Articles tagged with Cancer Patients
A study by German Cancer Research Center discovered that citric acid from lemon juice can alter the morphology of norovirus particles, reducing their infectivity. The researchers found that citrate binds to specific proteins on the virus, preventing it from attaching to host cells.
A new analysis found that patients taking certain heart medications to manage stress may have a longer survival time than those not taking these drugs. Nonselective beta blockers showed the most significant benefit in extending median survival time, particularly among patients with hypertension.
A study found that fertility concerns led a third of young women with breast cancer to decline or discontinue tamoxifen. The study also showed that a quarter of women who started tamoxifen stopped taking it before the recommended treatment period ended.
Researchers from MSK Cancer Center announce results from the first published basket study, a clinical trial design that explores drug responses based on specific tumor mutations. The study found preliminary clinical efficacy of vemurafenib in multiple non-melanoma BRAFV600-mutated cancers.
A study of over 100,000 women with ductal carcinoma in situ (DCIS) found that the 20-year breast cancer-specific death rate was 3.3 percent, higher for women under 35 and black women compared to non-Hispanic white women. Preventing ipsilateral invasive recurrence did not reduce mortality from breast cancer, according to researchers.
A study by UC Davis researchers has identified two biomarkers that can detect lung cancer up to six months before diagnosis, with an 80% accuracy rate. The findings offer a promising alternative to expensive low-dose CT scans, which involve X-ray radiation.
A study of 900 cancer patients found that heparin treatment did not significantly reduce recurrent blood clots or deaths compared to warfarin, but was associated with lower nonmajor bleeding rates. Heparin was also shown to be safe in this population, supporting its use over warfarin.
Researchers have discovered that a type of jumping gene called LINE-1 is actively inserted into the human genome in various gastrointestinal cancers. The findings suggest that these insertions may occur early in cancer development and could potentially serve as a marker for early cancer diagnosis.
A Mayo Clinic-led study has validated the National Cancer Institute's Patient Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), a tool used to track side effects in cancer clinical trials. The study found that PRO-CTCAE was accurate, reliable and responsive compared to other measures.
A new method for personalizing bladder cancer treatments has been developed by researchers at the University of California - Davis Health. The approach uses tumor xenografts to identify effective therapies, which can be tested in mice before being administered to patients.
A study found that screening women with suspected hereditary breast or ovarian cancer risk for additional genes provides important information for changing clinical management. Most patients with identified mutations were recommended for enhanced screening or preventive measures, and close relatives should also be screened.
A study by University of California, San Diego researchers found that Medicare reimbursement for radiation therapy varies widely among patients with breast, lung, and prostate cancer. Factors such as provider type, location, and clinic type accounted for most of the variation in costs.
Research reveals that spiritual beliefs are significantly associated with better physical health, reduced anxiety and depression, and improved social roles in cancer patients. Emotional aspects of religion and spirituality have the strongest links to positive mental and social outcomes.
A study at the University of Texas MD Anderson Cancer Center found that CSN6 is overexpressed in colorectal cancer tissue samples, leading to poor survival rates. The biomarker's deregulation can lead to cancer development through cellular signaling pathways.
A new Cancer Research UK study reveals that England's cancer survival rates remain lower than those of countries with similar healthcare systems, despite steady improvements. The study found five-year survival from breast cancer improved more in England than in four leading countries, but overall cancer survival was lowest in England.
Two California Initiative to Advance Precision Medicine projects aim to treat pediatric cancer with genetic analysis and diagnose acute infections using DNA sequencing. The projects, led by UCSF researchers, have the potential to deliver precision medicine tests and therapies within 18-24 months.
The George Washington University Cancer Institute has been awarded a $250,000 Engagement Award by the Patient-Centered Outcomes Research Institute (PCORI) to create an online Community of Practice for patient-centered care. The project aims to disseminate patient-centered outcomes research broadly and foster collaboration among researc...
A study of over 70,000 cancer patients found that those referred late by their GP were more likely to be dissatisfied with their care. Patients who experienced referral delays reported negative experiences across various aspects of their care, including diagnosis and treatment.
Researchers at the University of North Carolina have discovered a rare type of stem cell that is immune to radiation damage due to high levels of Sox9. This finding could lead to new ways to protect the gastrointestinal system of cancer patients before treatment, allowing for more aggressive treatments to be used.
A new study found evidence of activity in response and disease stabilization rates, reduction in liver metastasis volume, and improved quality of life scores in patients with advanced pancreatic cancer treated with omega-3 fatty acids. The results suggest potential benefits of combining omega-3 fatty acids with chemotherapy agents.
