Articles tagged with Cancer Patients
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A new study from UCLA Health Jonsson Comprehensive Cancer Center introduces a combined genetic and functional profiling approach to predict how glioblastoma will respond to therapy. The approach helps identify new ways to target and treat the tumors more effectively, including using an experimental drug called ABBV-155.
Among cancer survivors, male patients ages 15-39 have the highest rate of death by suicide. Suicide deaths increased three-fold in this age group between 2000 and 2021, with one in 65 deaths attributed to suicide in 2021.
Researchers found that sacubitril-valsartan, a commonly prescribed heart failure medication, can help prevent heart damage related to chemotherapy treatment among high-risk cancer patients. The study highlights the importance of identifying patients at high risk for heart damage and suggests strategies for early intervention.
Neuro-oncology experts developed guidelines to standardize AI use in brain cancer diagnosis and treatment. The recommendations aim to ensure reliable clinical trial results and protect patients.
A new study found that a remote telemedicine tool called SpotCheck is highly accurate in diagnosing melanoma, with experts able to remotely examine skin lesions using dermoscopy. The tool has the potential to address diagnostic and treatment disparities for lower-income populations with limited access to dermatologists.
A new combination of immunotherapy and epigenetic drug may transform resistant pancreatic tumors into susceptible ones, according to a study by Johns Hopkins Medicine researchers. The treatment showed promise in a subset of patients, with tumor shrinkage and durable responses observed over several months.
A Chinese Medical Journal study reveals that patients with prostate cancer can undergo surgical removal without a pre-operative biopsy, using a combination of mpMRI and PSMA PET/CT imaging. This approach reduces costs and complications associated with traditional biopsy methods.
Testicular cancer is a highly treatable condition with high survival rates when detected early, but patients with the highest-risk disease face a lower prognosis. New genetic changes have been identified using whole genome sequencing, offering potential new treatment strategies.
New treatment combinations and predictive biomarkers hold promise for improving bladder cancer outcomes. The NIAGARA trial showed that combining immune checkpoint inhibitors with chemotherapy can significantly increase two-year survival rates and reduce cancer recurrences.
Patients receiving MRI-guided SBRT experienced significantly fewer urinary and bowel side effects compared to CT-guided treatment. MRI guidance also correlated with improved scores on specific quality-of-life measures, including bowel function and sexual health.
Researchers developed a new AI-powered diagnostic system, FastGlioma, which reveals invisible cancerous tissue in brain tumor surgery. The technique may delay or prevent recurrence of high-grade tumors and improve patient survival.
The new NCCN Guidelines for Patients: Quitting Smoking provide critical support and guidance for individuals with cancer seeking to quit smoking. The guidelines offer a fresh perspective and renewed hope, featuring multiple evidence-based options, including nicotine replacement therapy, behavior therapy, and non-nicotine medicines.
The new hospital will provide patient-centered care with personalized, compassionate treatment and groundbreaking research. Patients will have access to top specialists and pioneering therapies in cancer treatment.
Researchers created tiny lab-grown models of human immune systems to study immune function in cancer and predict disease treatment response. The miniature models support longer cell function, allowing processes like antibody formation to occur similar to the human body.
Researchers have discovered a new strategy to overcome docetaxel resistance in advanced prostate cancer patients, which may improve the efficacy of chemotherapy and prolong overall survival. The approach involves inhibiting cholesterol and lipid biosynthesis, reinducing sensitivity to the drug docetaxel.
A recent study found that only half of young cancer patients report discussing fertility preservation options with their healthcare provider. The study, which included 473 patients between the ages of 18 and 49, highlights the need for comprehensive reproductive health care in oncology treatment. Fertility preservation discussions were...
A new real-world study found that Comprehensive Genomic Profiling (CGP) leads to better personalized treatment and patient outcomes when done early in a cancer diagnosis. CGP-assessed patients received biomarker-driven targeted therapy or immunotherapy, significantly improving overall survival of 25 months compared to chemotherapy alone.
A new clinical trial found that the addition of immunotherapy drug pembrolizumab to standard treatment improved disease-free survival rates for patients with stage 3 soft tissue sarcoma. The study showed that pembrolizumab reduced recurrence or death for patients by 15 percentage points compared to standard treatment.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center have shown that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with advanced small cell bladder cancer and small cell/neuroendocrine prostate cancer. The study found that the combination treatment resul...
The Wyss Institute's iNodes team has been awarded an ARPA-H Sprint for Women's Health to develop implantable immune organs for treating ovarian cancer. The iNodes concept is based on the formation of lymphoid organs in tumors, which can be reprogrammed to attack cancer cells and retain a long-term immune memory.
