Articles tagged with Cancer Patients
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A recent study discovered that microRNA miR-181a suppresses tumor cell proliferation and survival in highly aggressive large B-cell lymphomas by reducing NFkappaB signaling. This finding provides hope for developing novel therapies targeting this pathway.
Researchers identified a class of drugs called histone deacetylase (HDAC) inhibitors that stimulate T cell movement into tumors and enhance their activity. HDAC inhibitor romidepsin combined with PD-1-targeting antibody leads to lung tumor regression.
Researchers have determined the atomic structure of separase, an enzyme that breaks down proteins and plays a central role in cell division. This discovery could lead to better treatments for cancer, which occurs when cells divide out of control.
Researchers have discovered that a cancer drug can effectively treat venous malformations, a condition characterized by deformed blood vessels. The treatment uses a topical cream that targets the mutations causing VMs, offering new hope for patients with this often incurable condition.
A large study from Japan found that cancer patients who died at home tended to live longer than those who died in hospitals. The study suggests that oncologists should not hesitate to refer patients for home-based palliative care. Home death may have a positive influence on survival, contrary to previous concerns.
A new two-drug combination significantly reduces the number and size of precancerous polyps in the small intestine of hereditary cancer patients. Researchers found a 71% overall reduction in polyps, with most side effects being tolerable, offering a promising prevention treatment for this high-risk patient group.
A study found that a drug combination of sulindac and erlotinib effectively reduced duodenal polyp burden and number in familial adenomatous polyposis patients. However, the treatment was associated with acne-like rash and other adverse events.
Researchers at TGen highlight the advantages of using RNA sequencing in disease detection and management, including its potential for non-invasive diagnosis and guiding treatment selection. The analysis reveals the promise of RNA-based measurements for broad application across diverse areas of human health.
A study presented at the 2016 USCAP Conference found that HER4 expression is associated with chemotherapy resistance and a lower survival rate in ovarian serous cancer patients. The research, led by Moffitt Cancer Center pathologists, suggests that HER4 may be a prognostic and potentially predictive marker for this type of cancer.
Advanced genomic sequencing helped identify a potentially deadly fungus, Sarocladium kiliense, in tainted anti-nausea medication given to dozens of cancer patients in Chile and Colombia. The use of whole-genome sequence typing revealed nearly genetically indistinguishable isolates from patient samples and unopened medication vials.
Researchers at Moffitt Cancer Center found that neutralizing the acidic tumor environment increases the efficacy of several immune-targeting cancer therapies. Sodium bicarbonate, combined with PD-1 or CTLA-4 inhibitors, reduced melanoma and pancreatic tumor growth in mice.
A study analyzing US cancer survivor data reveals nearly 29% face financial burden due to cancer diagnosis and treatment. Cancer survivors with financial problems experience lower physical and mental health-related quality of life, higher risk of depressed mood and psychological distress.
Researchers at UT Southwestern Medical Center have developed a novel approach to improve cancer immunotherapy by recruiting T cells into tumors using a fusion protein called antibody-LIGHT. The study found that this strategy can overcome tumor resistance and increase the response rate to immune checkpoint blockade therapy.
A new study found that active surveillance for low-risk prostate cancer significantly improves urinary function, reduces incontinence, and enhances sexual satisfaction. Men on active surveillance reported a similar quality of life to those without cancer, highlighting its potential as an alternative to curative treatment.
A new study from the University of Texas M. D. Anderson Cancer Center found that neurofeedback significantly reduces chronic pain and improves quality of life in cancer patients with chemotherapy-induced neuropathy. The treatment, which uses electroencephalogram biofeedback to modify brain activity, showed a 73% improvement rate in pai...
A new study has revealed significant biological differences between male and female breast cancers, shedding light on why male patients often receive delayed diagnoses. Researchers hope this knowledge will enable better treatment choices for Male BC patients, including the use of chemotherapy and targeted agents.
A new study found that low expression of SMARCA4/BRG1 gene in lung tumors may indicate patients who will benefit from certain chemotherapy regimens. The findings suggest an alternative therapy for these patients to spare them from cisplatin's side effects and allow them to try a different treatment sooner.
A Swedish cohort study found that surgeons need to perform at least 15 operations to obtain stable survival results during the first months after oesophagectomy. The learning curve for achieving optimal long-term survival takes 60 operations, highlighting the importance of proper mentorship and training programs.
A study of 3879 patients found that 3.6% developed venous thromboembolism within a month, increasing to 4.7% at 2 months and 5.4% at 3 months. Most VTE events occurred after hospital discharge, and the study identified no strong predictive factors for the condition.
