Articles tagged with Cancer Patients
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A promising new approach to treating solid tumors with radiation has been developed, which uses an injectable substance that spontaneously assembles into a radioactive seed after injection. This technique shows great efficacy and minimal toxicity in a mouse model of cancer, providing a useful alternative to existing brachytherapy.
A study by Georgetown University Medical Center researchers found that high glucose diets increase mutant p53 gene expression in mice, which drives tumor growth. Reducing glucose intake through starvation or low-carb diet slows down cancer growth.
A new study by Dana-Farber Cancer Institute researchers found that patients who discussed end-of-life care several months before their death were less likely to receive aggressive therapy and more likely to enter hospice care. These conversations enabled patients to think through their options more carefully, leading to better quality ...
A study published in the Journal of Clinical Oncology found that earlier end-of-life care discussions are associated with less aggressive care and increased use of hospice care for patients with advanced cancer. Initiating these discussions before the last month of life allows patients to make informed decisions about their care.
A study led by Michigan State University researcher Gwen Wyatt found that reflexology can significantly ease cancer symptoms such as shortness of breath, improve physical functioning, and reduce fatigue. The results suggest that reflexology may be a useful complementary therapy for mainstream care.
Researchers at Ohio State University Wexner Medical Center discovered that high levels of interleukin-15 can cause large granular lymphocytic leukemia, a rare and usually fatal form of cancer. The study led to the development of a treatment with no discernible side effects.
A new study by the University of Cambridge reveals substantial inequalities in cancer stage at diagnosis, which can impact survival. The research highlights the importance of awareness campaigns to improve early diagnosis for specific patient groups, including those living in poorer neighborhoods or with different tumour sub-types.
A new study found that black patients with kidney cancer have a survival disadvantage compared to white patients, even when diagnosed at early stages or receiving less aggressive treatment. The study analyzed nearly 40,000 renal cell carcinoma patients and confirmed poorer survival rates for blacks.
PARP inhibitor olaparib traps PARP proteins at DNA damage sites, leading to cell toxicity. Researchers identify genetic mutations that sensitize cells to trapped PARP complexes, suggesting new therapeutic targets.
A new computer program has been developed to improve genetic test results for Lynch syndrome, a hereditary predisposition to colon cancer. The program helps assess the risk of colon cancer development by evaluating missense substitutions in mismatch repair genes.
Researchers at Fox Chase Cancer Center found that low lymphocyte counts are associated with poor survival rates in Merkel cell carcinoma patients. Patients with higher lymphocyte counts tend to live longer after treatment and have better disease-free survival.
A large study published in the Journal of National Cancer Institute has identified a genetic route by which vitamin D may prevent bladder cancer. High levels of 25(OH)D3 in plasma were found to be associated with lower risk of bladder cancer, particularly in patients with more aggressive cancers.
A study by University of Texas M.D. Anderson Cancer Center reveals that doxorubicin's cardiotoxicity is linked to the Top2b enzyme, which drives DNA damage and affects heart muscle metabolism. The discovery could lead to a simple blood test to predict sensitivity to the drug.
Researchers found that the risk of rectal cancer spreading to lymph nodes increases with age, with younger patients being more likely to have affected nodes. The study suggests that doctors should hunt aggressively for lymph node involvement in younger patients.
A nationwide study led by Dana-Farber Cancer Institute found that 69% of advanced lung cancer and 81% of advanced colorectal cancer patients believe chemotherapy can cure their disease. However, skilled clinicians can set realistic expectations without losing hope or trust.
Researchers found that Avastin increases survival in around 10-15% of bowel cancer patients by targeting the growth-promoting VEGF165 protein. Patients with lower levels of VEGF165b benefited from the treatment, while those with higher levels saw no improvement.
A UNM Cancer Center researcher is investigating the link between mitochondrial DNA and ovarian cancer. She hopes to identify genetic markers that could lead to a screening test or therapy, potentially increasing survival rates.
A study on histone modification could lead to targeted drugs for cancer treatment. Dr. Osley's research focuses on how ubiquitin attaches to H2B and its impact on DNA copying, potentially targeting quiescent cancer cells.
A team-based smoking cessation program with financial incentives improved abstinence rates among healthcare workers. The study found that team support created peer pressure and encouragement, leading to higher long-term quit success rates.
Researchers found that green tea extract Polyphenon E inhibited vascular endothelial growth factor and hepatocyte growth factor, promoting tumor cell growth, migration, and invasion. Women taking the extract had a significant reduction in hepatocyte growth factor levels, but no long-term effects were observed.
