Articles tagged with Cancer Patients
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Researchers found that increasing doses of cisplatin were associated with increased hearing loss at most tested frequencies, and high blood pressure was also linked to hearing loss in these patients. Comprehensive hearing assessments are recommended for survivors given cisplatin-based chemotherapy.
Researchers at Johns Hopkins found an association between microbiome makeup and head and neck cancer. The study suggests that specific bacterial populations may be used to discriminate between patients with cancer and healthy individuals.
Researchers have identified a protein called GlyRS that contributes to higher mortality in breast cancer patients by launching cancer growth. The study suggests targeting this protein could lead to the development of new anti-cancer therapies.
A new treatment developed by UTSA researcher Matthew Gdovin can kill up to 95% of cancer cells in two hours using a single dose and a beam of light. The method involves injecting a chemical compound into the tumor and then exposing it to a beam of light, causing the cells to become acidic and commit suicide.
A study of patients who died at VA hospitals found that family-reported end-of-life care was significantly better for those with cancer or dementia than for those with other serious illnesses. Increasing access to palliative care may improve quality of end-of-life care for patients dying of heart, lung, and kidney diseases.
The study found that families reported better quality of end-of-life care for patients with cancer or dementia compared to those with end-stage renal disease (ESRD), cardiopulmonary failure, or frailty. Palliative care consultations, do-not-resuscitate orders, and setting of death were associated with improved quality of care.
Obese male mice produce female pups that are overweight and have delayed breast tissue development, linked to increased breast cancer risk. Researchers found epigenetic changes in miRNA signatures of dad's sperm and daughter's breast tissue
Researchers at Johns Hopkins Medicine report a link between cancer immunotherapy drugs and rheumatologic diseases, including inflammatory arthritis. The study highlights the need for awareness among patients and clinicians about potential side effects of these drugs.
A Yale-led study found that the EGFR cancer gene silences tumor suppressor genes in lung and glioblastoma brain cancers using a common mechanism. This discovery informs future research directions and may help determine how effective treatments will be against different EGFR mutations.
A landmark study has identified five new potential genes linked to bowel cancer, while also confirming the role of major existing genes in increasing risk. The research suggests that minor DNA variations play a significant role in inherited risk and environmental factors, with potential implications for prevention and treatment.
Researchers developed a new CAR T cell therapy that targets solid tumors using an antibody-carbohydrate combination. The therapy was shown to be effective in mouse models of pancreatic cancer, with increased survival rates and no damage to normal human cells.
Researchers at H. Lee Moffitt Cancer Center & Research Institute used a mathematical model to show that tumor cells on the edge and interior develop distinct characteristics, investing resources in survival or invasion, respectively.
Researchers have identified three primary molecular sub-groups of bladder cancer, with distinct characteristics and disease-developing patterns. The findings may enable more effective risk assessment and tailored treatment options for patients with superficial tumours.
Researchers identified a small-molecule inhibitor that disrupted the recruitment of Mastermind-like protein 1 to the Notch transcription complex, inhibiting cancer cell growth and supressing tumor growth in mouse xenograft studies. This discovery represents a new paradigm for Notch-based anticancer therapeutics.
A new fluorescent agent and imaging system guided surgeons in real-time to remove additional ovarian tumors that were not visible without fluorescence or could not be felt during surgery. This improved visualization allowed for the detection of an additional 29% of malignant lesions.
A novel CT-based calculation method, SULps, accurately measures lean body mass using computed tomography, leading to more precise PET imaging results. This improvement enables better staging of disease and therapy monitoring in cancer patients.
Scientists at Washington University School of Medicine identified over 850 DNA mutations linked to cancer that may be responsive to existing drugs. The study provides a list of mutations and associated drugs that could benefit patients, expanding the number of cancer treatments available.
Researchers found that blocking PRMT5 forces resistant brain-tumor cells into senescence, slowing or stopping tumor growth. This approach may offer a new treatment option for patients with glioblastoma.
A recent survey found that less than half of family physicians believe that lung cancer screening using low-dose computed tomography (LDCT) reduces lung cancer-related deaths. Despite the American Cancer Society's support for LDCT screening, many physicians are unsure about current recommendations.
Researchers at University of California - Davis Health found that patients with late-stage lung cancer who undergo surgery have better survival rates than those who don't. However, only 11% of these patients receive surgery, highlighting a need for improved access to care.
A new mutation in the ZBTB7A gene boosts energy metabolism in leukemia cells, promoting their growth and survival. This discovery offers a promising therapeutic target for treating acute myeloid leukemia (AML) patients.
