Articles tagged with Cancer Patients
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A study published in JAMA Network Open found that body mass index (BMI) has a more complex relationship with mortality risk during cancer therapy than previously thought. For patients with advanced non-small cell lung cancer, higher BMI was associated with lower mortality when undergoing immunotherapy or conventional chemotherapy. Howe...
CAR-T cell therapy, a regenerative immunotherapy, has shown promise in treating blood cancers but struggles with T-cell exhaustion. Researchers have discovered that overproduction of the IL-4 protein causes this exhaustion and used CRISPR gene-editing technology to remove it, improving CAR-T cell therapy outcomes.
A study by IRB Barcelona researchers has identified five independent factors that determine patients' response and survival after receiving checkpoint inhibitors, a type of immunotherapy. These findings provide a framework for current and future biomarkers of immunotherapy response and could lead to more accurate patient classification.
A groundbreaking study has provided novel insights into the molecular underpinnings of gastric cancer peritoneal spread, paving the way for more effective treatments. The research also demonstrated the safety and potential efficacy of a new treatment approach in a clinical trial.
A new study published in Annals of Oncology found that long-course radiotherapy is safer and more effective than short-course radiotherapy for preserving organs in rectal cancer patients. The treatment was shown to prevent regrowth of the primary tumour, but had similar overall survival rates.
Researchers at NTU Singapore and Oxford have identified a new process called nucleophagy that helps cells remove harmful DNA-protein lesions, promoting genetic material stability and cell survival. This discovery may improve cancer treatment outcomes for patients with colorectal cancer.
A recent study published in JAMA found that telehealth delivery of early palliative care is equivalent to in-person care in terms of quality of life outcomes for patients with advanced non-small cell lung cancer. This finding highlights the potential benefits of expanding access to this evidence-based care model through telehealth.
Researchers at WVU are working on a project to inhibit the myeloperoxidase enzyme, which feeds pancreatic cancer growth. By targeting this enzyme, they hope to boost the body's immune system to fight cancer, showing promise in mouse models and potential for future clinical trials.
New vaccines are being explored as a promising approach to treating glioblastoma, a highly lethal brain cancer with limited treatment options. These vaccines have been generally well-tolerated and have shown promise in improving survival rates for GBM patients.
Research found that first-degree relatives and spouses of cancer patients are at higher risk of developing psychological and cardiovascular illnesses. The study used data from the Utah Population Database to compare 77,938 relatives and spouses with 81,022 controls, finding a 10% increase in psychological condition risks and a 28% incr...
Researchers found that omitting the bolus-specific 5-fluorouracil (5-FU) portion from common chemotherapy regimens improves tolerability without sacrificing treatment effectiveness. The study of 11,765 patients shows no decrease in overall survival but a notable reduction in cytopenias.
A groundbreaking study published in Nature Medicine reports the first sustained remission of HIV infection following a bone marrow transplant in a patient without the CCR5-delta 32 mutation. Despite remaining susceptible to HIV, the virus remains undetectable nearly three years after antiretroviral treatment was stopped.
A University of Leicester study has found that certain gut bacteria may influence whether a patient's immune system is successful in fighting mesothelioma, an aggressive form of cancer. Researchers suggest that dietary changes, such as increased fibre intake, could improve the benefits of immunotherapy for these patients.
A team at NUS Yong Loo Lin School of Medicine leveraged an artificial intelligence-derived platform, CURATE.AI, to guide treatment for a patient with Waldenström macroglobulinemia, a rare blood disorder. The trial demonstrated substantial improvement in red blood cell levels and minimised side effects.
A Mass General Brigham-led study found that a large language model improves the accuracy of immune-related adverse event detection, identifying additional cases not picked up by manual adjudication. The model demonstrated excellent specificity and sensitivity, opening up opportunities for collaboration among institutions.
A recent study reveals racial disparities in cancer stage at diagnosis and survival for adolescents and young adults, highlighting the need for tailored interventions to achieve cancer care equity. The findings support health policy and funding implications, emphasizing the importance of addressing these disparities.
Researchers explore AI's role in addressing challenges in immunotherapy, developing new biomarkers for precise disease characterization and predicting treatment response. A comprehensive review applied AI/radiomics to cross-sectional imaging, showcasing the current landscape in IO treatment.
Women with regular annual mammograms had higher overall survival and lower late-stage cancer rates than those screened less frequently. The study's findings contradict current guidelines, suggesting a significant benefit to annual screening for women over 40.
A phase II clinical trial found that olaparib, a precision oncology drug, can induce durable complete remissions in recurrent prostate cancer patients with BRCA2 mutations. The study showed that 13 participants, including all 11 with BRCA2 mutations, had a decrease in PSA of at least 50% after treatment.
