Articles tagged with Cancer Patients
A pilot study reveals that whole genome sequencing can refine diagnoses and provide new treatment options for children with cancer. The study found genetic variants that could change prognosis or suggest hereditary causes of the cancers, as well as treatments that may be effective but were not previously considered.
According to experts, half of patients with two common subtypes of advanced breast cancer may live for five years or longer. The new guidelines also aim to improve treatment options for triple-negative breast cancer patients.
A study found that arginine treatment improved outcomes in cancer patients with brain metastases, showing a complete or partial response in nearly 78% of patients. The amino acid may be useful as an anticancer therapy when combined with radiotherapy or other treatments.
A study published in Nature Communications found that neuroendocrine tumors in the small intestine often originate from different cells with unique genetic mutations. This breakthrough challenges conventional wisdom on cancer development and highlights the importance of removing all detected tumors to prevent late relapses.
COVID-19 vaccinations have been shown to be safe for advanced breast cancer patients, with no notable differences between vaccine brands. The second dose is crucial to induce an immune response, which has been found in 80% of patients with solid tumours.
Researchers have identified genetic mutations in genes CBP and p300 that drive radiation resistance in head and neck tumors. Inhibiting these proteins with certain drugs makes tumor cells more susceptible to radiotherapy.
Researchers at Children's Hospital of Philadelphia have developed a novel therapy that targets proteins essential for tumor growth and survival. Using a multi-omics approach, they identified peptides unique to neuroblastoma tumors, which are then targeted by peptide-centric chimeric antigen receptors (PC-CARs).
A recent survey of advanced breast cancer patients in the UK reveals that only 14% have been recruited to a trial, highlighting a need for improved access. Patients often face barriers, including clinician reluctance to discuss trials and a lack of patient-friendly databases.
A Tulane University study successfully leverages artificial intelligence to identify and diagnose colorectal cancer with a performance comparable to, if not better than, highly experienced pathologists. The AI-powered program achieves an average accuracy of .98 in accurately identifying colorectal cancer from tissue scans.
A new pilot study reveals a prostate cancer urine test can identify men with intermediate-risk disease, allowing them to opt for active surveillance instead of immediate treatment. The test assesses the amount of aggressive cancer in the prostate without needing a biopsy.
A major global study found that the risk of breast cancer spreading to other parts of the body ranges from 6% to 22%. Younger women and those diagnosed with larger tumours face a higher risk. The study also sheds light on how many people develop advanced breast cancer, a gap in knowledge until now.
Researchers from MUSC Hollings Cancer Center, UCLA Jonsson Comprehensive Cancer Center, and Winship Cancer Institute discovered that pre-surgical anti-PD-1 immunotherapy is safe and effective for OCSCC patients. The studies identified potential molecular biomarkers in blood and tumors to predict treatment response.
Researchers found that certain T cells stop working before entering the tumor due to changes in gene expression, making ICB therapies less effective. Combining ICB with other forms of immunotherapy targeting different aspects of T cell function may improve response rates for non-small cell lung cancer patients.
A multi-center study demonstrated improved overall survival and quality of life for inoperable pancreatic cancer patients treated with MRIdian SMART, with a median survival of 26 months. The treatment showed low rates of major adverse events and was more effective than standard radiation therapy.
Researchers found immune cell patterns within tumours that can predict if patients with kidney cancer will respond to immunotherapy. The study identified a specific 'clonal' T cell receptor pattern linked to a greater chance of positive immunotherapy response.
A new study by Dana-Farber Cancer Institute found that younger patients with metastatic colorectal cancer have a similar overall survival time as older patients, defying expectations. The study included data from the CALGB/SWOG 80405 clinical trial and compared survival times in 514 younger patients under 50 with 1,812 older patients.
Researchers at Duke University and UC Irvine identify Kenpaullone, a cancer drug, as an effective analgesic for chronic and challenging-to-treat pain. The compound enhances Kcc2 gene expression, which resets maladaptive genetic switches in neurons, leading to pain signal silencing.
A team of researchers has developed an ensemble-based machine learning model that can predict how cancer patients will respond to certain drugs with high accuracy. The model was trained on data from 499 independent cell lines and validated against a clinical dataset containing seven chemotherapeutic drugs.
A new report reveals that cancer patients in the US bear a significant financial burden, with total out-of-pocket costs reaching over $21 billion in 2019. The majority of these costs are associated with breast and prostate cancers, which are among the most prevalent types in the country.
A Singapore clinical trial has introduced a new way to treat advanced hepatocellular carcinoma by combining nivolumab, an immunotherapy drug, with yttrium-90 resin microspheres radioembolisation. The study shows promising results in treating intermediate and advanced HCC, with an overall response rate of 30.6%.
