Articles tagged with Cancer Patients
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A Dartmouth study found that Diffuse Optical Spectroscopic Tomography (DOST) imaging can accurately predict which patients will respond well to neoadjuvant chemotherapy, enabling earlier and more effective treatment. This breakthrough could significantly improve disease-free survival rates for breast cancer patients.
A new study found that nearly two-thirds of patients treated for stage 3 colorectal cancer reported some measure of financial burden due to their treatment. The burden was greatest among patients who received chemotherapy and younger patients in low-paying jobs.
Two patients with cardiac lymphoma presented with brain metastasis, highlighting the need for identifying prognostic factors that predict brain relapse. Cardiac lymphoma is a rare condition often overlooked due to its potential for central nervous system metastasis.
A UCLA study found that patients with bladder cancer who did not receive optimal biopsies had a significantly higher risk of death from the disease. In fact, about half of patients' biopsies lacked sufficient material to accurately stage their cancer, leading to incorrect tumor staging and increased mortality rates.
Cancer patients often use dietary supplements without telling their doctors, which can lead to unneeded risks. Researchers emphasize the importance of open communication between patient and doctor to create a personalized treatment plan based on reliable information.
The Van Andel Research Institute-funded epigenetics dream team will focus on epigenetic mechanisms in cells to control gene expression. The team will move forward with more extensive clinical trials in other cancer types to improve upon the progress already made.
A long-term study of patients with HER2-positive breast cancer shows that adding trastuzumab to chemotherapy improves overall and disease-free survival by 37% and 40%, respectively. The regimen is now the standard of care for early stage HER2-positive breast cancer.
The University of Hawai`i Cancer Center has received a $3.5 million NCORP grant to improve cancer care and prevention among minority and underserved populations in Hawaii. The grant will fund clinical trials and research aimed at reducing cancer disparities and enhancing patient outcomes.
A large-scale population-based study found that removing the entire lobe of lung may offer better overall survival compared to partial resection and stereotactic ablative radiotherapy. The study also suggests that SABR may be a suitable alternative to surgery for elderly patients with multiple medical problems.
The EMA is exploring alternative approaches to clinical trials in rare cancers, recognizing the challenges of small sample sizes and the need for innovative methods. These discussions aim to enhance the evidence base for treatments in rare cancer patients, who face limited treatment options.
Researchers have identified key factors contributing to pancreatic cancer, including inherited genetic predisposition and a higher risk of developing other cancers. Active smoking was also found to significantly impact age at diagnosis.
A new technique using bioimpedance measurement reduces image degradation caused by respiratory motion during PET scans, enabling more accurate detection of cancers and heart conditions. This improved imaging quality can lead to better diagnosis reliability and treatment response monitoring.
Dartmouth researchers have identified nine traits that predict single nucleotide polymorphism (SNP) reproducibility without relying on P-values. The Replication Score (RS) model can select SNPs for validation and prioritization, improving the accuracy of genetic association studies.
A team of researchers at UT Southwestern Medical Center has identified PPARγ as a crucial metabolic pathway that can be targeted to stop the growth of lung cancer cells. By activating PPARγ with antidiabetic drugs, they were able to inhibit tumor cell division and induce oxidative stress, leading to cancer cell death.
Fertility experts advocate for making ovarian tissue and egg freezing options widely available to healthy women. The techniques have restored fertility in female cancer patients and enabled the birth of nearly 2000 babies without an increase in birth defects.
University of Minnesota researchers have identified microRNAs miR-182 and miR-503 that contribute to the development of colon polyps into cancerous tumors. By targeting these microRNAs, physicians may be able to provide earlier and more specialized treatment for patients with a higher risk of colon cancer.
A gene mutation that causes a rare premature aging disease could lead to the development of drugs that block rapid cell division in cancer. Researchers discovered a protein mutation that inhibits telomerase, allowing for the potential treatment of cancer and bone marrow failure.
The charity will focus on understanding the root causes of cancer problems in Yorkshire and developing strategies to reduce cancer incidence and mortality rates. The investment will also support research into improving screening methods and increasing access to clinical trials.
A survey of 80 female Greek oncologists found that women are under-represented in leadership positions, with team leaders being men in 82% of cases. The European Society for Medical Oncology launches a new initiative to promote the exchange of ideas among female oncologists and support women with cancer.
A survey of 895 doctors in Europe, South America, and Asia revealed that over three-quarters of oncology specialists believe their patients are not well-informed about treatment options. The majority (90%) use biomarker testing to choose treatments, but many identify cost or lack of reimbursement as key barriers.