A new study by Cedars-Sinai reveals that significant percentages of older men with intermediate- and high-risk prostate cancers are being subjected to aggressive treatments that may not extend their lives, highlighting the need for a more personalized approach to cancer treatment. The study suggests that better estimation, communicatio...
The VANCE trial demonstrates that Singapore has the expertise and capabilities to run large-scale global cell therapy trials. The study shows promising results for patients with recurrent or metastatic NPC treated with EBV-CTL therapy, with median survival rates of up to 29.9 months.
AI models trained on limited data may misdiagnose certain populations, particularly those in underserved communities. Researchers propose six key strategies to develop fair AI models, including using diverse datasets and transparent decision-making processes.
Researchers at MD Anderson Cancer Center present promising new treatments, including a gastric cancer therapy using T cell antigen coupler technology. Additionally, COVID-19 mRNA vaccines are shown to improve responses to immune checkpoint inhibitors in patients with non-small cell lung and melanoma cancers.
A new study published in The British Journal of Cancer found that whole genome sequencing can help identify treatment recommendations for cancer patients. The study evaluated the regional implementation of the 100,000 Genomes Project and found that different types of cancer were associated with varying rates of recommended actions.
Researchers developed a new imaging technique using fluorescence-guided surgery to enhance visibility of tumors and nerves during head and neck cancer surgery. The technique uses two near-infrared fluorophores, one for tumors and another for facial nerves, allowing for clear differentiation between cancerous tissues and nerves.
Clinicians should avoid using 'never words' that can scare, offend, or diminish agency in patients and families dealing with serious illness. Researchers recommend alternative language and methods for clinicians to identify their own never words.
The National Comprehensive Cancer Network has updated its guidelines for genetic/familial high-risk assessment, incorporating the latest scientific research and expert recommendations to enhance screening practices and treatment options. The expanded guidelines cover various cancer types and provide guidance on genetic testing, heredit...
Researchers analyzed tumor samples from 64 SCLC patients, identifying promising results for biomarkers DLL3 and TTF-1. These biomarkers showed potential as targets for therapies like Tarlatamab and improved survival rates in patients with TTF-1-positive tumors.
A new study from Japan confirms that definitive criteria for lower cachexia prevalence rates are linked to reduced survival rates in cancer patients. The study found that the diagnostic criteria used for cachexia detection can affect reported prevalence and survival outcomes, emphasizing the need for accurate diagnosis.
A new study has found that Canadian women who did not identify as White have an earlier peak age of breast cancer diagnosis and higher proportions of cases diagnosed under age 50. They also experience an earlier peak age of death, with a 7-year gap in mortality rates compared to their White counterparts.
Researchers document remarkable response to pembrolizumab in patient with metastatic adenosquamous pancreatic cancer (ASCP) and KRAS G12C mutation. The study highlights potential shift in treatment of ASCP, a rare form of pancreatic cancer traditionally underserved by current therapies.
A study of over 650,000 patients in Ontario found that nearly a third visited emergency departments in the months leading up to their cancer diagnosis. Most visits were related to symptoms specific to their type of cancer.
A new initiative, CAL-PALS, aims to expand access to life-saving lung cancer screening for marginalized groups in Los Angeles County. The program will engage physicians and staff to create system-level changes increasing access to high-quality services.
A phase 2 clinical trial found that the combination of vidutolimod and nivolumab led to tumor control in 55% of patients, with higher levels of immune-related proteins detected in responders. The study also uncovered unique signatures of TLR9 activation and a link between gut microbiome and response to therapy.
The National Comprehensive Cancer Network has joined forces with the Vietnam National Cancer Hospital to create Harmonized Guidelines for Vietnam, a framework for improving and standardizing cancer care in the country. The guidelines are based on NCCN's Clinical Practice Guidelines in Oncology, with modifications to reflect local needs.
A study led by Dr. Clint Cary found that traditional open surgery is the most effective approach for removing lymph nodes behind the intestines in patients with testicular cancer. The study showed excellent cancer cure rates and low blood loss, short hospital stay, and rare major postoperative complications.
A post hoc analysis of the ARCADIA trial found no significant difference in major ischemic and hemorrhagic events between apixaban and aspirin in patients with a history of cancer and cryptogenic stroke. The study suggests that both treatments may be effective, but further research is needed to confirm these results.
A new study finds that quitting smoking within six months of a cancer diagnosis significantly improves survival, with the largest benefit among patients who quit soonest. This evidence-based approach highlights the urgent need for cancer centers to offer smoking cessation programs to all patients.
This prospective cohort study found that evidence-based smoking cessation treatment within 6 months of a cancer diagnosis significantly improves survival outcomes. Smoking cessation is an essential early clinical intervention for patients with cancer, supporting the maximization of survival benefits.
