Articles tagged with Cancer Patients
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Researchers at Kumamoto University found that aging cells in abdominal fluid contribute to peritoneal dissemination of gastric cancer by promoting cellular senescence and inflammation. This understanding could lead to new treatments targeting cancer cells and associated fibroblasts.
The CCC19 study found associations between laboratory measures, clinical factors, and poor clinical outcomes in patients with cancer diagnosed with SARS-CoV-2 infection. Patients with COVID-19 and cancer had a higher risk of hospitalization and death compared to the general population.
A new study found that most people with cancer produce antibodies at a rate comparable to the general population, suggesting they should respond well to COVID-19 vaccines. However, patients with blood cancers had a lower seroconversion rate due to immunosuppressive treatments.
A new technique for sampling and testing cells from Barrett's esophagus patients can detect specific chromosomal alterations, including the presence of esophageal adenocarcinoma. The approach combines esophageal brushing with massively parallel sequencing to provide an accurate assessment of disease stages and identify high-risk patients.
Researchers at Vall d'Hebron Institute of Oncology are conducting a first-in-human Phase I trial to evaluate the safety and efficacy of Peptomyc's novel Myc inhibitor Omomyc in treating advanced solid tumors. The trial aims to confirm the compound's therapeutic potential, particularly for patients with progressed disease.
A cancer oncologist reflects on advising patients with cancer about travel during the pandemic. The author considers the importance of weighing the potential benefits of travel against the increased risk of complications.
A recent SWOG Cancer Research Network study found that even with access to clinical trials, cancer patients living in the poorest neighborhoods have a nearly 30% greater chance of dying from their disease. The disparity persists despite uniform high-quality care.
A study reveals that over one in ten lung cancer patients are unsure of their tumor type, highlighting the need for improved communication between patients and healthcare providers. Language differences and complex treatments contribute to these misunderstandings, jeopardizing patient care.
A new study found that cancer survivors have a significantly higher risk of cardiovascular disease in the next decade. Researchers estimate that about 8% of cancer survivors will develop heart disease or stroke over the 10-year period, compared to 5% of those without a cancer history.
A minimally invasive treatment known as radiofrequency ablation (RFA) provides quick and sustained pain relief, improving quality of life for cancer patients with bone tumors. The benefits last more than 12 months, significantly outperforming radiation treatment.
Scientists detected novel pathogens in colorectal cancer patients near tumors, triggering chronic inflammation that promotes cancer development. BMMFs were more frequently found near malignant tumors than healthy tissue.
Researchers analyzed sociodemographic and hospital characteristics of patients undergoing cancer surgery before and during the pandemic. The study found significant differences in these factors among patients with varying levels of access to care.
Researchers conducted a randomized intervention that improved continuity of care and interprofessional collaboration between lung cancer patients and their family physicians. The bidirectional exchange of patient information and care summaries led to enhanced patient and family physician perceptions of care, resulting in better outcomes.
A new study found that global clinical trials enrolled less than half the proportion of Black patients as U.S. trials, highlighting a trend that may exacerbate racial disparities in cancer research and care. The study suggests that globalization of cancer clinical trials may be a key driver of these disparities.
Researchers at Yale University have developed a model where human red blood cells are rescued in circulation using combined liver and growth factor humanization. This breakthrough has the potential to treat diseases such as myelodysplastic syndrome, sickle cell disease, and malaria.
A new study found that cancer survivors who walked at a slow pace had a significantly increased risk of death from any cause, with the association holding for nine cancer types. The researchers call for more research into targeted interventions to improve walking ability and increase survival among cancer patients.
Researchers used induced pluripotent stem cells to identify correlations between genetic variants and altered expression patterns in human cells. The study found thousands of disease-associated genetic variants linked to specific diseases, including coronary heart disease and hereditary cancers.
Researchers at Harvard Medical School and Dana-Farber Cancer Institute found that cancer-causing mutations can arise decades ago, in some cases as far back as 40 years before diagnosis. The study used genetic sequencing and phylogenetic analysis to reconstruct the lineage history of cancer cells in two patients with a rare blood cancer.
A new study found that cancer patients who died by suicide were generally older and less likely to have histories of physical and psychiatric problems. These patients were also more likely to communicate about their suicidal intent before death.
Utah researchers identify mutation hotspots and find that approximately 2% of healthy participants had the same mutations as cancer patients. This study provides new insights into the development of blood cancers and may help identify people at risk.
