Articles tagged with Cancer Patients
A recent genome-sequencing study discovered at least one-third of patients' tumors have genetic mutations that can guide precision therapy. Blood tests detecting DNA shed from tumors predicted cancer recurrence more than half a year earlier than standard imaging methods.
A recent study found that while advance care planning has increased among cancer patients, it hasn't led to a decrease in aggressive medical care received in the last weeks of life. In fact, nearly 40% of respondents reported that their loved ones didn't discuss end-of-life care preferences with them.
Researchers have identified five recurrent fusion genes in gastric cancers, which lead to increased susceptibility to damage and diminished healing. The study also found that these fusion genes promote invasive tendencies in cells, aiding in cancer progression.
A new study published in Journal of Immunotherapy demonstrates that T cells derived from lymph nodes can be expanded and activated to attack melanoma. This innovative approach, called adoptive immunotherapy, is being tested in a human clinical trial at UH Seidman Cancer Center.
Ezrin regulates osteosarcoma's spread by acting as an air traffic controller, coordinating multiple functions within cancer cells and allowing them to survive stress conditions. Researchers have developed molecules that block ezrin's function, preventing osteosarcoma spread in mouse models.
A team of Pitt scientists has developed consensus guidelines for thyroid cancer molecular testing to help clinicians make informed decisions about diagnosing the condition. The new guidelines incorporate newly available tests that better incorporate personalized medicine into diagnosing thyroid cancer.
Researchers found that neutrophils divert to nearby precancerous skin cells, causing rapid cell division and potentially leading to melanoma. The study suggests a physical link between wound-associated inflammation and skin cancer progression.
The Damon Runyon Cancer Research Foundation has established a new award to increase the number of physician-scientists in cancer research. The grant provides $100,000 per year for three years and up to $100,000 of medical school debt repayment. Two awardees will investigate novel approaches to fighting cancer.
Researchers at the University of Rochester Medical Center have identified a subgroup of follicular lymphoma patients who experience early disease recurrence despite modern treatments. These patients may require personalized therapy approaches, such as targeted sequencing or gene-expression profiling, to improve their outcomes.
A small pilot study found an experimental treatment approach can send deadly leukemia into remission in patients who have failed standard therapy. The combination of immunotherapy and gene manipulation buys critical time for patients to receive a potentially life-saving stem cell transplant.
A new breath test has shown encouraging results in diagnosing esophageal and gastric cancer by detecting unique chemical compounds in exhaled breath. The test is 90% accurate and can be performed in minutes, compared to hours using traditional methods.
The American College of Cardiology seeks to expand cardio-oncology services to address the growing need for specialized care in cardiovascular health for cancer patients. Currently, many hospital training programs lack formal training or services in this area, and a nationwide survey reveals gaps in resources and best practices.
A new study found that higher levels of soluble TNF receptor type two (sTNF-RII) are linked to reduced memory performance among breast cancer patients before treatment. Memory impairment was observed in patients compared to age-matched control subjects.
A large clinical trial led by The Ottawa Hospital and the University of Ottawa found that CT scans do not improve cancer detection in people with unexplained blood clots. Approximately four percent of patients from each group were diagnosed with cancer within the next year, with no difference in cancer-associated deaths.
The Alberta Cancer Exercise (ACE) pilot study explores a community-based approach to support cancer survivors in regaining their strength and energy levels. Participants receive either standard care or supervised group exercise training, showing promising results for improved physical fitness and mental well-being.
A study by Moffitt Cancer Center researchers highlights the need for stress management tools for Latina women undergoing chemotherapy for breast cancer. Despite facing significant stress-inducing factors, many patients reported a lack of access to these resources.
A consortium of healthcare professionals, game developers, and oncology educators is developing intelligent 'games' to help cancer patients manage their illness through mobile phones. The iManageCancer project aims to provide psychological benefits, greater wellbeing, quality of life, and social support for young cancer patients.
Researchers found that abdominal blood clots are associated with an increased risk of developing undiagnosed cancer, particularly liver and pancreatic cancer. Patients with these clots had poorer survival outcomes compared to those without the clots.
Researchers found that younger thyroid cancer patients with lymph node involvement have a lower survival rate compared to those with no spread. The number of lymph nodes involved plays a role in survival, with six or more nodes increasing the risk of death.
Researchers found that patients positive for HPV16 E1, E4-7, L1, L2, and E2 antibodies had better overall and progression-free survival compared to those negative. This suggests that these antibodies may be used to identify patients at risk of oropharyngeal cancer recurrence and death.
Researchers at Kansas State University have developed a nanoplatform technology that detects human cancer cells and tumors in the early stages. The technology has been awarded US Patent 8,969,027 and shows a 95% success rate in detecting cancer at stage one and beyond.