A cross-sectional survey found that detailed clinician communication can alleviate patient distress associated with incidental pulmonary nodules. Patients who received accurate information about their nodule size and diagnosis had a more reassuring experience, reducing anxiety and improving overall well-being.
Glioblastoma patients with high BIRC3 expression have shorter overall survival rates, while those with low expression live longer. Analyzing BIRC3 tissue levels could help detect treatment resistance earlier.
Scientists have discovered unique mutations on all cancer cells, known as tumour antigens, which can be targeted by the immune system. This breakthrough could lead to more effective immunotherapies and personalized treatment plans for patients with advanced stages of cancer.
A pilot study analyzed 1,516 tweets containing lung cancer-related content, finding that most were about support or prevention, while clinical trials were underrepresented. The study suggests that Twitter may be a useful tool for clinical researchers but also poses challenges related to privacy and noncoercive content.
Researchers found that nearly 18% of lung cancer tweets were about clinical trials, with many focused on immunotherapy. However, none of these tweets were used for recruitment and did not provide links to enrollment websites.
Researchers found that patients with lung and colorectal cancer who had financial distress at diagnosis reported significantly increased pain, symptom burden, and poorer quality of life. The study highlights the need for clinicians to target resources and treatments for patients struggling financially.
A study found that patients with inflammatory bowel disease and a history of cancer did not experience a significant increase in cancer risk when treated with anti-TNF therapy. In fact, 96% of patients were still alive and cancer-free after one year.
Scientists have identified a spectrum of genetic alterations, including some that may be clinically actionable and others that could improve diagnostics and screening for patients. The study's findings suggest targeted therapies and immunotherapies could be effective treatments for mesothelioma.
Researchers have discovered a new biomarker, guanine nucleotide exchange factors (GEFs), that triggers hyperactivity in proteins fueling cancer growth and spread. Elevated GEF expression is associated with shorter progression-free survival in patients with metastatic colorectal cancer.
Researchers at UT Southwestern Medical Center found that light reflectance spectroscopy can differentiate between malignant and benign prostate tissue with 85% accuracy. This technology aims to improve surgical decision-making and reduce the amount of healthy tissue removed during prostate cancer surgery.
A recent study found that over half of elderly colorectal cancer patients receive ineffective treatments, leading to significant financial burdens. The study examined data from over 20,000 Medicare patients between 2000 and 2009, revealing a 32% increase in treatment costs and only a one-month increase in median survival.
The Geographical Management of Cancer Health Disparities Program (GMaP) grant supports region-specific cancer research, education, outreach, and training needs. Moffitt serves as the hub for GMaP Region 2, which includes partner institutions in Alabama, Arkansas, Florida, Georgia, Louisiana, Missouri, Mississippi, and Puerto Rico.
Researchers at H. Lee Moffitt Cancer Center develop adaptive therapy to keep resistant cells in check, prolonging survival without disease progression in mouse models of triple-negative and ER+ breast cancer. The approach is being tested in a clinical trial for prostate cancer patients.
A recent study has found that most US cancer prevention guidelines do not provide sufficient information on benefits and harms, making it difficult for clinicians and patients to make informed decisions. The researchers analyzed data from various guidelines and found that 39% of recommendations were given comparable ratings, while 14.5...
Researchers found that children with ALL who live in high-poverty areas are substantially more likely to experience early relapse, which is harder to treat. Despite receiving the same treatment, these patients have a higher risk of relapse within 36 months after first achieving complete remission.
A study of 105 cancer patients found significant sleep disturbances before radiotherapy treatment. These problems were associated with cancer progression, prior treatments like chemotherapy, and anxiety. Researchers warn that addressing these issues is crucial for improving patient quality of life.
A study published in the JNCI: Journal of the National Cancer Institute found that PET scans did not improve two-year survival rates for lung and esophageal cancer patients. The researchers suggest potential overuse of PET scans in detecting recurrence, warranting efforts to decrease unnecessary utilization.
A study from Lund University in Sweden found that childhood cancer survivors who received certain types of chemotherapy may experience impaired eye movement and balance. The study, which included 23 childhood cancer survivors, compared their eye movement skills to those of healthy individuals of the same age.
A study published in Cancer found that combining chemotherapy with radiation therapy improves survival rates among a subset of elderly head and neck cancer patients, specifically those aged 71 to 79. This improvement was not previously shown in patients older than 70 years.
Uninsured and Medicaid patients with head and neck cancer more likely to present with advanced tumors, experience higher mortality rates. Radiation therapy and surgery used less often for these patients.