A new study shows that children with cancer can benefit from adapted physical activities, such as dog sledding, which improves their physical and psychological health. The expedition successfully completed by the children demonstrated statistically significant improvement in both areas.
Researchers at DKFZ found a new control mechanism that regulates mitochondrial fusion and fragmentation, improving energy production. Adding stearic acid to fly food enhanced mitochondrial performance, suggesting potential therapeutic applications for mitochondrial diseases.
A Phase 1 trial of LOXO-101 demonstrated a rapid and significant response in the first patient with a TRK fusion cancer. The patient's tumors substantially regressed after four months of treatment, meeting partial response criteria.
A new study found that young cancer patients often have limited knowledge about fertility preservation options, which can impact their treatment plans. Males are more likely to discuss fertility preservation with clinicians than females, but both sexes face barriers such as lack of insurance coverage and education.
Leading cancer experts recommend several measures to reduce high cancer drug prices, including a post-approval price review mechanism and Medicare negotiations. The recommendations aim to improve patient care and alleviate the financial burden on those affected by high cancer drug costs.
A new special issue in ecancermedicalscience explores the complex relationship between diet, metabolism, and cancer. Researchers investigate the role of antioxidants, obesity, and biomarkers in cancer development and prevention.
A study published in JAMA Oncology found that chemotherapy was associated with worse quality of life near death for patients who could still perform many life functions. The researchers concluded that chemotherapy use may be unnecessary and potentially harmful for patients with progressive metastatic disease.
The MD Anderson Cancer Center has been selected as a Genome Characterization Center to analyze patient samples from multiple NCI programs. The center will focus on functional proteomics, enabling the study of protein expression and modification in cancer tumors.
Researchers developed new diagnostic criteria to differentiate between malignant and benign mediastinal masses in children. The criteria use symptoms, laboratory tests, and CT scans to identify a better way to refine diagnoses, potentially leading to earlier detection of cancers like lymphomas and neuroblastomas.
A recent study published in Nature Communications found that genetic variation in the gene FOPNL is associated with poorer survival rates in multiple myeloma patients. The study, which included over 1,600 patients from North America and Europe, identified a significant link between the FOPNL variant and reduced survival.
Researchers found no statistically significant association between pioglitazone use and bladder cancer risk. However, a small increased risk was observed, as well as associations with increased prostate and pancreatic cancer risks.
A national clinical trial involving two effective drug combinations will be compared in a new study. The trial, led by Dr. Michael B. Atkins at Georgetown Lombardi Comprehensive Cancer Center, aims to determine the best sequencing of treatment regimens for patients with melanoma.
Researchers developed a 'Cytosponge' to collect cells from the gullet, reducing variation between biopsies. The study found patterns of mutations that provide a 'fingerprint' of cancer causes, helping doctors catch the disease earlier.
Patients with advanced disease experienced significant clinical response after receiving genetically engineered T-cells. The therapy was generally well-tolerated and showed long-term ability to fight tumors.
Waldman will lead research on STAG2, a gene commonly mutated in human cancer, aiming to understand its role in Ewing sarcoma and develop new therapies. The $250k grant from Alex's Lemonade Stand Foundation Innovation Grant will support Waldman's two-year project.
A clinical trial found that patients with activated B-cell-like (ABC) subtype of DLBCL responded better to ibrutinib than those with germinal center B-cell-like (GCB) subtype. This study suggests the use of ABC gene signature to identify patients likely to respond to the drug.
Researchers at Stanford University School of Medicine have developed a database that integrates gene expression patterns of 39 types of cancer with data on patient survival rates. The PRECOG database identifies key pathways and genes associated with poor or good survival outcomes, including FOXM1 and KLRB1.
Patients whose colorectal cancer is detected during a screening colonoscopy tend to live longer than those who wait until symptoms appear. The study found that these patients had cancer at an earlier stage and were more likely to survive beyond the study period, with about 55% surviving beyond the time of diagnosis.
A new study found that cancer survivors may face limited options for adoption due to agency policies, but a training program for oncology healthcare providers can provide valuable information. Cancer survivors often turn to adoption due to infertility caused by cancer treatments, but the process is long and costly.
Two studies examined end-of-life care for teens and young adults with cancer, finding that 68% received at least one medically intensive measure. Advances in care planning, such as durable power of attorney assignment and living wills, have increased over the past decade.