A phase III trial showed that Rolapitant significantly reduced nausea and vomiting in patients receiving cisplatin-based chemotherapy. The study found that 72.7% of patients experienced complete response, with improved quality of life outcomes.
The phase III trials indicate that anamorelin is safe and well-tolerated in treating symptoms of advanced non-small cell lung cancer anorexia-cachexia. Patients experienced improvements in lean body mass, body weight, and patient symptoms/concerns regarding appetite over 12 weeks.
A substantial proportion of potential subjects are reflexively excluded from lung cancer clinical trials due to prior cancer. The exclusion criterion was applied in more than two-thirds of trials in which survival was not the primary endpoint, resulting in up to 18% exclusion rate.
A simple blood test could be used to identify patients at risk of cancer due to high levels of calcium in the blood. Researchers found that in men, even mild hypercalcaemia conferred a risk of cancer in one year of 11.5%, while in women, the corresponding figure was 4.1%. The study suggests that hyperparathyroidism may be responsible f...
Researchers at USC Keck Medicine have discovered a dual purpose of the cancer drug decitabine in regulating gene expression. The study found that the drug not only reactivated tumor suppressor genes but also down-regulated overexpressed oncogenes, which are responsible for cancer progression. This new mechanism may provide additional t...
The European Organisation for Research and Treatment of Cancer (EORTC) will showcase its latest cancer research findings at the ESMO 2014 Congress. The conference will feature various sessions, including a joint symposium on clinical trials and posters focused on immunotherapy and gastrointestinal tumors.
The 1st EORTC Cancer Survivorship Summit has reported improved survival rates for patients with cancer, while also highlighting the need to address late adverse treatment effects. The summit addressed various topics including second malignancies, cardiovascular disease, and psycho-social problems following cancer treatment.
A new study of 1074 cancer patients who smoke found that e-cigarette use did not help with quitting traditional cigarettes. The study, published in the American Cancer Society journal, found a three-fold increase in e-cigarette use among smokers over two years.
A new research study reveals that many patients with advanced, incurable cancer do not receive palliative care, despite the presence of designated centres promoting integrated oncology and care. The study found significant gaps in palliative care delivery, highlighting the need for increased budget allocation.
Researchers found that combining targeted radiation therapy (SBRT) with the drug cetuximab improved treatment outcomes for patients with recurrent squamous cell carcinoma of the head and neck. The study showed a significant reduction in severe toxicity, allowing patients to complete treatments faster.
A genetic discovery has led to a highly accurate test for aggressive prostate cancer recurrence, identifying new avenues for treatment. The test is 91 percent accurate and could potentially lead to a cure through genetic therapy.
Researchers found alterations in genes BAP1, KDM6A, and others contributing to bladder cancer development. These findings suggest potential therapeutic targets for specific subtypes of the disease.
A study published in Nicotine & Tobacco Research suggests that a mix of gain- and loss-framed messages may work best to help convince smokers to quit. The research found that
A new radiotherapy strategy for treating advanced small-cell lung cancer significantly prolongs long-term survival and reduces cancer recurrence in the chest. The study found that patients treated with thoracic radiation therapy had a 50% lower risk of cancer recurrence compared to those who did not receive it.
A new Penn Medicine study reveals that certain patient characteristics, such as being male, married, and younger than 65, may be associated with shorter hospice stays. The study also found that patients with blood cancers and Medicaid or uninsured status tend to enroll in hospice earlier in their illness
Georgetown Lombardi Comprehensive Cancer Center has received a five-year, $11.25 million P30 Cancer Center Support Grant to continue its laboratory science, clinical research and population-based programs. The NCI designation reaffirms the high quality work of dedicated cancer researchers at Georgetown.
A phase Ib clinical trial found that olaparib tablets were safe and effective in heavily pretreated ovarian cancer patients, particularly those with BRCA mutations. The treatment regimen provided a response rate of 66 percent and no grade 4 toxicities, making it a promising option for improving cure rates and quality of life.
A study of German cancer centers found that many patients do not receive a dignified death due to inadequate staff training and facilities. Palliative care staff reported better conditions than other hospital wards, with 95% indicating that patients die with dignity.
Researchers found that the protein RBM4, crucial to gene splicing, is drastically decreased in multiple forms of human cancer, including lung and breast cancers. This discovery offers a new route toward therapies targeting altered genetic pathways that allow cancer cells to proliferate and spread.
A recent MD Anderson study found that socio-economic barriers continue to preclude women from receiving breast-conserving therapy, despite overall rates improving. The study identified disparities related to insurance, income, and education, with significant disparities still existing in areas outside the medical field.
