Articles tagged with Cancer Patients
The Society for Cardiovascular Angiography and Interventions has released a consensus statement providing guidance for treating patients with concomitant cardiovascular disease and cancer. The document aims to increase the competency of cardiovascular professionals in caring for cancer patients, who are expected to increase to 20 milli...
A new study reveals that adult retinoblastoma survivors are at higher risk of developing various medical problems, including second cancers, compared to unaffected individuals. Despite this, the majority of survivors report excellent general health and minimal long-term impact on their psychological or socio-economic outcomes.
A new study published in JAMA Oncology found that solid-organ transplant recipients have a significantly higher cancer death rate than the general population. The research, which analyzed data from over 11,000 transplanted patients between 1991 and 2010, revealed that SOTRs were at increased risk of cancer death regardless of age, sex,...
A recent study published in PLOS ONE found that statins increased overall survival among late-stage SCLC patients, while other medications showed no benefit. Radiotherapy was also identified as an independent predictor of survival.
Scientists at USC have discovered the Achilles heel of hepatocellular carcinoma, a leading cause of cancer deaths worldwide. Researchers identified the carcinogenic pathway of stem cell marker NANOG, which promotes cancer spread by rewiring metabolism in mitochondria.
The Association for Cancer Physicians has released a new strategy to improve cancer patient services and outcomes in the UK. The comprehensive plan focuses on delivering excellent and safe medical oncology care, contributing to NHS development, and providing innovative approaches to cancer care.
Researchers have identified NORAD, a long noncoding RNA, as crucial in maintaining proper chromosome numbers. Absence of NORAD leads to genomic instability and cells losing or gaining whole chromosomes.
A study by Case Western Reserve University School of Medicine found that a tailored video education program improved cancer patients' knowledge and reduced negative attitudes towards clinical trials. The PRE-ACT program was more effective than text-based information in encouraging participants to consider clinical trials.
A study published in PLOS Genetics found that members of four unrelated US families shared an identical BAP1 gene mutation, which increases cancer risk. The researchers traced the ancestral connection back to a couple who immigrated from Germany in the early 1700s.
A recent study published in the Journal of the American Medical Association found that paid sick leave can significantly reduce the financial burden on cancer patients. The study, which surveyed over 1,300 patients with stage 3 colorectal cancer, showed that those with paid sick leave were nearly twice as likely to retain their jobs af...
A new analysis found that nearly 60% of metastatic cancer patients experience some change in employment due to illness. Controlling symptoms is key for many patients to remain employed, with better performance status and non-Hispanic White ethnicity/race being associated with continued work.
A study found that postmenopausal women with periodontal disease were more likely to develop breast cancer than those without the condition. The risk was particularly high among women who had quit smoking recently, suggesting a potential link between bacterial exposure and breast cancer risk.
A study published in Gastrointestinal Endoscopy found ESD to be a safe and effective treatment for superficial pharyngeal cancer, achieving an en bloc resection rate of 100% and complete resection rate of 79.5%. The procedure showed minimal side effects, with a three-year overall survival rate of 97.7%.
A study published in The Journal of Urology found that patients with low mental health self-assessments before radical cystectomy had higher rates of high-grade complications, highlighting the importance of preoperative assessment.
Researchers found that family members of CUP patients have a higher risk of developing cancers such as lung, pancreas, and colon cancer. The study identified specific sites where these cancers may originate, providing new guidance for physicians and potentially improving treatment outcomes.
The ESMO Asia 2015 Congress brought together cancer experts to discuss the latest treatment solutions and patient care. Researchers presented promising findings on immunotherapy and targeted therapy for difficult-to-treat head-and-neck cancers, as well as combination therapies for endocrine-resistant breast cancer.
A new study by the American College of Surgeons found that preoperative use of blood-thinning drugs does not increase major bleeding rates in cancer patients undergoing major operations. The study also revealed a lower risk of developing deep vein thrombosis and pulmonary embolism in patients who received preoperative VTE prophylaxis.
New research reveals that current genome analysis approaches miss detecting complex cancer mutations in well-known genes that could be targeted by existing drugs. The developed software tool, Pindel-C, identifies a large number of such events in critical cancer genes.
Improved screening and detection efforts have reduced cancer incidence and mortality rates in several common types of cancer in high-income countries. However, many low-and middle-income countries have seen a rise in cancer rates due to factors such as lifestyle changes and inadequate screening or prevention measures.
A new study reveals that Latinos from Mexico have the lowest chance of getting colorectal cancer, while those from Central or South America are diagnosed with the disease before age 50 at a higher rate. The research aims to pave the way for personalized cancer care and reduce disparities in treatment
Thyroid cancer patients report poor quality of life after diagnosis and treatment compared to other patients with more lethal cancers. Researchers found that thyroid cancer survivors reported an average quality of life score of 5.56 out of 10, which is worse than other cancer types.
