Articles tagged with Cancer Patients
Researchers at UT Southwestern Medical Center discovered that between 14 to 25 percent of lung cancer patients also have immune disease, making them unsuitable for immunotherapy treatments. This finding raises critical questions about the effectiveness and toxicity of these treatments among patients with autoimmune diseases.
A study found that genes involved in the Wnt signaling pathway are more frequently altered in younger patients with colorectal cancer. This pathway drives the growth and proliferation of cancer stem cells. The research suggests targeting this pathway may be a promising strategy for treating aggressive CRC in young patients
A study found that while overall colorectal cancer rates are decreasing, the incidence of late-stage cancer in young patients is increasing. The study, which analyzed data from Colorado patients, reveals a significant rise in late-stage CRC diagnoses among those under 50.
Researchers from UH Seidman Cancer Center will present data on a new online tool for estimating individualized survival probabilities in patients with newly diagnosed glioblastoma. The studies also explore promising new treatments, including pembrolizumab for head and neck squamous cell carcinoma, and improve patient participation in c...
A University of Colorado study found that Hispanic white and non-Hispanic black young adults are more likely to die from cancer than their white counterparts, with mortality risks ranging from 1.36 to 1.77 times higher.
A recent study found that over one-in-four cancer patients struggle to afford medical care, leading to missed appointments and prescription delays. The researchers highlight the need for support programs to help patients navigate financial difficulties.
A new study finds that delivering genetic test results to patients at risk for cancer-causing mutations over the phone reduces costs and access burdens. Patients who received phone counseling reported fewer barriers to accessing genetic counseling services than those who received in-person counseling.
Dr. Glen Weiss presents five innovative cancer studies at ASCO, including liquid biopsies for predicting treatment improvements and promising results with avelumab against recurrent-refractory ovarian cancer. Brigatinib shows substantial antitumor activity in ALK non-small cell lung cancer patients.
Researchers at the University of Rochester Medical Center found that exercise can significantly reduce neuropathic symptoms in cancer patients undergoing chemotherapy. The study, which involved over 300 participants, showed that a six-week walking routine with gentle resistance-band training reduced pain and sensitivity to cold. Exerci...
In a phase 3 study, Lutathera treatment results in improved progression-free survival and higher objective radiographic response rates compared to Octreotide LAR. The safety profile of Lutathera was also favorable with low-grade adverse events.
A Moffitt Cancer Center study found that combining nivolumab and ipilimumab is an active treatment option for small cell lung cancer patients who have failed initial therapy. The two-drug immunotherapy regimen resulted in responses that lasted longer than many other investigational agents, with 20% of patients showing a response.
A study of nearly 49,000 obese patients found that bariatric surgery significantly lowers mortality rates, with a 57% reduction in all-cause deaths compared to non-surgical patients. Cardiovascular disease and cancer were the leading causes of death in both groups.
Researchers discovered that Pten's phosphatase activity counteracts PI3 kinase activity, leading to uncontrolled cell proliferation and survival. Mutant mice lacking critical amino acids form tumors at high frequency, making them susceptible to targeted cancer therapy.
A new study from Mount Sinai researchers reports a high success rate for a personalized medicine program that uses an integrated genomic approach to guide cancer treatment. The program led to therapeutic recommendations for 91% of patients, outperforming targeted cancer panels in clinical use.
A study by University of Houston Graduate College of Social Work researchers examines the perceptions and preferences of older Latinos with advanced cancer regarding news on their diagnosis or prognosis. The investigation aims to identify culturally appropriate training for physicians and providers, promoting quality end-of-life care.
Incorporating laboratory mice that are old and obese into immunotherapy treatments for cancer can hasten therapeutic breakthroughs. The use of young, healthy mice is often preferred, but this approach may not accurately reflect the human immune system's response to treatment.
A new blood test has identified a subset of patients with stomach cancer who are most likely to respond to treatment. The test measures the number of copies of the FGFR2 gene in cancer DNA circulating in the bloodstream, revealing that tumours with many copies of this gene were particularly susceptible to an experimental drug.
Researchers developed a new method of diagnosing colorectal cancer using 3D hydrogel biochips, which detect tumor-associated glycans and improve sensitivity. The study analyzed sera from 33 patients with colorectal cancer, 69 healthy donors, and 27 patients with inflammatory bowel disease.
Researchers aim to reduce unnecessary surgeries and pelvic sepsis by analyzing magnetic resonance images and pathological specimens. They will develop a risk-assessment scoring system to determine which patients need surgery after chemotherapy and radiation treatments.