A new study finds that high-dose radiation therapy can lengthen progression-free survival for people with advanced lung cancer when systemic therapy has not fully halted tumor growth or spread. Stereotactic body radiation therapy (SBRT) shows promise in treating oligoprogressive, metastatic lung and breast cancer.
A recent clinical trial found that a shortened course of radiation therapy after prostate removal surgery does not increase long-term side effects or lower quality of life compared to conventional treatment. Patients who underwent hypofractionated, post-operative radiation therapy experienced comparable genitourinary and gastrointestin...
A new analysis of US national data finds that external-beam radiation therapy is a proven treatment option for patients with unresectable liver cancer but is rarely prescribed, with only 3.6% of patients receiving it. The study suggests that institutional and regional practice patterns play a key role in driving treatment decisions.
Two studies investigate the factors associated with cancer centers offering telehealth services, revealing regional disparities and socio-economic influences. Researchers aim to increase access to care for patients who may be underserved or lack technology to participate in remote visits.
ImCheck's ICT01 selectively activates Vγ9Vδ2 T cells through all three isoforms of BTN3A, overcoming prior limitations. The therapy demonstrates anti-tumor activity in solid and hematologic cancer models.
The MUSC Hollings Cancer Center researchers are exploring the role of macroenvironment in pancreatic cancer-induced cachexia to address this debilitating condition. The team aims to provide new biological insight, which will be coordinated by four cores within the program project grant.
A study published in JNCCN found that 45% of people with cancer prefer telemedicine over in-person visits, while general patient satisfaction scores are equally high. The research also revealed that patients preferred video conferencing over audio-only appointments and that telemedicine can reduce treatment-related costs.
The new ESMO Clinical Practice Guideline provides comprehensive guidance on diagnosing, staging, and treating patients with metastatic breast cancer. The guideline incorporates recent clinical trial data to inform treatment choices, taking into account tumour biology and emerging targeted therapies.
A new study found that translocator protein 18 kDa (TSPO) correlates with worse survival outcomes in male glioblastoma patients compared to females. The variation in the protein's structure is associated with shorter overall and progression-free survival times, suggesting its potential as a prognostic biomarker.
Patients with multiple myeloma often mount a poor antibody response to COVID-19 vaccines and have a weak T cell response, underscoring the need for booster vaccination and safety precautions. Researchers found that these patients are at high risk of severe COVID-19 infection.
Researchers from UPV/EHU and Biocruces pathologists use game theory to study tumor cell interactions, finding that higher cell diversity may be beneficial for patients. This approach reveals the importance of collective stability in tumor cells' pursuit of better environments.
Researchers at the University of Copenhagen have discovered that the BRCA2 gene requires a specific enzyme, PP2A-B56, to repair DNA damage. This finding may pave the way for more targeted treatment of cancer patients with certain mutations.
Scientists developed a fluorescent spray that specifically targets and illuminates cancerous tissue, enabling precise tumor detection and removal during surgery. The innovative approach offers a solution to the challenge of distinguishing between healthy tissue and cancerous cells.
A survey of breast cancer patients found that nearly half use cannabis to alleviate pain, fatigue, and other symptoms while undergoing treatment. Physicians are often unaware of patients' cannabis use, highlighting the need for informed conversations about its potential benefits and risks.
A peptide-drug conjugate called CBX-12 has been shown to enhance the efficacy of immune checkpoint inhibitors in preclinical cancer models by targeting the acidic environment of cancer cells. The treatment exhibited significantly delayed tumor growth, improved survival, and complete tumor regressions compared to immunotherapy alone.
A recent study found that non-Hispanic Black patients who received immunotherapy for advanced-stage non-small cell lung cancer had a lower risk of death compared to non-Hispanic white patients. The researchers controlled for access-related issues and found disparities persisted in certain populations.
A new study reveals that COVID-19 lockdowns led to significant delays in cancer surgery, resulting in potentially more cancer deaths. Patients in lower income countries and those with advanced disease were most affected, with one in seven missing their scheduled operation.
MUSC researcher Haizhen Wang receives R37 grant to investigate CDK6's role in T-cell acute lymphoblastic leukemia, a aggressive cancer. The research aims to understand how the immune system can be used to reduce leukemia progression.
A new study from the University of Eastern Finland and Kuopio University Hospital found that liquid biopsy can accurately identify patients with poor breast cancer prognosis. High integrity of circulating DNA is associated with a poor prognosis, enabling earlier and more accurate detection of breast cancer. The study's findings have si...
A research team at TUM has discovered that the protein TIMP1 is associated with a significantly higher risk of liver metastasis and death in male patients, particularly those with pancreatic, colon, and melanoma cancers. This finding may lead to improved diagnosis and targeted therapy options for men.
