Articles tagged with Cancer Patients
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A new study examines the safety of COVID-19 vaccines in patients with cancer, providing insights into potential risks and benefits. The research found that while some cancer treatments may interact with COVID-19 vaccines, the overall risk is low.
Researchers at Huntsman Cancer Institute discovered that nicotinamide phosphoribosyltransferase (NAMPT) plays a key role in how immune cells fight melanoma tumors. The study found that disrupting the NAMPT pathway impairs antitumor function, and novel therapies targeting this pathway may lead to improved outcomes for patients.
A phase II study by Penn Medicine shows rucaparib helped control cancer growth in patients with BRCA or PALB2 genetic mutations. The results support the use of rucaparib as a maintenance therapy for pancreatic cancer patients, offering a safe and effective alternative to chemotherapy.
A new study found that individuals experiencing pre-loss grief symptoms can adjust, but certain factors such as gender and caregiving burden exacerbate the experience. The research documented a significant correlation between dementia patients' family members and severe pre-loss grief.
A new UCSF study reports that cancer patients experience a deep sense of loneliness during the COVID-19 pandemic, with 53% of participants classified as lonely. The study also found higher levels of depression, fatigue, and sleep disturbance among lonely patients.
Researchers screened over 60,000 blood samples from asymptomatic individuals for IgG antibody to the viral spike protein, finding strong correlations between high anti-S IgG levels and neutralizing activity. The study also showed age-related differences in antibody responses and a higher prevalence of COVID-19 among African Americans.
Researchers developed an AI system, TOAD, that accurately predicts the origin of tumors in cancer cases with unknown primary sites. The model, trained on gigapixel pathology images, correctly identified cancer types and listed diagnoses as top predictions 96% of the time.
A new study aims to evaluate the effectiveness of an automated, smartphone-based approach to incentivizing smoking cessation among low-income adults in Oklahoma. The 5-year project will enroll 532 participants and assess the impact of monetary incentives on smoking abstinence.
A computational method using machine learning and feature sets derived from molecular simulation can predict the functional consequences of genetic variation in cancer drugs. This technology has the potential to accurately diagnose cancer variants and improve treatment outcomes by tailoring therapy to individual genetic profiles.
A study at ESMO Breast Cancer 2021 Virtual Congress reveals breast cancer survivors experience varying levels of symptoms after treatment, with some requiring active symptom management. Patients with comorbidities, such as heart disease and diabetes, are more likely to experience a high symptom burden.
A team of researchers, including Saket Navlakha and Dr. Sejal Morjaria, developed a computational tool to predict COVID-19 severity in cancer patients. The tool has an accuracy rate of 70-85% and prevents unnecessary expensive testing, improving patient care.
New research reveals patients with multiple comorbidities are more likely to be screened for colorectal cancer than those without any health conditions. Regular screenings significantly reduce cancer mortality.
A new set of guidelines developed by AATS and ESTS recommends a 30-day course of Venous Thromboembolism (VTE) prophylaxis post-discharge for patients undergoing surgical resection for lung or esophagus cancer. The guideline panel endorsed by American Society of Hematology and International Society on Thrombosis and Haemostasis found th...
A new test, called Guardant Reveal, can detect residual cancer DNA in the blood of patients after treatment without knowing the specific mutations present in their tumor. The study found that this approach was similar in sensitivity and specificity to traditional methods.
Breast cancer patients experience frequent job changes after diagnosis, with around ten percent reporting involuntary changes. The study suggests that a supportive work environment and understanding from managers can facilitate a satisfactory return to work.
A new study from the University of Missouri School of Medicine found that people of color, those with a higher income, and younger individuals are more likely to participate in cancer clinical trials. The analysis of 20,053 respondents showed an average overall clinical trial participation rate of 6.51%, with significant differences in...
A recent study found that only 16% of male teenagers received the HPV vaccine, highlighting a significant gap in vaccination rates. The vaccine is essential for preventing oropharyngeal cancer, which affects 80% of male patients diagnosed with this condition.
A recent study by the University of Eastern Finland found that middle-aged men who experience loneliness are at an increased risk of developing cancer. The study, which followed 2,570 men over time, found that loneliness was associated with a 10% higher risk of cancer.
A multi-institutional team of researchers has identified genetic abnormalities that drive pre-cancer cells into becoming invasive head and neck cancer. The study found that patients with specific genetic imbalances are less likely to respond to immunotherapy.
The NCI-MATCH cancer clinical trial is expanding with the addition of a new treatment arm, Arm Z1M, which targets mismatch repair deficiency and LAG-3 protein expression. This brings the total number of available treatment arms to 12, addressing 12 unique molecular targets and corresponding drugs that have shown efficacy evidence.
