Articles tagged with Cancer Patients
Scientists at MD Anderson Cancer Center have discovered genetic mutations in a subset of endometrial cancer patients that are associated with a more lethal form of the disease. The identification of these mutations could lead to the development of targeted treatments and improved patient outcomes.
A team of researchers has developed a mathematical model for epigenetic silencing, which reveals how DNA sequences are silenced in cancer cells. The model explains how histone and DNA methylation work together to regulate gene expression, and could lead to new strategies for preventing cancer development.
A Mayo Clinic study found that patients with poor quality of life before cancer surgery are nearly three times more likely to experience serious postoperative complications. Addressing these quality-of-life issues may reduce stress, speed recoveries and save healthcare costs.
Researchers are urging experts to study the functions of 'assemblages' - cloud-like protein formations that may hold clues to new treatments for diseases like Ewing sarcoma. These assemblages are made up of intrinsically disordered proteins that can trap and interact with other biological molecules.
Researchers found that high out-out assortativity in transcription factor networks contributes to robustness, with similar numbers of outgoing connections among connected TFs. This signature is a predictor of robustness, with an above-average number of connected TFs exhibiting this property.
The Herbert Irving Comprehensive Cancer Center has been awarded an $18 million grant to continue its groundbreaking research and provide high-quality patient care. The center, led by Dr. Stephen Emerson, is recognized as one of the top cancer centers in New York City and the country.
A new integrated treatment programme is more effective at reducing depression and improving quality of life than current care for depressed cancer patients. The programme, called 'Depression Care for People with Cancer', includes both antidepressants and psychological therapy.
Kids Konnected and the Breast and Gyn Health Project in California will each receive $8,500 awards to support their work assisting cancer patients and their families. The organizations will also be featured at ASTRO's Annual Meeting in San Francisco.
Patients with advanced laryngeal cancer who underwent surgery had significantly better disease-specific and overall survival rates compared to those treated with nonsurgical chemoradiation. The study analyzed data from over 5,000 patients diagnosed between 1992 and 2009.
A study at Huntsman Cancer Institute found compound mutations containing T315I confer complete resistance to all available TKIs, highlighting the need for new treatment options. Researchers have created a dataset that can help clinicians decide which drug will be most effective for each mutation combination.
Researchers have identified a biomarker, STAT3 protein, strongly associated with basal-like breast cancer, a highly aggressive and resistant carcinoma. This finding suggests a potential target for new therapeutics designed to treat this deadly cancer subtype.
The VCU Massey Cancer Center has been awarded a $4.4 million grant to establish a statewide cancer clinical trials network in Virginia, focusing on minority access and addressing cancer disparities. The network will provide cancer patients with opportunities to participate in clinical trials in their local communities.
Researchers at VCU Massey Cancer Center found that protein AEG-1 interferes with retinoic acid's ability to treat leukemia and liver cancer, highlighting a potential target for new therapies. The study's results could impact the treatment of countless cancer patients by enabling doctors to screen for AEG-1 expression levels.
A large study published in European Urology has found that needle-guided tumor destruction procedures, such as partial nephrectomy and radiofrequency ablation, offer near equivalent lengths of local cancer control compared to surgery for patients with small kidney cancer tumors.
Beaumont Health System receives a five-year National Cancer Institute Community Oncology Research Program grant to conduct cancer research and clinical trials in Michigan communities. The program aims to reduce cancer disparities and improve patient outcomes.
The LSU Health Sciences Center New Orleans has received a $5.6 million NCI grant to build a regional cancer clinical trials network, focusing on minority and underserved patients who die at higher rates from cancer. The program aims to provide access to state-of-the-art treatments and create jobs in the biomedical workforce.
A recent study published in the Journal of Clinical Oncology suggests that patient navigation can lead to better breast cancer care for high-risk populations, including minority women. Researchers found that patients assisted by trained navigators were more likely to start recommended treatments, such as hormonal therapy.
Researchers have found a link between tumor suppressor mutations and missing segments of genetic material in squamous cell head and neck cancers. The study suggests that treating tumors with both markers may intensify treatment, while those with only one marker may benefit from de-intensified treatment.
Researchers have developed a first-of-its-kind molecular test kit that can predict treatment and survival outcomes in kidney cancer patients based on their tumor profile. The assay was able to distinguish patients into groups with different survival and treatment outcomes, allowing for more educated choices in treatment options.
Researchers at CWRU aim to boost cancer trial participation by educating oncology nurses. The $1.6 million NCI grant-funded program will test a web-based educational tool, Oncology Nurse IMPACT, to address barriers and increase discussions about clinical trials between nurses and patients.
