Articles tagged with Cancer Patients
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Researchers at DTU Systems Biology have developed a new diagnostic technology, TumorTracer, which identifies the source of cancer with 85% certainty. The method uses advanced self-learning computer algorithms to analyze DNA mutations in cancer tissue samples.
Researchers have discovered four unique metabolites in urine samples that can accurately distinguish between malignant and benign adrenal tumors. These biomarkers show high sensitivity (94.7%) and specificity (82.6%) for diagnosing cancer, potentially improving treatment decisions for patients with adrenal incidentalomas.
UT Southwestern researchers have developed a classification model for cancers caused by KRAS, the most frequently mutated gene in cancer. The model helps predict the propensity of different KRAS mutants to signal through RAF kinase and could lead to more effective targeted therapies.
Researchers describe a case of a 53-yr-old male with early T-cell precursor leukemia who achieved complete remission after treatment with the NOTCH inhibitor BMS-906024. Genetic and epigenetic analysis revealed that the patient's cancer was driven by hyperactive NOTCH1 signaling, which was successfully targeted by GSI treatment.
Two studies found that minimally invasive laparoscopic-assisted resection did not provide better cancer outcomes compared to open resection for patients with stage II or III rectal cancer. Laparoscopic resection was also shown to be inferior in terms of cancer control and adequacy of removal.
A randomized clinical trial published in JAMA found that laparoscopic surgery for rectal cancer has not yet been established as a routine procedure. The ALaCaRT trial showed similar success rates and fewer complications compared to open surgery, but with some concerns about margin involvement.
A genetic polymorphism in the EPAS1 gene has been associated with poor prognosis and enhanced expression in patients with non-small cell lung cancer. The study found that individuals with the A allele had a significantly shorter overall survival time compared to those with the G allele.
Cancer cases worldwide are projected to reach almost 22 million by 2030, with low- and middle-income countries facing unsustainable economic burdens. Effective cancer prevention campaigns have shown promising results in Taiwan, Rwanda, and Brazil, highlighting the importance of rapid implementation of control programs.
Researchers have discovered a new approach to understanding cancer mechanisms, biomarkers, and treatments using RNA editing events. The study, published in Cancer Cell, found that specific RNA editing processes could selectively affect drug sensitivity and may lead to the development of targeted therapies.
A Mayo Clinic study found that genetic differences among races affect colon cancer recurrence. Tumors from whites were twice as likely to have BRAF mutations, while black tumors had the highest frequency of KRAS mutations, leading to a higher risk of recurrence among young blacks.
KW-0761 efficiently eliminates Tregs from the blood of patients with lung or esophageal cancer, potentially augmenting the natural anticancer immune response. The study found a modest induction of antitumor immune responses and no marked clinical responses in patients treated with KW-0761 monotherapy.
A study of 47,000 patients found that nearly a third received more than 25 radiation treatments, despite guidelines recommending no more than 15. Privately insured patients were 40% more likely to be overtreated, highlighting the need for education and financial transparency.
The Lancet Oncology Commission highlights the vital role of primary care doctors in preventing, detecting, survivorship, and palliative care. Effective integration between primary and specialist care is crucial to meet the growing demand for cancer care.
The article explores eight big questions in cancer research, including the role of genetic mutations, tumor microenvironments, and epigenetics. Researchers discuss the importance of targeted treatments, prevention, and screening, as well as the potential for precision medicine to improve cancer outcomes.
A major new Commission reveals that over three-quarters of people with cancer worldwide have no access to safe surgery, with the global economy facing potential losses of over $6 trillion by 2030. The shortage is worst in low-income countries, where as many as 95% of people with cancer do not receive basic cancer surgery.
Cancer patients with high cardiovascular hormone/peptide levels have a shorter survival rate, even without clinical signs of heart disease or infection. These biomarkers indicate heart tissue damage directly linked to cancer progression.
The CheckMate 057 trial shows that nivolumab improves overall and 12-month survival rates compared to docetaxel in non-squamous non-small cell lung cancer patients. Nivolumab also demonstrated better patient-reported outcomes, including quality of life and slower disease deterioration.
A large study found that aspirin use after a cancer diagnosis significantly increases overall survival rates for patients with gastrointestinal tumours. The researchers analysed data from nearly 14,000 patients and discovered a strong association between aspirin use and improved survival.
A phase III trial has shown that 177Lu-DOTATATE significantly improves progression-free survival in patients with mid-gut neuroendocrine tumours, a rare and hard-to-treat disease. The treatment outperforms standard care in terms of time without disease progression.