Researchers develop a new method to analyze genetic sequences, known as SURVIV, which can predict cancer patients' survival times with greater accuracy. This technique may also enable doctors to target specific genetic sequences that could fight disease, according to the study published in Nature Communications.
A new breath test has been developed to identify lung cancer after surgery, using a simple, affordable process that analyzes carbonyl volatile organic compounds in exhaled breath. The test shows great potential for detecting lung cancer at any point, both as primary screening and post-surgery monitoring.
The Harold Alfond Foundation's charitable gift will support The Jackson Laboratory's efforts to enhance cancer diagnostics and treatment in Maine. JAX aims to provide precision cancer care using the latest genetic technologies to determine the best treatment for each patient.
Scientists identified 11 major groups of AML, each with unique genetic changes driving the disease. The study's findings improve diagnosis and treatment for young AML patients by predicting survival rates based on genetic complexity.
A study by Loyola Medicine found that mesothelioma surgery, specifically pleurectomy and decortication, improves quality of life in patients. The procedure can control fluid buildup, improve breathing, and reduce cancer pain, with benefits observed as early as one month after surgery.
A study published in JNCI found that patients treated at high-volume centers had statistically significant longer overall survival compared to those at low-volume centers. The difference was greater than 10% at two years, suggesting improved disease control and management of adverse effects.
Regular skin checks during PCP visits improve melanoma detection and treatment outcomes. Thinner melanomas detected through screening have a better prognosis than thicker ones.
Researchers from Scripps Research Institute have been awarded $1.3 million to optimize probes for a new cancer treatment approach. The study focuses on the retinoic acid receptor-related orphan receptors (ROR) gamma and molecules that bind to it, aiming to trigger immune cells to attack tumor cells.
Researchers analyzed data from Washington State hospital database and found no difference in cancer rates between patients who received rhBMP and those who did not. The study's findings suggest that additional follow-up is needed to rule out any longer-term increase in cancer risk.
A study found that nearly two-thirds of younger cancer patients with metastatic disease received hospitalization, emergency room visits, or chemotherapy in their last 30 days. Researchers call for earlier discussions on palliative care to improve quality of life.
Researchers from Thomas Jefferson University have identified a panel of microRNAs in blood samples that can predict patients at high risk of developing hepatocellular carcinoma, the most common type of liver cancer, in individuals infected with hepatitis B virus.
Preliminary results suggest that the selinexor combination regimen is active in relapsed and refractory multiple myeloma. Of 10 evaluable patients, two each achieved a very good partial response, a partial response, and a minimal response.
A Phase II clinical trial conducted by MD Anderson Cancer Center found that nivolumab significantly improves outcomes for patients with squamous cell carcinoma of the anal canal, with a control rate of 70%. The study enrolled 39 patients and demonstrated efficacy in both HIV-positive and non-HIV positive populations.
A clinical trial shows atezolizumab, a checkpoint inhibitor, is effective in treating advanced bladder cancer, shrinking tumors and stopping new growth. The drug was well-tolerated, with mild side effects, and half of patients responded within 15 weeks.
A clinical trial found that patients with tumors overexpressing DLL3 responded better to the experimental drug rovalpituzumab tesirine (Rova-T), achieving stabilization of disease and significant tumor reductions. The results suggest Rova-T may be a promising treatment option for advanced small cell lung cancer.
A Phase 3 clinical trial found that patients with high-risk neuroblastoma who received two autologous stem-cell transplants had higher event-free and overall survival rates compared to those who underwent a single transplant. The study also showed improved outcomes when immunotherapy was added to the treatment regimen.
A Phase I/II clinical trial found that nivolumab reduced tumor burden in 24.4 percent of patients with metastatic bladder cancer, regardless of PD-L1 marker presence. The treatment was well-tolerated and showed a median survival of at least one year for 45.6% of patients.
Researchers at H. Lee Moffitt Cancer Center report a safe and effective treatment regimen for recurrent high-grade glioma brain tumors, with durable disease control in three patients. The combination of pembrolizumab, bevacizumab, and radiation therapy shows promise as a potential new approach to treating these patients.
A new pre-surgery technique using an expandable tube may make colostomy bags redundant for emergency bowel cancer patients. The study found that less than half of those who had their bowel unblocked needed a colostomy bag, while more than two-thirds required one after emergency surgery.
Researchers at UT Southwestern Medical Center discovered that between 14 to 25 percent of lung cancer patients also have immune disease, making them unsuitable for immunotherapy treatments. This finding raises critical questions about the effectiveness and toxicity of these treatments among patients with autoimmune diseases.