A global survey found that COVID-19 had a significant impact on childhood cancer care, with 78% of hospitals reporting disruptions. Disruptions included reduced clinical staff, unavailable chemotherapy and radiotherapy, and treatment abandonment.
Advanced liver fibrosis worsens cancer-specific and overall survival in iCCA patients, regardless of surgical resection. Patients with advanced fibrosis are at increased risk of mortality across follow-up periods.
A study by the Mays Cancer Center at UT Health San Antonio found that bladder cancer is more advanced and deadly in South Texas residents than in many parts of the country. The disease disproportionately affects Latinos and women, with worse survival rates regardless of geographic location.
A new study reveals that one-third of cancer survivors experienced disruptions in healthcare treatments and financial worries due to the pandemic. Cancer survivors reported feeling isolated and concerned about their health, with some unable to bring a companion to in-person appointments.
A machine learning-based model predicts the probability of lung cancer among patients with multiple pulmonary nodules, achieving high accuracy in validation cohorts. The PKU-M model also surpasses prior logistic regression-based models and a previously established AI tool in diagnosis.
A new study by Yale Cancer Center found sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. The findings suggest a possible new approach in the prevention and treatment of endometrial cancer recurrence, which is currently being evaluated in a multi-center trial.
Patients with cancer and multiple physical comorbidities are more likely to experience high psychological distress and consult mental healthcare professionals. These findings highlight the importance of considering physical conditions when addressing mental health in cancer patients.
A phase III randomized study found that lenvatinib plus pembrolizumab significantly prolonged survival in patients with advanced kidney cancer. Treatment combinations showed improved progression-free and overall survival rates compared to sunitinib.
Researchers identified a protein, netrin-4, associated with tumour and vessel softness, which determines cancer spread even before cancer develops in several types. Removing or increasing this protein reduces cancer spread.
A new study shows that liquid biopsies can detect lingering disease in patients with oligometastatic colorectal cancer, guiding treatment decisions. The biopsies identify patients who may benefit from immune therapies or targeted treatments based on mutations detected in blood samples.
A collaboration between George Mason University and Rutgers Cancer Institute aims to validate a new test for measuring HER2 biomarkers, which can predict patient response to treatment. The test uses advanced technology to analyze tissue samples and identify specific therapies for individual patients.
A urine test has been found to be extremely accurate at detecting aggressive prostate cancer with few false negatives. The test avoids unnecessary biopsies for patients with slow-growing or no cancer, reducing costs and invasive procedures.
Researchers found that activating STING molecule reduced GVHD severity and mortality rates in a mouse model. The study suggests that a STING-activating drug might protect bone marrow transplant recipients from GVHD.
A single strain of Bacteroides fragilis significantly reduced graft-versus-host disease by protecting gut integrity, according to a proof-of-concept study. The bacteria increased overall gut microbial diversity and reduced donor T cell proliferation, which triggers GVHD.
Inherited genetic variation plays a role in who responds best to checkpoint inhibitors, which release the immune system's brakes. The study identified 22 regions or genes with significant effects on the immune system's response to cancer.
Researchers used a mouse cachexia model to investigate myocardial damage in tumor-bearing mice, finding suppressed oxidative phosphorylation and glycolysis. The study validates the model for studying cancer-derived myocardial impairment, revealing various changes associated with cancer cachexia.
Researchers found that vitamin D supplementation could reduce cancer mortality rates by around 13 percent, resulting in potential savings of €254 million per year. The study suggests that widespread vitamin D supplementation among Germans over 50 could prevent up to 30,000 cancer deaths annually and gain more than 300,000 years of life.
A nationwide study aims to better understand the intersection of COVID-19 and cancer, examining long-term outcomes and treatment protocols. The research hopes to identify key factors that make certain patients more prone to severe COVID-19 infections.
Researchers found fecal transplant increased immune cell activation and decreased immunosuppression in responders, suggesting a link between gut microbiome changes and treatment effectiveness. The study's results raise hope for microbiome-based therapies of cancers.
Scientists at Case Western Reserve University have discovered biomarkers using AI analysis of simple tissue scans to predict which lung cancer patients will be harmed by immunotherapy. This new work builds on previous research that used AI and machine learning to identify patients who will benefit from the treatment.
The European Union has funded a project to develop diagnostic tools and combination treatments for ovarian cancer using AI. The research aims to identify patients whose cancer is not responding to current treatments and discover effective, personalized therapies.
