Articles tagged with Cancer Patients
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A new study found that certain genetic variants, such as ALDH2 and VCAM1, can predict bladder cancer recurrence in patients. These variants can help identify high-risk patients who require more frequent screenings and aggressive treatment, improving quality of life for all bladder cancer patients.
Researchers estimate that up to 100% of lung cancer patients experience sexual dysfunction, which can persist after treatment. Experts call for open discussions and specialized help from healthcare professionals to address these issues.
Researchers developed a predictive tool that analyzes gene expression changes to predict patient survival. The tool, based on mouse studies, has shown promise in predicting treatment risk for early-stage breast cancer and certain lung cancers.
Scientists have developed a method to freeze testicular tissue in boys undergoing chemotherapy and radiation treatments for cancer, allowing them to preserve fertility. The study found that cancer cells were eliminated during the process of reproducing sperm-producing stem cells, making this option safe for future use.
Researchers discovered that breast cancer tumors can hijack patients' repressive gene regulatory machinery, permanently blocking cancer-killing genes. This allows the cancer to continue growing despite treatment with aromatase inhibitors, which block estrogen synthesis.
A new study identified genetic variants associated with increased risk of bladder cancer recurrence. Inheriting certain DNA sequences may affect a patient's prognosis, allowing physicians to tailor surveillance and treatment plans.
A study at Dana-Farber Cancer Institute found wide variation in oncologists' attitudes towards offering cancer gene testing, with those having high genomic confidence more likely to prescribe the test. The survey revealed that 42% of doctors approved telling patients about uncertain test results, highlighting concerns about delivering ...
Researchers found that people with a rare chromosome abnormality have a 2,700-fold increased risk of a rare childhood leukemia. The fusion of chromosomes 15 and 21 led to chromothripsis, which shattered the chromosome and created an optimised genome for leukaemia.
A groundbreaking study led by TGen has identified a genetic mutation in the SMARCA4 gene as the primary driver of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), a rare and aggressive form of ovarian cancer. This discovery holds promise for developing targeted therapies and improving diagnosis.
New research by USC Norris Comprehensive Cancer Center scientists suggests that elevated CTC counts after chemotherapy indicate a higher risk of death, while reduced CTCs cut the risk in half. This study demonstrates CTCs as an important biomarker for cancer research and treatment.
A new study found that CDK4 inhibitors may promote the development and progression of certain B-cell lymphomas driven by the MYC oncogene. Inhibiting CDK4 leads to genetic instability and genomic alterations associated with cancer growth.
A study by researchers from Huntsman Cancer Institute found that about 6 percent of colorectal cancers are missed during colonoscopies, particularly in patients over 65 and those with a family history of the disease. The cancers may develop rapidly after the procedure or be overlooked due to factors like polyp size or location.
Cologuard detects precancer and cancer with high sensitivity rates, surpassing existing non-invasive tests, offering a user-friendly approach to expand screening effectiveness and curb colorectal cancer rates. The test's accuracy has transformed how we think about colorectal cancer screening.
Researchers at TGen identified the ALK-EML4 gene fusion as the genetic driver of an aggressive type of thyroid cancer. The study's findings suggest that this fusion can be targeted with existing drug crizotinib, offering a new treatment option for patients with radioiodine-resistant aggressive papillary thyroid cancer.
Using big data analytics, researchers can predict the type of breast, lung, or oropharyngeal cancers with high accuracy. This technology may enable doctors to use MRI scans to diagnose more aggressive cancers earlier, leading to faster treatment options and improved patient outcomes.
The Ohio State University has partnered with MedVax Technologies Inc. to develop a cancer peptide vaccine technology for the treatment and prevention of several types of cancer. The partnership aims to bring this groundbreaking technology into clinical trials in the near future, with the goal of improving patient outcomes.
Researchers at UC Davis hope to prove that mobile health technology improves cancer patient care, quality, and reduces costs. The project uses a unique social networking tool to connect patients with their nurse coordinators, family, caregivers, and clinicians.
Research published in Diabetologia found that cancer patients with diabetes have a higher risk of early death due to the combination of diabetes and cancer. Patients treated with insulin had the highest mortality rate, while those with oral hypoglycaemic agents or no treatment showed lower risks
A new national analysis of trends and outcomes reveals that pancreatic cancer surgery remains under-utilized for patients with the deadly disease. Researchers identified factors associated with not receiving surgery in patients with localized pancreatic cancer, including age, race, and location.
A phase I trial found a complete response for 14 months to everolimus and pazopanib in a patient with advanced bladder cancer and rare mTOR genetic mutations. Genomic profiling revealed two alterations that activated the mTOR-mediated cell signaling pathway, rendering the cancer sensitive to the mTOR inhibitor.
