Articles tagged with Cancer Patients
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A new study found that drugs to combat anemia in cancer patients may actually increase the risk of death and serious blood clots. The use of these agents should not be routine therapy unless proven safe and clinically beneficial.
A meta-analysis of 53 cancer trials found that erythropoiesis-stimulating agents (ESAs) increased mortality in all patients with cancer by 17%. The treatment's benefits must be weighed against the increased risks of death and thromboembolic events.
The OHSU Knight Cancer Institute is evaluating the effectiveness of the Calypso system in delivering precise radiation therapy to head and neck cancer patients. The system uses electromagnetic transponders implanted in a customized mouth guard to monitor patient movement and improve treatment accuracy.
Research found that women with tumors carrying TOP2A gene alterations had better outcomes when treated with anthracycline-based regimens, similar to those seen in HER2-positive tumors. The study suggests that TOP2A gene alteration is associated with increased benefit from anthracycline therapy.
A new diagnostic technique using blue light and a special study drug has been shown to detect more bladder tumors, reducing the rate of recurrence by 22% in patients with papillary bladder tumors. The study found that this method detected an additional tumor in 16.9% of patients compared to traditional white-light detection.
A study by Fox Chase Cancer Center found that patients with Medicare are less likely to undergo kidney-sparing surgery for renal cell carcinoma compared to those with private insurance. This disparity affects the quality of care and has implications for healthcare reform.
The American Cancer Society has awarded 143 national research and training grants totaling over $51 million to investigators at 83 institutions nationwide. The grants support groundbreaking research into the molecular genetics, biochemistry, and cell biology of cancer.
Researchers at M. D. Anderson Cancer Center have discovered a drug, AZ23, that reduces AML cell burden by 50% in mice with no immune system. The study also found 60% of treated mice had long-term survival without leukemia cells.
Researchers at the University of Texas M. D. Anderson Cancer Center have discovered a new drug combination that significantly hinders neuroblastoma tumor growth in pre-clinical tests. The combination of vandetanib and 13-cis-retinoic acid reduced tumors by 86 percent, offering new hope for children with this childhood cancer.
Researchers at the University of Texas M. D. Anderson Cancer Center have discovered a new drug that inhibits neuroblastoma blood supply, reducing tumor growth by 75%. The drug, AMD3100, blocks interaction between SDF-1a and its receptor CXCR4, preventing tumors from growing rapidly by disrupting their blood supply.
A study at the University of California San Francisco Medical Center found certain ultrasound features indicative of cancer, allowing for non-invasive management. Microcalcifications, taller-than-wide shape, and hypoechogenicity were identified as high-risk features.
A new cancer drug, 3-BrOP, has been found to reduce neuroblastoma growth by 75 percent in pre-clinical studies. The drug works by blocking the main energy source, glucose, thereby starving cancer cells and disrupting their ability to grow.
A survey found that thinner melanomas are more likely to be detected by physicians, while thicker tumors are often self-detected. Physician skin examination and improved public awareness are key targets for new interventions to promote earlier detection.
Researchers at the University of Texas M.D. Anderson Cancer Center report that acupuncture treatments can significantly improve symptoms of xerostomia, a debilitating condition caused by radiation therapy for head and neck cancer. The treatment showed highly statistically significant improvements in saliva flow and quality-of-life scores.
Researchers at Georgetown University Medical Center have discovered that phenethyl isothiocyante (PEITC) can selectively deplete mutant p53 in tumor cells. This restoration of wild-type function increases the sensitivity of mutant p53-expressing tumor cells to PEITC-induced cytotoxicity.
A genetic analysis revealed that variants in the iNOS gene may predict the risk of recurrence among patients with non-muscle invasive bladder cancer treated with Bacillus-Calmette-Guerin (BCG) therapy. Patients with the variant allele had a significantly longer survival time, up to 96.7 months, compared to those without the variant.
A phase II study led by Ohio State University researchers has found a targeted agent to be effective in treating advanced biliary cancer. The study showed that the agent, AZD6244, achieved an average progression-free survival of 5.4 months and stable disease in many patients.
A nationwide study by TGen and Scottsdale Healthcare shows that molecular profiling can identify specific treatments for individuals, helping keep their cancer in check for significantly longer periods. The study included 66 patients who experienced significant periods of time when their tumors did not progress.
Researchers have confirmed six gene variants linked to chronic lymphocytic leukemia (CLL), the most common adult leukemia in the US. The study found that patients with CLL are more likely to have these genetic changes, increasing their risk of developing the disease.
