Articles tagged with Cancer Patients
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Researchers at CWRU aim to boost cancer trial participation by educating oncology nurses. The $1.6 million NCI grant-funded program will test a web-based educational tool, Oncology Nurse IMPACT, to address barriers and increase discussions about clinical trials between nurses and patients.
A study published in the British Journal of Cancer found that bladder cancer patients with high levels of the protein HIF-1α are more likely to benefit from a treatment called CON, which makes radiotherapy more effective. High levels of the protein were linked to better survival rates when patients had radiotherapy and CON.
Researchers at the University of Pennsylvania have developed a new technique to help surgeons see the entire tumor during surgery, increasing the likelihood of a positive outcome. The approach uses an injectable dye that accumulates in cancerous tissues, allowing surgeons to remove the entire malignancy.
Researchers have found an irreversible inhibitor, SML-8-73-1, that selectively and irreversibly interferes with the activity of mutated KRAS genes. This breakthrough has significant potential to target cancer cells and improve treatment outcomes for patients with lung, pancreas, and colon cancers.
Researchers have devised a simple blood test that can diagnose cancer with high accuracy, saving time and preventing costly procedures. The Lymphocyte Genome Sensitivity (LGS) test measures DNA damage caused by ultraviolet light, distinguishing between cancerous and healthy cells.
A molecular testing panel developed at UPMC has improved the chances of correct initial surgery for thyroid cancer patients by 30 percent. The test, available at the UPMC/UPCI Multidisciplinary Thyroid Center, bypasses initial surgeries and allows for more efficient removal of cancerous tissue.
Patients with diabetes are at a higher risk for developing head and neck cancers, which account for about 6% of all cancer cases globally. A study found that the incidence of HNC was 1.47 times higher in diabetic patients compared to those without diabetes.
Researchers tested genetically engineered virus alongside isolated limb perfusion chemotherapy, finding it more effective in rats than either treatment alone. The combination slowed tumour growth and prolonged survival by 50%, offering hope for avoiding amputation and improving quality of life.
Patients with advanced cancer can experience improvement in fatigue, physical endurance, and mood through rehabilitation programs combining exercise and nutritional counselling. Palliative care services should incorporate these elements to enhance patient outcomes.
Researchers at Queen's University have made a significant breakthrough that may benefit patients with bowel cancer. The team discovered how two genes cause bowel cancer cells to become resistant to treatments, leading to the development of a new approach to target these genes in aggressive forms of the disease.
Huntsman Cancer Institute will become a key partner in the National Clinical Trials Network, providing access to clinical trials for patients across the Intermountain West region. The institute's unique research assets, including the Utah Population Database and Center for Quantitative Imaging Excellence, will enable multi-institutiona...
Research reveals that white fat transforming into brown fat may stimulate weight gain and muscle strength in cancer patients suffering from cachexia. The browning process is triggered by inflammation, and anti-inflammatory therapies show promise in alleviating the condition.
A new study by Henry Ford Health found that robot-assisted surgery can control prostate cancer for up to 10 years. The research followed 483 men who had not spread cancer beyond the prostate and received robot-assisted radical prostatectomy (RARP) as their first treatment, with 98.8% surviving the disease for 10 years.
Certain cancers have a characteristic age at which they occur, and their incidence decreases beyond that age. This 'developmental origin of disease hypothesis' suggests many cancers originate early in life, possibly before birth.
Two studies suggest that primary androgen deprivation therapy (ADT) for low-risk prostate cancer is not associated with improved survival rates. Alternative treatments may be more effective for patients, but must consider the potential adverse effects and costs of ADT.
A large population-based study of European adults with blood cancers found that regional differences in treatment and care quality contribute to varying survival rates. The study analyzed data from 30 cancer registries covering all patients diagnosed in 20 European countries between 1997 and 2008.
A new study has identified a molecular cause of cachexia and suggests a potential treatment using an anti-PTHrP antibody. The research found that blocking the effects of PTHrP can prevent wasting and improve muscle mass in mice with lung tumors.
The U.S. Department of Health and Human Services has awarded a three-year, $4.7 million grant to University Hospitals Case Medical Center Seidman Cancer Center to test a new national model aimed at improving care for adult cancer patients with late-stage disease. The project will enhance care through individualized interventions, inclu...
Researchers have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, expanding therapeutic targets and potentially identifying treatable mutations. The study found that 75% of patients with lung adenocarcinoma have actionable mutations that can be treated with existing or under-development drugs.