A new treatment approach has been confirmed effective in a major study, showing that locally advanced rectal cancer patients can experience complete tumour disappearance without needing surgery. This method reduces the risk of recurrence and preserves normal bowel function, offering a promising alternative to traditional treatments.
A systematic review and meta-analysis found that cognitive behavioral therapy (CBT) moderately improves mental health and quality of life in people with past or current cancer. CBT was more effective for younger individuals and in-person delivery compared to technology-based platforms.
A pivotal study supports belzutifan approval for patients with advanced kidney cancer, with belzutifan demonstrating a 25% lower risk of progression compared to everolimus. The HIF-2 inhibitor offers a novel therapeutic mechanism in advanced renal cell carcinoma treatment.
A new study published in Nature Medicine shows that precision therapy can improve survival for men with metastatic castration-resistant prostate cancer. The treatment, which involves analyzing the genetic profile of the tumor, has been shown to be more effective than chemotherapy in patients whose tumors have specific mutations.
The Chinese College of Interventionalists has introduced a consensus statement on TACE refractoriness in hepatocellular carcinoma, providing a framework for clinicians to identify and manage the condition. This move aims to optimize treatment strategies and improve patient outcomes, particularly in China where HCC incidence is high due...
A new study by Korea University College of Medicine shows that direct-acting antivirals significantly reduce liver-related clinical outcomes and lower the risk of disease progression to cancer or cirrhosis, increasing life expectancy for patients with Hepatitis C. The treatment approach has a high effectiveness rate of 90%.
A recent review of 57,470 patient cases shows that rare cancer patients are nearly three times more likely to develop anxiety and depression compared to common cancer patients. The study highlights the need for early identification and intervention to address mental health risks in this group.
Patients with high-risk liver cancer who received neoadjuvant immunotherapy before surgery had comparable outcomes to those who received surgery upfront. Successful resection rates were higher among those treated with immunotherapy, leading to improved median recurrence-free survival.
The Ontario Institute for Cancer Research is providing nearly $6 million to eight research teams across Ontario, supporting studies that aim to diagnose and treat cancers more effectively. The Clinical Translational Pathway program will advance new discoveries and bring them to the healthcare system.
A new Cleveland Clinic study reveals that diet-derived molecules called metabolites are the main drivers of young-onset colorectal cancer risk, particularly those associated with red and processed meat. The research suggests that addressing diet with doctors can help prevent colon cancer in younger adults.
A Rice University-led team is developing an affordable system to improve tumor removal accuracy for breast and head and neck cancer. The AccessPath system enables rapid, automatic tumor margin classification, revolutionizing real-time surgical guidance.
Researchers at MUSC Hollings Cancer Center are developing a new model of care delivery to reach out to cancer survivors with depression, using a mobile app-based treatment called Moodivate that delivers behavioral activation. The grant aims to provide timely and tailored mental health treatment to this growing population.
Researchers uncovered how combining immunotherapies targeting PD1 and LAG3 enhances CD8+ T cell responses, leading to improved cancer-killing prowess and enhanced survival rates. The studies also revealed that relatlimab is not inert and can be combined with other immunotherapies to improve responses.
Researchers found that a simplified two-question test can predict smoking abstinence in cancer patients with equal accuracy as the full Fagerström Test. However, the test may not work well for Non-Hispanic Black people with a cancer diagnosis. The study aims to help doctors tailor tests for different groups.
A trial at UT Health San Antonio found that Sacituzumab Govitecan was well-tolerated and showed signs of effectiveness for patients with breast cancer who had progressed to brain tumors. The drug has been shown to deliver a topoisomerase inhibitor into tumors, providing promising clinical signals of efficacy.
Researchers identified a potential antigen for TCR recognition in melanoma, suggesting that RNLS protein could be recognized by T cells leading to local immune responses against the cancer. The study found that chemical complementarity between melanoma-resident TCR CDR3s and renalase-1 protein correlates with increased melanoma survival.
A new study suggests that MRI scans can help doctors identify patients with more aggressive prostate cancer, allowing for earlier treatment or active surveillance. The research found that suspicious lesions on an MRI test were associated with a higher risk of advanced disease in five years.
Researchers developed a drug that enhances killer T cells' fighting power while reducing the toxicity of unmodified IL-2 treatments, overcoming inhibitory Tr1 cells and increasing immunotherapy's effectiveness. The study aims to personalize cancer immunotherapy for more patients.
The study found that 29% of patients experienced progression-free survival at five years and 40% achieved overall survival. However, important survivorship issues were identified, including nonrelapse mortality rates of 16.2%, with over half occurring beyond two years post-treatment.
A recent study published in CANCER found that patients with metastatic non–small cell lung cancer treated with immunotherapy had improved overall and cancer-specific survival rates compared to those without it. The median overall survival was eight months, while cancer-specific survival was 10 months.