A large US-based study found that nearly 26% of women with breast cancer have p53 gene mutations, leading to poorer outcomes. Postmenopausal women with higher body mass index (BMI) were more likely to develop these high-grade tumors.
Researchers have made significant advancements in cancer treatment, with studies on combined PI3K and MEK inhibition showing anti-tumor activity. Another study found that combining a histone deacetylase inhibitor with an mTOR inhibitor may provide a new therapeutic approach for pancreatic cancer.
The online tool provides a roadmap for managing health after treatment, addressing late effects of cancer therapies and promoting informed discussions with healthcare teams. Researchers surveyed 3,343 individuals who created OncoLife plans, reporting high user satisfaction and encouragement to share their plans with providers.
A new study led by Memorial Sloan-Kettering Cancer Center compares traditional 'open' surgery to laparoscopic gastrectomy, a minimally invasive procedure. The findings demonstrate that laparoscopic surgeries yielded shorter hospital stays and fewer complications after surgery while maintaining similar rates of recurrence-free survival.
A study published in the Journal of Clinical Sleep Medicine suggests that sleep problems lead to increased ratings of pain and fatigue in cancer patients. The research indicates that addressing sleep issues may improve pain management for this patient population.
A study found that black patients with non-small cell lung cancer are 37% less likely to receive recommended surgery and 42% less likely to receive recommended chemotherapy than white patients. The disparity remains despite efforts to address inequalities in medical treatment.
Researchers discovered a receptor in the colon that has cancer-killing potential and is silenced by cancer. Activating this receptor with butyrate or a related compound may provide a new treatment for colon cancer and inflammatory bowel disease.
Patients given an omega-3 enriched supplement maintained all aspects of their body composition after surgery, while those without it suffered clinically severe weight loss. The study suggests that omega-3 fatty acids may reduce the risk of post-surgical complications by suppressing inflammation.
UT Southwestern University Hospital has received the Commission on Cancer Outstanding Achievement Award, recognizing its commitment to providing high-quality cancer care. The award is based on rigorous evaluations of the hospital's cancer program standards, including leadership, data management, and clinical services.
A retrospective analysis of 20,713 patients with early bladder cancer found that more intensive treatment was not associated with improved overall survival. In fact, those who received more intense care were more likely to require major medical interventions later on.
A retrospective analysis found that multiple lung tumors in patients often arise from a single cancer cell, suggesting multifocal lung cancers should be classified as advanced-stage cancers. The study analyzed 70 tumor samples and concluded that 77% of patients had multiple tumors originating from a single clone.
Researchers found no correlation between aggressive treatment and improved survival rates for early stage bladder cancer patients. Aggressively treated patients were more likely to undergo major surgery, resulting in higher treatment costs.
Researchers at Seattle Cancer Care Alliance found Avastin to be effective in delaying brain tumor progression and improving quality of life for patients with recurrent Grade 3 brain tumors. The treatment improved survival time while reducing the impact of steroids on patients, who experienced a marked improvement in their condition.
Researchers found that brief behavioral interventions prior to and after surgery improved short- and long-term outcomes, including lower mood disturbance and better quality of life. The study's findings suggest that pre-surgical stress management can have a lasting impact on patients' well-being.
Compassion fatigue is a syndrome experienced by healthcare providers caring for individuals facing dire consequences, leading to symptoms such as chronic tiredness, irritability, and lack of joy. The study highlights the need for better training and supportive work environments to prevent compassion fatigue.
A new study from the University of Michigan Comprehensive Cancer Center found that health choices at diagnosis play a major role in head and neck cancer survival. Patients with better habits such as not smoking, exercising regularly, eating enough fruits, and limiting alcohol use had longer survival times.
A Virginia Tech and Wake Forest University study found that altering taste and smell can negatively impact cancer patients' survival chances. Researchers identified management strategies to improve taste and odor abnormalities in cancer patients.
A study published in Radiology found that patients who undergo numerous CT scans over their lifetime may be at increased risk for cancer due to cumulative radiation exposure. The study estimated lifetime attributable risk (LAR) of cancer for each patient, based on their CT exposures.
Researchers found that phosphatase regenerating liver 3 (PRL-3) is a new independent prognostic indicator for gastric cancer, predicting tumor recurrence and survival rates. Positive PRL-3 expression was associated with advanced TNM stages, lymph node metastasis, and poorer overall survival rates.
A randomized controlled trial found that a 3-drug chemotherapy combination of docetaxel, cisplatin, and 5-fluorouracil (TPF) increased organ preservation rates in patients with locally advanced larynx cancer. Compared to the single-agent TPF, the addition of docetaxel improved larynx function and overall response rates.