A recent study found that over two-thirds of adolescent and young adult cancer patients utilize aggressive interventions in the last month of life, including intensive care and chemotherapy. The researchers suggest a need for further research into supporting these patients to make informed end-of-life choices.
A recent genome-sequencing study discovered at least one-third of patients' tumors have genetic mutations that can guide precision therapy. Blood tests detecting DNA shed from tumors predicted cancer recurrence more than half a year earlier than standard imaging methods.
A recent study found that while advance care planning has increased among cancer patients, it hasn't led to a decrease in aggressive medical care received in the last weeks of life. In fact, nearly 40% of respondents reported that their loved ones didn't discuss end-of-life care preferences with them.
Researchers have identified five recurrent fusion genes in gastric cancers, which lead to increased susceptibility to damage and diminished healing. The study also found that these fusion genes promote invasive tendencies in cells, aiding in cancer progression.
A new study published in Journal of Immunotherapy demonstrates that T cells derived from lymph nodes can be expanded and activated to attack melanoma. This innovative approach, called adoptive immunotherapy, is being tested in a human clinical trial at UH Seidman Cancer Center.
Ezrin regulates osteosarcoma's spread by acting as an air traffic controller, coordinating multiple functions within cancer cells and allowing them to survive stress conditions. Researchers have developed molecules that block ezrin's function, preventing osteosarcoma spread in mouse models.
A team of Pitt scientists has developed consensus guidelines for thyroid cancer molecular testing to help clinicians make informed decisions about diagnosing the condition. The new guidelines incorporate newly available tests that better incorporate personalized medicine into diagnosing thyroid cancer.
Researchers found that neutrophils divert to nearby precancerous skin cells, causing rapid cell division and potentially leading to melanoma. The study suggests a physical link between wound-associated inflammation and skin cancer progression.
The Damon Runyon Cancer Research Foundation has established a new award to increase the number of physician-scientists in cancer research. The grant provides $100,000 per year for three years and up to $100,000 of medical school debt repayment. Two awardees will investigate novel approaches to fighting cancer.
Researchers at the University of Rochester Medical Center have identified a subgroup of follicular lymphoma patients who experience early disease recurrence despite modern treatments. These patients may require personalized therapy approaches, such as targeted sequencing or gene-expression profiling, to improve their outcomes.
A small pilot study found an experimental treatment approach can send deadly leukemia into remission in patients who have failed standard therapy. The combination of immunotherapy and gene manipulation buys critical time for patients to receive a potentially life-saving stem cell transplant.
A new breath test has shown encouraging results in diagnosing esophageal and gastric cancer by detecting unique chemical compounds in exhaled breath. The test is 90% accurate and can be performed in minutes, compared to hours using traditional methods.
The American College of Cardiology seeks to expand cardio-oncology services to address the growing need for specialized care in cardiovascular health for cancer patients. Currently, many hospital training programs lack formal training or services in this area, and a nationwide survey reveals gaps in resources and best practices.
A new study found that higher levels of soluble TNF receptor type two (sTNF-RII) are linked to reduced memory performance among breast cancer patients before treatment. Memory impairment was observed in patients compared to age-matched control subjects.
A large clinical trial led by The Ottawa Hospital and the University of Ottawa found that CT scans do not improve cancer detection in people with unexplained blood clots. Approximately four percent of patients from each group were diagnosed with cancer within the next year, with no difference in cancer-associated deaths.
The Alberta Cancer Exercise (ACE) pilot study explores a community-based approach to support cancer survivors in regaining their strength and energy levels. Participants receive either standard care or supervised group exercise training, showing promising results for improved physical fitness and mental well-being.
A study by Moffitt Cancer Center researchers highlights the need for stress management tools for Latina women undergoing chemotherapy for breast cancer. Despite facing significant stress-inducing factors, many patients reported a lack of access to these resources.
A consortium of healthcare professionals, game developers, and oncology educators is developing intelligent 'games' to help cancer patients manage their illness through mobile phones. The iManageCancer project aims to provide psychological benefits, greater wellbeing, quality of life, and social support for young cancer patients.
Researchers found that abdominal blood clots are associated with an increased risk of developing undiagnosed cancer, particularly liver and pancreatic cancer. Patients with these clots had poorer survival outcomes compared to those without the clots.
Researchers found that younger thyroid cancer patients with lymph node involvement have a lower survival rate compared to those with no spread. The number of lymph nodes involved plays a role in survival, with six or more nodes increasing the risk of death.