A study by UT Southwestern found a five-fold increase in cancer patients using MyChart from 2009 to 2015, with those over 60 making up the majority of frequent users. The technology's convenience and ease of use contribute to its widespread adoption among this demographic.
A new study by the University of Edinburgh has found that bowel cancer patients with high levels of vitamin D in their blood are more likely to survive the disease. Patients with the highest levels of vitamin D have half the risk of dying compared to those with the lowest levels, according to the research.
A study found that variations in the TANC1 gene are associated with a greater risk of radiation-driven side effects in prostate cancer patients. The research team developed a predictive genomic test to optimize treatment plans, allowing for improved quality of life for many cancer survivors.
A study published in Nature Communications found that pseudogene expression profiles can help explain how cancer occurs and aid in discovering new biomarkers. This knowledge is crucial for developing targeted therapies and predicting patient outcomes.
A study found that trials with broader age limits resulted in a significant increase in teenage cancer patients participating in clinical trials. The study showed a 13% rise in 15-19 year old patients and a 5% rise in 20-24 year olds, as well as an increase in children under 14 taking part in trials.
Researchers from Case Western Reserve University report a high degree of satisfaction among caregivers who received support teams for terminal cancer patients. The intervention improved satisfaction in five areas: pain relief, managing pain, speed in treating symptoms, information about side effects, and coordination of care.
A new approach identified two mutated tumor targets, KIF2C and POLA2, that play important roles in cell proliferation and may stimulate immune responses. This study provides a technical solution to identify mutated tumor targets for adoptive T-cell therapy, which has shown promise in treating metastatic melanoma.
A recent study published in Annals of Internal Medicine found that current standard medical guidelines for childhood cancer survivors can be reduced, saving large cost-savings and little reduction in overall quality of patient care. The study suggests that screenings can be safely done cost-effectively and improve the quantity of patie...
A new study found that HIV-infected people diagnosed with early-stage cancer are two to four times more likely to receive inadequate treatment. The research suggests that a lack of clinical trial data and guidelines on treating HIV patients with cancer may contribute to this disparity.
A recent study published in Nature Genetics has discovered a single gene that defines the difference between fast-growing, aggressive tumors and slow-growing, non-aggressive ones. The gene mutation GTF2l was found to be present in almost all indolent forms of thymoma, suggesting potential implications for treatment.
Researchers identified two antidepressant classes, including the alpha-2-adrenergic receptor antagonist Mianserin, that improve symptoms of depression in cancer patients. However, these treatments may be less well-tolerated due to potential side effects.
Researchers have developed a therapeutic vaccine targeting mutant IDH1, a common genetic mutation in brain tumors. The vaccine was tested on mice and showed promising results, with immune cells recognizing and attacking cancer cells. A clinical trial is planned to test the safety of the vaccine in human patients.
A team of researchers at UT Arlington has developed a low-cost, non-invasive device to detect bladder cancer cells in urine. The device uses nanotechnology and can identify as few as two cancer cells in a full liter of urine, making it a promising tool for early detection.
A recent study published in Cancer suggests that family dysfunction is a strong predictor of emotional problems in children of cancer patients. The research analyzed data from 235 families and found that general family dysfunction was the best predictor of emotional and behavioral symptoms in children.
The foundation has committed nearly $49 million to support the careers of 77 physician-scientists across the US since 2000. The Clinical Investigator Award program aims to address the shortage of physicians capable of translating scientific discovery into new cancer breakthroughs.
Researchers discover distinct mutational signature and nine significantly mutated genes associated with nasopharyngeal cancer. The findings provide an enhanced road map for studying the molecular basis of this disease, which has limited understanding compared to other cancers.
A new tool, COST (COmprehensive Score for financial Toxicity), measures a patient's risk for and ability to tolerate financial stress in cancer care. The study found that financial toxicity affects 30% of cancer survivors, with significant impact on workability and quality of life.
Researchers have developed a clinically relevant mouse model for squamous cell lung cancer, driven by the misregulation of genes sox2 and lkb1. The discovery uncovers new treatment strategies and provides insights into potential targeted therapies.
A study of over 56,000 patients with inflammatory bowel disease found no association between TNF inhibitor use and increased cancer risk. However, the authors emphasize the need for continued long-term follow-up to monitor potential risks.
A study of over 59,000 patients found that 3D digital breast tomosynthesis increased overall cancer detection by 28.6% and invasive cancer detection by 43.8%. The technology also reduced recall rates in community-based radiology practice.
Researchers are testing the safety and effectiveness of AG-120, a new drug designed for patients with IDH1 gene mutations, in a clinical trial at the Virginia G. Piper Cancer Center Clinical Trials. The study aims to improve treatment options for patients with solid tumors, including brain tumors and gallbladder bile duct cancer.
