Articles tagged with Cancer Patients
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A study published in the Journal of General Internal Medicine found that patients who use a web-based risk appraisal tool are more likely to have important family history documented, leading to better cancer screening and reduced mortality. The tool may help increase communication between physicians and patients about their risk factors.
The National Institutes of Health (NIH) emphasizes the importance of genomic knowledge for nursing care, highlighting its relevance to advancing patient care. Genomic studies published in the Journal of Nursing Scholarship provide insights on genetic applications in nursing practice, including cancer risk assessment and prevention.
A recent book chapter reviews psilocybin's potential to alleviate psychological distress in cancer patients, including anxiety, depression, and existential distress. The hallucinogen treatment model has been shown to induce mystical or spiritual experiences, leading to improved psychological, spiritual, and existential well-being.
Research found that a large majority of head and neck cancers have deregulated PI3K/AKT/mTOR pathway, but this doesn't necessarily mean the tumor is dependent on it for survival. The study used tumor explant model to distinguish driver mutations from passenger mutations, which could help stratify patients for response to mTOR inhibitors.
Researchers from MD Anderson Cancer Center found that qigong reduces depressive symptoms and improves quality of life in women undergoing radiotherapy for breast cancer. The study suggests that qigong may prevent a delayed symptom burden and expedite recovery, especially for women with elevated depressive symptoms.
A recent study found that stress can accelerate prostate cancer development in mice, with adrenaline blocking cancer cell death. Conversely, drugs that inhibited adrenaline signaling ablated the effect of stress on prostate cancer. This suggests that beta-blockers could enhance the effectiveness of anti-cancer therapies.
Researchers at BRIC, University of Copenhagen, have found that blocking the enzyme Lysyl Oxidase (LOX) can significantly decrease metastasis in breast cancer models. This breakthrough suggests a new approach to prevent tumour microenvironment scarring and enhance patient outcomes.
Researchers found that lung and head and neck cancer patients who quit smoking before surgery had significantly lower relapse rates compared to those who smoked during the week prior to surgery. The study also identified factors such as high fears regarding cancer recurrence, depression, and low belief in quitting abilities as predicto...
A University of Colorado study reveals that lung and GI cancer patients are more prone to E. coli and Klebsiella pneumoniae infections, particularly after aminopenicillin treatment. This knowledge can inform targeted antibiotic therapy before complications arise.
Researchers discover protein OTUD7B, which regulates TRAF3's destruction and controls NF-kB pathway implicated in autoimmune diseases and cancer. Cells with intact OTUD7B suppress non-canonical NF-kB signaling, leading to increased lymphoid cell growth and hyper-responsiveness to antigens.
A new multiple gene expression profile test can predict the presence of harmful BRCA1 or BRCA2 mutations in otherwise healthy women. The test showed a sensitivity of 95% and specificity of 88%, and has the potential to replace expensive sequencing tests, making it an affordable option for high-risk carriers.
A multi-center Phase III clinical trial demonstrates that Abraxane plus gemcitabine extends survival of late-stage pancreatic cancer patients compared to standard treatment. The study showed a 59 percent increase in one-year median survival rates and a doubling of two-year survival to 9%.
A new model developed by scientists can predict which patients with colorectal cancer will respond to chemotherapy. The model measures the stress required for a cancer cell to die without harming healthy tissue, and has been shown to robustly predict patient outcomes.
Researchers identified a genetic marker in over 300 women with breast cancer, finding that those with this marker were more likely to experience recurrence. This breakthrough could enable doctors to tailor treatment strategies for high-risk patients based on their unique genetic profiles.
Researchers at Michigan Medicine have discovered a genetic anomaly that could improve diagnosis and treatment of rare solitary fibrous tumors. The NAB2-STAT6 gene fusion was found in every tumor sample analyzed, providing a potential target for therapies.
Research reveals that a gene switch in the liver is responsible for lowering blood fat levels in cancer patients, leading to dramatic weight loss. The study found that silencing this gene switch in the liver can restore normal lipid levels and muscle mass.
A new study published in Cancer found that smoking intensity affects the course of bladder cancer, with more aggressive and deadly disease developing in those who smoke intensely. A panel of nine molecular markers can predict which cases are at highest risk for a fatal outcome.
A gene called NEK2 promotes drug resistance in cancer, leading to faster growth and poorer patient outcomes. The finding may improve diagnostic and prognostic tools for cancer care.
The American Cancer Society recommends low-dose computed tomography (CT) screening for patients aged 55-74 with a 30-pack-year smoking history. A thorough discussion of benefits, limitations, and risks is essential before screening. Screening can reduce lung cancer mortality in high-risk groups.