A single dose of psilocybin significantly decreases anxiety and depression in cancer patients, with positive effects lasting up to 6 months. The study suggests that psilocybin may be a sufficient treatment for mood disturbances in cancer patients.
A study identified significant differences in cancer genome sequencing procedures and quality among research institutions, leading to inconsistencies in detected mutations. A reference mutation dataset has been established to improve procedures for identifying true somatic mutations in cancer genomes.
Recent studies present new data on the myRisk Hereditary Cancer test, highlighting its ability to identify patients with deleterious mutations who may have been missed by traditional genetic testing. The test demonstrated a significant increase in identifying BRCA-related mutations among those tested without BRCA1/2 results.
A gold standard data record has been established to improve cancer genome analysis and detect somatic mutations reliably. The record, obtained from interlaboratory testing, provides a basis for laboratories to evaluate their bioinformatic methods and thresholds for detecting specific mutations.
Research from the University of Pennsylvania School of Medicine found that pre- and post-test counseling for genetic mutations increases knowledge and decreases anxiety in BRCA-negative patients. After testing, most women reported declines in general anxiety and improvements in genetic knowledge.
A Singapore-led team, with support from the Swiss Rising Tide Foundation, is conducting a Phase III clinical trial to evaluate Aspirin as secondary prevention therapy for patients with established colorectal cancer. The study aims to determine the effectiveness of Aspirin in reducing cancer recurrence and mortality.
A phase I/II clinical trial found that acalabrutinib promotes high response rates and durable results in patients with relapsed chronic lymphocytic leukemia while producing minimal side effects. The drug's selective blockade of the BTK pathway may offer improved tolerability compared to other treatments.
Researchers developed a new index identifying concurrent but unrelated diseases among AYA cancer patients, highlighting prevalence of mental illness, obesity, and cardiovascular conditions. The AYA HOPE Comorbidity Index can predict service needs and improve treatment outcomes for young cancer patients.
A study of 87 CLL patients found 12 genetic mutations that can be targeted by therapies already available for other cancers, including PARP and BRAF inhibitors. These mutations were detected through next-generation sequencing and may offer new treatment options for patients who fail current therapies.
Yale researchers developed a high-dose flu vaccine strategy that lowered infection rates by 64% among patients with immune system cancers. The novel dosing schedule improved protection against all flu strains in 66% of patients, offering promising results for cancer patient populations.
Researchers report improvements in four children treated with gene therapy for Wiskott-Aldrich syndrome, including reduced bleeding events and improved immunologic symptoms. The treatment's long-term safety and efficacy remain to be assessed as the children are monitored for 15 years.
Scientists create virtual tumors to test drug treatments, achieving an 85-86% correlation with lab results. The goal is a patient-specific workflow for early diagnosis and effective treatment identification.
A new study in mice successfully preserved fertility using ovarian follicles, producing live births and addressing concerns about reintroducing cancer cells. The technique could be beneficial for women with cancer who cannot afford to delay treatment.
The EurocanPlatform project has led to the establishment of Cancer Core Europe, a long-term initiative between six leading cancer centers aiming to create a single virtual 'e-hospital' with powerful translational platforms. This will provide robust computational biology pipelines and standardized imaging for personalized cancer medicine.
Researchers found that different regions of a single tumor shared varying levels of genetic mutations, ranging from 67% to 93%. This variation could make it harder for targeted therapies to work effectively. The study's findings have significant implications for treatment recommendations and patient care.
A feasibility study found that women with breast cancer experienced improved feelings of positivity, control, and meaning after tending small indoor 'garden bowls'. The benefits were attributed to the process of nurturing and reflecting on the garden, suggesting a simple ecotherapy-based intervention can have significant impacts.
Researchers at Kyoto University have discovered that an antibody called nivolumab may help patients with platinum-resistant ovarian cancer heal themselves by targeting the PD-1 signal. A phase II clinical trial found that most patients treated with nivolumab experienced a median overall survival of 20 months.
A study published in Radiology found that MRI-detected multicentric cancers are larger and potentially more aggressive than index cancers detected by mammography, necessitating treatment changes. In 25% of cases, these multicentric cancers were over 1 centimeter in size.
A recent EORTC study identified key health-related quality of life (HRQOL) components to prioritize in caring for older cancer patients. The study found that HRQOL improves with age for social functioning and financial problems, while physical functioning and constipation worsen.
A preclinical study finds that AR-42, an HDAC inhibitor, preserves muscle health and function while stopping life-threatening muscle wasting associated with advanced cancers. The experimental agent was shown to have a strong protective effect against tumor-associated muscle wasting in two preclinical models.