The University of Chicago Medical Center will build a state-of-the-art cancer pavilion with a $75 million donation from the AbbVie Foundation. The facility aims to address health inequities in cancer outcomes and provide access to cutting-edge treatments, as part of UChicago Medicine's efforts to advance global cancer care.
Researchers at Tel Aviv University have discovered a new cancer mechanism that prevents the immune system from attacking tumors. The discovery was made by reversing this mechanism, which stimulates the immune system to fight cancer cells, including those resistant to prevailing forms of immunotherapy.
A remarkable clinical and metabolic response is reported in a metastatic BRAF V600E-mutated glomangiosarcoma treated with encorafenib and binimetinib. The combination of BRAF and MEK inhibitors achieves a long-lasting complete morpho-metabolic response in the patient.
Researchers identified three long noncoding RNAs associated with worse outcomes in colorectal cancer patients, potentially serving as prognostic markers. The study's findings could enable doctors to separate high-risk patients from those at low risk of disease recurrence, leading to more effective treatment strategies.
Researchers developed a method to assess which patients with metastatic triple-negative breast cancer can benefit from immunotherapy. The tool uses predictive biomarkers and machine learning-based approaches to identify patients who are likely to respond to treatment.
A pilot study by NCCN Cancer Center demonstrates the usability of HERC in advancing equitable cancer care delivery, with all participating sites strongly agreeing on its applicability. The tool features 19 practice evaluation and change recommendations to address disparity and bias in care delivery.
Researchers identified a previously unknown form of lymph node-like structures in liver tumors that are associated with greater treatment response and lower recurrence rates. The structures, found in patients treated with immune checkpoint inhibitors, contain infection-fighting immune B cells and tumor-killing immune T cells.
Researchers have developed a technology called FarrSight-Twin that creates digital twins of real cancer patients to predict treatment response. The approach was tested on published clinical trials and showed accurate predictions in all simulated studies, with 75% response rate among patients receiving the predicted best treatment.
Non-Hispanic Black patients are more likely to receive inadequate care and experience poor survival outcomes due to delays in treatment initiation. Guideline-concordant care is crucial in improving survival rates among these patients.
TYRA-300 shows promise in treating metastatic bladder cancer patients with FGFR3 gene mutations, achieving a 50% overall response rate and 100% disease control rate. The treatment also displays improved tolerability with lower side effects compared to existing pan-FGFR inhibitors.
A new study published in JNCCN found that Medicaid expansion was associated with longer survival rates and reduced treatment delays for patients with HR-negative, HER2-positive breast cancer. The study used data from the National Cancer Database to review results for women diagnosed with this type of breast cancer between 2010 and 2018.
Researchers have developed a 'mini-protein' that targets cancer cells expressing Nectin-4, allowing for direct delivery of radiation to tumours. The treatment shows promise in targeting multiple types of cancers and has the potential to be safe for repeated administrations.
Researchers have discovered key mutations in certain cancer cells that render WRN inhibitors ineffective. The study found that prolonged exposure to these inhibitors can lead to the acquisition of mutations in the WRN gene, allowing cancer cells to survive and develop resistance.
The myeloMATCH program offers a portfolio of biomarker-driven treatment trials to accelerate precision medicine in myeloid malignancies. Patients can enroll in clinical trials throughout their cancer treatment journey, with test results returned quickly to assign them to the most appropriate trial.
The Colorectal Cancer Alliance's Project Cure CRC has awarded nearly $5 million in research grants to advance urgent science in colorectal cancer. Recent awardees are working on topics such as radioimmunotherapy, CRISPR technology, and the protein drug ProAgio to better understand and treat this disease.
Researchers found that physically fitter patients with metastatic lung cancer live longer and respond better to chemotherapy. The study identified biomarkers in blood plasma that can indicate which patients are most likely to respond to treatment.
A new study suggests that MRI can predict patient outcomes and the risk of tumor reccurrence or spread for patients with rectal cancer who have undergone chemotherapy and radiation. This information could help doctors determine the best course of treatment, including whether to spare patients from invasive surgery.
The UCLA Urology department has been awarded $6 million to continue the IMPACT program, providing comprehensive prostate cancer treatment for underinsured and uninsured Californians. The program has helped over 2,300 men receive treatment services since its inception.
Researchers reported a complete and long-lasting response to immunotherapy in a stage IV non-small cell lung cancer patient with brain metastases. The patient achieved overall survival of 87 months and progression-free survival of 73 months after treatment sequencing.
Younger adults diagnosed with colorectal cancer have later-stage disease with more aggressive types of tumors. Obesity, family history, inflammatory bowel disease, and symptoms are strongly associated factors. These findings highlight disparities in colon cancer incidence among younger adults, particularly non-Hispanic Black patients.