Articles tagged with Cancer Patients
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Researchers at Johns Hopkins Medicine have developed a new experimental therapy that prevents premature birth using nanosized particles of drugs. The treatment decreases contractions in uterine muscles and could be a clinical option for preventing preterm labor.
Dartmouth researchers have developed a method to convert standard linear accelerators to deliver ultra-high-dose rate radiation therapy beams, known as FLASH. The beams have been shown to protect normal tissues from excess damage while maintaining the same treatment effect on tumor tissues.
The NRG Oncology phase II clinical trial determined that the combination of total neoadjuvant therapy with pembrolizumab and chemoradiotherapy is safe for patients with locally-advanced rectal cancer (LARC). However, it may not offer any statistically significant improvement in downstaging of the cancer at the time of surgery.
A study of 1,347 pediatric tumors found NTRK fusions in 29 cases, detected in 13% of papillary thyroid carcinomas and 1.9% of CNS tumors, offering new insights into prioritizing screening for targeted treatment with TRK inhibitors.
Researchers found that mice with different types of T cells responded differently to tumors, with some rejecting them and others succumbing to development. The study aims to develop more effective personalized immunotherapy for cancer patients by understanding the role of T cells in immune response variation.
A new study by Johns Hopkins Medicine found that various oral sex behaviors may increase the risk of oral HPV infection and head and neck cancer. Behaviors such as having multiple partners, early age of sexual initiation, and higher 'intensity' of oral sex were associated with a higher risk of the disease.
Research at Charité - Universitätsmedizin Berlin found that patients' immune systems before chemotherapy determine treatment success in bladder cancer. High levels of CXCL11 and CXCR3alt receptors indicate a strong immune response, leading to increased survival rates.
The COVID-19 pandemic significantly affected cancer screening test utilization and subsequent cancer diagnoses in the largest US healthcare system. Researchers analyzed data to understand the impact of the pandemic on cancer care.
A UK trial using computer algorithms shows that early-stage cancer patients can better manage their symptoms and improve their physical wellbeing through remote monitoring. The eRAPID system provided instant advice on symptom management, leading to a cost-effective solution with better patient outcomes.
A new study found that a Mediterranean-style diet may help slow the progression of prostate cancer in men who are not seeking immediate treatment. Men with localized prostate cancer who followed a more plant-based diet had a lower risk of cancer growth or advancement, regardless of their age, PSA levels, or tumor volume.
Virtual care during COVID-19 accelerated at Princess Margaret Cancer Centre, showing high patient and physician satisfaction. The study found significant cost savings for patients and comparable or better quality of care.
A new study published in JAMA Network Open shows that deep learning can help predict occult peritoneal metastasis in stomach cancer. The researchers developed a deep learning model called Peritoneal Metastasis Network (PMetNet) to predict clinically occult peritoneal metastasis using preoperative computed tomography images.
Researchers developed a gene expression signature that robustly predicts patient survival in patients with peritoneal carcinomatosis, a form of metastatic gastric cancer. The signature is associated with tumor cell populations and lineage compositions, offering potential for tailored treatment strategies.
A new study published in Cancer suggests that inflammation from ADT is linked to higher levels of fatigue in prostate cancer patients. The researchers found an increase in the inflammation marker IL-6 in this group, which may contribute to symptoms.
The COVID-19 pandemic significantly challenges cancer prevention and control in Africa, diverting resources away from cancer patients. However, this crisis also creates opportunities for innovation and improved access to cancer care.
Researchers have classified angiosarcomas into three subtypes based on genomic and immune profiles, enabling personalized treatment approaches. The study suggests that checkpoint immunotherapy can be effective for clusters one and three, while tumour-promoting genes in cluster two may be explored as potential targets.
Researchers have identified seven DNA fingerprints that define cancer risk, including a protective germline pattern and six that present a higher risk. The discovery refines the long-held view that lifestyle factors contribute to cancer risk and sheds light on the role of genetics in cancer development.
Researchers discovered that abatacept reduced severity of myocarditis in genetic mouse model and human patients. The study provides a potential new treatment option for patients with immune-related side effects from immunotherapies.
A landmark study by researchers from the SWOG Cancer Research Network has found that 2.8 percent of cancer patients develop osteonecrosis of the jaw within three years of starting zoledronic acid treatment. The study, which followed 3,491 patients over three years, also identified risk factors and impact on quality of life.
The COVID-19 pandemic has significantly affected cancer treatment outcomes, with social distancing efforts potentially leading to better or worse results for patients. The study explores the implications of these measures on health behaviors and their consequences for cancer control.
The FDA has approved pembrolizumab, a new immunotherapy drug, as the first-line treatment for patients with advanced colorectal cancer. This approval was made possible by early results from a phase III clinical trial funded by Stand Up To Cancer (SU2C) research.