A study found that genes involved in the Wnt signaling pathway are more frequently altered in younger patients with colorectal cancer. This pathway drives the growth and proliferation of cancer stem cells. The research suggests targeting this pathway may be a promising strategy for treating aggressive CRC in young patients
A study found that while overall colorectal cancer rates are decreasing, the incidence of late-stage cancer in young patients is increasing. The study, which analyzed data from Colorado patients, reveals a significant rise in late-stage CRC diagnoses among those under 50.
Researchers from UH Seidman Cancer Center will present data on a new online tool for estimating individualized survival probabilities in patients with newly diagnosed glioblastoma. The studies also explore promising new treatments, including pembrolizumab for head and neck squamous cell carcinoma, and improve patient participation in c...
A University of Colorado study found that Hispanic white and non-Hispanic black young adults are more likely to die from cancer than their white counterparts, with mortality risks ranging from 1.36 to 1.77 times higher.
A recent study found that over one-in-four cancer patients struggle to afford medical care, leading to missed appointments and prescription delays. The researchers highlight the need for support programs to help patients navigate financial difficulties.
A new study finds that delivering genetic test results to patients at risk for cancer-causing mutations over the phone reduces costs and access burdens. Patients who received phone counseling reported fewer barriers to accessing genetic counseling services than those who received in-person counseling.
Dr. Glen Weiss presents five innovative cancer studies at ASCO, including liquid biopsies for predicting treatment improvements and promising results with avelumab against recurrent-refractory ovarian cancer. Brigatinib shows substantial antitumor activity in ALK non-small cell lung cancer patients.
Researchers at the University of Rochester Medical Center found that exercise can significantly reduce neuropathic symptoms in cancer patients undergoing chemotherapy. The study, which involved over 300 participants, showed that a six-week walking routine with gentle resistance-band training reduced pain and sensitivity to cold. Exerci...
In a phase 3 study, Lutathera treatment results in improved progression-free survival and higher objective radiographic response rates compared to Octreotide LAR. The safety profile of Lutathera was also favorable with low-grade adverse events.
A Moffitt Cancer Center study found that combining nivolumab and ipilimumab is an active treatment option for small cell lung cancer patients who have failed initial therapy. The two-drug immunotherapy regimen resulted in responses that lasted longer than many other investigational agents, with 20% of patients showing a response.
A study of nearly 49,000 obese patients found that bariatric surgery significantly lowers mortality rates, with a 57% reduction in all-cause deaths compared to non-surgical patients. Cardiovascular disease and cancer were the leading causes of death in both groups.
Researchers discovered that Pten's phosphatase activity counteracts PI3 kinase activity, leading to uncontrolled cell proliferation and survival. Mutant mice lacking critical amino acids form tumors at high frequency, making them susceptible to targeted cancer therapy.
A new study from Mount Sinai researchers reports a high success rate for a personalized medicine program that uses an integrated genomic approach to guide cancer treatment. The program led to therapeutic recommendations for 91% of patients, outperforming targeted cancer panels in clinical use.
A study by University of Houston Graduate College of Social Work researchers examines the perceptions and preferences of older Latinos with advanced cancer regarding news on their diagnosis or prognosis. The investigation aims to identify culturally appropriate training for physicians and providers, promoting quality end-of-life care.
Incorporating laboratory mice that are old and obese into immunotherapy treatments for cancer can hasten therapeutic breakthroughs. The use of young, healthy mice is often preferred, but this approach may not accurately reflect the human immune system's response to treatment.
A new blood test has identified a subset of patients with stomach cancer who are most likely to respond to treatment. The test measures the number of copies of the FGFR2 gene in cancer DNA circulating in the bloodstream, revealing that tumours with many copies of this gene were particularly susceptible to an experimental drug.
Researchers developed a new method of diagnosing colorectal cancer using 3D hydrogel biochips, which detect tumor-associated glycans and improve sensitivity. The study analyzed sera from 33 patients with colorectal cancer, 69 healthy donors, and 27 patients with inflammatory bowel disease.
Researchers aim to reduce unnecessary surgeries and pelvic sepsis by analyzing magnetic resonance images and pathological specimens. They will develop a risk-assessment scoring system to determine which patients need surgery after chemotherapy and radiation treatments.
Clinical trials of the anti-cancer agent PAC-1 are continuing to expand, thanks to a $7 million angel investment. The U.S. Food and Drug Administration has granted PAC-1 orphan drug status for the treatment of glioblastoma multiforme, a deadly brain cancer with limited therapeutic options.