Articles tagged with Cancer Patients
A retrospective clinical study found that patients with melanoma who received both ipilimumab and local peripheral treatments had significantly prolonged overall survival compared to those who received only ipilimumab. The median overall survival for these patients was 93 weeks, compared to 42 weeks for those receiving only ipilimumab.
A new study found delirium to be relatively frequent and underdiagnosed among advanced cancer patients visiting the emergency department, regardless of age. The study highlights the need for better assessment and monitoring of delirium in this population.
A study by Rice University and MD Anderson Cancer Center found significant differences in adherence to recommended cancer treatment for elderly patients across 22 Texas hospital referral regions. Regional variations in treatment rates persist despite the presence of treatment specialists and teaching hospitals.
The review highlights the effectiveness of WHO cancer pain relief guidelines in promoting cancer pain relief. The guidelines have been widely adopted despite initial release in 1986, making them a valuable resource for healthcare providers.
A phase II clinical study found that treating metastatic thyroid cancer patients with the BRAF mutation showed promising anti-tumor activity in a third of patients, with an overall response rate of 38%. The therapy vemurafenib joins other effective treatments for this patient population.
Sorafenib treatment reduces immune-suppressive phenotypes in HCC patients, including decreased PD-1 expression and lower regulatory T cells. These responses correlate with increased overall survival.
A new study found that while more imaging after thyroid cancer treatment identifies recurrence, it does not always lead to improved survival. Radioiodine scans, however, were associated with better outcomes.
A high dietary intake of omega 3 fatty acids from oily fish may help lower the risk of death from bowel cancer in patients diagnosed with the disease. Patients with a higher omega 3 intake were found to have a 41% lower risk of dying from their disease, according to researchers.
Cancer Research UK has tripled its investment in pancreatic cancer research, aiming to improve diagnosis and treatment. The charity hopes to develop better treatments and improve survival rates for patients affected by the disease.
Researchers discovered a correlation between rare POLE mutations in bowel cancers and improved patient outcomes. These tumours are less likely to recur, particularly when diagnosed at an early stage.
Researchers found daily meetings between physicians and intensivists, care protocols, and pharmacist presence are associated with increased survival rates among cancer patients in ICUs. These simple processes can reduce mortality by up to 70% and promote cost reduction.
A study at the University of Texas MD Anderson Cancer Center found that genetic mutations in DNA mismatch repair deficiency (dMMR) are present in 15% of colorectal cancer cases. The study identified MSH2 and MSH6 as the most commonly affected genes, providing a new approach to diagnosis and treatment using precision medicine.
The GW Cancer Center will train patients and healthcare providers on how to improve communications for better health, with a focus on patient health literacy and cultural sensitivity. The project aims to examine the impact of various factors such as gender, race, and income on the patient-provider relationship.
Researchers have found an association between adjuvant chemotherapy and improved survival in stage 2 colon cancer patients, contradicting current clinical guidelines. The study analyzed 153,110 patients with stage 2 colon cancer and found that those who received adjuvant chemotherapy survived longer than those who did not.
The Damon Runyon Cancer Research Foundation has awarded over $4 million to 10 top clinical investigators to support patient-oriented cancer research. The award aims to address the shortage of physicians capable of translating scientific discovery into new breakthroughs for cancer patients.
A study found that nearly all cancer patients overestimate their chances of survival compared to their doctors' estimates. The researchers emphasize the importance of accurate communication between physicians and patients in making informed treatment decisions.
A new study finds that most patients with advanced cancer report optimistic survival expectations despite clinicians' more conservative estimates. Patients from diverse backgrounds also show disparities in understanding their oncologists' opinions.
A national initiative prioritized research on venous thrombosis (VTE) in cancer patients, citing a 20% prevalence rate and increased risk with chemotherapy. The study identified key areas for future research, including platelet contributions to VTE and the impact of cancer therapies on blood cells.
A new study found that patients who develop heart failure after their first heart attack are at a higher risk of developing cancer. After an average of 4.9 years of follow-up, 21% of these patients were diagnosed with cancer, compared to 8.2% of those without heart failure.
The Moffitt Cancer Center is conducting a nationwide study on e-cigarette use, tracking 2,500 adult smokers who use both cigarettes and e-cigarettes. The study aims to understand the long-term impact of e-cigarettes on traditional cigarette use.