A research team has identified novel biomarkers in cervical mucus samples that show high diagnostic power for detecting cervical cancer. The findings suggest that analyzing local expression levels may offer a superior diagnostic strategy, potentially reducing the need for invasive procedures.
Researchers highlight acute need for mental health services and support for men with prostate cancer. The study found that 15% of prostate cancer patients started anti-anxiety and antidepression medications at diagnosis, while only 6% sought help from mental health services.
A new study found no racial or ethnic disparities in prior authorization outcomes for Black and Hispanic patients, but Asian patients had higher rates of approvals compared to White patients. The study analyzed data from 18,041 cancer patients diagnosed between 2017 and 2020.
A new AI protocol called DeepHRD enables accurate, instantaneous detection of cancer genomic biomarkers directly from tumor biopsy slides. This breakthrough technology saves weeks and thousands of dollars from clinical oncology treatment workflows, providing access and equity in cancer care for resource-constrained settings.
A new AI algorithm assesses immune cells in early-stage bowel cancer tumours to predict recurrence risk. The CD3 Score test has been shown to reliably identify high-risk cancers that are more likely to recur within five years of surgery, enabling clinicians to make informed decisions about chemotherapy treatment.
A new study uses artificial intelligence to predict which breast cancer patients are most at risk for developing chronic pain, with anxiety and depression being leading factors. The AI model was built with detailed data on over 1,000 breast cancer patients and correctly predicted chronic pain more than 80% of the time.
Researchers found that abnormal results from routine blood tests were linked to a higher risk of being diagnosed with cancer within a year. The study estimated that taking these results into account could lead to an extra six people with undiagnosed cancer being urgently referred for treatment.
Researchers at MedUni Vienna have identified AF1Q as a promising biomarker to predict gastric cancer recurrence risk. The study found that 97.8% of tumour samples had elevated AF1Q levels, associated with higher recurrence risk and lower survival chances.
A new study finds that combining an inhibitor of a metabolic pathway with chemotherapy could improve treatment outcomes in triple negative breast cancer brain metastases. Inhibiting fatty acid synthase, an enzyme critical for cancer cell survival, shows promise in improving chemotherapy efficacy.
A recent study published in Frontiers in Immunology highlights the crucial role of tissue-resident memory T cells in non-small cell lung cancer. The research found that these cells can significantly impact patient outcomes and guide personalized treatment strategies, particularly those involving immunotherapy.
A study published in PLOS Medicine found that abnormal routine blood test results can predict cancer risk in patients with abdominal symptoms. The researchers analyzed data from over 470,000 patients and identified specific blood abnormalities linked to increased cancer risk across different age groups and sex.
A new clinical algorithm developed at the University of Gothenburg can accurately identify highly aggressive forms of basal cell carcinoma. The algorithm uses a combination of clinical and dermoscopic images to distinguish between low-risk and high-risk tumors, allowing for more effective treatment and better patient outcomes.
A recent review article highlights the importance of genetic testing for men carrying BRCA1 or BRCA2 mutations, which increase their risk of developing prostate, pancreatic, and breast cancers. The guidelines emphasize the need for personalized cancer screening to help identify high-risk individuals.
A study identifies a 10-gene biomarker that can predict whether stage II or III colon cancer patients will benefit from adjuvant chemotherapy. The gene signature also has the potential to predict which patients may respond to immunotherapy.
Researchers found correlations between MIF and DDT levels with patient survival outcomes in melanoma patients. Higher CD74:MIF and CD74:DDT levels were associated with improved survival and enrichment of inflammatory markers.
Scientists discovered that Tumour Treating Fields (TTFs) improve Natural Killer cell killing by increasing degranulation, a sign of better cell function. The findings offer promising implications for treating glioblastoma and other cancers.
Women with bilateral mastectomy have a greatly diminished risk of contralateral breast cancer, yet experience similar mortality rates as patients treated with lumpectomy or unilateral mastectomy. The study highlights the importance of considering long-term risks and benefits in breast cancer treatment decisions.
A new study found that two Medicaid policies can interact to increase oncology clinical trial enrollment among Black and Hispanic patients. Medicaid expansion under the ACA alone did not improve diversity, but states with pre-existing mandates requiring coverage of clinical trial costs saw a significant increase.
Researchers at UCLA Health Sciences identified three distinct patient preference-based profiles among men with low-risk prostate cancer. Despite differences in preferences, physician recommendations played a crucial role in determining treatment choices. The study highlights the need for better integrating patient preferences into trea...
A clinical trial found that fecal microbiota transplants can boost the effectiveness of immunotherapy in a range of gastrointestinal cancers. The study identified specific bacterial strains associated with better or worse responses, and showed promise for improving treatment outcomes.
A blood test measures lymphocyte count to predict treatment response in relapsed multiple myeloma. Patients with higher lymphocyte counts experience better cancer control for longer periods.