The UK Markey Cancer Center has launched a clinical trial to evaluate the anti-cancer activity of ArtemiLife coffee products in preventing ovarian cancer recurrence. Participants will drink coffee up to four times daily for five months after completing treatment, aiming to delay or eliminate cancer return.
Researchers at Ohio State University Comprehensive Cancer Center identified distinct mutational and molecular changes in four SCLC subtypes, providing new insights into treatment resistance. The findings suggest that subtyping patients before systemic therapy could play a role in drug development and therapy selection.
A new algorithm, MMRDetect, identifies tumours with mismatch repair deficiencies that can be targeted by immunotherapies. The algorithm uses mutational signatures from genome sequencing data to personalize cancer treatments.
Dr. David Lyden, a Weill Cornell Medicine physician-scientist, has been inducted into the Association of American Physicians for his pioneering work on cancer metastasis and spread. His research reveals that tumors produce factors that prime distant organs to become hospitable sites for cancer growth.
A UT Southwestern Medical Center review of Texas Cancer Registry data found that Black and Hispanic patients under 40 with cancer have lower survival rates compared to their white counterparts. The study also showed that poverty and lack of insurance coverage exacerbate these disparities.
The UVA Center for Engineering in Medicine has developed a robust process to help researchers win funding from institutions like the National Institutes of Health. The center's first seed grant cohorts have achieved astonishing results, including $12 million in follow-on funding with just a $2 million initial investment.
Researchers developed a test using artificial intelligence to measure proteins in advanced bowel cancer patients, predicting treatment benefits. The technique could help doctors and patients decide on the best treatment options, targeting those with higher protein levels.
A new analysis published in Psycho-Oncology found that fear of cancer recurrence leads to increased use of healthcare resources by cancer survivors. Implementing existing effective interventions for fear of cancer recurrence may improve both mental health and reduce unnecessary healthcare usage.
A new Penn State study has found that higher mushroom consumption is associated with a lower risk of cancer. The systematic review and meta-analysis analyzed data from over 19,500 cancer patients and found individuals who ate 18 grams of mushrooms daily had a 45% lower risk of cancer compared to non-mushroom eaters.
A Mayo Clinic study found that 15.5% of patients with colorectal cancer had inherited gene mutations, which can be detected through universal testing and broader gene panels. This discovery has the potential to lead to targeted cancer therapies and earlier disease detection in families.
The Herringbone Microfluidic Probe (HB-MFP) effectively isolates Circulating Tumor Cells from blood samples, providing insights into cancer metastasis. Researchers believe this technology has great promise for diagnosing and prognosticating prostate cancer using liquid biopsies.
City of Hope's Betty Ferrell is honored with the 2021 ONS Lifetime Achievement Award for her decades-long dedication to improving pain management and quality of life for cancer patients. With over $70 million in grant funding, she has trained millions of nurses and clinicians globally on palliative care.
A study published in JAMA Network Open found that treating older patients with early-stage breast cancer did not improve survival rates and may cause harm. Researchers analyzed data from over 3,000 women aged 70 and found that omitting treatments like sentinel lymph node biopsy and radiotherapy did not affect recurrence or survival rates.
The NCCN Foundation has awarded $150,000 in funding to six young investigators advancing research on cancer prevention, racial disparities in screening, and CAR T-cell therapy. The recipients will present their research at the NCCN 2023 Annual Conference.
Researchers have identified specific super-enhancers that stimulate the activity of critical cancer genes in triple-negative breast cancer (TNBC). The study reveals that deleting certain super-enhancers can reduce tumour cell growth and improves survival chances. Dr Rebecca Chin and Dr Wang Xin's findings may lead to the development of...
A new registry study linked non-alcoholic fatty liver (NAFLD) to a 17-fold increased risk of liver cancer, particularly hepatocellular carcinoma. NAFLD patients were also found to have a higher risk of other cancers, emphasizing the need for targeted interventions and personalized screening strategies.
A study of over 1000 patients found UK cancer patients were 1.5 times more likely to die after a COVID-19 diagnosis compared to European counterparts. This increased mortality rate may be attributed to the UK's lagging cancer care and patient frailty.
Researchers at Yale Cancer Center have advanced a tumor-targeting and cell penetrating antibody that can deliver payloads to stimulate an immune response against melanoma. The study achieved almost complete tumor suppression in mice with melanoma tumors following intravenous injection of antibody/RNA complexes.
Researchers at Yale Cancer Center discovered that acquired resistance to immune checkpoint inhibitors is linked to reduced MHC-II molecule expression and increased tumor hypoxia. Combining immune checkpoint inhibitors with anti-hypoxia agents can slow the development of resistance.
A recent study by Yale Cancer Center reveals that young patients with early-onset colorectal cancer (under age 50) have a better survival rate than those diagnosed at older ages. After adjusting for stage at diagnosis, these patients had a 5% lower risk of death compared to those diagnosed between 51-55 years old.
