Articles tagged with Cancer Patients
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A new study found evidence of activity in response and disease stabilization rates, reduction in liver metastasis volume, and improved quality of life scores in patients with advanced pancreatic cancer treated with omega-3 fatty acids. The results suggest potential benefits of combining omega-3 fatty acids with chemotherapy agents.
A new study shows that children with cancer can benefit from adapted physical activities, such as dog sledding, which improves their physical and psychological health. The expedition successfully completed by the children demonstrated statistically significant improvement in both areas.
Researchers at DKFZ found a new control mechanism that regulates mitochondrial fusion and fragmentation, improving energy production. Adding stearic acid to fly food enhanced mitochondrial performance, suggesting potential therapeutic applications for mitochondrial diseases.
A Phase 1 trial of LOXO-101 demonstrated a rapid and significant response in the first patient with a TRK fusion cancer. The patient's tumors substantially regressed after four months of treatment, meeting partial response criteria.
A new study found that young cancer patients often have limited knowledge about fertility preservation options, which can impact their treatment plans. Males are more likely to discuss fertility preservation with clinicians than females, but both sexes face barriers such as lack of insurance coverage and education.
Leading cancer experts recommend several measures to reduce high cancer drug prices, including a post-approval price review mechanism and Medicare negotiations. The recommendations aim to improve patient care and alleviate the financial burden on those affected by high cancer drug costs.
A new special issue in ecancermedicalscience explores the complex relationship between diet, metabolism, and cancer. Researchers investigate the role of antioxidants, obesity, and biomarkers in cancer development and prevention.
A study published in JAMA Oncology found that chemotherapy was associated with worse quality of life near death for patients who could still perform many life functions. The researchers concluded that chemotherapy use may be unnecessary and potentially harmful for patients with progressive metastatic disease.
The MD Anderson Cancer Center has been selected as a Genome Characterization Center to analyze patient samples from multiple NCI programs. The center will focus on functional proteomics, enabling the study of protein expression and modification in cancer tumors.
Researchers developed new diagnostic criteria to differentiate between malignant and benign mediastinal masses in children. The criteria use symptoms, laboratory tests, and CT scans to identify a better way to refine diagnoses, potentially leading to earlier detection of cancers like lymphomas and neuroblastomas.
A recent study published in Nature Communications found that genetic variation in the gene FOPNL is associated with poorer survival rates in multiple myeloma patients. The study, which included over 1,600 patients from North America and Europe, identified a significant link between the FOPNL variant and reduced survival.
Researchers found no statistically significant association between pioglitazone use and bladder cancer risk. However, a small increased risk was observed, as well as associations with increased prostate and pancreatic cancer risks.
A national clinical trial involving two effective drug combinations will be compared in a new study. The trial, led by Dr. Michael B. Atkins at Georgetown Lombardi Comprehensive Cancer Center, aims to determine the best sequencing of treatment regimens for patients with melanoma.
Researchers developed a 'Cytosponge' to collect cells from the gullet, reducing variation between biopsies. The study found patterns of mutations that provide a 'fingerprint' of cancer causes, helping doctors catch the disease earlier.
Patients with advanced disease experienced significant clinical response after receiving genetically engineered T-cells. The therapy was generally well-tolerated and showed long-term ability to fight tumors.
Waldman will lead research on STAG2, a gene commonly mutated in human cancer, aiming to understand its role in Ewing sarcoma and develop new therapies. The $250k grant from Alex's Lemonade Stand Foundation Innovation Grant will support Waldman's two-year project.
A clinical trial found that patients with activated B-cell-like (ABC) subtype of DLBCL responded better to ibrutinib than those with germinal center B-cell-like (GCB) subtype. This study suggests the use of ABC gene signature to identify patients likely to respond to the drug.
Researchers at Stanford University School of Medicine have developed a database that integrates gene expression patterns of 39 types of cancer with data on patient survival rates. The PRECOG database identifies key pathways and genes associated with poor or good survival outcomes, including FOXM1 and KLRB1.
Patients whose colorectal cancer is detected during a screening colonoscopy tend to live longer than those who wait until symptoms appear. The study found that these patients had cancer at an earlier stage and were more likely to survive beyond the study period, with about 55% surviving beyond the time of diagnosis.
A new study found that cancer survivors may face limited options for adoption due to agency policies, but a training program for oncology healthcare providers can provide valuable information. Cancer survivors often turn to adoption due to infertility caused by cancer treatments, but the process is long and costly.
Two studies examined end-of-life care for teens and young adults with cancer, finding that 68% received at least one medically intensive measure. Advances in care planning, such as durable power of attorney assignment and living wills, have increased over the past decade.
