Articles tagged with Cancer Patients
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A study analyzing Reddit posts reveals that breast cancer patients struggle with unmet emotional and financial concerns during treatment and long after. The research highlights the importance of providing adequate support and education to address these concerns.
Researchers at Weill Cornell Medicine have discovered a biomarker that can predict which patients with liver cancer are likely to benefit from immunotherapy. The study found that high levels of the immune-suppressing protein NBR1 may identify patients who will not respond to treatment, while lowering NBR1 levels may help shrink tumors.
Researchers developed an AI model that uses machine learning and combination theory to predict suspicious skin lesions. The new C4C Risk Score has an accuracy of 69% and significantly outperformed existing methods, including 7PCL and Williams score.
The two-year progression-free survival rate was 92% on the N-AVD arm compared to 83% on the BV-AVD arm, with fewer side effects and lower mortality rates. The study's results support the use of nivolumab-AVD as a standard treatment for stage 3-4 classic Hodgkin lymphoma.
A groundbreaking study has demonstrated the clinical success of a new nanoparticle-based, laser-guided therapy for prostate cancer treatment. The therapy successfully eliminated cancerous cells in 73% of patients after 12 months while preserving key functions and side effects.
Children who survived childhood brain cancer are more likely to struggle academically, with a greater chance of being held back and performing poorly on state testing. The study's findings highlight the need for better support and resources to help these students succeed.
A study by Johns Hopkins Medicine found distinct immune 'signatures' in patients who developed adverse events while taking immunotherapy. These signatures, including increases in white blood cells known as Th2 and Th17, predict the development of immune-related adverse events and may be targeted for treatment.
Researchers found that certain factors increased the risk of death after sepsis, including advanced age, dementia, heart disease, cancer, and previous hospitalizations. A total of 50.6% of patients with sepsis died within two years, highlighting the need for closer monitoring and follow-up care.
A new study has found that using a higher dosage of radioembolisation treatment with yttrium-90 microspheres can improve overall survival outcomes for liver cancer patients. Patients who received this elevated dose had significantly better results, with some experiencing prolonged survival and even curative treatments.
Aerobic physical activity was associated with modest short-term and long-term reductions of depression among adults with cancer. The study suggests that aerobic exercise may be an effective strategy for managing depression in cancer patients.
A recent analysis reveals that the Dependent Coverage Expansion (DCE) provision of the Affordable Care Act has improved the survival rates and reduced the death rates of young adults diagnosed with cancer. The study found a significant improvement in both cancer survival and death rate trends after ACA implementation, particularly for ...
Researchers have used AI to analyze digital images of pathology slides and identified risk factors for aggressive brain tumors that differ between men and women. These findings could lead to more individualized care and improved treatment outcomes for glioblastoma patients.
A non-invasive blood test measuring circulating tumor cells can predict treatment response, disease progression, and overall survival in men with metastatic prostate cancer. Patients with more CTCs had shorter median survival lengths and a greater risk of death.
Recent clinical trials of neoadjuvant therapy before radical prostatectomy, such as the ACDC-RP trial, have struggled to show significant survival benefits. Researchers recommend maximal androgen blockade with an androgen receptor pathway inhibitor as the 'backbone' of neoadjuvant therapy trials.
A new CAR-T cell therapy targeting CD7 on leukaemia cells has shown promising results in treating T-ALL patients who have exhausted all standard treatment options. The therapy achieved complete remission in 16 out of 17 patients, with some remaining in remission for over five years.
A study published in Blood reported high response rates of 89% and complete responses of 70% among patients with relapsed or refractory multiple myeloma who received cilta-cel infusions. The results were comparable to those seen in clinical trials, suggesting the therapy's effectiveness in real-world settings.
A new study published in JAMA Network Open found that racial and ethnic minorities are more likely to have claims for free preventive care denied by insurance plans, leading to unexpected bills or lack of access. Healthcare providers also charge disadvantaged groups a higher amount for preventive services.
A new non-invasive imaging technique has been shown to accurately detect clear-cell renal cell carcinoma, the most common form of kidney cancer. The technique uses a monoclonal antibody drug that targets the protein CA9, highly expressed in up to 95% of clear cell kidney cancers.
A randomized phase 3 trial found that extended lymph node removal in bladder cancer surgery does not improve disease-free or overall survival but increases the risk of complications and death. The standard bilateral pelvic lymphadenectomy is considered a sufficient approach for these patients.
Researchers discovered TERT gene activation as a key factor in determining the clinical course of pulmonary carcinoid tumours, with aggressive growth linked to telomerase activation. The study aims to improve treatment planning and targeted therapeutic strategies for cancer types.