A new study found that individuals with diabetes may have a higher risk of developing cancer before and immediately after a diabetes diagnosis. The study suggests that type 2 diabetes may increase the risk of several types of cancer, particularly shortly after diagnosis.
Researchers at H. Lee Moffitt Cancer Center discovered a novel way to control SETDB1 protein activity through monoubiquitination, which inhibits target gene expression and could lead to new cancer therapeutics. This breakthrough suggests E2 enzymes as attractive targets for cancer treatment.
A diagnosis of high cholesterol is associated with reduced mortality and improved survival in four common cancers: lung, breast, prostate, and bowel cancer. Statins are linked to lower risk of death, with significant reductions seen in all four types of cancer.
A recent study has discovered a strong link between genetic mutations and sensitivity to specific drugs in patient-derived cancer cell lines. The researchers found that these cell lines harbor most of the same genetic changes found in patients' tumors, making them useful models for identifying effective treatments.
A study led by Boston Children's Hospital researchers finds that the loss of let-7 microRNA family is central to neuroblastoma development. The study suggests strategies focused on restoring let-7 could provide a fresh, low-toxicity approach to treating this childhood cancer.
A genetic test that spots cancer-related DNA in blood can accurately predict colon cancer recurrence, according to a study of Australian patients. The 'liquid biopsy' detected DNA fragments in the blood of 20 patients with early-stage colon cancer, 11 of whom developed recurrences.
A phase II study evaluates the safety of palbociclib in African American patients, including those with benign ethnic neutropenia. The study aims to determine if these patients can safely use the drug, which was previously excluded due to risk of infection.
The research team will explore the biological and genetic underpinnings of breast cancer in African-American women, with a focus on identifying novel genes and gene pathways. The study aims to improve knowledge of breast cancer biology, particularly for this population.
A genetic test detecting tumor DNA in blood accurately predicts colon cancer recurrence in some patients. The test could help clinicians decide which patients need additional treatment after surgery, improving diagnostic approaches and potentially increasing survival rates.
A new study reveals that Argentine tango practice can significantly improve balance and reduce falls risk among cancer patients experiencing peripheral neuropathy. The dance intervention course reduced standing postural sway by 56% in just five weeks, providing a promising balance intervention for cancer survivors.
Researchers identified genetic mutations in immune system genes that may lead to synchronous colorectal cancer, a rare type of bowel tumor. The study found that these patients have inherited damaging mutations that can cause an inflammatory environment in the gut, increasing the frequency of independent cancer-initiating events.
The article introduces a new 'game plan' for oncologists to incorporate new therapies and approaches into clinical guidelines quickly. CancerLinQ, a web-based rapid-learning system, will provide point-of-care clinical decision support with the latest evidence-based recommendations.
MABp1 improves symptoms, reduces inflammation and increases clinical response rate by 76%, with a 3x longer survival time for responders. Excellent safety and tolerability were also observed.
The study projects that by 2040, there will be 26.1 million cancer survivors in the US, with 73% aged 65 or older. Increasing age increases the chance of comorbid conditions, and gaps exist between men and women in older age groups.
A phase III trial found that chemoradiotherapy after surgery for gastric cancer (GC) does not achieve better outcomes than post-operative chemotherapy. The study, which involved 788 patients, showed equivalent five-year survival rates of 40.8% in both treatment arms.
A new study reveals that only 8% of patients with large, apparently benign polyps have cancer, suggesting advanced endoscopic treatments like EMR and ESD as viable options. This finding could improve patient outcomes, reduce complications, and lower healthcare costs.
Researchers developed a novel method to identify likely cancer drivers among hundreds of genomic alterations. The technique uses tumor gene alterations to report on cancer progression, pinpointing GON4L as a potential driver and therapeutic target.
A Rice University lab developed a predictive model to treat leukemia patients, using a unique set of patient data. The top-performing models were able to predict patient response to therapy with an accuracy of close to 80 percent.
A study found that adults with acute leukemia had a significantly higher risk of death if they lived in certain North Carolina regions with limited healthcare resources. Researchers analyzed data from 2003 to 2009 and found that patients in these areas were more likely to die, even after controlling for other factors.
Researchers found that increasing doses of cisplatin were associated with increased hearing loss at most tested frequencies, and high blood pressure was also linked to hearing loss in these patients. Comprehensive hearing assessments are recommended for survivors given cisplatin-based chemotherapy.