The AMEN protocol provides a script to help doctors and nurses talk to dying patients and families about their hopes for a miracle. This approach aims to respect patients' beliefs and values while maintaining trust and open communication, even when discussing futile treatments.
A recent study found that most elderly women with non-metastatic breast cancer comply with hormone therapy recommendations. However, non-white women were more likely to discontinue treatment, highlighting a need for targeted interventions.
Researchers found that combining low doses of bortezomib with an oncolytic virus significantly improves the ability to kill cancer cells. The combination treatment suppressed tumor growth by 92% in a glioma model and improved survival rates, offering a novel therapeutic strategy for solid tumors.
New research links low blood cholesterol to more advanced tumor stages and reduced cancer survival rates in kidney cancer patients. High cholesterol levels are associated with a lower risk of death from the disease, suggesting a potential new prognostic tool for monitoring patient outcomes.
The Phase 2B clinical trial of CRS-207 and GVAX Pancreas vaccines aims to improve treatment outcomes for patients with advanced pancreatic cancer. The combination regimen shows promise in improving survival rates, with no serious treatment-related adverse side effects.
Researchers at UNC have found that Set2 plays a crucial role in DNA repair, which can lead to the development of cancer cells if impaired. The discovery offers insights into creating more targeted therapies for various forms of cancer.
Researchers found that early palliative support services significantly reduced depression and feelings of overwhelm among family caregivers, improving overall quality of life. The study suggests that timely intervention can better equip caregivers to cope with the demands of caring for patients with advanced cancer.
Researchers found that fasting can replenish stem cells in the blood, combating chemotherapy-induced and aging-related changes in immune cell function. Fasting has also been shown to rejuvenate the immune system of old mice and protect against white blood cell loss in human patients.
A new drug called MM-398 has shown a significant overall survival rate in patients with advanced pancreatic cancer when given in combination with 5-flourouracil and leucovorin. The study achieved an overall survival of 6.1 months, a 1.9 month improvement over the control arm.
A recent study suggests that expanded health coverage under the Affordable Care Act (ACA) may lead to better cancer outcomes for young adults. The study found that patients with insurance coverage were more likely to receive definitive therapy and had a higher survival rate compared to uninsured individuals.
The challenges in cancer molecular testing require effective communication between oncologists and pathologists. Close communication, systems approaches, and new institutional protocols can help ensure efficient testing and optimal patient outcomes.
Researchers have found that crizotinib produces significant responses in patients with intermediate and high MET amplification, resulting in a 60-67% overall objective response rate. The drug showed early activity against MET-dependent cells in preclinical laboratory studies.
A non-invasive breath test has been developed to detect lung cancer by analyzing volatile organic compounds in exhaled breath. The device can distinguish between patients with lung cancer and chronic obstructive pulmonary disease (COPD), as well as define the stage of any present cancer.
Researchers report promising results from a phase I study on MPDL3280A, an investigational drug for treating advanced bladder cancer. The trial showed improved response rates among patients with PD-L1-positive tumors, with 7% achieving complete responses.
Research identifies new ways to ease cancer therapy effects and enhance patient well-being, from fertility preservation techniques to earlier palliative care. Studies show improved survival rates and reduced side effects for certain treatments.
A phase 3 study found that ibrutinib significantly lengthened progression-free survival as a second-line therapy for CLL, with 86% of patients on ibrutinib experiencing durable responses. Ibrutinib also showed superior results compared to ofatumumab in terms of overall survival and partial response rates.
The American Society for Clinical Oncology has released new clinical guidelines for cancer-related fatigue, developed in collaboration with Moffitt Cancer Center. The guidelines recommend regular screening and treatment of fatigue in cancer patients after treatment, as well as addressing other contributing factors such as depression, p...
Researchers at Fox Chase Cancer Center halted a trial after 23% of patients experienced severe cardiovascular events while receiving a chemotherapy regimen. The study aimed to investigate the effectiveness and safety of gemcitabine and cisplatin in patients with muscle-invasive bladder cancer.
Researchers at Fox Chase Cancer Center found that genetic mutations in three specific genes can predict which bladder cancer patients will benefit from early chemotherapy. Patients with these mutations are more likely to respond to treatment and have a higher chance of being cancer-free after surgery.
Chronic kidney disease is associated with a higher risk of developing renal and urothelial cancers. A recent study found that patients with reduced glomerular filtration rates were more likely to develop these types of cancer, particularly those with severe chronic kidney disease.