Researchers identified rare stem cells in testis that produce PAX7, helping give rise to new sperm cells and potentially restoring fertility. These stem cells were found to be highly resistant to cancer treatments, suggesting they may play a key role in recovering fertility.
Scientists at MD Anderson Cancer Center have discovered genetic mutations in a subset of endometrial cancer patients that are associated with a more lethal form of the disease. The identification of these mutations could lead to the development of targeted treatments and improved patient outcomes.
A team of researchers has developed a mathematical model for epigenetic silencing, which reveals how DNA sequences are silenced in cancer cells. The model explains how histone and DNA methylation work together to regulate gene expression, and could lead to new strategies for preventing cancer development.
A Mayo Clinic study found that patients with poor quality of life before cancer surgery are nearly three times more likely to experience serious postoperative complications. Addressing these quality-of-life issues may reduce stress, speed recoveries and save healthcare costs.
Researchers are urging experts to study the functions of 'assemblages' - cloud-like protein formations that may hold clues to new treatments for diseases like Ewing sarcoma. These assemblages are made up of intrinsically disordered proteins that can trap and interact with other biological molecules.
Researchers found that high out-out assortativity in transcription factor networks contributes to robustness, with similar numbers of outgoing connections among connected TFs. This signature is a predictor of robustness, with an above-average number of connected TFs exhibiting this property.
The Herbert Irving Comprehensive Cancer Center has been awarded an $18 million grant to continue its groundbreaking research and provide high-quality patient care. The center, led by Dr. Stephen Emerson, is recognized as one of the top cancer centers in New York City and the country.
A new integrated treatment programme is more effective at reducing depression and improving quality of life than current care for depressed cancer patients. The programme, called 'Depression Care for People with Cancer', includes both antidepressants and psychological therapy.
Kids Konnected and the Breast and Gyn Health Project in California will each receive $8,500 awards to support their work assisting cancer patients and their families. The organizations will also be featured at ASTRO's Annual Meeting in San Francisco.
Patients with advanced laryngeal cancer who underwent surgery had significantly better disease-specific and overall survival rates compared to those treated with nonsurgical chemoradiation. The study analyzed data from over 5,000 patients diagnosed between 1992 and 2009.
A study at Huntsman Cancer Institute found compound mutations containing T315I confer complete resistance to all available TKIs, highlighting the need for new treatment options. Researchers have created a dataset that can help clinicians decide which drug will be most effective for each mutation combination.
Researchers have identified a biomarker, STAT3 protein, strongly associated with basal-like breast cancer, a highly aggressive and resistant carcinoma. This finding suggests a potential target for new therapeutics designed to treat this deadly cancer subtype.
The VCU Massey Cancer Center has been awarded a $4.4 million grant to establish a statewide cancer clinical trials network in Virginia, focusing on minority access and addressing cancer disparities. The network will provide cancer patients with opportunities to participate in clinical trials in their local communities.
Researchers at VCU Massey Cancer Center found that protein AEG-1 interferes with retinoic acid's ability to treat leukemia and liver cancer, highlighting a potential target for new therapies. The study's results could impact the treatment of countless cancer patients by enabling doctors to screen for AEG-1 expression levels.
A large study published in European Urology has found that needle-guided tumor destruction procedures, such as partial nephrectomy and radiofrequency ablation, offer near equivalent lengths of local cancer control compared to surgery for patients with small kidney cancer tumors.
Beaumont Health System receives a five-year National Cancer Institute Community Oncology Research Program grant to conduct cancer research and clinical trials in Michigan communities. The program aims to reduce cancer disparities and improve patient outcomes.
The LSU Health Sciences Center New Orleans has received a $5.6 million NCI grant to build a regional cancer clinical trials network, focusing on minority and underserved patients who die at higher rates from cancer. The program aims to provide access to state-of-the-art treatments and create jobs in the biomedical workforce.
A recent study published in the Journal of Clinical Oncology suggests that patient navigation can lead to better breast cancer care for high-risk populations, including minority women. Researchers found that patients assisted by trained navigators were more likely to start recommended treatments, such as hormonal therapy.
Researchers have found a link between tumor suppressor mutations and missing segments of genetic material in squamous cell head and neck cancers. The study suggests that treating tumors with both markers may intensify treatment, while those with only one marker may benefit from de-intensified treatment.
Researchers have developed a first-of-its-kind molecular test kit that can predict treatment and survival outcomes in kidney cancer patients based on their tumor profile. The assay was able to distinguish patients into groups with different survival and treatment outcomes, allowing for more educated choices in treatment options.