Research highlights significant disparities in cancer care among migrants and refugees, with lower rates of early diagnosis and treatment. The European Society for Medical Oncology calls for policy changes to address these disparities and improve access to quality cancer care.
Researchers found molecular differences in younger-onset CRC tumors related to epigenetics and gene expression. This discovery could lead to tailored treatments for younger patients. The study analyzed genetic mutations in 126 under-50 patients and 368 over-50 patients, revealing distinctive patterns.
A global shortfall in radiotherapy resources has led to millions of unnecessary deaths, but investing in radiotherapy services could bring economic benefits of up to $365 billion over the next 20 years. Access to radiotherapy is currently unacceptably low, especially in Africa, where most countries have no facilities.
Patients with advanced throat cancer who underwent primary surgery had significantly higher overall survival rates compared to those who did not. The study found that radical surgery improved survival in both oropharyngeal and hypopharyngeal cancers, with notable benefits for patients with stage III and IVa disease.
The EUROCARE 5 study shows significant geographical variations in survival from blood cancers in Europe, with the highest five-year relative survival rate for Hodgkin lymphoma at 81% in Northern European countries. In contrast, chronic myeloid leukemia had a significantly lower survival rate of 53%, particularly in Eastern Europe.
The CheckMate 025 phase III clinical trial shows that nivolumab significantly prolongs survival in patients with advanced kidney cancer, regardless of PD-L1 expression. The study found a median overall survival of 25 months for nivolumab-treated patients compared to 19.6 months for those treated with everolimus.
Individualized medicine is revolutionizing patient care through precision diagnostics, such as preventing drug-related adverse effects and identifying disease susceptibility. Whole exome sequencing is also offering new diagnoses for patients with undiagnosed diseases.
Researchers suggest that combining epigenetic therapies with immunotherapies could restore cell-surface molecules that help the immune system eliminate cancer cells. Epigenetic drugs can also lower or eliminate immune cells that facilitate tumor growth.
A new study identifies USP19 as a potential drug target for muscle wasting diseases in cancer patients, improving quality of life and longevity. The research team discovered that inhibiting the USP19 gene could protect against muscle wasting in mice models.
A new study reveals that social factors such as insurance status, marital status, and county-level income significantly affect the chances of survival in young patients with acute myelogenous leukemia (AML). The findings highlight the need to address these non-biological patient characteristics to improve health outcomes.
A new study shows that a small implantable device can attract and capture malignant cells in breast cancer patients, potentially giving doctors earlier warnings of relapse. The device exploits the natural attraction of cancer cells to specific areas of the body, slowing down their spread to other organs.
Researchers discovered that Tie1 controls angiogenesis and vascular remodeling by differentially regulating Tie2 in tip and stalk cells, making it a promising therapeutic target for cancer treatment and eye diseases.
A multiple myeloma patient experienced complete remission after receiving a personalized cellular therapy called CTL019, which targets cancerous white blood cells. The treatment was combined with chemotherapy and an autologous stem cell transplant, and the patient remains in remission over 12 months after infusion.
Researchers found that microRNA 506 acts as a tumor suppressor in gastric cancer, inhibiting angiogenesis and metastasis. Patients with high miR-506 expression have significantly longer survival times compared to those with low expression levels.
Researchers at Baylor College of Medicine have discovered a new way to kill cancers driven by the MYC gene, which is responsible for aggressive behavior in many types of malignancies. By inhibiting the spliceosome, a complex machine within cancer cells, scientists can target and destroy tumor cells without harming normal tissues.
The use of contralateral prophylactic mastectomy (CPM) among US men with breast cancer has increased significantly, rising from 3% to 5.6% between 2004 and 2011. The procedure was more common in younger, white, and privately insured patients.
A study published in JAMA found that incorporating genomic sequencing and counseling into pediatric cancer treatment improved patient outcomes and changed treatment plans. The study showed that nearly half of patients had actionable findings that led to individualized actions, including genetic counseling and changes in treatment.
A new study found that using a patient's entire genome helped suggest personalized treatment options for nearly half of children with cancer. The approach led to specific treatment changes in a quarter of these patients and showed promise in treating difficult-to-treat cancers.
Researchers found that MACC1 expression is a key indicator of survival and recurrence risk in Klatskin carcinoma patients. Patients with low MACC1 levels have a good chance of benefiting from surgery, while those with high levels are at a higher risk of cancer recurrence.
Researchers at Ohio State University Comprehensive Cancer Center have designed an online database called CanDL to help molecular pathologists identify key cancer gene mutations. The freely accessible database includes information on 60 genes, 334 distinct variants and 169 unique matching literature references across multiple cancers.
