Articles tagged with Cancer Patients
Researchers identified and contacted patients with cancer who could benefit from targeted nonelectronic communication regarding COVID-19 immunization. The study used an analytics-based approach to reach marginalized populations, highlighting the importance of targeted outreach in increasing vaccine uptake.
Researchers identified DSS1 as a critical protein in breast cancer progression and found that depleting it makes cancer cells more responsive to lower doses of anti-cancer drugs. This technique may reduce drug-induced side effects in breast cancer patients, providing a safer treatment option.
A recent study reveals that some prostate cancer survivors experience a persistent fear of cancer recurrence (FCR) even many years after diagnosis and treatment. The study identified patient and clinical risk factors linked with FCR, highlighting the need for ongoing monitoring and psychosocial care.
Researchers at Tel Aviv University successfully printed the first entirely active and viable glioblastoma tumor using a 3D printer. The 3D-bioprinted model includes functional blood vessels that simulate a real tumor, making it a promising tool for predicting treatment efficacy and drug development.
A new study investigated the benefits of patient participation in tumour conferences for complex cancer cases. Most respondents perceived their participation as a positive experience, finding it informative and recommended to others. However, some patients reported feelings of fear and uncertainty after participating in the conference.
Researchers at the University of Pennsylvania School of Medicine have identified a new mechanism of resistance in advanced chronic lymphocytic leukemia (CLL) patients to CAR T cell therapy. They found that inhibiting the BET protein with the small molecule inhibitor JQ1 can reinvigorate exhausted T cells and increase their production.
Researchers found that four patients with rare angiosarcoma partially or completely responded to treatment with a combination of ipilimumab and nivolumab. Stable disease was maintained by two more patients, with at least one patient experiencing complete tumor disappearance.
Researchers investigated SARS-CoV-2 BNT162b2 mRNA vaccine response in cancer patients and healthy controls. The study found that the vaccine's antispike IgG antibody response wanes over time in patients on active anticancer treatment.
Scientists investigated a method to enhance immunotherapy for lung cancer and found that combining it with certain chemotherapy drugs could eliminate harmful immune cells. This approach showed promising results in preclinical studies, inducing the regression of about 70% of tumors.
A first-of-its-kind study from the University of Pennsylvania School of Nursing clarifies the post-trial needs of patients who withdraw from cancer clinical trials. The study defines what constitutes responsible transitions when patients exit CCTs, providing insights into patient experiences and care after withdrawal.
The study analyzed 444 cancer treatment trials and found that 8.4% of patients enrolled were in the 15-39 age range, more than double the national average. AYA patients were also found to be more racially and ethnically diverse than older patients.
A big data study from UNSW Sydney found that Australian cancer patients kept up their pharmaceutical treatments during last year's COVID-19 lockdowns. The researchers attribute the good news to relatively low rates of COVID-19 infections in Australia, which minimally impacted cancer treatment patterns.
A world-first study found that cancer patients receiving chemotherapy intravenously have more than double the risk of developing a blood clot or thrombosis if the vein is too small and the catheter occupies more than 45% of the vein. Researchers identified specific limits on catheter-to-vein ratios to reduce risks for cancer patients.
Researchers analyzed patient specimens and clinical trial data from thousands of patients to assess the importance of immune cell molecules called Fc gamma receptors (FCGRs) in the therapeutic efficacy of two antibody drugs. High levels of FCGR2B on tumor cells were found to prevent rituximab efficacy, while obinutuzumab was not impact...
Despite initial drops in enrollment, cancer clinical trials in the US showed significant resilience during the 2020-2021 COVID-19 pandemic. Treatment trial enrollments remained remarkably stable, while cancer control and prevention studies were disproportionately affected.
Patients with cancer who experience clinically significant fatigue before treatment have shorter overall survival times and more side effects. Researchers analyzed four clinical trials testing lung and prostate cancer treatments, confirming that pretreatment fatigue may be an important prognostic factor in oncology.
A new clinical guideline from ASTRO provides guidance on the use of radiation therapy to treat adult patients with soft tissue sarcoma, recommending optimal radiation dosing and techniques. The guideline also addresses the role of radiation therapy for retroperitoneal sarcomas.
A prospective cohort study found that quitting smoking after being diagnosed with early-stage non-small cell lung cancer can slow disease progression and decrease mortality. Patients who quit smoking lived longer overall, had a longer time to death from lung cancer, and experienced improved survival without cancer recurrence.
A study by St. Jude Children's Research Hospital demonstrates the power of comprehensive whole genome, whole exome and RNA sequencing to better understand and treat each patient's unique cancer. The research found that 86% of patients had at least one clinically significant variation in tumor or germline DNA.