Researchers identify two rare mutations in the mTOR gene associated with a complete response to everolimus and pazopanib, leading to improved treatment options for patients. The study provides new insights into personalized medicine and targeted therapies for bladder cancer.
Dr. Robert D. Schreiber receives AACR-CRI Lloyd J. Old Award in Cancer Immunology for his groundbreaking contributions to the field of cancer immunology, including identifying IFNγ as a key cytokine and developing the cancer immunoediting concept.
Researchers have found a potential new treatment for patients with advanced melanoma and kidney cancer. The study used an antibody that targets the tumor-enhancing protein TGFβ, which is involved in cell growth and spread of tumors.
A recent study by Queen's University Belfast highlights the disparities in cancer care for older patients, citing 'undertreatment' and a 'survival gap'. The editorial argues that clinical trials should be without an upper age limit to redress these disparities and improve outcomes.
A new pill called idelalisib shows promise in treating relapsed leukemia and lymphoma patients, with a significant response rate of 72% for CLL patients. However, MCL patients experienced less favorable responses, highlighting the need for further research to improve this therapy.
Dr. Daniel D. Von Hoff, a leading physician and scientist, has made significant advancements in cancer treatment with the development of multiple anticancer agents, including gemcitabine and nab-paclitaxel. His work has improved patient care and survival rates for patients with stage IV pancreatic cancer.
Researchers identified cancer markers and a previously unknown gene role in airways of smokers with lung cancer, suggesting earlier detection and treatment strategies. The study found that normal-appearing tissue near tumors has tumor-associated molecular abnormalities, potentially aiding in diagnosis and treatment.
Researchers found that injecting a virus directly into one melanoma tumor can induce a potent anti-tumor immune response, destroying both infected and non-infected tumors. This combination therapy overcomes the limitations of oncolytic virotherapy and checkpoint blockade.
The Northwestern Medicine Developmental Therapeutics Institute has received a significant $2 million pledge from The Woman's Board of Northwestern Memorial Hospital. This funding will support the launch of the institute, establish its first clinics, and create a fellowship program for physician-scientists specializing in developmental ...
Research suggests that palliative chemotherapy can lead to more invasive medical procedures and a higher risk of death in intensive care units among advanced cancer patients. The findings highlight the need for clearer discussion of the harms and benefits of palliative chemotherapy at the end of life.
Research suggests that terminally ill cancer patients who receive chemotherapy in the last months of life are more likely to undergo intensive medical care and die in an intensive care unit. The study highlights the importance of end-of-life discussions between patients and physicians.
Patients receiving nivolumab survived for an average of 16.8 months, with 62% alive one year after treatment initiation and 43% alive two years later. The drug also shrank tumors in 31% of patients, with some able to remain on the treatment for up to two years.
Dr. Curtis Harris is being recognized for his landmark scientific contributions to the fields of integrative and molecular epidemiology of human cancer and cancer biomarkers. His research has significantly impacted the field of cancer risk assessment and our understanding of the molecular pathogenesis of human cancer.
Researchers at Ohio State University found that inhibiting the enzyme PRMT5 can significantly improve survival in an animal model of GBM. High levels of PRMT5 are associated with aggressive growth and lower overall survival rates in brain cancer patients.
Researchers from the University of Surrey launch eSMART, a programme using mobile phone technology to remotely monitor patients undergoing chemotherapy for breast, bowel and blood cancers. The system assesses symptoms and triggers alerts to doctors or nurses within minutes.
Researchers discovered an unusual genetic mutation in patients with fibrolamellar hepatocellular carcinoma, a rare and aggressive form of liver cancer. The mutated gene, called a chimera, is constantly active and drives the growth of tumor cells.
A recent study found that patients with invasive lobular carcinoma receive less benefit from standard adjuvant therapies compared to those with ductal carcinoma. The research indicates a potential target for drug therapy in future clinical trials, which could lead to more effective treatment options for this subtype of breast cancer.
A new study published in Supportive Care in Cancer has linked handgrip strength to survival rates among patients with advanced-stage cancers. The test measures peak grip strength using a simple device called a dynamometer, providing a direct assessment of body strength and helping doctors determine interventions needed.
In the UK, bladder cancer is the 7th most common cancer and has a high recurrence rate, affecting 28 people daily. Early detection is crucial, as 5-year survival rates can be as high as 80% if treated early.