Two UCF cancer researchers, Alicja Copik and Debbie Altomare, have received $100,000 grants from the Florida Breast Cancer Foundation to develop new treatments for breast cancer. They focus on enhancing natural killer cells to fight cancer and harnessing the body's immune system to create new therapies.
The American College of Chest Physicians has released a new clinical guideline on endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimen processing and handling to standardize the process. The guidelines aim to improve diagnostic yield and specimen preservation for downstream ancillary testing.
A retrospective analysis of over 2,600 patients found that Black children were more likely to suffer severe graft-versus-host disease but overall survival rates improved across all racial groups. The study suggests that cord blood transplants are a vital lifeline for many patients and improve care for those without a matched donor.
A randomized trial halted after patients in the control arm reached a record high two-year progression-free survival rate of 98%. Deintensified treatments involving lower radiation dose and immunotherapy did not perform as well as standard chemoradiation.
A multi-center phase III trial found photon- and proton-based radiation therapies to be similarly safe and effective in treating low- and intermediate-risk prostate cancer. Patients treated with either IMRT or proton therapy reported no significant differences in quality of life, tumor control, or progression-free survival.
A survey found that spiritual beliefs and distrust of clinical research contribute to Black patients' hesitation to enroll in cancer trials. Despite trusting their medical teams, some patients express concerns about the purpose of research and its potential impact on their health and community.
A new study found that the IOTA ADNEX ultrasound model can detect up to 96% of ovarian cancers in postmenopausal women, outperforming the current standard test. The research team recommends replacing the risk of malignancy (RMI1) test with the IOTA ADNEX model.
A new study found that hypofractionation does not increase complications for patients with breast cancer who undergo mastectomy and plan breast reconstruction. The trial enrolled 898 patients and showed that reducing treatment time by nearly half is safe and effective, saving patients time and money.
A study published in Blood Advances found that CAR-T therapy can be administered safely and effectively on an outpatient basis in community hospitals, mitigating barriers to access. The treatment showed high efficacy rates, with 80% of patients experiencing an objective response and 54% achieving a complete response.
A new trial suggests that adding immunotherapy to chemoradiation can extend survival in patients with limited-stage small cell lung cancer. However, the findings also indicate that delivering the treatments at different times yields varying results, with concurrent treatment not offering improved survival benefits.
A pooled analysis of three large, phase III clinical trials found that more than 40% of brain metastases patients can fully reverse cognitive losses with conformal radiation techniques. Recovery was more likely for those treated with highly targeted radiation compared to standard whole-brain treatment.
A phase II clinical trial found that radiopharmaceuticals, specifically 177Lu-Dotatate, can extend progression-free survival for patients with refractory meningioma by nearly 80% after six months. The therapy offers a safe and effective treatment option for those with aggressive tumor growth.
Early-stage HR+ breast cancer survivors experience weight gain, particularly those with healthy BMI or overweight at diagnosis. Black women have higher rates of obesity and related comorbidities compared to White women, leading to a 40% higher breast cancer mortality rate.
A recent study reveals that pharmaceutical industry sponsors dominate US cancer research, with a substantial increase in industry-sponsored clinical trials over the past decade. Federally funded studies have been underinvested and have missed opportunities for scientific advancements.
UCLA investigators presented data on chemoradiotherapy in rectal cancer, MRI-guided radiotherapy for prostate cancer, and symptom self-reporting during treatment. Researchers developed a predictive model to identify patients most likely to respond to chemoradiotherapy in rectal cancer.
A new online tool has been shown to reduce decisional conflict in women with breast cancer undergoing mastectomy, supporting informed decisions on immediate breast reconstruction. The study found that patients who used the tool felt better prepared for decision-making and had a lower rate of clinically significant decisional conflict.
Researchers have developed a new method to detect melanoma using tumour-specific antibodies, which can accurately identify stage I and II melanoma patients. The study found that these antibodies showed high sensitivity and specificity in detecting melanoma, with an AUC value of up to 0.981.
A new study has found that baseline testosterone, age, and duration of ADT are key predictors of testosterone recovery. The researchers developed a nomogram to estimate recovery times based on patient-specific characteristics, providing valuable insights for improving patient outcomes.
Dr. Roger Lo has been awarded a $2 million NIH grant to investigate ways to prevent drug resistance in melanoma treatment and improve the effectiveness of MAPK inhibitors. The team aims to target genetic instability and immune evasion to stabilize the melanoma genome and make it more vulnerable to immune attacks.
A new risk prediction model identifies patients with advanced cancer who are at highest risk for unplanned emergency room visits and hospital stays. The model, developed by researchers from the SWOG Cancer Research Network, considers factors such as performance status, comorbidities, and cancer type.
The Affordable Care Act has led to increased guideline-concordant care for non-white patients, rural residents, and those from the most deprived neighborhoods in Pennsylvania. This improvement is associated with better cancer outcomes, including survival rates.