Researchers discovered that loss of function of FAT1 promotes hybrid EMT phenotype, characterized by co-expression of epithelial and mesenchymal genes in tumor cells, leading to metastasis and poor clinical outcome. FAT1 mutated cancers are highly resistant to several drugs, including EGFR inhibitor.
A UK national study found that children with cancer who test positive for COVID-19 have mild infections or are asymptomatic, with no deaths reported and only 5% requiring intensive care support. The study's real-time data helped inform shielding advice for this group of patients.
The Patient Researcher Forum allows patients and researchers to learn from each other, fostering interdisciplinary collaboration. The program has a positive impact on perspectives of both parties, with patients gaining insight into the importance of cancer research and researchers becoming more patient-centered in their work.
A large retrospective study found that patients with non-small cell lung cancer who developed two immune-related side effects had improved patient survival and delayed tumor progression. The researchers identified a correlation between multisystem immune-related adverse events and improved survival outcomes.
A new study suggests that most rectal cancer patients can replace aggressive surgery with radiochemotherapy and close surveillance, with a low risk of tumor regrowth. Almost 70% of patients who underwent the 'watch and wait' protocol remained cancer-free for years, making intensive follow-up possible.
A study published in Journal of the American College of Surgeons found that financial toxicity among breast cancer patients is independently associated with worse psychological well-being. Even small improvements in financial pressure can lead to better mental well-being and higher patient satisfaction with breast reconstruction.
Researchers developed a new model to predict kidney function in cancer patients, enabling more accurate chemotherapy dosing and minimizing harm. The model takes into account various factors like age, gender, and body mass index, providing clinicians with a valuable tool for guiding treatment decisions.
A survey is being conducted to characterize marijuana use among cancer patients receiving care at MUSC Hollings Cancer Center. The study aims to explore how often patients are using marijuana, why they're using it, and their perceptions of its efficacy in managing symptoms. The findings will provide insight into the prevalence and spec...
A recent study analyzed risk factors and racial disparities among US patients with specific types of cancer who contracted COVID-19. The research found significant differences in outcomes between cancer types and racial groups.
Researchers found that adding an immune checkpoint inhibitor to standard chemotherapy for patients with early-stage breast cancer does not decrease their ability to perform daily activities. The study, based on data from the IMpassion031 trial, showed increased response rates and no significant impact on quality of life.
A new treatment approach called 'organ preservation' uses radiotherapy followed by local keyhole surgery to remove only the part of the rectum affected by cancer. Patients who received this treatment reported fewer side effects, such as diarrhoea and the need for a permanent colostomy bag, compared to those who underwent major surgery.
Researchers found non-pharmacological interventions such as fan therapy and bilevel ventilation to be effective in improving breathlessness in patients with advanced cancer. In contrast, medications like opioids had limited impact on symptom relief.
A study of 193 NYC hospital patients found that 71.6% of Black patients required hospitalization for COVID-19, compared to 46.0% of non-Blacks. Disparities were driven by a higher prevalence of comorbidities among Black patients, not cancer or treatment.
A recent study reveals unique mutation patterns in the genes PIK3CA, GNAS, SMAD3, and TSC2 among young patients with appendiceal cancer. These findings suggest potential for targeted therapies, such as alpelisib, which have already been approved for advanced breast cancer.
A new framework helps determine the exact timing of DNA mutations in cancer genomes, enabling more targeted and personalized treatments. By analyzing 22 different algorithms on nearly 300 prostate cancer samples, UCLA researchers identified biases and variability to improve treatment outcomes.
A study by researchers at Dartmouth's Geisel School of Medicine found that active surveillance can be successfully implemented in patients with low-risk thyroid cancer. The study shows that 91% of patients adhered to the prescribed ultrasonography schedule and retention rates were high, with only 4.5% choosing surgery after two years.
Researchers at Huntsman Cancer Institute have identified a potential drug combination to treat uveal melanoma by targeting genes GNAQ and GNA11. The study showed that using trametinib and hydroxychloroquine together led to more cell deaths than the drugs alone.
National mortality trends following cancer surgery improved for Black and white patients, with a 0.12% and 0.14% decline per year, respectively. However, the racial gap in mortality rates persisted, indicating a need for targeted efforts to address disparities in cancer surgery outcomes.
State crisis standards of care (CSC) guidelines in the US allocate scarce healthcare resources among cancer patients, requiring careful consideration of prioritization methods. The guidelines include provisions for blood products and palliative care, highlighting the need for nuanced decision-making in resource allocation.
