Articles tagged with Cancer Patients
Researchers found that patients with colorectal cancer had a 57-93% decreased risk of death from their cancer depending on the presence and type of mitochondrial DNA mutations. Mitochondrial DNA mutations were present in almost 60% of tumour samples, suggesting potential for improved treatment outcomes.
A newly released position paper from ESMO and SIOPE defines a common vision for improving outcomes for AYAs with cancer in Europe. The paper highlights the key challenges of AYA care, including limited awareness of cancer biology, availability of specialist centres, and access to clinical trials.
The Bertarelli Rare Cancers Fund has awarded over $9 million in grants to nine teams representing 19 lead investigators, advancing research into rare cancers that affect tens of thousands of patients annually. The fund aims to improve detection, diagnosis, treatment, and prevention of rare cancers through multidisciplinary collaborations.
A study published in Radiology found that digital breast tomosynthesis (DBT) reduces the rate of interval cancers, which are more aggressive than screen-detected cancers. The study suggests that DBT may contribute to lower breast cancer mortality by detecting rapidly growing cancers with poorer prognosis.
A collaboration between Michigan State University, Spectrum Health, and Niowave is testing a new radiotherapy approach for bladder cancer. The therapy combines radiotherapy with immunotherapy, which helps the patient's immune system fight off disease, aiming to improve safety and effectiveness.
A collaborative team identified multiple genes with recurrent alterations in uLMS, including HRD, ALT, C-MYC/BET, and PI3K-AKT-mTOR pathway, as potential targets for new treatments.
A new study suggests removing additional tissue around the tumor cavity can reduce positive margins in patients with ductal carcinoma in situ (DCIS) by nearly 65%. Achieving clear margins is crucial in decreasing cancer recurrence, and this technique should be considered for DCIS patients.
A study published in JAMA Network Open found that over 60% of US adults who vape are interested in quitting, with former cigarette smokers having the highest intentions. Despite e-cigarettes being seen as a potential tool for smoking cessation, many users struggle to quit, and current treatments may not be effective for all users.
The study analyzed 412 high-risk NMIBC patients treated with BCG therapy and found significant differences in outcomes according to specific features of the disease. Total median costs at one, two, and five years from start of BCG induction were $29,459, $55,267, and $117,361, respectively.
A cohort study of 672 cancer patients found a cumulative incidence of venous thromboembolism at 12.9% and arterial thromboses at 1.8%. This risk appears to be independent of underlying cancer type or immune checkpoint inhibitor used.
The funding supports development of a new drug testing platform to predict treatment outcomes for patients with cancer. Researchers will leverage tissue bioengineering advances and genomic technologies to reconstruct and grow patient-derived tumor organoids in the presence of different drugs.
Research reveals associations between circulating tumor cell (CTC) mutations and clinical outcomes in metastatic castrate-resistant prostate cancer (mCRPC). The study identified novel genetic alterations linked to response to AR inhibitors, including gains of ATM, NCOR2, and HSD17B4, which were associated with sensitivity to treatment.
A new study reveals that patients with newly diagnosed incurable cancer experience significant physical and emotional distress, including anxiety and depression. Comprehensive palliative care services are essential to address these needs and improve quality of life for patients.
The conference explored updates to NCCN Clinical Practice Guidelines, new research, and strategies for preventing HPV-associated cancers. Experts discussed ways to improve racial equity in cancer care, including reducing disparities and promoting guideline-adherent care.
A team at Washington University in St. Louis has developed an imaging technique using acoustic resolution photoacoustic microscopy co-registered with ultrasound and paired with deep learning to differentiate between residual tumors and healthy tissue in rectal cancer patients after chemotherapy and radiation. This technique shows promi...
Scientists genetically engineered myeloid cells to deliver an anticancer signal, shrinking tumors and preventing cancer from spreading to other parts of the body. The study shows promise as a potential treatment for metastatic cancer, with treated mice living substantially longer and experiencing reduced metastatic cancer.
A clinical trial tested a mutation-specific vaccine against IDH1-mutated gliomas, a type of diffuse brain tumor. The vaccine proved safe and triggered the desired immune response in 93% of patients, with some experiencing pseudoprogression and tumor growth slowing.
Researchers at Kumamoto University found that aging cells in abdominal fluid contribute to peritoneal dissemination of gastric cancer by promoting cellular senescence and inflammation. This understanding could lead to new treatments targeting cancer cells and associated fibroblasts.