Researchers mapped molecular signatures in HPV-positive throat cancer patients based on smoking status. Heavy smokers had higher rates of mutations, including HLA-A and tobacco-exposure associated genes, which predicted poorer survival outcomes. These findings support more aggressive treatment for some patients.
Research found that advanced age, black ethnicity, and pre-existing illnesses like cancer significantly increase the likelihood of bowel obstruction in hospitalized ischemic stroke patients. These complications can worsen recovery chances and lead to increased hospital length of stay and costs.
Researchers at the University of Cincinnati have discovered that a human cancer-causing gene called DEK can be detected in the plasma of head and neck cancer patients. High levels of DEK may indicate better outcomes for patients, while low levels are associated with advanced cancers.
Most recurrences of HPV-positive oropharyngeal cancer can be detected through imaging and physical exams within 6 months after treatment. The study found that disease characteristics, such as lymph node size and number, increase the likelihood of recurrence.
A large-scale analysis of patient records found that chemotherapy before radiation therapy did not improve overall survival rates for head and neck cancer patients. Patients who received concurrent chemotherapy and radiation had slightly longer median overall survival times compared to those receiving chemotherapy alone.
A large-scale analysis of patient records found that induction chemotherapy did not improve overall survival rates or increase the likelihood of receiving a full course of radiation therapy. The study compared more than 8,000 patients who received induction chemotherapy with those who received concurrent chemoradiation.
A combination of durvalumab and tremelimumab has been found to be effective in treating advanced non-small cell lung cancer patients, with 23% achieving a complete or partial response. The treatment also appears to be active in PD-L1-negative tumors.
Colorectal cancer patients require follow-up colonoscopy after surgery to detect second cancers and polyps, with recommended intervals varying from one to nine years. The US Multi-Society Task Force updates guidelines to emphasize the role of colonoscopy in post-surgical surveillance.
Two leading research groups independently discovered ONC201's ability to activate the integrated stress response, a powerful anti-cancer pathway. This understanding supports Oncoceutics' oncology indications and demonstrates ONC201's potential as an important therapeutic.
Researchers found that viewing graphic anti-smoking images on cigarette packs triggers activity in brain areas involved in emotion, decision-making and memory. The findings suggest these images could effectively warn smokers about cigarettes' health consequences and motivate a change in behavior.
Researchers at MD Anderson Cancer Center proposed a new staging system for HPV-related oropharyngeal cancer, which better separates patients with different survival rates. The new groupings were proven to have greater predictive power than the current system, particularly in identifying stage III disease with a high risk of death.
The Cancer Treatment Centers of America is hosting its second Annual New Treatments in Oncology (ANTO) conference on March 5 at the W Scottsdale hotel. The event will feature leading oncologists discussing recent advances and innovations in cancer research, treatment options, and patient care.
A UCLA study reveals that cancer surgery significantly increases the risk of injuries and age-related health issues in older patients, leading to prolonged hospital stays, increased healthcare costs, and a higher risk of death. The study highlights the importance of discussing potential events with doctors before surgery.
A new test has shown that patients with advanced bowel cancer who have high levels of two proteins can benefit from a combination of drugs, leading to improved cancer growth. The test could help select the best treatment for each individual patient, potentially improving survival rates and quality of life.
Cancer patients face financial distress due to rising medication costs, according to Dr. Scott Ramsey's editorial. To address this issue, policy interventions are proposed, including price negotiations with manufacturers and greater transparency of pricing.
Researchers analyze 500 scientific articles to develop a mathematical model for muscle-invasive bladder cancer. They identify potential biomarkers and clinical parameters to accurately determine cancer stage and develop individual treatment strategies.
The Journal of Pain Research publishes commentary on terminology of chronic pain, highlighting the need to redefine terms to better understand and treat patients. The authors suggest using origin- and generator-based terms to improve diagnosis and treatment outcomes.
Researchers found four Ly6 genes are overexpressed in various cancers, leading to poorer survival rates and drug resistance. The study uses big data analysis to identify novel targets for new drugs.
Researchers at Johns Hopkins University found a possible marker for recurring HPV-linked oropharyngeal cancers. The study suggests that an increase in E6 antibody levels after treatment may indicate a higher risk of cancer returning.
A 28-year-old transgender woman experienced a delay in testicular cancer diagnosis due to inadequate access to insurance coverage and transportation challenges. The case study emphasizes the importance of addressing biopsychosocial needs and creating venues for medical providers to learn appropriate care for transgender patients.
A set of risk factors can predict the magnitude of survival benefit offered by radiation therapy following breast cancer surgery. Radiation therapy provides a significant survival benefit for patients with more aggressive cancer, particularly those with higher prognostic scores.