A study found that Black women with breast cancer are more likely to experience vaginal dryness, reduced libido, and painful intercourse, leading to lower mental quality of life. These symptoms were associated with decreased adherence to treatment in these patients.
A nonrandomized clinical trial found that wearable devices can increase moderate-to-vigorous physical activity and reduce dyspnea at 6 months post-lung cancer surgery. This suggests a promising role for wearable devices in personalizing perioperative rehabilitation strategies.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center developed a biobank of 294 samples from 126 patients with 25 different subtypes of bone and soft tissue sarcoma. The team created tumor organoids that retained key characteristics of the original tumors, which were then subjected to high-throughput drug screening. They iden...
A new study found that vulnerable patients treated at Commission on Cancer-accredited hospitals had a 9% lower mortality rate and were more likely to receive guideline-based care. This is attributed to CoC accreditation requirements for treatment guideline adherence, community engagement, and addressing barriers to care.
A phase 1b/2 clinical trial found a combination of immunotherapy and FGFR inhibitor to be safe and tolerable in patients with locally advanced or metastatic bladder cancer. The treatment showed increased response rates, including 54% for patients with high FGFR mRNA expression.
Researchers discovered ponsegromab, a monoclonal antibody, improves symptoms of cachexia by blocking the GDF-15 hormone. The treatment shows minimal side effects and boosts weight gain and patient activity in cancer patients.
A recent study found a correlation between higher anti-PD-1 autoantibody levels and lower survival rates in patients with advanced liver cancer, suggesting these autoantibodies as potential biomarkers for predicting treatment response. The discovery aims to improve treatment regimens for patients with liver cancer.
Researchers have developed a novel platform for testing radiation therapy effects on brain cells, providing insights into how the brain reacts to cancer treatment. The study aims to improve treatment strategies by understanding the impact of radiation on neural circuits, ultimately leading to personalized care for patients.
A clinical trial found that an oral cancer drug reduced nosebleed severity and improved quality of life in patients with hereditary hemorrhagic telangiectasia (HHT). The PATH-HHT study showed significant improvements in disease manifestations, including severe nosebleeds and chronic gastrointestinal bleeding.
A Northwestern University study finds that cancer patients prefer their providers assess their financial concerns early in treatment. Most patients (83%) want their providers to reach out regarding financial needs, with 82% preferring this at diagnosis or starting treatment.
A meta-analysis by Mass General Brigham researchers found that Black women face higher mortality rates from breast cancer across all tumor subtypes, attributed to socioeconomic inequality, delayed diagnosis, and inadequate access to timely quality treatment. This disparity is not limited to hormone-positive tumors, with differences als...
The CABINET trial demonstrates that cabozantinib significantly improves median progression-free survival (PFS) for patients with advanced pancreatic and extra-pancreatic neuroendocrine tumors. The treatment also shows promise across all clinical subgroups, including primary tumor site and grade.
Patients with low-risk cancers undergoing active surveillance experience anxiety caused by uncertainty, a problem that persists even after diagnosis, leading to negative responses such as fear and avoidance of decision-making. Medical interventions are needed to address this anxiety and improve patient-centered care.
A new clinical trial shows that immunotherapy treatment with pembrolizumab can significantly extend the cancer-free period for patients with high-risk, muscle-invasive bladder cancer. The study found that adjuvant pembrolizumab treatment nearly doubled the median length of time patients remained cancer-free compared to observation.
A double-blind randomized phase 3 clinical trial found no additional benefits from high-dose vitamin D3 when added to standard chemotherapy for patients with untreated metastatic colorectal cancer. However, a potential benefit was observed for left-sided disease patients.
Two studies found breastfeeding after breast cancer diagnosis is safe and feasible for young patients with specific genetic variations, as well as hormone receptor-positive breast cancer survivors. A third study shows a telephone-based coaching program can significantly increase physical activity in overweight patients, potentially imp...
The CheckMate 067 trial showed that combining nivolumab and ipilimumab improved outcomes for metastatic melanoma patients, with a median survival time over six years. Long-term follow-up found no new safety signals for the treatment, and metastatic melanoma survivors become increasingly likely to die of other causes as they age.
The RESILIENCE clinical trial explores the effectiveness of remote ischemic conditioning to prevent cardiotoxicity in lymphoma patients undergoing anthracycline-based chemotherapy. The trial aims to reduce heart failure prevalence and improve quality of life for cancer survivors.
A drug that delivers chemotherapy directly to tumors has shown substantial and durable activity in treating brain metastases of HER2-positive breast cancer. The treatment, trastuzumab deruxtecan, has improved progression-free survival and objective response rates in patients with advanced disease.