The CCC19 study found associations between laboratory measures, clinical factors, and poor clinical outcomes in patients with cancer diagnosed with SARS-CoV-2 infection. Patients with COVID-19 and cancer had a higher risk of hospitalization and death compared to the general population.
A new study found that most people with cancer produce antibodies at a rate comparable to the general population, suggesting they should respond well to COVID-19 vaccines. However, patients with blood cancers had a lower seroconversion rate due to immunosuppressive treatments.
A new technique for sampling and testing cells from Barrett's esophagus patients can detect specific chromosomal alterations, including the presence of esophageal adenocarcinoma. The approach combines esophageal brushing with massively parallel sequencing to provide an accurate assessment of disease stages and identify high-risk patients.
Researchers at Vall d'Hebron Institute of Oncology are conducting a first-in-human Phase I trial to evaluate the safety and efficacy of Peptomyc's novel Myc inhibitor Omomyc in treating advanced solid tumors. The trial aims to confirm the compound's therapeutic potential, particularly for patients with progressed disease.
A cancer oncologist reflects on advising patients with cancer about travel during the pandemic. The author considers the importance of weighing the potential benefits of travel against the increased risk of complications.
A recent SWOG Cancer Research Network study found that even with access to clinical trials, cancer patients living in the poorest neighborhoods have a nearly 30% greater chance of dying from their disease. The disparity persists despite uniform high-quality care.
A study reveals that over one in ten lung cancer patients are unsure of their tumor type, highlighting the need for improved communication between patients and healthcare providers. Language differences and complex treatments contribute to these misunderstandings, jeopardizing patient care.
A new study found that cancer survivors have a significantly higher risk of cardiovascular disease in the next decade. Researchers estimate that about 8% of cancer survivors will develop heart disease or stroke over the 10-year period, compared to 5% of those without a cancer history.
A minimally invasive treatment known as radiofrequency ablation (RFA) provides quick and sustained pain relief, improving quality of life for cancer patients with bone tumors. The benefits last more than 12 months, significantly outperforming radiation treatment.
Scientists detected novel pathogens in colorectal cancer patients near tumors, triggering chronic inflammation that promotes cancer development. BMMFs were more frequently found near malignant tumors than healthy tissue.
Researchers analyzed sociodemographic and hospital characteristics of patients undergoing cancer surgery before and during the pandemic. The study found significant differences in these factors among patients with varying levels of access to care.
Researchers conducted a randomized intervention that improved continuity of care and interprofessional collaboration between lung cancer patients and their family physicians. The bidirectional exchange of patient information and care summaries led to enhanced patient and family physician perceptions of care, resulting in better outcomes.
A new study found that global clinical trials enrolled less than half the proportion of Black patients as U.S. trials, highlighting a trend that may exacerbate racial disparities in cancer research and care. The study suggests that globalization of cancer clinical trials may be a key driver of these disparities.
Researchers at Yale University have developed a model where human red blood cells are rescued in circulation using combined liver and growth factor humanization. This breakthrough has the potential to treat diseases such as myelodysplastic syndrome, sickle cell disease, and malaria.
A new study found that cancer survivors who walked at a slow pace had a significantly increased risk of death from any cause, with the association holding for nine cancer types. The researchers call for more research into targeted interventions to improve walking ability and increase survival among cancer patients.
Researchers used induced pluripotent stem cells to identify correlations between genetic variants and altered expression patterns in human cells. The study found thousands of disease-associated genetic variants linked to specific diseases, including coronary heart disease and hereditary cancers.
Researchers at Harvard Medical School and Dana-Farber Cancer Institute found that cancer-causing mutations can arise decades ago, in some cases as far back as 40 years before diagnosis. The study used genetic sequencing and phylogenetic analysis to reconstruct the lineage history of cancer cells in two patients with a rare blood cancer.
A new study found that cancer patients who died by suicide were generally older and less likely to have histories of physical and psychiatric problems. These patients were also more likely to communicate about their suicidal intent before death.
Utah researchers identify mutation hotspots and find that approximately 2% of healthy participants had the same mutations as cancer patients. This study provides new insights into the development of blood cancers and may help identify people at risk.
A global survey found that COVID-19 had a significant impact on childhood cancer care, with 78% of hospitals reporting disruptions. Disruptions included reduced clinical staff, unavailable chemotherapy and radiotherapy, and treatment abandonment.
Advanced liver fibrosis worsens cancer-specific and overall survival in iCCA patients, regardless of surgical resection. Patients with advanced fibrosis are at increased risk of mortality across follow-up periods.