Researchers found that elevated hormone levels, except for DHEAS, tracked closely with increased risk for HR-positive breast cancer. Women in the highest 25 percent of SHBG levels had a 30% lower risk for breast cancer compared to those in the lowest 25 percent.
UK scientists have developed a new drug that primes the immune system to fight cancer, with promising early laboratory results showing it can lead to long-term survival in lymphoma patients. The treatment uses a chemical called R848, which signals to certain immune cells to attack cancer.
Researchers at MD Anderson Cancer Center found that low depressive symptoms and longer telomere length are associated with prolonged survival in bladder cancer patients. Patients with short telomeres and high levels of depression have a three-fold risk of mortality.
Patients with depression and short telomeres have a threefold increased risk for bladder cancer mortality, according to researchers. Lifestyle changes such as smoking cessation, weight loss, and increased physical activity may slow telomere shortening and improve survival.
A study of 284 controls and 142 children with acute lymphoblastic leukemia found a higher risk associated with longer formula feeding and later solid food introduction. The risk increased by 16% for every month of formula feeding and 14% for each month the introduction of solid foods was delayed.
African-Americans and those living in high-poverty areas were more likely to present with an emergency diagnosis, indicating missed opportunities for screening. The study highlights the need to address these disparities to reduce mortality from colorectal cancer.
Researchers found that referring cancer patients to higher-volume hospitals did not lead to lower mortality rates, but some hospitals still performed better. Mechanisms should be created to refer patients to these hospitals to achieve better outcomes.
The Robert Wood Johnson Foundation's 2012 Community Health Leaders Award recognizes individuals who have made significant contributions to improving health and healthcare in their communities. The recipients include Kay Branch, Fred Brason, Debbie Chatman Bryant, Beth Farmer, Amy Johnson, and Ifeanyi Anne Nwabukwu, who are addressing i...
A recent study found that nearly 38% of lesbians in the US had not been screened for cervical cancer according to recommended guidelines. Women who disclosed their sexual orientation to healthcare providers were more likely to undergo routine screening, highlighting the importance of effective communication between patients and providers.
Researchers at Moffitt Cancer Center have developed a promising treatment approach for metastatic melanoma using chemotherapy and adoptive cell transfer (ACT) with tumor-infiltrating lymphocytes (TIL). The therapy achieved an impressive response rate of 38% in patients. A second-generation ACT TIL trial is currently enrolling patients.
A new study at the University of Southampton aims to develop a method to predict who is at higher risk of getting cancer. The CANcer DIagnosis Decision rules (CANDID) study collects and analyzes data from 20,000 patients with lung or colon cancer.
A research group recommends that patient-reported symptoms and health-related quality of life measures should be assessed in comparative effectiveness studies. This approach is crucial for adequate evaluation of cancer treatments, as patients' experiences directly impact their ability to function and maintain quality of life.
Researchers identified tissue mechanisms that may increase a woman's risk of breast cancer after exposure to low-dose ionizing radiation. Gene expression profiles show women with specific gene expressions are more likely to survive breast cancer, while others are at higher risk.
A common birth control device has been shown to be effective in treating early-stage endometrial cancer, particularly in morbidly obese and high-risk patients. The intrauterine device releases progestin levonorgestrel, successfully used as a contraceptive for the past decade, and successfully reversed abnormal cell growth in all patients.
A study found that enzyme levels in routine blood tests are a better predictor of liver cancer risk than hepatitis infection or other factors. The research used data from over 428,000 people and predicted 91% of liver cancer cases.
Dartmouth College researchers have found that variations in white blood cell patterns can help predict the onset of certain cancers and diagnose them. By analyzing methylation signatures in leukocytes, they discovered correlations between specific cancers and unique patterns of immune cell subsets.
A Mayo Clinic study found that only 21% of urologists and radiation oncologists recommended active surveillance for low-risk prostate cancer, while 47% preferred surgery and 32% chose radiation therapy. The study suggests that physicians' recommendations may be influenced by their area of expertise.
Researchers discovered a new function of PARP-1 that regulates both DNA damage repair and androgen receptor activity, suggesting that inhibiting this enzyme could slow prostate cancer growth. This finding provides a new approach to treating advanced prostate cancer, which currently has limited treatment options.
Researchers found that patient navigation services significantly decreased the time to diagnosis for female patients with abnormal breast or cervical cancer screening results. The study supports recent standard recommendations for all cancer care centers to provide patient navigation services.
A multi-center team of scientists will focus on identifying causes of resistance in advanced prostate cancer and tailoring therapy for patients. The goal is to revolutionize treatment through personalized medicine, sparing unnecessary treatment.