Clinical trials of the anti-cancer agent PAC-1 are continuing to expand, thanks to a $7 million angel investment. The U.S. Food and Drug Administration has granted PAC-1 orphan drug status for the treatment of glioblastoma multiforme, a deadly brain cancer with limited therapeutic options.
Researchers identified 2,314 genetic changes in polyps and adjacent mucosa, revealing potential drug targets for colorectal cancer prevention. The study also found similarities between premalignant and cancerous tissue, suggesting that polyps with more genetic changes may be more likely to develop into CRC.
A phase I clinical trial showed that abemaciclib achieved durable clinical activity in patients with breast cancer, non-small cell lung cancer, glioblastoma, and melanoma. Radiographic responses were observed for some patients with hormone receptor-positive breast cancer and NSCLC.
The Damon Runyon Cancer Research Foundation has selected five physician-scientists to receive the Physician-Scientist Training Award, providing them with resources to pursue cancer research. The awardees will receive grants totaling $2.3 million to aid their work in addressing the growing need for cancer research.
Researchers at Dana-Farber Cancer Institute present studies on the influence of tumor location on colorectal cancer survival, breast cancer clinical trial participation among older patients, and support for medical marijuana use in children with cancer. The findings suggest that consistent reporting of tumor location is crucial for imp...
A new study shows success with a combination therapy of the sugar 2-Deoxy-D-glucose (2-DG) and fenofibrate, which selectively starves slow-growing cancer cells while sparing normal cells. This approach eliminates toxic chemotherapy side effects, paving the way for non-toxic treatments for various cancers.
Researchers discover USP14 as a promising biomarker for predicting endometrial cancer recurrence. Women with high levels of USP14 are seven times more likely to recur than those with low levels, highlighting the potential for tailored treatment approaches.
The Samfund, a Boston-based cancer organization, will receive $8,500 from ASTRO for its work in supporting young adult cancer survivors financially. The grant funding will support the development of new financial programs and tools to aid in recovery.
A new study finds HIV-infected patients are more likely to lack cancer treatment for various cancers, including head and neck, upper gastrointestinal tract, and lung cancers. The disparity remains after adjusting for insurance status and comorbidities.
A new study published in Nature Medicine highlights the potential of big data to unlock the secrets inside cancer cells and enable more effective personalised treatments. The study proposes a blueprint for sharing patient data to improve patient outcomes.
Analysis of NCDB data shows that patients who received four quality measures had significantly higher overall median survival, increasing more than three-fold. However, compliance with these measures varies widely among patients, with only 13% receiving all four interventions.
Researchers from Memorial Sloan Kettering Cancer Center share results of experience with over 500 patients with pulmonary metastases from STS, identifying prognostic factors associated with improved survival. The study found that leiomyosarcoma histologic subtype, primary tumor size, and minimally invasive resections were significantly...
A genetic variation in the VAC14 gene is highly associated with docetaxel-induced peripheral neuropathy in prostate cancer patients. This finding could lead to more personalized treatment approaches and reduced side effects.
Research shows that 1 in 5 colorectal cancer patients are depressed at diagnosis, and this can significantly impact their quality of life. The study highlights the importance of considering psychological factors in patient care and support.
Boston Cancer Support, a nonprofit organization, will receive an $8,500 ASTRO Survivor Circle grant to support its work providing patient transportation and online resources. The organization aims to alleviate one of the largest issues faced by cancer patients: affordable transportation to treatments.
The Society of Surgical Oncology and European Society of Surgical Oncology propose a global curriculum to address training variations and inadequacies. The curriculum aims to create a robust workforce of well-trained surgical oncologists to meet the growing need resulting from the rising global cancer burden.
A new chemical sensor developed by Polish researchers can detect the presence of neopterin, a biomarker for certain cancers. The sensor uses molecular imprinting technology to capture molecules of neopterin from body fluids, with high accuracy and selectivity.
The report, based on over 3,000 patient surveys, sheds light on the physical, emotional, financial, practical, and informational needs of cancer patients during and after treatment. It aims to inform program development and address patient needs throughout their continuum of care.
Researchers discovered that cancer cells can escape the immune system by disabling the NLRC5 gene, which regulates MHC class I genes. This finding provides a new biomarker for predicting cancer patient survival and could lead to novel therapeutic strategies.
A new study found that cancer increases the risk for certain health issues beyond normal aging, including declines in activities of daily living and physical function. However, having a cancer diagnosis did not increase the likelihood of developing arthritis or vision/hearing problems, and did not exacerbate existing conditions.
A study published in Cancer Cell identified a third class of ACC, associated genes, and potential treatment targets. The research aims to provide better treatments for this rare cancer with significant side effects from current therapies.
