Articles tagged with Cancer Patients
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Researchers discovered ovarian cancer cells can lock into survival mode and avoid chemotherapy destruction. The study, published in Nature, used whole genome sequencing to analyse tumour DNA samples from 91 patients with high-grade serous ovarian cancer.
A new study found that cancer patients' attitudes and beliefs about complementary and alternative medicine are key predictors of its use. Researchers identified specific factors such as expectation of therapeutic benefits, cost concerns, and physician opinions, which varied by sex, race, and education level.
Exposure to aflatoxin, a liver carcinogen, is associated with an increased risk of gallbladder cancer in a small Chilean study. The study found higher levels of aflatoxin-albumin adducts in patients with gallbladder cancer compared to controls.
A clinical trial at University of Colorado Anschutz Medical Campus demonstrates an intervention that successfully reduces caregiver stress in cancer patients treated with stem cell transplantation. The study shows significant lower stress levels and improved quality of life for caregivers.
In a small clinical trial, researchers safely used immune cells grown from patients' own bone marrow to treat multiple myeloma. Thirteen of 22 patients experienced partial responses, with seven achieving at least 90% tumor cell reduction and living up to 25.1 months without cancer progression.
A traditional Chinese medicine herbal mixture called Ren Shen Yangrong Tang (RSYRT) significantly reduced fatigue in cancer patients with moderate to severe symptoms. In a Phase I/II trial, RSYRT was found to be safe and effective in improving Qi deficiency, a key factor contributing to fatigue.
A new large study finds that women who are diagnosed with breast cancer and have a family history of the disease face no worse of a prognosis after treatment than other women with breast cancer. Successful treatment for breast cancer is just as likely in young patients with a family history of breast cancer, as in those without.
A study has quantified the different mutational profiles of cancer cells in individual tumors, revealing a high degree of variability within one tumor. The researchers found that certain genes behave differently in cancer cells, with some tumors composed of multiple groups with distinct molecular alterations.
Flawed prostate specific antigen data in the SEER program has been removed due to quality control checks. This may affect previous research studies and analyses that rely on these data. Noted urologist Dr. David F. Penson cautions against relying on large administrative databases without proper validation.
A three-year study of 2,000 cancer survivors found that information needs differ depending on cancer type and stage. Breast cancer survivors sought more information about late effects and family risks in early years, while female colon cancer survivors increased their interest in these topics later on.
A phase 1b study has shown impressive response rates of 60-75% in patients with untreated non-small cell lung cancer treated with chemotherapy and an anti-PD-L1 agent. The combination therapy was well-tolerated, with no unexpected toxicities.
A phase III randomized clinical trial suggests that Stereotactic Ablative Radiotherapy (SABR) is equally effective to surgery in treating operable stage I non-small cell lung cancer patients, with better survival rates and lower toxicity. SABR appears to be a suitable alternative for elderly and comorbidity-prone patients.
A recent study from the University of Texas MD Anderson Cancer Center suggests that profiling normal DNA provides an opportunity to identify inherited mutations critical for patients and their families. Researchers sequenced tumor and normal DNA from patients with advanced cancer, identifying germline mutations in nearly all cases.
A Loyola University Medical Center study found that among 205 cases of mesenchymal chondrosarcoma, more than half survived at least five years and 43 percent survived at least 10 years. Survival rates varied depending on tumor location, with axial tumors showing worse outcomes.
A phase I study found that Sym004, a double-targeting EGFR antibody, provides better outcomes than current anti-EGFR therapies in patients with resistant colorectal cancer. The treatment resulted in significant antitumor activity and improved disease-control rates.
Researchers used organoids derived from human tumor samples to test cancer drugs and predict patient response. The findings demonstrate the power of organoids to capture complex mutations in tumours.
A study by Manchester researchers has identified genetic subtypes in high-risk endometrial cancer patients, allowing for more targeted treatments. The classification of these subtypes can predict patient relapse and identify specific mutations that can be targeted with anti-cancer drugs.
Researchers grew 22 organoids from tumor tissue of 20 patients with colorectal cancer and found they closely replicate key properties of the original tumors. These cultures can be used to predict drug sensitivity and pave the way for personalized treatment approaches.
A recent study found that almost half of patients opted out of comprehensive cancer gene screening due to concerns about uncertainty and potential distress. Pre-test counseling significantly reduced anxiety in these patients, but highlighted the need for individualized guidance before genetic testing.
A new study at Ohio State University has identified Foxo1 as a negative regulator of natural killer cell maturation and homing behavior. The findings suggest that reducing Foxo1 expression can enhance NK-cell maturation, providing an opportunity to boost cancer and viral immunity.
