His doctor advises patients on capecitabine to carry a letter explaining their condition for travel to the USA.
Breast cancer patients with high levels of C-reactive protein (CRP) and serum amyloid A (SAA) are more likely to die sooner or have their cancer return. Elevated CRP is also linked to increased risk of heart disease.
A meta-analysis of 12,294 patients found bevacizumab significantly increases the risk of gastrointestinal perforation, especially in those with advanced colorectal and renal cell cancers. The study also showed a dose-dependent relationship between bevacizumab dose and GI perforation risk.
A study at Dartmouth Hitchcock Medical Center found that nearly 20% of patients with recent breast cancer diagnoses had additional malignant tumors detected only by Breast MRI. The detection of these 'unsuspected' cancers is critical for patient health and survival.
Researchers have pinpointed a new class of gene mutations that identify cases of childhood acute lymphoblastic leukemia with a high risk of relapse and death. The discovery suggests specific drugs could treat this subtype, building on previous studies hinting at kinases' role in the disease.
Overall median survival improved from 3.5 months in period A to 12 months in period C, despite stage of disease at presentation affecting survival. Surgical resection is the only curative treatment, but many patients present with advanced-stage disease.
A Stanford University study found that disrupting the interferon pathway, a critical immune signaling mechanism, can lead to cancer progression and impaired immune response. This defect was detected in patients with breast, melanoma, and gastrointestinal cancers, suggesting a possible explanation for treatment failures.
Researchers at the University of Cincinnati analyzed lung, colon, breast, prostate, bladder, kidney and skin cancer data in transplant recipients compared to the general population, finding worse disease-specific survival rates for each type of cancer. Immunosuppressive therapies may play a role in the poorer outcomes.
The Pathfinder program, which focuses on body, mind, and spirit, has been found to improve distress and despair in women with metastatic breast cancer. The program provides patient navigation, counseling, and coping skills training, resulting in a higher quality of life for participants.
A study led by Duke University Medical Center found that wireless computers used by cancer patients to log symptoms improved care and furthered cancer research. Patients reported symptoms more honestly, remembered all symptoms since their last appointment, and benefited from personalized educational content.
A study found that 45% of older women with early-stage breast cancer choose chemotherapy, higher than the national average. The researchers suggest that these women are weighing risks and benefits more thoroughly, making informed decisions about their treatment.
A study by Fox Chase Cancer Center found that targeted educational initiatives improved the number of lymph nodes retrieved during colorectal cancer surgery. The interventions increased the percentage of operations with at least 12 nodes removed over four years, leading to more accurate staging and improved survival for patients.
Researchers at NYU Langone Medical Center report early promise in animal studies for a novel antiparasitic drug as a potential treatment for metastatic melanoma. Additionally, the study found associations between specific microRNAs and patient survival in metastatic melanoma and early-stage lung cancer.
Researchers at Mayo Clinic found that pazopanib stops new blood vessel growth, slowing aggressive differentiated thyroid cancer. The treatment showed promising results in about two-thirds of patients with fast-growing cancers that had spread to lungs and other organs.
A phase III study found that adding an antibody-based therapy improved the survival rate of children with high-risk neuroblastoma by 66%, increasing their chances of living disease-free for at least two years. The therapy targets a specific glycan on cancer cells, enabling immune cells to attack and kill them.
A novel therapy using the anti-viral drug ribavirin has shown promising results in treating 30% of cancers, including breast and prostate cancer. The study demonstrated that ribavirin suppresses the eIF4E gene, which is dysregulated in 30% of cancers.
A physicist at Brookhaven National Laboratory has developed a compact and cost-effective gantry design for delivering tumor-killing particle beams, reducing weight and size by up to 100 times. This new design could make precision particle therapy available to more cancer patients worldwide.
A home-based program aimed at improving exercise and diet can lead to significant improvements in physical function among older long-term cancer survivors. The study found that the intervention group had higher levels of physical function compared to the control arm, with declines in functional decline of almost five points versus slig...
A new study from Henry Ford Hospital found that radical prostatectomy significantly increases long-term survival for men under 50 with prostate cancer. The procedure improved cancer-specific and overall survival rates compared to radiotherapy or watchful waiting, making it the recommended treatment option for younger patients.
A study found that half of patients with multiple CT scans within a year accrued additional radiation-induced cancer risks above baseline greater than 1 in 110. Researchers advise reviewing patient's CT imaging history and cumulative radiation dose before performing another CT exam.
A systematic review found that hospital volume is associated with short-term mortality rates for certain cancer types, but individual studies often fail to show this association. The review concludes that case volume may be an imperfect proxy for healthcare quality and highlights the need for more direct quality measures.