A new surgical technique, lymphaticovenular bypass, shows promise in reducing lymphedema fluid by up to 39% in breast cancer patients. The minimally invasive procedure is a viable option for managing the condition, which affects up to 30% of women after surgery and radiation therapy.
A recent study by ECCO-the European CanCer Organisation analyzed data from the EUROCARE-4 Working Group, revealing a steady rise in cancer survival rates across Europe. The proportion of patients cured of lung, stomach, and colorectal cancers increased significantly between 1988-1990 and 1997-1999.
Cancer patients experiencing malnutrition are at a higher risk of psychological distress. Researchers found that the level of distress is positively correlated with nutritional status, highlighting the need for evaluation of nutrition in cancer care.
A new study analyzing UK cancer survival data reveals a modest improvement in survival rates since the introduction of the NHS cancer plan in 2000. However, significant regional variations in survival remain, with affluent southern regions showing better outcomes.
Recent research suggests that monoclonal antibodies can stimulate both innate and adaptive immune responses, leading to more powerful control of cancer. This breakthrough could lead to the development of new treatments that alter antibodies to induce long-lasting immunity.
Local rectal cancer excision is effective for stages Tis and T1 cancers, with prevention of recurrence and postoperative follow-up increasing efficacy. Administering salvage therapy also improves outcomes.
According to the study, approximately half of patients with early-stage laryngeal cancer who undergo radiotherapy develop malnutrition, defined as weight loss of at least 5%. Patients with neck lymph node irradiation are more than four times as likely to become malnourished.
A new study from University of Pennsylvania School of Medicine identifies genes associated with the BRCA1 protein and their involvement in the DNA repair pathway. MERIT40, a previously unknown protein, was found to work with BRCA1-RAP80 complex to achieve DNA repair.
Patients with advanced cancer who used religious faith to cope were more likely to receive intensive life-prolonging medical care, according to a study. Positive religious coping was associated with nearly three times the odds of receiving mechanical ventilation and preferring heroic measures.
Researchers at Dana-Farber Cancer Institute found that patients who draw on religion to cope with their illness are more likely to receive intensive, life-prolonging medical care as death approaches. This study suggests that physicians tend to comply with religious patients' wishes for more aggressive care.
A multi-center study recommends that men diagnosed with low-risk prostate cancer can safely choose observation over immediate treatment, closely monitored. This approach is associated with a low risk of metastatic spread and is not a total disregard for patients with prostate cancer.
A team of Columbia University researchers has identified a new investigational therapy for bladder cancer, inhibiting the mTOR signaling pathway with rapamycin. The discovery demonstrates that p53 and PTEN tumor suppressor genes are inactivated in invasive bladder cancer.
A new study has found that maintenance rituximab therapy improves progression-free survival in patients with stage III-IV indolent lymphoma. The treatment showed significant benefits, including a 22% improvement in disease response and a 68% three-year progression-free survival rate.
Researchers found that study methods and definitions of lead time significantly impact estimates of prostate cancer screening's effectiveness. The study suggests a need for clear methodology to accurately interpret findings.
A new study published in the Archives of Internal Medicine found that many terminally ill patients feel abandoned by their doctors due to a lack of continuity and closure. The study identified two themes: before death, concerns about loss of communication, and at the time of death or after, feelings of abandonment from a lack of closur...
A study found that patients who had end-of-life conversations with their doctors had significantly lower health-care expenses ($1,876 vs. $2,917) and better quality of life during their final week. The study suggests a strategy to reduce healthcare costs and improve patient care.
A study found that patients who discussed end-of-life care with their physicians had lower healthcare costs in the final week of life. Another report revealed higher healthcare costs among black and Hispanic patients compared to white patients, regardless of cause of death. The findings highlight racial disparities in end-of-life care.
A short course of radiation therapy followed by high-quality surgery is the most effective treatment for patients with operable rectal cancer. Recent trials have shown a reduction in local recurrence with radiotherapy and chemotherapy before or after surgery.
The IU Simon Cancer Center has launched a new web site section providing information on diagnosis, treatments, and unexpected symptoms for cancer patients. The section, funded by the Walther Cancer Foundation, aims to improve patient support and communication between patients and healthcare providers.
A recent study found that consuming two or more alcoholic drinks per day may slightly increase the risk of developing pancreatic cancer. The research pooled data from 14 studies involving over 862,000 individuals and identified a higher risk among men who consumed three or more drinks daily.
The US stimulus package is unlikely to address the financial struggles of cancer patients, who face high costs for treatment and uncertain treatment outcomes. The package's limited funding for cancer research and care may exacerbate existing inequalities in healthcare access.