A novel therapeutic agent, MS21, has been developed to disrupt a biological pathway that helps cancer survive. The therapy shows high effectiveness in vitro by causing the degradation of AKT, an enzyme overly active in many cancers.
The new center aims to understand the causes of cardiovascular disease and cancer in Blacks, with a focus on identifying early indicators of heart problems from cancer treatment. Research will also investigate how socioeconomic disparities and obesity contribute to increased risk of both conditions.
A new study found that one-third of popular cancer treatment articles on social media contain misinformation, which can negatively impact patient outcomes. The vast majority of this misinformation garners more attention and engagement than evidence-based information.
A study published by The BMJ found that remote 24-hour monitoring for cancer patients receiving chemotherapy significantly reduces symptom burden, anxiety, and work limitations. Patients who used the system experienced improved quality of life and reduced supportive care needs.
Researchers developed patient-specific tumor organoids to test immunotherapy treatments for appendiceal cancer. The study found that various types of immunotherapies can achieve personalized results, identifying beneficial treatments while sparing patients from harmful side effects.
A Ludwig Cancer Research study has found that transient chromosomal instability events can lead to the formation of tumors in mice. The researchers induced random chromosome instability in mice for one week and found that this was enough to trigger harmful chromosomal patterns that spur tumorigenesis.
Researchers at UC Davis Comprehensive Cancer Center are investigating whether turmeric can successfully reduce joint pain in breast cancer patients and improve their quality of life. The study aims to provide important data on the safety and effectiveness of using turmeric with oral anti-estrogen therapy.
Researchers investigated CEA as a blood-based biomarker for anal cancer. Although CEA levels correlated with disease progression, they were not associated with survival outcomes or clinically relevant in managing the disease. Novel approaches with serum biomarkers are necessary for this rare and increasing diagnosed malignancy.
Researchers found a 40% objective response rate for patients with advanced malignant peritoneal mesothelioma treated with atezolizumab and bevacizumab. The treatment was well-tolerated, with improved progression-free and overall survival rates compared to standard chemotherapy.
A new study found that obese patients with advanced prostate cancer survive longer than their overweight and normal-weight counterparts. Obesity was associated with a 10% higher survival rate over 36 months. The 'obesity paradox' suggests that high body mass index may be protective in certain cases.
Researchers will analyze and map environmental, social, and economic factors that impact cancer diagnosis in a regional patient data set. The study aims to identify correlations between potential causes and common types of cancer in the region.
A recent study published in the American Journal of Roentgenology found that reduced-dose CT scans can detect greater than 90% of lung nodules in children and young adults with cancer. This could lead to a reduction in patient dose while maintaining high diagnostic accuracy.
A new study predicts patient responses to immunotherapy using tumor fragments in the lab, offering hope for personalized cancer treatment. The researchers identified specific immune cell markers that can predict treatment response and resistance.
A pilot study found that patients with high cotinine levels were four times more likely to have their cancer return. The researchers aim to develop a simple urine test for cotinine to reduce invasive investigations for bladder cancer patients.
Research found nearly two-thirds of patients with non-muscle-invasive bladder cancer had multiple co-existing chronic conditions, leading to a mean treatment burden of 8.9 days. Rural patients consistently had higher treatment burden than urban counterparts.
Researchers have developed a novel method for generating metabolic profiles of individual cells, enabling the analysis of over 100 metabolites and lipids from thousands of cells per hour. The method, called SpaceM, uses a combination of fluorescence microscopy and mass spectrometry to analyze single-cell metabolism.
Researchers discover pharmacological activation of p53 triggers viral mimicry response, abolishing tumor immune evasion and promoting anti-tumor immunity. The findings have potential for developing new combination therapies that can increase cancer patient access to immunotherapy.
A recent study found that nearly all patients with cancer developed good immune responses to COVID-19 mRNA vaccines, with 94% developing antibodies. However, a small subset of high-risk patients showed no response, raising concerns about future vaccination strategies.
The RESILIENCE project seeks to prevent anthracycline-induced cardiotoxicity in cancer patients through remote ischaemic preconditioning, with over 600 patients enrolled in a randomised clinical trial. Cardiac function will be evaluated using state-of-the-art cardiac magnetic resonance imaging.
A new assessment tool has been found to predict ovarian damage in girls with cancer, helping doctors determine which patients should undergo fertility preservation. The Edinburgh selection criteria identify high-risk patients who are more likely to develop premature ovarian failure.
Researchers have developed a chemical compound that produces a powerful oxygen reaction when exposed to light, selectively killing cancer cells while leaving surrounding tissue intact. The photodrug is currently in clinical trials for patients with recurring bladder cancer resistant to traditional therapies.