A recent study found that over two-thirds of adolescent and young adult cancer patients utilize aggressive interventions in the last month of life, including intensive care and chemotherapy. The researchers suggest a need for further research into supporting these patients to make informed end-of-life choices.
A recent genome-sequencing study discovered at least one-third of patients' tumors have genetic mutations that can guide precision therapy. Blood tests detecting DNA shed from tumors predicted cancer recurrence more than half a year earlier than standard imaging methods.
A recent study found that while advance care planning has increased among cancer patients, it hasn't led to a decrease in aggressive medical care received in the last weeks of life. In fact, nearly 40% of respondents reported that their loved ones didn't discuss end-of-life care preferences with them.
Researchers have identified five recurrent fusion genes in gastric cancers, which lead to increased susceptibility to damage and diminished healing. The study also found that these fusion genes promote invasive tendencies in cells, aiding in cancer progression.
A new study published in Journal of Immunotherapy demonstrates that T cells derived from lymph nodes can be expanded and activated to attack melanoma. This innovative approach, called adoptive immunotherapy, is being tested in a human clinical trial at UH Seidman Cancer Center.
Ezrin regulates osteosarcoma's spread by acting as an air traffic controller, coordinating multiple functions within cancer cells and allowing them to survive stress conditions. Researchers have developed molecules that block ezrin's function, preventing osteosarcoma spread in mouse models.
A team of Pitt scientists has developed consensus guidelines for thyroid cancer molecular testing to help clinicians make informed decisions about diagnosing the condition. The new guidelines incorporate newly available tests that better incorporate personalized medicine into diagnosing thyroid cancer.
Researchers found that neutrophils divert to nearby precancerous skin cells, causing rapid cell division and potentially leading to melanoma. The study suggests a physical link between wound-associated inflammation and skin cancer progression.
The Damon Runyon Cancer Research Foundation has established a new award to increase the number of physician-scientists in cancer research. The grant provides $100,000 per year for three years and up to $100,000 of medical school debt repayment. Two awardees will investigate novel approaches to fighting cancer.
Researchers at the University of Rochester Medical Center have identified a subgroup of follicular lymphoma patients who experience early disease recurrence despite modern treatments. These patients may require personalized therapy approaches, such as targeted sequencing or gene-expression profiling, to improve their outcomes.
A small pilot study found an experimental treatment approach can send deadly leukemia into remission in patients who have failed standard therapy. The combination of immunotherapy and gene manipulation buys critical time for patients to receive a potentially life-saving stem cell transplant.
A new breath test has shown encouraging results in diagnosing esophageal and gastric cancer by detecting unique chemical compounds in exhaled breath. The test is 90% accurate and can be performed in minutes, compared to hours using traditional methods.
The American College of Cardiology seeks to expand cardio-oncology services to address the growing need for specialized care in cardiovascular health for cancer patients. Currently, many hospital training programs lack formal training or services in this area, and a nationwide survey reveals gaps in resources and best practices.
A new study found that higher levels of soluble TNF receptor type two (sTNF-RII) are linked to reduced memory performance among breast cancer patients before treatment. Memory impairment was observed in patients compared to age-matched control subjects.
A large clinical trial led by The Ottawa Hospital and the University of Ottawa found that CT scans do not improve cancer detection in people with unexplained blood clots. Approximately four percent of patients from each group were diagnosed with cancer within the next year, with no difference in cancer-associated deaths.
The Alberta Cancer Exercise (ACE) pilot study explores a community-based approach to support cancer survivors in regaining their strength and energy levels. Participants receive either standard care or supervised group exercise training, showing promising results for improved physical fitness and mental well-being.
A study by Moffitt Cancer Center researchers highlights the need for stress management tools for Latina women undergoing chemotherapy for breast cancer. Despite facing significant stress-inducing factors, many patients reported a lack of access to these resources.
A consortium of healthcare professionals, game developers, and oncology educators is developing intelligent 'games' to help cancer patients manage their illness through mobile phones. The iManageCancer project aims to provide psychological benefits, greater wellbeing, quality of life, and social support for young cancer patients.
Researchers found that abdominal blood clots are associated with an increased risk of developing undiagnosed cancer, particularly liver and pancreatic cancer. Patients with these clots had poorer survival outcomes compared to those without the clots.
Researchers found that younger thyroid cancer patients with lymph node involvement have a lower survival rate compared to those with no spread. The number of lymph nodes involved plays a role in survival, with six or more nodes increasing the risk of death.