Researchers found that patients with GIST are at higher risk of developing other sarcomas, non-Hodgkin's lymphoma, carcinoid tumors, melanoma, and various types of colorectal, esophageal, pancreatic, and renal cell cancers. This association was particularly notable in smaller tumor sizes.
A study published in Cancer Epidemiology & Biomarkers & Prevention found that prolonged statin use after a lung cancer diagnosis was associated with a reduced risk of dying from lung cancer. Patients who used at least 12 prescriptions of statins had a 19% lower risk of lung cancer-specific deaths.
Researchers found that ITIM-receptor signaling supports AML development and suggests blocking this pathway may be an effective strategy for treatment. The study provides new insights into the immune system's role in cancer and may lead to novel therapies for acute myeloid leukemia.
A phase 1/2 trial of rociletinib in EGFR-mutant non-small cell lung cancer showed a 59% response rate and 13.1 month progression-free survival, offering hope for patients with previously treated disease.
Patients with locally advanced esophageal cancer who survive 5 years after surgery are at risk for recurrence, new primary cancers, and chronic pulmonary disease. Continued surveillance is necessary to mitigate these risks, particularly for patients with nodal metastases.
A Cancer Research UK study found that only a third of bowel cancer patients received physical activity advice, despite evidence showing its link to better survival rates. Most patients who received advice were more likely to be physically active than those who didn't.
A new analysis of the Surveillance, Epidemiology, and End Results (SEER) database found significant variation in health insurance coverage among cancer patients based on demographics and cancer type. Younger, non-White, and rural patients were more likely to be uninsured, while males were less likely than females to have insurance.
Survivors of Hodgkin lymphoma have a persistently increased risk of cardiovascular disease throughout life, with a cumulative risk of 50% at 40 years after diagnosis. The study found that mediastinal radiotherapy and anthracycline-containing chemotherapy significantly increased the risks of cardiovascular events.
New research suggests that persistent swollen lymph glands in the neck are a high-risk indicator for lymphoma. By referring patients with unexplained swollen neck glands for further investigation, doctors can help reduce cancer-related deaths in the UK.
A population-based study found brachytherapy with external beam radiation improved overall survival by 13% for women with inoperable stage 1 endometrial cancer. Brachytherapy was also associated with lower deaths from endometrial cancer after three years.
Researchers discovered that cancer rates among hepatitis C patients are significantly higher than those without the virus. The study found a 2.5 times higher rate of all cancers and almost twice as high when liver cancer is excluded.
A new study by Brigham and Women's Hospital finds that breast conserving therapy was successful in over 90% of women who became eligible after treatment with chemotherapy. Despite this, 31% of those eligible chose mastectomy, highlighting the need for further exploration of patient and surgeon factors.
Researchers identified specific genetic markers in African American women with triple negative breast cancer, associated with improved survival rates. The study suggests that these molecular differences may hold the key to improving treatment outcomes for this high-risk population.
A recent study from Huntsman Cancer Institute found that childhood cancer survivors are more than five times as likely to be enrolled in federal social security disability assistance programs compared to individuals without a cancer history. The study identified survivor socio-demographic and treatment characteristics associated with a...
Researchers have discovered a damaged DNA lesion that may serve as an early biomarker for liver cancer. Polyphenon E, a green tea extract, also shows promise in suppressing the lesion and preventing tumor development.
Researchers have identified methylated DNA markers in blood samples with 80% accuracy, enabling potential non-invasive screening for cancer. The discovery could lead to earlier diagnosis and improved patient outcomes for rare cancers like pancreatic cancer.
The $20 million SU2C-American Cancer Society Lung Cancer Dream Team will focus on targeting KRAS mutant lung cancer using a three-pronged approach. The team aims to develop novel therapies that combine targeted drug therapies with immunotherapies to improve patient outcomes.
A collaborative study by the University of Colorado Cancer Center and National Cancer Institute reports TERT gene promoter alterations in 69% of bladder cancers. The study suggests these alterations may be an early precursor to the disease and could lead to genetic testing for screening.
A large study found that fewer than 10% of patients with adverse pathologic features after surgery received postoperative radiotherapy within six months. Despite strong evidence, the utilization of radiation therapy for these patients is declining in the US.
Multiparametric MRI and ultrasound fusion enables targeted biopsies of high-suspicion foci with increased diagnostic accuracy for prostate cancer. For patients on active surveillance, this method better characterizes the prostate gland and detects higher-grade disease.