Researchers from MD Anderson Cancer Center present promising results on RET fusion-positive cancers, HGG, LGG, and ovarian cancer. The FDA-approved selpercatinib shows clinical benefits in preventing or inhibiting tumor growth beyond lung and thyroid cancers.
A personalized cancer vaccine developed using a computational platform raised no safety concerns and showed potential benefit in patients with high-risk cancer recurrences. The vaccine was well-tolerated, with minor injection-site reactions, and demonstrated early potential benefits after administration.
A study published in Clinical Cancer Research found that specific gene signatures and immune cells can predict response to immunotherapy in bladder cancer patients. The researchers identified potential biomarkers for treatment resistance and new combination therapeutic approaches to overcome such resistance.
Researchers found that patients with colorectal cancer had a 57-93% decreased risk of death from their cancer depending on the presence and type of mitochondrial DNA mutations. Mitochondrial DNA mutations were present in almost 60% of tumour samples, suggesting potential for improved treatment outcomes.
A newly released position paper from ESMO and SIOPE defines a common vision for improving outcomes for AYAs with cancer in Europe. The paper highlights the key challenges of AYA care, including limited awareness of cancer biology, availability of specialist centres, and access to clinical trials.
The Bertarelli Rare Cancers Fund has awarded over $9 million in grants to nine teams representing 19 lead investigators, advancing research into rare cancers that affect tens of thousands of patients annually. The fund aims to improve detection, diagnosis, treatment, and prevention of rare cancers through multidisciplinary collaborations.
A study published in Radiology found that digital breast tomosynthesis (DBT) reduces the rate of interval cancers, which are more aggressive than screen-detected cancers. The study suggests that DBT may contribute to lower breast cancer mortality by detecting rapidly growing cancers with poorer prognosis.
A collaboration between Michigan State University, Spectrum Health, and Niowave is testing a new radiotherapy approach for bladder cancer. The therapy combines radiotherapy with immunotherapy, which helps the patient's immune system fight off disease, aiming to improve safety and effectiveness.
A collaborative team identified multiple genes with recurrent alterations in uLMS, including HRD, ALT, C-MYC/BET, and PI3K-AKT-mTOR pathway, as potential targets for new treatments.
A new study suggests removing additional tissue around the tumor cavity can reduce positive margins in patients with ductal carcinoma in situ (DCIS) by nearly 65%. Achieving clear margins is crucial in decreasing cancer recurrence, and this technique should be considered for DCIS patients.
A study published in JAMA Network Open found that over 60% of US adults who vape are interested in quitting, with former cigarette smokers having the highest intentions. Despite e-cigarettes being seen as a potential tool for smoking cessation, many users struggle to quit, and current treatments may not be effective for all users.
The study analyzed 412 high-risk NMIBC patients treated with BCG therapy and found significant differences in outcomes according to specific features of the disease. Total median costs at one, two, and five years from start of BCG induction were $29,459, $55,267, and $117,361, respectively.
A cohort study of 672 cancer patients found a cumulative incidence of venous thromboembolism at 12.9% and arterial thromboses at 1.8%. This risk appears to be independent of underlying cancer type or immune checkpoint inhibitor used.
The funding supports development of a new drug testing platform to predict treatment outcomes for patients with cancer. Researchers will leverage tissue bioengineering advances and genomic technologies to reconstruct and grow patient-derived tumor organoids in the presence of different drugs.
Research reveals associations between circulating tumor cell (CTC) mutations and clinical outcomes in metastatic castrate-resistant prostate cancer (mCRPC). The study identified novel genetic alterations linked to response to AR inhibitors, including gains of ATM, NCOR2, and HSD17B4, which were associated with sensitivity to treatment.
A new study reveals that patients with newly diagnosed incurable cancer experience significant physical and emotional distress, including anxiety and depression. Comprehensive palliative care services are essential to address these needs and improve quality of life for patients.
The conference explored updates to NCCN Clinical Practice Guidelines, new research, and strategies for preventing HPV-associated cancers. Experts discussed ways to improve racial equity in cancer care, including reducing disparities and promoting guideline-adherent care.
A team at Washington University in St. Louis has developed an imaging technique using acoustic resolution photoacoustic microscopy co-registered with ultrasound and paired with deep learning to differentiate between residual tumors and healthy tissue in rectal cancer patients after chemotherapy and radiation. This technique shows promi...
Scientists genetically engineered myeloid cells to deliver an anticancer signal, shrinking tumors and preventing cancer from spreading to other parts of the body. The study shows promise as a potential treatment for metastatic cancer, with treated mice living substantially longer and experiencing reduced metastatic cancer.
A clinical trial tested a mutation-specific vaccine against IDH1-mutated gliomas, a type of diffuse brain tumor. The vaccine proved safe and triggered the desired immune response in 93% of patients, with some experiencing pseudoprogression and tumor growth slowing.