A new study suggests that fecal microbiota transplants can help patients with advanced melanoma respond to immunotherapy drugs. After receiving a transplant, six out of 15 patients showed improved cancer stability or tumor reduction.
The BeamSite Cherenkov imaging camera system captures real-time images of the beam directly on the patient, allowing radiation oncologists to verify accuracy of dose and beam delivery. This technology has improved treatment quality, precision, and patient safety during radiation therapy.
A study by Mayo Clinic researchers found that certain biomarkers can help diagnose acute kidney inflammation in cancer patients treated with immune checkpoint inhibitors. These biomarkers, such as serum creatinine and C-reactive protein, may aid in distinguishing treatment-associated kidney injury from other causes.
Researchers found that healthcare professionals have knowledge gaps when caring for LGBTQ2SPIA+ cancer patients, affecting their ability to provide emotional support and tailored care. The study concludes that patient-centered care requires specific resources and education for radiation therapists.
A new ultrasound technique called MRI-guided focused ultrasound ablation (MRgFUS) effectively treats intermediate-risk prostate cancer with minimal side effects. Treatment was successfully completed in all 44 men, with no major adverse events and 93% disease-free at the treatment site.
A new 523-gene panel has been developed to diagnose and treat acute myeloid leukemia (AML), identifying more genetic mutations and potential treatment targets. The panel has shown high sensitivity and specificity in detecting AML and has the potential to improve patient outcomes.
A novel metabolic gatekeeper mechanism for leukemia has been discovered by Yale researchers, highlighting the importance of glucose and energy supply in leukemic transformation. High expression levels of PON2 enable glucose uptake activity in B-cell acute lymphoblastic leukemia cells, leading to a more aggressive course of disease.
Research found that black patients diagnosed with non-small cell lung cancer are more likely to be diagnosed at an advanced stage and have lower chances of receiving surgery. Additionally, they experience significantly reduced cancer-specific survival rates compared to their white counterparts.
A new study reveals that older minority cancer patients with poor social determinants experience negative surgical outcomes, including higher complication rates and mortality. Researchers suggest integrating vulnerability assessments into national standard of care models to improve outcomes.
A study found that older cancer patients residing in areas with high social vulnerability are less likely to achieve textbook outcomes following surgery. The research used the Social Vulnerability Index (SVI) to analyze the impact of socioeconomic challenges on health outcomes.
Researchers found a high prevalence of cardiovascular conditions in male breast cancer patients, including overweight, high blood pressure, and high cholesterol. The study highlights the need for cardiologists and cardio-oncologists to be involved in treatment due to common risk factors and potential cardiotoxic effects.
Research found cancer patients in low-income countries are up to four times more likely to die following surgery, with less post-operative care infrastructure and oncology services. Patients from upper middle-income countries were two times as likely to die compared to high-income countries.
The COVID-19 pandemic saw a decrease in radiotherapy treatment courses, particularly among older patients. The new study reveals that the English NHS adapted its services quickly to protect patients, with some types of cancer seeing increased use of radiotherapy.
A phase 1b/2 trial shows that combining eprenetapopt with azacitidine improves overall response rate to 71% in TP53 mutant MDS and AML patients. The median overall survival is 10.8 months, with improved outcomes for those who responded to treatment.
The global demand for cancer surgery is projected to increase by 52% between 2018 and 2040, with the largest relative increase in low-income countries. Improving care systems worldwide is crucial to reduce mortality rates from complications.
A study of nearly 16,000 patients across 82 countries found that low-and lower-middle-income countries had significantly higher mortality rates following surgery due to inadequate facilities and care plans. Investing in proper recovery spaces, trained staff, and critical care facilities can greatly improve surgical outcomes.
Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol called MultiMMR that can identify mismatch repair (MMR) deficiency in a single test. This alternative to complex testing workflows determines causes of MMR deficiency often missed by current clinical tests.
Researchers develop bioengineered microscale organotypic models (BMOMs) to address cancer treatment limitations. BMOMs can be integrated with microscopes and sensors to monitor biological processes in high resolution, reducing the need for animal models.
A new study from Penn Medicine reveals that patients with inactive cancer and not currently undergoing treatments are significantly more likely to experience severe COVID-19 illness. The research highlights the importance of COVID-19 mitigation measures, such as social distancing and mask-wearing, and vaccinations for all patients.