TGen's Dr. Daniel Von Hoff delivers his lecture on a molecular pursuit approach to take out pancreatic cancer, honoring the memory of patient Lori Groetken who fought the disease for two years. The award recognizes his significant contributions to genomic research and novel therapy development in pancreatic cancer.
New research findings show that rural colon cancer patients are more likely to receive late-stage diagnosis and inferior treatment, leading to poorer outcomes. Rural residents also have higher odds of dying from colon cancer than urban patients.
New studies report that robotic-assisted bladder procedures and minimally invasive colorectal operations can improve outcomes in older patients. Robotic-assisted bladder surgery, which was previously not offered to patients over 80, showed a seven-day hospital stay and only three complications within 90 days.
A new French study found that anticoagulants significantly reduce the incidence of catheter-related deep vein thrombosis in cancer patients. However, guidelines recommending prophylactic anticoagulant treatment for these patients are still under review.
Researchers have developed a noninvasive method to measure interstitial fluid pressure in tumors, which may help identify aggressive tumors. The technique uses dynamic contrast-enhanced MRI to evaluate the velocity of fluid flow from tumors and has been shown to correlate with tumor aggressiveness.
A new study published in the American Journal of Gastroenterology found that smoking and heavy drinking can lead to an earlier onset of pancreatic cancer. The study analyzed data from 811 patients with pancreatic cancer and found that those who smoked heavily or drank excessively were diagnosed at a younger age than those who did not.
A landmark survey reveals that many countries fail to provide essential opioid medications for cancer pain relief, leaving hundreds of millions of patients suffering. The study's findings highlight the need to reformulate national plans and repeal excessive restrictions on cancer care.
Phase III data show gefitinib improves quality-of-life measures and extends progression-free survival in esophageal cancer. The COG study included 450 patients who had progressed after first line chemotherapy and received either placebo or the EGFR-inhibitor gefitinib.
The first-ever estimate of cancer's economic burden in Europe reveals that cancers cost the European Union €124 billion each year, with lung cancer responsible for the highest overall burden. Caring for cancer patients also takes a toll on caregivers, who experience impairments in physical and mental health.
Researchers tracked tumor evolution in a patient with maxillary sinus carcinoma, identifying genetic changes that contribute to drug resistance. The study provides a roadmap for treating this rare and aggressive cancer.
Scientists focus on RNA processing differences in cancer cells to understand their role in tumor development. Alternative RNA splicing occurs more frequently in cancerous cells, but its biological importance is unknown.
Researchers discovered that MYC protein boosts existing gene expression, rather than turning genes on or off, leading to a universal amplifier effect. This understanding could lead to new therapeutic strategies for cancers, such as targeting MYC activity instead of eliminating it.
Researchers used a new cell technology to treat a patient with a rare type of lung tumor. The treatment, which uses conditionally reprogrammed cells, showed promising results, including some tumor shrinkage and stabilization of tumors after just three months.
A new study published in the journal Head & Neck has demonstrated the safety and efficacy of robotic surgery through the mouth for removing tumors from the throat and voice box. The procedure resulted in minimal blood loss, no surgical complications, and short hospital stays.
A University of Colorado study shows that bladder cancer patients with high CD24 expression have worse prognoses and may benefit from anti-androgen therapies. CD24 expression depends on androgens, and blocking these hormones may diminish the proliferative and metastatic power of bladder cancer cells.
Researchers at Ohio State and the Sarawak Biodiversity Centre are collaborating on the development of silvestrol, a tropical tree-derived compound showing promise in treating acute and chronic leukemia. The team aims to isolate and purify the agent for laboratory and animal studies.
A recent study by Mayo Clinic researchers found that men with high levels of 'cancer-specific anxiety' after prostate cancer surgery are more likely to experience low sexual satisfaction and depression. Counseling may be beneficial in addressing these concerns and improving quality of life for these patients.
A team of researchers from MD Anderson Cancer Center has identified the LIFR protein as a novel suppressor of breast cancer metastasis. The study found that restoring LIFR expression or function could be used to block the spread of breast cancer. Loss of LIFR is associated with poor clinical outcomes in breast cancer patients.
The European Society for Medical Oncology (ESMO) has awarded 16 new centers with integrated oncology and palliative care accreditation. A new study from Italy highlights the underuse of adjuvant analgesics in cancer pain management, emphasizing close patient follow-up.
A phase II study found denosumab decreased giant cells and increased new bone formation in patients with giant-cell tumor of the bone, offering an alternative to radical surgery. The treatment reduced tumor burden by 90% or greater in all 20 patients, improving outcomes for young patients who previously required joint replacements.