A Michigan State University study found that many cancer patients struggle to follow complex chemo prescriptions, leading to poor adherence and reduced treatment efficacy. The researchers suggest an automated calling system could help patients take their drugs properly.
The UCSF Helen Diller Family Comprehensive Cancer Center has received a $36 million grant from the National Cancer Institute to fund its research programs and clinical trials. The center's excellence in laboratory, clinical, and population-based research was recognized by the NCI.
A high-fiber diet, rich in inositol hexaphosphate (IP6), can control prostate cancer progression by inhibiting tumor growth and slowing glucose metabolism. Researchers found that IP6 reduced tumor volumes and slowed glucose metabolism in prostate cancer models.
Researchers found that microscopic hematuria does not necessarily indicate cancer, and patients with this condition may avoid unnecessary tests. A new model, the Hematuria Risk Index, predicts renal and bladder cancer risk, reducing unnecessary work-ups.
A recent study published in Mayo Clinic Proceedings found that microscopic hematuria is an unreliable indicator of urinary tract malignant tumors. The study developed a Hematuria Risk Index to predict cancer risk, identifying low-risk patients who may not need further evaluation and reducing unnecessary evaluations.
A large-scale Swedish study has found that oesophageal cancer patients who undergo surgery by high-volume surgeons have a significantly lower long-term mortality rate. The study's main finding is that centralization to fewer surgeons results in better survival after esophageal cancer surgery.
The University of Kentucky's Markey Cancer Center will continue the Jin Shin Jyutsu program in 2013 thanks to a $25,000 grant. The program, which uses ancient touch therapy, has shown significant improvement in pain, stress, and nausea for patients.
Researchers have found that commonly used algorithms for identifying patients with recurrent cancer are flawed and often mislead researchers. These algorithms rely on billing codes or secondary tumors to identify patients, but this approach can be inaccurate, as it may not distinguish between new cancers and recurrences.
Research found that low iron levels accelerate H. pylori-induced carcinogenesis in rodents and humans, increasing the risk of gastric cancer. Iron deficiency is associated with more virulent H. pylori strains and greater inflammation, highlighting the importance of iron levels in identifying high-risk patients.
A retrospective analysis of over 36,000 patients with colon cancer found that those with early stage disease and diabetes or high blood pressure have a greater risk for cancer return and death compared to patients without these conditions. High lipid levels were also found to be protective against recurrence.
A new study highlights the importance of considering immediate health risks when weighing benefits and potential future radiation-induced cancer risks. The researchers found that for patients with testicular cancer undergoing CT surveillance, the near-term risk of death from the condition was more significant than lifetime cancer risk.
Scientists have developed a new device that captures and preserves cancer cells circulating in the bloodstream, allowing for non-invasive diagnosis and insight into cancer spread. The technology could enable doctors to detect tumor cells earlier and provide valuable information on how cancer spreads throughout the body.
A new analysis suggests that individuals with Lynch syndrome, who have a high risk of developing colorectal and other cancers, may lower their risk by adopting an eating pattern low in snack foods. The study found that those with higher intakes of snack foods were twice as likely to develop precancerous lesions.
A Phase 2 clinical trial of ibrutinib in relapsed or refractory mantle cell lymphoma reported a 68% overall response rate and 22% complete remission rate, with few side effects. The drug's efficacy was consistent across different patient populations, making it a promising treatment option for patients with this aggressive disease.
A recent study found that rural US residents are less likely to follow colorectal cancer screening guidelines due to the time required for travel and limited access to healthcare. The researchers also noted that lack of health insurance and primary care provider shortages contribute to this disparity.
A new screening approach identified potential anticancer drug combinations that target RAS and BRAF mutations in melanoma. The study found that pairing cholesterol-reducing drugs with cyclin-dependent kinase inhibitors showed efficacy against RAS-driven melanomas.
A new Dream Team project, Immunologic Checkpoint Blockade and Adoptive Cell Transfer in Cancer Therapy, aims to expand and optimize combinations of two novel immunotherapies. The team will unite laboratory and clinical efforts to develop durable responses in patients suffering from various types of cancer.
A new study suggests that age affects treatment outcomes for chronic lymphocytic leukemia (CLL) patients. Researchers found that optimal therapy differs between younger and older patients, with CD20 antibody therapies showing promise as front-line treatment for all CLL patients regardless of age.
Researchers discovered that FAIM can affect cancer cell proliferation and silencing its expression destroys myeloma cells. Higher levels of FAIM correlate with poorer survival outcomes, making it a useful biomarker for multiple myeloma patients.
Researchers found that a weekly dose of the targeted drug inotuzumab ozogamicin reduces side effects and maintains its effectiveness against acute lymphocytic leukemia (ALL) in patients. The treatment showed an overall response rate of 57% with manageable toxicities.