A study published in the British Journal of Cancer found that bladder cancer patients with high levels of the protein HIF-1α are more likely to benefit from a treatment called CON, which makes radiotherapy more effective. High levels of the protein were linked to better survival rates when patients had radiotherapy and CON.
Researchers at the University of Pennsylvania have developed a new technique to help surgeons see the entire tumor during surgery, increasing the likelihood of a positive outcome. The approach uses an injectable dye that accumulates in cancerous tissues, allowing surgeons to remove the entire malignancy.
Researchers have found an irreversible inhibitor, SML-8-73-1, that selectively and irreversibly interferes with the activity of mutated KRAS genes. This breakthrough has significant potential to target cancer cells and improve treatment outcomes for patients with lung, pancreas, and colon cancers.
Researchers have devised a simple blood test that can diagnose cancer with high accuracy, saving time and preventing costly procedures. The Lymphocyte Genome Sensitivity (LGS) test measures DNA damage caused by ultraviolet light, distinguishing between cancerous and healthy cells.
A molecular testing panel developed at UPMC has improved the chances of correct initial surgery for thyroid cancer patients by 30 percent. The test, available at the UPMC/UPCI Multidisciplinary Thyroid Center, bypasses initial surgeries and allows for more efficient removal of cancerous tissue.
Patients with diabetes are at a higher risk for developing head and neck cancers, which account for about 6% of all cancer cases globally. A study found that the incidence of HNC was 1.47 times higher in diabetic patients compared to those without diabetes.
Researchers tested genetically engineered virus alongside isolated limb perfusion chemotherapy, finding it more effective in rats than either treatment alone. The combination slowed tumour growth and prolonged survival by 50%, offering hope for avoiding amputation and improving quality of life.
Patients with advanced cancer can experience improvement in fatigue, physical endurance, and mood through rehabilitation programs combining exercise and nutritional counselling. Palliative care services should incorporate these elements to enhance patient outcomes.
Researchers at Queen's University have made a significant breakthrough that may benefit patients with bowel cancer. The team discovered how two genes cause bowel cancer cells to become resistant to treatments, leading to the development of a new approach to target these genes in aggressive forms of the disease.
Huntsman Cancer Institute will become a key partner in the National Clinical Trials Network, providing access to clinical trials for patients across the Intermountain West region. The institute's unique research assets, including the Utah Population Database and Center for Quantitative Imaging Excellence, will enable multi-institutiona...
Research reveals that white fat transforming into brown fat may stimulate weight gain and muscle strength in cancer patients suffering from cachexia. The browning process is triggered by inflammation, and anti-inflammatory therapies show promise in alleviating the condition.
A new study by Henry Ford Health found that robot-assisted surgery can control prostate cancer for up to 10 years. The research followed 483 men who had not spread cancer beyond the prostate and received robot-assisted radical prostatectomy (RARP) as their first treatment, with 98.8% surviving the disease for 10 years.
Certain cancers have a characteristic age at which they occur, and their incidence decreases beyond that age. This 'developmental origin of disease hypothesis' suggests many cancers originate early in life, possibly before birth.
Two studies suggest that primary androgen deprivation therapy (ADT) for low-risk prostate cancer is not associated with improved survival rates. Alternative treatments may be more effective for patients, but must consider the potential adverse effects and costs of ADT.
A large population-based study of European adults with blood cancers found that regional differences in treatment and care quality contribute to varying survival rates. The study analyzed data from 30 cancer registries covering all patients diagnosed in 20 European countries between 1997 and 2008.
A new study has identified a molecular cause of cachexia and suggests a potential treatment using an anti-PTHrP antibody. The research found that blocking the effects of PTHrP can prevent wasting and improve muscle mass in mice with lung tumors.
The U.S. Department of Health and Human Services has awarded a three-year, $4.7 million grant to University Hospitals Case Medical Center Seidman Cancer Center to test a new national model aimed at improving care for adult cancer patients with late-stage disease. The project will enhance care through individualized interventions, inclu...
Researchers have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, expanding therapeutic targets and potentially identifying treatable mutations. The study found that 75% of patients with lung adenocarcinoma have actionable mutations that can be treated with existing or under-development drugs.
A study by UT Southwestern found a five-fold increase in cancer patients using MyChart from 2009 to 2015, with those over 60 making up the majority of frequent users. The technology's convenience and ease of use contribute to its widespread adoption among this demographic.
A new study by the University of Edinburgh has found that bowel cancer patients with high levels of vitamin D in their blood are more likely to survive the disease. Patients with the highest levels of vitamin D have half the risk of dying compared to those with the lowest levels, according to the research.