Boston University School of Medicine has received a grant of $2.7M from the American Heart Association to study disparities in cardio-oncology and their impact on cardiovascular disease among diverse populations. The research aims to better understand the causes, consequences, treatment, and prevention of CVD among cancer patients.
A large cohort study found that patients with heart failure are more likely to develop cancer compared to those without. The incidence of cancer was significantly higher among heart failure patients, particularly for certain types of cancer such as lip, oral cavity, and pharynx cancers.
A pilot study found children with acute lymphocytic leukemia were four times more likely to live near oil and gas sites than other cancer patients. The new study aims to determine if there's a potential link between benzene emissions from oil and gas production and childhood ALL.
A study evaluated a panel of 142 mutation-signature–associated metrics for predicting cancer progression in patients. The P142 panel successfully predicted cancer progression status in some, but not all, analyzed cancer types.
An international study on rare childhood cancer, rhabdomyosarcoma, found that mutations in genes TP53, MYOD1, and CDKN2A are associated with a more aggressive form of the disease. The study provides genetic clues for developing targeted therapies.
Researchers developed a new dietary fiber formulation that modulates the gut microbiome, improving potency of immunotherapies against cancer. The inulin gel doubled the rate of tumor eradication in rodents with colon carcinoma and melanoma, expanding beneficial microbes in the gastrointestinal tract.
Researchers identified FTO as a key regulator of cancer metastasis and found that lowering its levels enhances WNT signaling, making tumors more sensitive to WNT inhibitors. This discovery offers encouraging prospects for treating aggressive cancers.
The 2021 ESMO World Congress on Gastrointestinal Cancer presented new concepts in clinical trials, advances in surgery and transplant, and novel immuno-oncology mechanisms. Researchers shared findings on the effects of drug interactions in GI oncology and strategies to improve outcomes for patients with metastatic pancreatic cancer.
Researchers developed a blood test that analyzes circulating tumor DNA to predict treatment response in metastatic HPV-positive throat cancer. The test showed promise in identifying non-responding patients months earlier than standard imaging scans.
Researchers at Memorial Sloan Kettering Cancer Center developed a machine-learning approach that accurately predicts how human breast cancer tumors will evolve. By analyzing genetic makeup of thousands of individual cells, the team created a model that can predict tumor behavior and identify potential relapse sites.
Researchers at USC Norris Comprehensive Cancer Center found that family-based cancer clustering occurs more frequently among Latino, African American, and Asian/Pacific Islander families. The study suggests a higher inherited risk of early-onset cancer in these minority populations compared to non-Latino white families.
A new treatment sequence for esophageal cancer may improve patient outcomes by treating microscopic disease first. The approach adds chemotherapy for two to three months before radiation and surgery, potentially reducing mortality rates.
A recent study found that statin use among patients with heart failure is associated with a 16% lower risk of developing cancer and a 26% reduced risk of dying from cancer over an average of four years. The longer patients remained on statins, the greater the reduction in their cancer risk.
Ovarian cancer is the most lethal gynaecological cancer with an absence of screening programmes, leading to late diagnosis and poor prognosis. Despite targeted therapies, personalized medicine remains a challenge due to inconsistent symptoms and resistance to chemotherapy.
A blood test detecting tiny amounts of circulating cancer DNA may identify risk of cancer recurrence and guide precision treatment in bladder cancer following surgery. The study found patients with a particular cancer DNA marker in their blood had a higher likelihood of cancer relapse, suggesting the potential for personalized treatment.
Researchers from the University of Texas Health Science Center at San Antonio developed a new tool to stop hiccups, FISST, which showed nearly 92% success rate in relieving symptoms. Users reported high degrees of effectiveness and ease of use, with most finding it easy to use and very happy with results.
A new classification of metastatic testicular cancer enables more targeted treatment, improving survival rates. The study reveals significant improvements in prognosis for patients with testicular cancer, with increased 5-year survival rates across all groups.
A recent study found a direct molecular link between red meat consumption and colorectal cancer development, revealing genetic mutations indicative of DNA damage. High red meat intake was associated with increased cancer-related mortality and poorer patient survival.
Researchers at Moffitt Cancer Center have developed a non-invasive method to measure PD-L1 biomarker levels in lung cancer patients using PET/CT scan images. This approach uses deep learning to predict checkpoint inhibitor outcomes, which could help determine optimal treatment strategies for patients.
Five researchers, supported by a $12.8 million grant, will investigate computational methods for predicting immunotherapy responses, genetic elements controlling gene expression, and protein assemblies regulating gene expression in cancer.