Scientists at Helmholtz Munich discovered that fasting induces the production of a protein called GADD45β, which reduces fatty acid absorption in the liver and improves sugar metabolism. This finding holds promise for therapeutic intervention in metabolic diseases like type 2 diabetes.
A new study by researchers at the University of Pennsylvania's Abramson Cancer Center found that testing non-breast cancer genes in high-risk women does not add clinical benefit. The study analyzed a large panel of genes and found that many variants were of uncertain significance, adding complexity to genetic counseling.
A new staging system aims to explain revision rhinoplasty complexity and manage patient expectations. The PGS Staging System assesses three components: problem, graft, and previous surgical procedures, as well as a 'patient expectations' component.
Researchers found no association between cancer and a decreased risk for Alzheimer's disease, contrary to previous studies. Higher mortality rates among cancer patients suggest other factors contribute to the development of the neurodegenerative disorder.
Loyola researchers identified a tumor gene that predicts survival outcomes in mouth and tongue cancer patients. The spectrin gene is expressed in 4.6 times more likely to die, requiring more aggressive treatment.
Five teams of cancer researchers received a total of $1 million to advance 'innovation in collaboration' through new research projects. The awards will support novel collaborations between senior and junior researchers, exploring questions arising from existing SU2C-supported Teams.
Dr. Murtaza and Dr. Antoni Ribas are awarded $200,000 to investigate whether microbiome analysis can predict patient response to immunotherapy in melanoma patients. Their study aims to analyze the relationship between microbial composition and immunotherapy outcomes.
A large study found a significant association between long-term exposure to fine particulate matter and an increased risk of mortality from various cancers, including breast and lung cancer. The study suggests that reducing air pollution could have a substantial impact on cancer deaths in urban populations.
Cancer drug costs have increased by six times over the past decade, with newly approved medications costing an average of $11,325 per month, compared to $1,869 for those introduced in 2000. This trend may impact patients' ability to access these drugs and their financial burden.
A recent cancer diagnosis was associated with an increased risk of mental health disorders, including depression and anxiety, peaking in the first week after diagnosis. The study also found increased use of psychiatric medications among patients with cancer, remaining elevated two years post-diagnosis.
A clinical trial found narrow band imaging (NBI) significantly reduces bladder tumor recurrence in low-risk patients compared to conventional TURBT surgery. NBI detected small tumors that might be overlooked by white light cystoscopy, leading to a 5.6% recurrence rate versus 27.3% with traditional methods.
A new gene testing technology has been developed to identify mutations and prioritize variants in breast and ovarian cancer genes. The method reveals gene variants that were missed by conventional genetic testing, increasing the number of patients that can be properly diagnosed.
Leading UK oncologists argue that staying in the EU is crucial to maintaining the country's prominent role in cancer research and care. The authors point out the benefits of EU-wide cooperation, including improved standards of care, research, and patient rights, as well as strengthened collaboration with EU partners.
Researchers found that about 5% of patients experienced unexpected relapses of cancer after laparoscopic radical cystectomy (LRC) despite favorable pathology. The use of pneumoperitoneum during LRC may have played a role in these recurrences, according to the study published in The Journal of Urology.
A study found that patients with lower literacy levels tend to visit websites promoting products or services, while those with higher education seek non-commercial sites. The study highlights the need for clinicians to guide patients towards reputable online health information sources.
A new study reveals how retroviral DNA insertion complexes hunt for suitable spots and insert rapidly, with search times exceeding 2-3 seconds and insertion happening in under half a second at chosen sites. The findings could improve treatments for HIV infection and make gene therapy safer and more efficient.
A new study found that organ recipients with a history of cancer are at a higher risk of dying from any cause, dying from cancer, or developing a new cancer. The association between these outcomes did not vary by the type of transplanted organ, according to researchers at St. Michael's Hospital.
A systematic review of scientific literature found that taking low-dose aspirin alongside cancer treatment can reduce mortality and cancer spread by up to 20%. Researchers from Cardiff University suggest this may be due to a mutation in PIK3CA, which appears to explain the reduction in colon cancer mortality.
A study analyzing 727 articles found that 45% of media coverage about celebrity diagnoses mentioned double mastectomy. Meanwhile, the number of women undergoing double mastectomy at a Michigan hospital nearly five-fold during this time. The
In a clinical trial, half of 25 patients with Merkel cell carcinoma experienced substantial tumor shrinkage lasting nearly three times as long as conventional chemotherapy. Several patients had no remaining evidence of disease. The results suggest that immunotherapy drugs may be effective for other virus-associated cancers.