Researchers identified microRNAs associated with oligometastatic progression, which differ from those associated with widespread metastatic disease. These findings suggest a biological basis for oligometastasis and potential use in identifying patients suitable for curative interventions.
A Phase 2 clinical trial found that combining ibrutinib and rituximab produced profound responses in high-risk CLL patients with minimal side effects. Researchers hope to further develop the treatment for this aggressive form of leukemia.
Patients who viewed a simulated CPR procedure were less likely to choose CPR, while those watching the video found it helpful. The study suggests that educational videos can supplement patient-doctor relationships and provide patients with more knowledge to make informed decisions about end-of-life care.
A clinical trial at Dana-Farber Cancer Institute found that intensified chemotherapy significantly reduces relapse odds for young patients with B-precursor acute lymphoblastic leukemia (B-ALL). The treatment regimen improved event-free survival rates to 76% five years after complete remission.
A new study finds that a reduced intensity conditioning regimen before marrow transplant significantly boosts disease-free survival rates among older AML patients. With a rate of 39%, this approach outperforms traditional methods in preventing relapse and improving patient outcomes.
Researchers found that ibrutinib effectively treats CLL with high response rates and durable remissions, particularly in elderly patients. The study also showed manageable toxicities, with only non-severe side effects observed.
The study found that 71% of previously untreated older patients experienced a complete or partial response to ibrutinib treatment. After 22 months of follow-up, the disease had not progressed in 96% of previously untreated patients. Ibrutinib's potential as a highly active, well-tolerated first-line therapy for CLL is promising.
Researchers have developed a new approach to enhance NK cell activity against cancer, leading to significant slowing of tumor growth and improved survival rates. The study found that prior radiation treatment enhances the effectiveness of the therapy.
Researchers have developed a simple breath analysis technique that can screen for colorectal cancer with an accuracy of over 75%. The method analyzes volatile organic compounds in exhaled breath, which are different in patients with cancer.
The American Society of Clinical Oncology (ASCO) has released its annual report on the top cancer advances of 2012, showcasing significant developments in precision medicine and targeted treatments. The report highlights seven new FDA approvals for anticancer agents, including therapies for breast and prostate cancers.
Researchers have found that targeting resistant lung cancer 'pockets' with focused radiation can prolong disease control in patients who initially respond to crizotinib or erlotinib. This approach showed significant benefits in patients whose cancers progressed in the brain, where the drugs are less effective.
Researchers found that people with Type 2 diabetes who received diabetes education after a cancer diagnosis had fewer visits to the emergency room and hospital admissions. They also tested their blood sugar levels more often, resulting in lower healthcare costs.
A phase I clinical trial has shown that ponatinib is highly active against patients with chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic lymphoma who have developed resistance to standard treatments. The study's findings suggest that ponatinib will expand the therapeutic armamentarium for these patients.
Several studies presented at the 2012 Quality Care Symposium provide insight into improving quality of cancer care. Researchers found that increasing awareness among physicians and patients can reduce the overuse of diagnostic imaging in young adult cancer survivors, resulting in decreased anxiety and unnecessary radiation exposure.
Researchers at Johns Hopkins Kimmel Cancer Center have created a test that combines blood DNA analysis with genome sequencing to detect cancers. The new approach was successful in identifying cancer-specific chromosome changes in the blood of patients, but may require larger clinical trials to determine its effectiveness.
The American Society of Clinical Oncology's Quality Care Symposium reveals important advances in cancer care quality measurement, physician adherence to quality standards, and end-of-life care. The studies also highlight the overuse of contralateral prophylactic mastectomy.
Despite the devastating effects of smoking on cancer treatment and survival, many cancer patients struggle to quit due to various obstacles. Nicotine addiction, limited access to support programs, and socioeconomic status are just a few of the hurdles that hinder smoking cessation.
A team of researchers at MD Anderson Cancer Center has identified a cancer-promoting protein's pathway into the cell nucleus and discovered how it fuels brain tumor growth. By targeting this pathway, they hope to develop new treatments for glioblastoma multiforme, the most common and lethal form of brain cancer.
Researchers found that natural killer cells in patients quickly eliminate anticancer viruses used to treat brain tumors, reducing their effectiveness. Blocking these immune cells may help improve treatment outcomes for glioblastoma patients.
Regorafenib has shown significant promise in treating bowel cancer and gastrointestinal stromal tumors (GISTs) after standard treatments fail. Patients receiving regorafenib experienced improved overall survival rates and delayed progression compared to placebo.
A new discovery reveals that chromatin remodeling complexes (CRCs) are intrinsically turned on, requiring specific instructions to turn them off. This finding has significant implications for understanding how CRC mutations contribute to cancer development.