Researchers found that patients positive for HPV16 E1, E4-7, L1, L2, and E2 antibodies had better overall and progression-free survival compared to those negative. This suggests that these antibodies may be used to identify patients at risk of oropharyngeal cancer recurrence and death.
Researchers at Kansas State University have developed a nanoplatform technology that detects human cancer cells and tumors in the early stages. The technology has been awarded US Patent 8,969,027 and shows a 95% success rate in detecting cancer at stage one and beyond.
Researchers have confirmed that eosinophils release special agents attracting immune system's professional killers into cancer tissue, leading to improved cancer rejection and increased survival rates in mice. Eosinophils also normalize blood vessels in the tumor, contributing to tumor rejection.
A new study published in the American Journal of Public Health found that messages with images depicting the harsh realities of melanoma are more powerful than text-only warnings in persuading young women to reconsider indoor tanning. Loss-framed messages emphasizing the risks of indoor tanning were more effective in decreasing intenti...
A joint investigation by UT Southwestern Medical Center and collaborators has identified an enzyme called 15-PGDH that regulates tissue regeneration in multiple organs. By blocking this enzyme with a newly discovered molecule, researchers were able to rescue damaged bone marrow, liver tissue, and colon tissue.
Researchers at UT Southwestern Medical Center have identified a key enzyme, Protein Kinase C (PKC), that regulates glucose transport into cells. This process is critical for maintaining proper glucose levels, which are often abnormal in diseases such as diabetes and cancer. The findings may lead to new treatments for these conditions.
Researchers found that genomic mutations in the TP53, APC, and CDKN2A genes were present in 75% of progressors with Barrett's esophagus. This ability to detect mutations in non-neoplastic mucosa can improve early detection and surveillance for patients at heightened risk for esophageal cancer.
A new study by Cancer Research UK found that breast cancer patients are disproportionately affected, with only 20% having surgery after an emergency diagnosis in hospital. In contrast, those diagnosed via urgent GP referrals have a much higher likelihood of receiving lifesaving surgery.
Researchers use 'Google Maps' for cancer genome analysis, identifying potential drug targets and monitoring treatment response. They provide a comprehensive view of the patient's multiple myeloma genome, showing notable mutations and larger-scale changes over time.
A new study published in Journal of Clinical Oncology finds that early palliative care consultation within six days of hospitalization reduces hospital costs by $1,312 compared to traditional care. Early provision also leads to a 14% reduction in hospital stay cost.
A new study found that patients with mutated IDH genes living with anaplastic astrocytoma had a significantly longer average lifespan compared to those without the mutation. The study also suggested that radiation therapy plus temozolomide may be more effective for patients with mutated IDH.
A Yale University study found that removing more tissue during a partial mastectomy can spare thousands of breast cancer patients from a second surgery. The study showed that cavity shave margins reduced positive margin rates in half without compromising cosmetic outcomes or increasing complication rates.
The myRisk Hereditary Cancer test assesses 25 genes for mutations associated with eight hereditary cancers. Recent studies have found that the test identifies 100.8% more mutations than BRCA1/2 testing alone, including increased mutations in breast and ovarian cancer patients.
Researchers identified a genetic biomarker that can predict which cancer patients will respond to immunotherapy drugs like pembrolizumab. Patients with mismatch repair gene defects showed improved responses to the treatment, offering hope for previously failed patients. Larger studies are needed to assess the potential for clinical use.
Cancer patients often experience significant alteration of their sense of taste during chemotherapy or radiation treatment, leading to malnutrition and weight loss. The study's findings suggest that activating a protein in the Wnt pathway may renew taste buds after chemotherapy.
Researchers at the University of Louisville have successfully treated stage IIIb to IV melanoma patients with a modified cold sore virus, resulting in improved survival rates. The therapy, talimogene laherparepvec (T-VEC), stimulates the immune system to fight cancer cells and has been shown to extend patient survival by 20 months.
A phase I study of ruxolitinib found no dose-limiting toxicities and improved symptoms in 15 evaluable CMML patients. Hematologic improvement and partial responses were observed, particularly in patients with B symptoms.
A study published in Cell Host & Microbe finds a causal link between bacterial infection and gallbladder cancer, suggesting that controlling typhoid fever could reduce the risk of this type of cancer. The researchers propose that prevention through proper treatment with antibiotics, vaccination programs, or better sanitary conditions c...
Researchers at CU Anschutz Medical Campus have discovered a crucial molecular pathway involved in the renewal of taste buds. This finding may help improve the quality of life for cancer patients suffering from chemotherapy-induced taste dysfunction.