Researchers analyzed data from nearly half a million cancer patients in the US between 15-39 years old to determine cancer cases in this age group. The results show a 30% rise in cancer diagnoses among adolescents and young adults, with kidney, thyroid, and gastrointestinal cancers increasing at the greatest rates.
A Memorial Sloan Kettering study is the first to link gut microbiota to changes in the human immune system. The research used over 10 years of data from more than 2,000 patients undergoing blood stem cell transplants, revealing a unique relationship between microbiota and immune cell concentrations.
A new therapy stimulating immune system response against cancer shows an acceptable safety profile when used alone or with checkpoint inhibitors. BMS-986178 demonstrates manageable adverse events and no dose-limiting toxicities, suggesting its potential as a treatment for patients with solid tumors.
The ESMO Immuno-Oncology Congress 2020 discussed the latest developments in cancer treatment, including adjuvant and neoadjuvant treatments, tumour microenvironments, and novel therapeutics. The event also examined the impact of COVID-19 on immunotherapy in cancer patients.
Researchers found that concurrent dexamethasone administration with an immune checkpoint inhibitor reduced survival in both immunosensitive and immunoresistant mouse models. In human patients, those taking dexamethasone at baseline had significantly worse overall survival compared to non-users.
A new therapeutic PD-1 cancer vaccine has been shown to be safe and effective in an animal study, activating both B- and T-cell functions to promote tumor clearance. The vaccine is targeted to block signaling pathways crucial for tumor growth and maintenance, offering a promising approach to immunotherapy.
Scientists have developed a novel approach to reprogram T cells into long-lived, highly active 'super immune cells' that can fight multiple types of cancer. This breakthrough could lead to more effective and durable anti-cancer responses with existing treatments.
African American cancer survivors in Detroit reported common social needs, including food insecurity and housing instability, which were associated with lower health-related quality of life. The study highlights the need for a social safety net to address these disparities.
Researchers at Huntsman Cancer Institute discovered that chromatin remodeling machines have a motor-like component that drives the machine along DNA, disrupting nucleosome beads. The team found cancer-causing mutations in an area of the hub regulating motor activity, leading to improper gene expression and cancer.
A study of patients with cancer who had exceptional responses to therapy has identified molecular changes in their tumors that contribute to these unexpected and long-lasting responses. The researchers used genomic characterizations to uncover genetic alterations that may help understand the mechanisms behind these rare responses.
The EA2176 study aims to enroll 205 patients in the US with inoperable advanced squamous cell anal cancer, comparing standard chemotherapy with or without nivolumab. The trial seeks to determine if adding immunotherapy will prolong progression-free survival and reduce symptoms.
Researchers found a vaccine created to prevent melanoma recurrence is about twice as effective when patients receive two immune-boosting components, Flt3L and poly-ICLC. This combination nearly doubled the vaccine's efficacy in promoting antibodies and T cells that can later fight melanoma.
A SWOG Cancer Research Network study found that the ipilimumab and nivolumab combination shrinks rare angiosarcoma tumors in 25% of patients, with a 60% response rate for those with facial or scalp lesions, offering new hope for treatment
A recent survey by the American Cancer Society found that nearly 1 in 5 cancer patients are less likely to enroll in clinical trials during the pandemic. The top reason cited is fear of COVID-19 exposure. This could lead to reduced enrollment in trials already struggling to find patients.
Recent studies have revealed that cardiovascular adverse events, such as heart failures and arrhythmias, are common in cancer patients treated with CDK 4/6 inhibitors. These agents have significantly improved survival rates for breast cancer patients but come with a risk of cardiac damage.
A clinical trial combining a personalized cancer vaccine with Pembrolizumab has reported a 50% response rate for patients with head and neck cancer, significantly higher than previous trials without the vaccine. The preliminary data, presented by Dr. Julie Bauman, is promising and suggests the treatment is safe and tolerable.
A study by UC Davis Comprehensive Cancer Center researchers found that young survivors of AML are at risk of developing late effects, including cardiovascular, endocrine, and respiratory diseases. Non-white patients and those living in deprived neighborhoods were disproportionately affected.
Researchers found that Medicaid expansion is associated with earlier stage of diagnosis, leading to decreased mortality rates for patients with newly diagnosed breast, lung, or colorectal cancer. In states with expanded Medicaid programs, mortality rates were significantly lower than in non-expansion states.
A Mayo Clinic study found that 13.5% of cancer patients had inherited genetic mutations associated with their cancer development. The discovery could lead to targeted cancer therapies and improved survival rates for patients with these high-risk mutations.
Researchers at UT Southwestern Medical Center found that patients with acute interstitial nephritis, an autoimmune reaction, respond to immune checkpoint inhibitor drugs. This finding may have broad implications for patients being treated with ICIs.