Researchers have confirmed that eosinophils release special agents attracting immune system's professional killers into cancer tissue, leading to improved cancer rejection and increased survival rates in mice. Eosinophils also normalize blood vessels in the tumor, contributing to tumor rejection.
A new study published in the American Journal of Public Health found that messages with images depicting the harsh realities of melanoma are more powerful than text-only warnings in persuading young women to reconsider indoor tanning. Loss-framed messages emphasizing the risks of indoor tanning were more effective in decreasing intenti...
A joint investigation by UT Southwestern Medical Center and collaborators has identified an enzyme called 15-PGDH that regulates tissue regeneration in multiple organs. By blocking this enzyme with a newly discovered molecule, researchers were able to rescue damaged bone marrow, liver tissue, and colon tissue.
Researchers at UT Southwestern Medical Center have identified a key enzyme, Protein Kinase C (PKC), that regulates glucose transport into cells. This process is critical for maintaining proper glucose levels, which are often abnormal in diseases such as diabetes and cancer. The findings may lead to new treatments for these conditions.
Researchers found that genomic mutations in the TP53, APC, and CDKN2A genes were present in 75% of progressors with Barrett's esophagus. This ability to detect mutations in non-neoplastic mucosa can improve early detection and surveillance for patients at heightened risk for esophageal cancer.
A new study by Cancer Research UK found that breast cancer patients are disproportionately affected, with only 20% having surgery after an emergency diagnosis in hospital. In contrast, those diagnosed via urgent GP referrals have a much higher likelihood of receiving lifesaving surgery.
Researchers use 'Google Maps' for cancer genome analysis, identifying potential drug targets and monitoring treatment response. They provide a comprehensive view of the patient's multiple myeloma genome, showing notable mutations and larger-scale changes over time.
A new study published in Journal of Clinical Oncology finds that early palliative care consultation within six days of hospitalization reduces hospital costs by $1,312 compared to traditional care. Early provision also leads to a 14% reduction in hospital stay cost.
A new study found that patients with mutated IDH genes living with anaplastic astrocytoma had a significantly longer average lifespan compared to those without the mutation. The study also suggested that radiation therapy plus temozolomide may be more effective for patients with mutated IDH.
A Yale University study found that removing more tissue during a partial mastectomy can spare thousands of breast cancer patients from a second surgery. The study showed that cavity shave margins reduced positive margin rates in half without compromising cosmetic outcomes or increasing complication rates.
The myRisk Hereditary Cancer test assesses 25 genes for mutations associated with eight hereditary cancers. Recent studies have found that the test identifies 100.8% more mutations than BRCA1/2 testing alone, including increased mutations in breast and ovarian cancer patients.
Researchers identified a genetic biomarker that can predict which cancer patients will respond to immunotherapy drugs like pembrolizumab. Patients with mismatch repair gene defects showed improved responses to the treatment, offering hope for previously failed patients. Larger studies are needed to assess the potential for clinical use.
Cancer patients often experience significant alteration of their sense of taste during chemotherapy or radiation treatment, leading to malnutrition and weight loss. The study's findings suggest that activating a protein in the Wnt pathway may renew taste buds after chemotherapy.
Researchers at the University of Louisville have successfully treated stage IIIb to IV melanoma patients with a modified cold sore virus, resulting in improved survival rates. The therapy, talimogene laherparepvec (T-VEC), stimulates the immune system to fight cancer cells and has been shown to extend patient survival by 20 months.
A phase I study of ruxolitinib found no dose-limiting toxicities and improved symptoms in 15 evaluable CMML patients. Hematologic improvement and partial responses were observed, particularly in patients with B symptoms.
A study published in Cell Host & Microbe finds a causal link between bacterial infection and gallbladder cancer, suggesting that controlling typhoid fever could reduce the risk of this type of cancer. The researchers propose that prevention through proper treatment with antibiotics, vaccination programs, or better sanitary conditions c...
Researchers at CU Anschutz Medical Campus have discovered a crucial molecular pathway involved in the renewal of taste buds. This finding may help improve the quality of life for cancer patients suffering from chemotherapy-induced taste dysfunction.
Researchers discovered ovarian cancer cells can lock into survival mode and avoid chemotherapy destruction. The study, published in Nature, used whole genome sequencing to analyse tumour DNA samples from 91 patients with high-grade serous ovarian cancer.
A new study found that cancer patients' attitudes and beliefs about complementary and alternative medicine are key predictors of its use. Researchers identified specific factors such as expectation of therapeutic benefits, cost concerns, and physician opinions, which varied by sex, race, and education level.