Researchers at Johns Hopkins found an association between microbiome makeup and head and neck cancer. The study suggests that specific bacterial populations may be used to discriminate between patients with cancer and healthy individuals.
Researchers have identified a protein called GlyRS that contributes to higher mortality in breast cancer patients by launching cancer growth. The study suggests targeting this protein could lead to the development of new anti-cancer therapies.
A new treatment developed by UTSA researcher Matthew Gdovin can kill up to 95% of cancer cells in two hours using a single dose and a beam of light. The method involves injecting a chemical compound into the tumor and then exposing it to a beam of light, causing the cells to become acidic and commit suicide.
A study of patients who died at VA hospitals found that family-reported end-of-life care was significantly better for those with cancer or dementia than for those with other serious illnesses. Increasing access to palliative care may improve quality of end-of-life care for patients dying of heart, lung, and kidney diseases.
The study found that families reported better quality of end-of-life care for patients with cancer or dementia compared to those with end-stage renal disease (ESRD), cardiopulmonary failure, or frailty. Palliative care consultations, do-not-resuscitate orders, and setting of death were associated with improved quality of care.
Obese male mice produce female pups that are overweight and have delayed breast tissue development, linked to increased breast cancer risk. Researchers found epigenetic changes in miRNA signatures of dad's sperm and daughter's breast tissue
Researchers at Johns Hopkins Medicine report a link between cancer immunotherapy drugs and rheumatologic diseases, including inflammatory arthritis. The study highlights the need for awareness among patients and clinicians about potential side effects of these drugs.
A Yale-led study found that the EGFR cancer gene silences tumor suppressor genes in lung and glioblastoma brain cancers using a common mechanism. This discovery informs future research directions and may help determine how effective treatments will be against different EGFR mutations.
A landmark study has identified five new potential genes linked to bowel cancer, while also confirming the role of major existing genes in increasing risk. The research suggests that minor DNA variations play a significant role in inherited risk and environmental factors, with potential implications for prevention and treatment.
Researchers developed a new CAR T cell therapy that targets solid tumors using an antibody-carbohydrate combination. The therapy was shown to be effective in mouse models of pancreatic cancer, with increased survival rates and no damage to normal human cells.
Researchers at H. Lee Moffitt Cancer Center & Research Institute used a mathematical model to show that tumor cells on the edge and interior develop distinct characteristics, investing resources in survival or invasion, respectively.
Researchers have identified three primary molecular sub-groups of bladder cancer, with distinct characteristics and disease-developing patterns. The findings may enable more effective risk assessment and tailored treatment options for patients with superficial tumours.
Researchers identified a small-molecule inhibitor that disrupted the recruitment of Mastermind-like protein 1 to the Notch transcription complex, inhibiting cancer cell growth and supressing tumor growth in mouse xenograft studies. This discovery represents a new paradigm for Notch-based anticancer therapeutics.
A new fluorescent agent and imaging system guided surgeons in real-time to remove additional ovarian tumors that were not visible without fluorescence or could not be felt during surgery. This improved visualization allowed for the detection of an additional 29% of malignant lesions.
A novel CT-based calculation method, SULps, accurately measures lean body mass using computed tomography, leading to more precise PET imaging results. This improvement enables better staging of disease and therapy monitoring in cancer patients.
Scientists at Washington University School of Medicine identified over 850 DNA mutations linked to cancer that may be responsive to existing drugs. The study provides a list of mutations and associated drugs that could benefit patients, expanding the number of cancer treatments available.
Researchers found that blocking PRMT5 forces resistant brain-tumor cells into senescence, slowing or stopping tumor growth. This approach may offer a new treatment option for patients with glioblastoma.
A recent survey found that less than half of family physicians believe that lung cancer screening using low-dose computed tomography (LDCT) reduces lung cancer-related deaths. Despite the American Cancer Society's support for LDCT screening, many physicians are unsure about current recommendations.
Researchers at University of California - Davis Health found that patients with late-stage lung cancer who undergo surgery have better survival rates than those who don't. However, only 11% of these patients receive surgery, highlighting a need for improved access to care.
A new mutation in the ZBTB7A gene boosts energy metabolism in leukemia cells, promoting their growth and survival. This discovery offers a promising therapeutic target for treating acute myeloid leukemia (AML) patients.