Cachexia is characterized by weight loss and muscle tissue shrinkage, driven by the immune system's response to chronic infections and diseases. Researchers from CeMM emphasize the need for more research into cachexia, highlighting the importance of interplay between the immune system and metabolism.
A new study found that six out of ten patients with common 'alarm' symptoms were not referred for urgent cancer investigation within two weeks, leading to a higher risk of delayed diagnosis. The study suggests that stricter adherence to guidelines and increased awareness of missed symptom groups could improve diagnosis rates.
A clinical trial found that obese prostate cancer patients who underwent regular exercise training for 12 weeks had increased levels of anti-cancer myokines, which suppressed tumour growth and helped fight cancerous cells. The study suggests exercise may be a key weapon in cancer patients' battle against the disease.
A new study finds oesophageal cancer cases have tripled in under 50s, with increases attributed to lifestyle-related risk factors such as smoking and poor diet. The study also shows improved relative survival rates for younger patients, highlighting the importance of early diagnosis and treatment.
Research published in the journal BMJ Quality & Safety found that six out of ten patients in England with 'red flag' symptoms indicative of possible cancer didn't receive an urgent referral for specialist assessment within two weeks. Nearly four percent of these patients were diagnosed with cancer within the next 12 months.
A recent study found that colorectal cancer diagnoses fell dramatically by 40% in a year during the COVID-19 pandemic. This decline was attributed to the suspension of screening programs and postponed non-urgent colonoscopy investigations.
A study published in JAMA Oncology found that the type of cancer treatment affects the vaccine response, with chemotherapy resulting in lower antibody levels. Vaccination is still recommended for cancer patients, but optimal protection requires ongoing measures.
A new treatment approach targets angiogenesis, inflammation, and oxidative stress in glioblastoma multiforme, reducing tumor volume and growth by up to 89%. The combination of LAU-0901, Elovanoids, and Avastin shows promise in improving survival rates for patients with this deadly cancer.
The MAP Virtual Congress 2021 focuses on integrating tumour sample analysis into daily practice, enabling personalized treatment. Key findings include actionable mutations in patient DNA and the role of the tumour microenvironment in metastasis.
Researchers found that antidepressants inhibit the growth of pancreatic and colon cancers in mice by blocking a mechanism used by cancer cells to evade the immune system. The findings suggest a promising approach for combining antidepressant drugs with immunotherapy to treat incurable cancers.
A new study at Ohio State University's Comprehensive Cancer Center is using rapid autopsies to gather biological samples after death to better understand how cancer cells overcome different treatments. This approach has already led to novel findings about drug resistance mechanisms, including the recent approval of a targeted therapy f...
Researchers have identified a way to restore the effectiveness of drugs in clinical trials for treating AML by using human alpha(1)-acid glycoprotein (AGP) as a 'decoy' to bind and inhibit FLT3-mutated leukemia cells. The approach has potential for improving patient outcomes, particularly for patients with FLT3-mutated AML.
New targeted therapies are being developed to target genetic alterations in cancer cells, such as the ARID1A mutation found in 10-50% of solid tumours. Early clinical trials suggest that these agents may be effective in treating multiple cancers, including breast, ovarian, and gastric cancer.
A new AI system developed by NYU and NYU Abu Dhabi researchers achieves radiologist-level accuracy in identifying breast cancer in ultrasound images. The system helps decrease false-positive findings and requested biopsies while maintaining sensitivity.
Patients with certain gene mutations are at high risk of fatal chemotherapy toxicity, with a 25-times increased risk detected in those with uncommon DPYD variants. The study suggests that adding pre-treatment screening may help prevent avoidable deaths without interrupting standard care.
Researchers discovered that adrenal gland metastases are unresponsive to checkpoint inhibitors due to the secretion of corticosteroids. Surgical removal is the current best course of action for patients with these metastases. The study's authors hope to develop a nonsurgical treatment option in the future.
The University of Helsinki-led research project partners with UCSF to develop new therapies targeting MYC cancer gene vulnerabilities. The goal is to create next-generation cancer drugs that selectively kill cancer cells while leaving normal cells unharmed.
Researchers analyzed data from over 3,200 brain metastatic tumors and discovered that different types of cancer tend to spread to specific parts of the brain. The study's findings may help predict where a particular cancer will metastasize and inform treatment strategies.
A study found disparities in care during terminal hospitalization for metastatic cancer, with patients from racial and ethnic minority groups more likely to receive low-value, high-cost interventions. Medicare or Medicaid coverage also increased the likelihood of such interventions.
Scientists use modern imaging technology to determine liver cancer subtypes, identifying specific sugar structures that correlate to different subtypes. This approach could lead to earlier detection and more personalized therapies for hepatocellular carcinoma.