A study by the Mays Cancer Center at UT Health San Antonio found that bladder cancer is more advanced and deadly in South Texas residents than in many parts of the country. The disease disproportionately affects Latinos and women, with worse survival rates regardless of geographic location.
A new study reveals that one-third of cancer survivors experienced disruptions in healthcare treatments and financial worries due to the pandemic. Cancer survivors reported feeling isolated and concerned about their health, with some unable to bring a companion to in-person appointments.
A machine learning-based model predicts the probability of lung cancer among patients with multiple pulmonary nodules, achieving high accuracy in validation cohorts. The PKU-M model also surpasses prior logistic regression-based models and a previously established AI tool in diagnosis.
A new study by Yale Cancer Center found sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. The findings suggest a possible new approach in the prevention and treatment of endometrial cancer recurrence, which is currently being evaluated in a multi-center trial.
Patients with cancer and multiple physical comorbidities are more likely to experience high psychological distress and consult mental healthcare professionals. These findings highlight the importance of considering physical conditions when addressing mental health in cancer patients.
A phase III randomized study found that lenvatinib plus pembrolizumab significantly prolonged survival in patients with advanced kidney cancer. Treatment combinations showed improved progression-free and overall survival rates compared to sunitinib.
Researchers identified a protein, netrin-4, associated with tumour and vessel softness, which determines cancer spread even before cancer develops in several types. Removing or increasing this protein reduces cancer spread.
A new study shows that liquid biopsies can detect lingering disease in patients with oligometastatic colorectal cancer, guiding treatment decisions. The biopsies identify patients who may benefit from immune therapies or targeted treatments based on mutations detected in blood samples.
A collaboration between George Mason University and Rutgers Cancer Institute aims to validate a new test for measuring HER2 biomarkers, which can predict patient response to treatment. The test uses advanced technology to analyze tissue samples and identify specific therapies for individual patients.
A urine test has been found to be extremely accurate at detecting aggressive prostate cancer with few false negatives. The test avoids unnecessary biopsies for patients with slow-growing or no cancer, reducing costs and invasive procedures.
Researchers found that activating STING molecule reduced GVHD severity and mortality rates in a mouse model. The study suggests that a STING-activating drug might protect bone marrow transplant recipients from GVHD.
A single strain of Bacteroides fragilis significantly reduced graft-versus-host disease by protecting gut integrity, according to a proof-of-concept study. The bacteria increased overall gut microbial diversity and reduced donor T cell proliferation, which triggers GVHD.
Inherited genetic variation plays a role in who responds best to checkpoint inhibitors, which release the immune system's brakes. The study identified 22 regions or genes with significant effects on the immune system's response to cancer.
Researchers used a mouse cachexia model to investigate myocardial damage in tumor-bearing mice, finding suppressed oxidative phosphorylation and glycolysis. The study validates the model for studying cancer-derived myocardial impairment, revealing various changes associated with cancer cachexia.
Researchers found that vitamin D supplementation could reduce cancer mortality rates by around 13 percent, resulting in potential savings of €254 million per year. The study suggests that widespread vitamin D supplementation among Germans over 50 could prevent up to 30,000 cancer deaths annually and gain more than 300,000 years of life.
A nationwide study aims to better understand the intersection of COVID-19 and cancer, examining long-term outcomes and treatment protocols. The research hopes to identify key factors that make certain patients more prone to severe COVID-19 infections.
Researchers found fecal transplant increased immune cell activation and decreased immunosuppression in responders, suggesting a link between gut microbiome changes and treatment effectiveness. The study's results raise hope for microbiome-based therapies of cancers.
Scientists at Case Western Reserve University have discovered biomarkers using AI analysis of simple tissue scans to predict which lung cancer patients will be harmed by immunotherapy. This new work builds on previous research that used AI and machine learning to identify patients who will benefit from the treatment.
The European Union has funded a project to develop diagnostic tools and combination treatments for ovarian cancer using AI. The research aims to identify patients whose cancer is not responding to current treatments and discover effective, personalized therapies.
A new study suggests that fecal microbiota transplants can help patients with advanced melanoma respond to immunotherapy drugs. After receiving a transplant, six out of 15 patients showed improved cancer stability or tumor reduction.
The BeamSite Cherenkov imaging camera system captures real-time images of the beam directly on the patient, allowing radiation oncologists to verify accuracy of dose and beam delivery. This technology has improved treatment quality, precision, and patient safety during radiation therapy.