The Translational Oncology Initiative aims to connect scientists and clinicians to develop life-saving therapies for cancer patients. The 'Trojan Horse' therapy uses a virus hidden in immune cells to destroy cancer cells from within.
A new template published by ASTRO streamlines post-treatment care for cancer survivors, facilitating consistency and reducing provider burden. The template includes elements required by CoC accreditation requirements, coordinating care among primary care providers, radiation specialists, and patients.
Researchers found that combinations of non-toxic chemicals, many derived from plants and foods, may stop untreatable cancers and prevent disease relapses. The task force identified 74 molecular targets with potential anti-cancer effects, paving the way for low-cost therapies.
Researchers at the University of Montreal Hospital Research Centre have developed a new injectable biogel that can deliver anti-cancer agents directly into cancerous tumours. The biogel is effective in killing cancer cells and has shown promising results in laboratory tests, including the destruction of melanoma and kidney cancer cells.
Researchers analyzed genomic data from 1,120 pediatric cancer patients and found that 8.5% had pathogenic germline mutations in cancer predisposition genes. This study suggests that comprehensive genomic screening may be necessary for all pediatric cancer patients, not just those with a family history of cancer.
A global task force of 180 scientists has identified high-priority molecular targets for improved patient outcomes in most cancers. The team recommends low-toxicity approaches using non-toxic chemicals, including those found in plants and foods, to reach a broad-spectrum of priority targets.
A novel immunotherapeutic approach, personalized peptide vaccination, showed significant improvement in overall survival for patients with advanced bladder cancer. The study found a median overall survival of almost twice as long as that for patients without the treatment, at 7.9 months versus 4.1 months.
A recent study found that 8.5% of children with cancer have genetic mutations increasing their risk, highlighting the need for improved counseling and family testing. The study's author, Dr. John M. Maris, emphasizes the importance of understanding how other genes interact with these mutations to cause cancer in children.
A broad-spectrum approach to cancer treatment and prevention is being developed by researchers, focusing on low-toxicity agents from plants and foods that target multiple pathways involved in cancer development. The approach aims to improve upon current targeted therapies and reduce costs associated with toxicity and treatment duration.
A meta-analysis of traditional Chinese medicine and nonpharmacological interventions found that they alleviate symptoms such as depression, fatigue, and pain in Chinese cancer patients. These interventions include acupuncture, therapeutic massage, stress management, cognitive behavioral therapy, and physical training.
Men with prostate cancer who undergo radiation therapy can benefit from yoga, which stabilizes fatigue, sexual health, and urinary incontinence. Yoga also improves general quality of life by reducing cancer-related fatigue and strengthening pelvic floor muscles.
African-American women with a healthier diet, based on the Alternate Healthy Eating Index-2010 (AHEI-2010), were 34% less likely to be diagnosed with ovarian cancer. The study found that higher vegetable intake and lower intake of empty calories contributed to the reduced risk.
Early-stage non-small cell lung cancer patients receive varying levels of curative-intent surgery across US states, with disparities seen by race and socioeconomic factors. The study found that Massachusetts had the highest rates of curative surgery, while Wyoming had the lowest rate at 25%.
A new study analyzed 527 patients who underwent spinal fusion surgery using recombinant human bone morphogenetic protein (rhBMP) and found high rates of successful fusion and low rates of complications. The study found no significantly increased risk of cancer, contradicting previous concerns.
A study found that kidney failure patients on dialysis were at high risk of kidney and thyroid cancers, while those post-transplant were at higher risk of non-Hodgkin lymphoma and melanoma. The findings highlight the importance of cancer screening and prevention in these patients.
Dr. Electra Paskett receives AACR Distinguished Lecture on Cancer Health Disparities for her decades-long contributions to reducing cancer health disparities among underserved populations. Her work has led to critically important improvements in cancer screening and care, earning her international recognition as a leader in the field.
A phase I clinical trial found that pevonedistat, a small-molecule inhibitor of the NEDD8-activating enzyme, was safe and tolerable in heavily pretreated patients with relapsed/refractory lymphoma. The therapeutic showed modest activity in these patients, with three achieving partial responses and 30 experiencing stable disease.
Researchers from the University of Leicester have announced a breakthrough advance in treating chronic lymphocytic leukemia and non-Hodgkin lymphoma patients who are refractory or resistant to current chemotherapies. The new drug, ONO/GS-4059, targets BTK protein and has shown promising results with minimal toxicities.
A new blood test can detect when breast cancers become resistant to standard hormone treatment, allowing for early identification and alternative treatment options. Researchers developed the test to identify ESR1 mutations, which convey resistance to hormone treatment.