Exposure to aflatoxin, a liver carcinogen, is associated with an increased risk of gallbladder cancer in a small Chilean study. The study found higher levels of aflatoxin-albumin adducts in patients with gallbladder cancer compared to controls.
A clinical trial at University of Colorado Anschutz Medical Campus demonstrates an intervention that successfully reduces caregiver stress in cancer patients treated with stem cell transplantation. The study shows significant lower stress levels and improved quality of life for caregivers.
In a small clinical trial, researchers safely used immune cells grown from patients' own bone marrow to treat multiple myeloma. Thirteen of 22 patients experienced partial responses, with seven achieving at least 90% tumor cell reduction and living up to 25.1 months without cancer progression.
A traditional Chinese medicine herbal mixture called Ren Shen Yangrong Tang (RSYRT) significantly reduced fatigue in cancer patients with moderate to severe symptoms. In a Phase I/II trial, RSYRT was found to be safe and effective in improving Qi deficiency, a key factor contributing to fatigue.
A new large study finds that women who are diagnosed with breast cancer and have a family history of the disease face no worse of a prognosis after treatment than other women with breast cancer. Successful treatment for breast cancer is just as likely in young patients with a family history of breast cancer, as in those without.
A study has quantified the different mutational profiles of cancer cells in individual tumors, revealing a high degree of variability within one tumor. The researchers found that certain genes behave differently in cancer cells, with some tumors composed of multiple groups with distinct molecular alterations.
Flawed prostate specific antigen data in the SEER program has been removed due to quality control checks. This may affect previous research studies and analyses that rely on these data. Noted urologist Dr. David F. Penson cautions against relying on large administrative databases without proper validation.
A three-year study of 2,000 cancer survivors found that information needs differ depending on cancer type and stage. Breast cancer survivors sought more information about late effects and family risks in early years, while female colon cancer survivors increased their interest in these topics later on.
A phase 1b study has shown impressive response rates of 60-75% in patients with untreated non-small cell lung cancer treated with chemotherapy and an anti-PD-L1 agent. The combination therapy was well-tolerated, with no unexpected toxicities.
A phase III randomized clinical trial suggests that Stereotactic Ablative Radiotherapy (SABR) is equally effective to surgery in treating operable stage I non-small cell lung cancer patients, with better survival rates and lower toxicity. SABR appears to be a suitable alternative for elderly and comorbidity-prone patients.
A recent study from the University of Texas MD Anderson Cancer Center suggests that profiling normal DNA provides an opportunity to identify inherited mutations critical for patients and their families. Researchers sequenced tumor and normal DNA from patients with advanced cancer, identifying germline mutations in nearly all cases.
A Loyola University Medical Center study found that among 205 cases of mesenchymal chondrosarcoma, more than half survived at least five years and 43 percent survived at least 10 years. Survival rates varied depending on tumor location, with axial tumors showing worse outcomes.
A phase I study found that Sym004, a double-targeting EGFR antibody, provides better outcomes than current anti-EGFR therapies in patients with resistant colorectal cancer. The treatment resulted in significant antitumor activity and improved disease-control rates.
Researchers used organoids derived from human tumor samples to test cancer drugs and predict patient response. The findings demonstrate the power of organoids to capture complex mutations in tumours.
A study by Manchester researchers has identified genetic subtypes in high-risk endometrial cancer patients, allowing for more targeted treatments. The classification of these subtypes can predict patient relapse and identify specific mutations that can be targeted with anti-cancer drugs.
Researchers grew 22 organoids from tumor tissue of 20 patients with colorectal cancer and found they closely replicate key properties of the original tumors. These cultures can be used to predict drug sensitivity and pave the way for personalized treatment approaches.
A recent study found that almost half of patients opted out of comprehensive cancer gene screening due to concerns about uncertainty and potential distress. Pre-test counseling significantly reduced anxiety in these patients, but highlighted the need for individualized guidance before genetic testing.
A new study at Ohio State University has identified Foxo1 as a negative regulator of natural killer cell maturation and homing behavior. The findings suggest that reducing Foxo1 expression can enhance NK-cell maturation, providing an opportunity to boost cancer and viral immunity.
Researchers found that patients with GIST are at higher risk of developing other sarcomas, non-Hodgkin's lymphoma, carcinoid tumors, melanoma, and various types of colorectal, esophageal, pancreatic, and renal cell cancers. This association was particularly notable in smaller tumor sizes.
A study published in Cancer Epidemiology & Biomarkers & Prevention found that prolonged statin use after a lung cancer diagnosis was associated with a reduced risk of dying from lung cancer. Patients who used at least 12 prescriptions of statins had a 19% lower risk of lung cancer-specific deaths.