A new American Cancer Society study reveals that uninsured adolescents and young adults are disproportionately diagnosed with late-stage cancer due to lack of insurance. The research suggests that expanding health coverage, such as the Affordable Care Act, can lead to fewer late-stage diagnoses and ultimately save lives.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that cancer patients seeking information from non-clinician sources were more likely to receive PET scans. The study suggests that exposure to cancer-related information and promotional materials may drive the use of unnecessary imaging procedures.
Secondary thyroid cancer is more deadly for young individuals compared to primary thyroid cancer. This study highlights the importance of screening young cancer survivors to detect potentially life-threatening tumors.
A new study found that each individual patient's molecular profile in pancreatic cancer is unique, with different genes and pathways disrupted compared to the group of patients as a whole. The researchers argue for personalized medicine, where treatment is tailored to each person's individual disease etiology.
Researchers found that sparing the contralateral submandibular gland during radiation therapy is possible with advanced stage cancers. The study involved 71 patients who received treatment to the bilateral neck, with no recurrences in the spared gland at a median follow-up of 27.3 months.
A retrospective analysis found that HPV-positive oropharyngeal squamous cell carcinoma patients had a higher overall survival rate than HPV-negative patients after disease progression, with median survival being nearly twice as long. The study also showed improved outcomes for patients who underwent surgery after cancer recurrence.
A study published in PLOS Genetics reveals that nearly 100 genes may explain the lower cancer incidence rate in patients with central nervous system diseases. Researchers found that specific genes were inversely activated in both diseases, suggesting a protective effect against cancer.
A study found that sparing bilateral level IB lymph nodes during radiation therapy for oropharyngeal cancer significantly improved patient-reported xerostomia scores. This reduction also led to lower radiation doses to nearby salivary organs, causing less damage to post-treatment salivary function.
Researchers at Memorial Sloan Kettering Cancer Center reported remarkable results from a clinical study using genetically modified T cells to treat advanced leukemia. The treatment achieved a 88% complete remission rate, exceeding the response rate of salvage chemotherapy alone.
A Phase III clinical trial found no significant improvement in overall survival or progression-free survival with bevacizumab treatment for new glioblastoma patients. Researchers also observed increased symptoms and neurocognitive decline among non-progressing patients treated with bevacizumab.
A four-year clinical study involving 461 patients with advanced cancers showed that earlier palliative care significantly improved quality of life and patient satisfaction. The study demonstrated the benefits of cancer centers providing early specialized palliative care in outpatient clinics.
A new MRI-based method detects tumors in young cancer patients without exposing them to radiation, reducing the risk of secondary cancers. The technique uses a novel contrast agent and is as effective as PET-CT scans in detecting tumors.
A new study by Georgetown University Medical Center researchers suggests that implementing comprehensive tobacco control recommendations could reduce smoking rates by about 40% and prevent 50 million deaths. The study estimates that raising taxes on tobacco products would have the greatest impact in reducing smoking rates.
Cancer doctors can cut costs without risk to patients by improving end-of-life care, reducing unnecessary medical imaging, and negotiating lower prices for new cancer drugs. These changes can save billions of dollars in healthcare spending while maintaining quality of life.
Researchers at the University of East Anglia have made a significant advance in understanding genetic changes associated with terminal prostate cancer. A genetic mutation has been identified as a key factor in the development of aggressive cancer later in life. This discovery could help identify patients who are at risk of developing f...
A panel of 55 genes impacted by loss of protein SYK predicts invasive breast cancer, with better survival rates for patients without gene changes. Researchers found that 80% of patients without genetic alterations were still alive after 18 years, compared to 20% with gene changes.
A study found that patients with high levels of vascular endothelial growth factor (VEGF) in their blood had poor response to treatment with immunotherapy ipilimumab. Combining immunotherapy with VEGF inhibitors may be a potential option for these patients.
Researchers at Ohio State University Comprehensive Cancer Center identified a molecular pathway that enables cancer cells to grow in low-oxygen environments. By targeting this pathway, therapeutic strategies may be developed to inhibit tumor growth with minimal side effects.
Professor Patrick Johnston, alongside leading experts and patient groups, aims to address disparities in cancer care across Europe. The European Cancer Patient's Bill of Rights, launched on World Cancer Day, sets a standard for optimal cancer care for all European citizens.
A study published in Cancer Prevention Research found that atypical ductal hyperplasia and atypical lobular hyperplasia have similar potential to develop into breast cancer. The study followed over 700 women with biopsy-confirmed atypia for an average of 12.5 years, finding that the ratio of breast cancer development was the same in bo...
Researchers have identified potential therapeutic targets for muscle-invasive bladder cancer, including genes and pathways disrupted in the disease. The study also found similarities between subtypes of bladder cancer and those of other cancers, such as breast, head and neck, and lung cancers.