Researchers found that long-time consumption of soyfoods boosts immune response against breast tumors, reducing cancer recurrence. Genistein in soyfoods activates anti-tumor immune responses and reduces immunosuppressive mechanisms.
African-American women with ER+ breast cancer experience poorer outcomes due to increased activation of the unfolded protein response (UPR) pathway, reducing sensitivity to tamoxifen treatment. Strategies targeting this pathway could improve therapy effectiveness.
Dr. Mario Capecchi has made significant contributions to cancer research through his development of gene targeting technology, revolutionizing the study of cancer genes and mechanisms of cancer development. He will be presented with the AACR Award for Lifetime Achievement in Cancer Research at the 2015 Annual Meeting.
A research team led by Charles Sawyers and Howard Scher discovered novel antiandrogen enzalutamide, which extended survival among patients with metastatic castration-resistant prostate cancer. The AACR Team Science Award recognizes the team's innovative work in advancing cancer research.
Dr. Carl June is being recognized for his contributions to cancer immunology, particularly his development of chimeric antigen receptor (CAR) T-cell therapy. His work has enhanced the promise of cancer immunotherapy and led to significant breakthroughs in treating leukemia.
David Baltimore is being recognized for his groundbreaking discoveries in immunology, virology, and cancer research. He will present a lecture on microRNAs, leukemia, and hematopoietic stem cells homeostasis at the AACR Annual Meeting 2015.
Margaret Foti, AACR CEO, will receive the Children's Champion Award for her outstanding pediatric cancer advocacy efforts. The award recognizes her leadership in advancing research and treatment for children with cancer.
A recent study by the Journal of the American College of Surgeons found that socioeconomic factors such as income level, education, and hospital type significantly impact lung cancer patients' odds of death within 30 days after surgery. Patients from lower-income households were 25% more likely to die than those in higher-income areas.
A new scoring method called MATH measures genetic variability among cancer cells within tumors from patients with head and neck cancer. High MATH scores correspond to tumors with many differences among gene mutations present in different cancer cells, correlating with lower patient survival.
James Allison, a renowned immunologist, has been recognized for his pioneering discovery that blocking CTLA-4 improves antitumor immune responses. His work led to the development of ipilimumab, an immune checkpoint inhibitor that transformed melanoma treatment.
A study by Dartmouth-Hitchcock's Camilo Fadul and colleagues found no correlation between regulatory T cells (Tregs) and patient survival in glioblastoma. The researchers used a novel epigenetic quantitative analysis methodology to quantify lymphocyte populations, including Tregs, in tumor tissue and peripheral blood.
James P. Allison is being acknowledged for his discovery that blocking CTLA-4 signaling improves antitumor immune responses, leading to the development of ipilimumab, a cancer immunotherapeutic. His research has transformed the lives of patients with melanoma and offers hope for other forms of cancer.
Dr. Coffey will receive the award for his pioneering work on prostate cancer, nuclear matrix, and mentoring of young researchers. He is also recognized for his outstanding leadership skills and advocacy for sustained funding for cancer research.
A new clinical trial found that early initiation of palliative care significantly improved one-year survival rates among patients with late-stage cancer. Additionally, caregivers experienced reduced depression and stress levels when interventions started earlier in the patient's life.
Researchers at Queen's University Belfast have launched a revolutionary personalized treatment program to improve bowel cancer survival rates. The S-CORT Consortium will employ state-of-the-art techniques to define the genetic make-up of bowel cancer cells, collected from over 2,000 patients, and develop personalized care plans.
Recent studies in Cancer Cell and Trends in Immunology review the intricate relationship between the immune system and cancer. Research has shown that harnessing anti-tumor immunity can be a promising approach to treating various cancers.
Researchers James P. Allison and Padmanee Sharma argue that combining targeted therapies with immunotherapy could be key to developing curative treatments for various cancer types, building on promising results from clinical trials.
Women with ductal carcinoma in situ breast cancer underwent axillary lymph node evaluation at high rates, defying guidelines. The study found that 17.7% of women undergoing breast-conserving surgery and 63% of those who had mastectomy underwent axillary evaluation.
A Yale study found that one in five Medicare patients with melanoma experience significant delays in getting surgery, affecting their psychological well-being and healthcare quality. The study analyzed data from over 32,000 Medicare patients and revealed that 22% waited longer than 1.5 months for treatment.
A study by Professor Rama Khokha found that genetically modified mice without TIMP1 and TIMP3 experienced youthful breast tissue, with stem cells remaining functional throughout their lifetime. The results challenge the assumption that large numbers of stem cells increase cancer risk.