A study found that variations in the TANC1 gene are associated with a greater risk of radiation-driven side effects in prostate cancer patients. The research team developed a predictive genomic test to optimize treatment plans, allowing for improved quality of life for many cancer survivors.
A study published in Nature Communications found that pseudogene expression profiles can help explain how cancer occurs and aid in discovering new biomarkers. This knowledge is crucial for developing targeted therapies and predicting patient outcomes.
A study found that trials with broader age limits resulted in a significant increase in teenage cancer patients participating in clinical trials. The study showed a 13% rise in 15-19 year old patients and a 5% rise in 20-24 year olds, as well as an increase in children under 14 taking part in trials.
Researchers from Case Western Reserve University report a high degree of satisfaction among caregivers who received support teams for terminal cancer patients. The intervention improved satisfaction in five areas: pain relief, managing pain, speed in treating symptoms, information about side effects, and coordination of care.
A new approach identified two mutated tumor targets, KIF2C and POLA2, that play important roles in cell proliferation and may stimulate immune responses. This study provides a technical solution to identify mutated tumor targets for adoptive T-cell therapy, which has shown promise in treating metastatic melanoma.
A recent study published in Annals of Internal Medicine found that current standard medical guidelines for childhood cancer survivors can be reduced, saving large cost-savings and little reduction in overall quality of patient care. The study suggests that screenings can be safely done cost-effectively and improve the quantity of patie...
A new study found that HIV-infected people diagnosed with early-stage cancer are two to four times more likely to receive inadequate treatment. The research suggests that a lack of clinical trial data and guidelines on treating HIV patients with cancer may contribute to this disparity.
A recent study published in Nature Genetics has discovered a single gene that defines the difference between fast-growing, aggressive tumors and slow-growing, non-aggressive ones. The gene mutation GTF2l was found to be present in almost all indolent forms of thymoma, suggesting potential implications for treatment.
Researchers identified two antidepressant classes, including the alpha-2-adrenergic receptor antagonist Mianserin, that improve symptoms of depression in cancer patients. However, these treatments may be less well-tolerated due to potential side effects.
Researchers have developed a therapeutic vaccine targeting mutant IDH1, a common genetic mutation in brain tumors. The vaccine was tested on mice and showed promising results, with immune cells recognizing and attacking cancer cells. A clinical trial is planned to test the safety of the vaccine in human patients.
A team of researchers at UT Arlington has developed a low-cost, non-invasive device to detect bladder cancer cells in urine. The device uses nanotechnology and can identify as few as two cancer cells in a full liter of urine, making it a promising tool for early detection.
A recent study published in Cancer suggests that family dysfunction is a strong predictor of emotional problems in children of cancer patients. The research analyzed data from 235 families and found that general family dysfunction was the best predictor of emotional and behavioral symptoms in children.
The foundation has committed nearly $49 million to support the careers of 77 physician-scientists across the US since 2000. The Clinical Investigator Award program aims to address the shortage of physicians capable of translating scientific discovery into new cancer breakthroughs.
Researchers discover distinct mutational signature and nine significantly mutated genes associated with nasopharyngeal cancer. The findings provide an enhanced road map for studying the molecular basis of this disease, which has limited understanding compared to other cancers.
A new tool, COST (COmprehensive Score for financial Toxicity), measures a patient's risk for and ability to tolerate financial stress in cancer care. The study found that financial toxicity affects 30% of cancer survivors, with significant impact on workability and quality of life.
Researchers have developed a clinically relevant mouse model for squamous cell lung cancer, driven by the misregulation of genes sox2 and lkb1. The discovery uncovers new treatment strategies and provides insights into potential targeted therapies.
A study of over 56,000 patients with inflammatory bowel disease found no association between TNF inhibitor use and increased cancer risk. However, the authors emphasize the need for continued long-term follow-up to monitor potential risks.
A study of over 59,000 patients found that 3D digital breast tomosynthesis increased overall cancer detection by 28.6% and invasive cancer detection by 43.8%. The technology also reduced recall rates in community-based radiology practice.
Researchers are testing the safety and effectiveness of AG-120, a new drug designed for patients with IDH1 gene mutations, in a clinical trial at the Virginia G. Piper Cancer Center Clinical Trials. The study aims to improve treatment options for patients with solid tumors, including brain tumors and gallbladder bile duct cancer.
The AMEN protocol provides a script to help doctors and nurses talk to dying patients and families about their hopes for a miracle. This approach aims to respect patients' beliefs and values while maintaining trust and open communication, even when discussing futile treatments.