Researchers have developed a blood test that can identify patients at risk of breast cancer relapse months before visible signs appear. The test detects cancer DNA in the bloodstream, allowing for early intervention and personalized treatment.
A Veterans Affairs team found that longer-lasting colonoscopies are associated with lower cancer rates. Doctors with average withdrawal times of under six minutes had patients more than twice as likely to have cancer. Experts recommend focusing quality-improvement efforts on withdrawal times of under six minutes.
A study by German Cancer Research Center discovered that citric acid from lemon juice can alter the morphology of norovirus particles, reducing their infectivity. The researchers found that citrate binds to specific proteins on the virus, preventing it from attaching to host cells.
A new analysis found that patients taking certain heart medications to manage stress may have a longer survival time than those not taking these drugs. Nonselective beta blockers showed the most significant benefit in extending median survival time, particularly among patients with hypertension.
A study found that fertility concerns led a third of young women with breast cancer to decline or discontinue tamoxifen. The study also showed that a quarter of women who started tamoxifen stopped taking it before the recommended treatment period ended.
Researchers from MSK Cancer Center announce results from the first published basket study, a clinical trial design that explores drug responses based on specific tumor mutations. The study found preliminary clinical efficacy of vemurafenib in multiple non-melanoma BRAFV600-mutated cancers.
A study of over 100,000 women with ductal carcinoma in situ (DCIS) found that the 20-year breast cancer-specific death rate was 3.3 percent, higher for women under 35 and black women compared to non-Hispanic white women. Preventing ipsilateral invasive recurrence did not reduce mortality from breast cancer, according to researchers.
A study by UC Davis researchers has identified two biomarkers that can detect lung cancer up to six months before diagnosis, with an 80% accuracy rate. The findings offer a promising alternative to expensive low-dose CT scans, which involve X-ray radiation.
A study of 900 cancer patients found that heparin treatment did not significantly reduce recurrent blood clots or deaths compared to warfarin, but was associated with lower nonmajor bleeding rates. Heparin was also shown to be safe in this population, supporting its use over warfarin.
Researchers have discovered that a type of jumping gene called LINE-1 is actively inserted into the human genome in various gastrointestinal cancers. The findings suggest that these insertions may occur early in cancer development and could potentially serve as a marker for early cancer diagnosis.
A Mayo Clinic-led study has validated the National Cancer Institute's Patient Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), a tool used to track side effects in cancer clinical trials. The study found that PRO-CTCAE was accurate, reliable and responsive compared to other measures.
A new method for personalizing bladder cancer treatments has been developed by researchers at the University of California - Davis Health. The approach uses tumor xenografts to identify effective therapies, which can be tested in mice before being administered to patients.
A study found that screening women with suspected hereditary breast or ovarian cancer risk for additional genes provides important information for changing clinical management. Most patients with identified mutations were recommended for enhanced screening or preventive measures, and close relatives should also be screened.
A study by University of California, San Diego researchers found that Medicare reimbursement for radiation therapy varies widely among patients with breast, lung, and prostate cancer. Factors such as provider type, location, and clinic type accounted for most of the variation in costs.
Research reveals that spiritual beliefs are significantly associated with better physical health, reduced anxiety and depression, and improved social roles in cancer patients. Emotional aspects of religion and spirituality have the strongest links to positive mental and social outcomes.
A study at the University of Texas MD Anderson Cancer Center found that CSN6 is overexpressed in colorectal cancer tissue samples, leading to poor survival rates. The biomarker's deregulation can lead to cancer development through cellular signaling pathways.
A new Cancer Research UK study reveals that England's cancer survival rates remain lower than those of countries with similar healthcare systems, despite steady improvements. The study found five-year survival from breast cancer improved more in England than in four leading countries, but overall cancer survival was lowest in England.
Two California Initiative to Advance Precision Medicine projects aim to treat pediatric cancer with genetic analysis and diagnose acute infections using DNA sequencing. The projects, led by UCSF researchers, have the potential to deliver precision medicine tests and therapies within 18-24 months.
The George Washington University Cancer Institute has been awarded a $250,000 Engagement Award by the Patient-Centered Outcomes Research Institute (PCORI) to create an online Community of Practice for patient-centered care. The project aims to disseminate patient-centered outcomes research broadly and foster collaboration among researc...
A study of over 70,000 cancer patients found that those referred late by their GP were more likely to be dissatisfied with their care. Patients who experienced referral delays reported negative experiences across various aspects of their care, including diagnosis and treatment.
Researchers at the University of North Carolina have discovered a rare type of stem cell that is immune to radiation damage due to high levels of Sox9. This finding could lead to new ways to protect the gastrointestinal system of cancer patients before treatment, allowing for more aggressive treatments to be used.