Articles tagged with Cancer Patients
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Researchers have discovered JAK3 gene mutations in NK/T-cell lymphoma cells from 23 patients, suggesting the enzyme as a potential drug target. A Janus Kinase inhibitor already in phase III clinical trials for rheumatoid arthritis may also be effective against this cancer
A new method of virtual colonoscopy, administered without laxatives, has been shown to be as accurate as conventional colonoscopy in detecting potentially cancerous polyps. The procedure uses a CT scanner and a tagging agent to identify polyps, and was found to detect clinically significant polyps with 91% accuracy.
Researchers sequenced the bonobo genome to identify key differences with humans and chimpanzees, finding over 2.5 million transposon insertions unique to the bonobo genome. These findings may help understand the genetic basis for traits shared among humans, chimpanzees, and bonobos.
The number of Americans with a history of cancer is expected to reach 18 million by 2022, with 45% of survivors aged 70 or older. Improved cancer survival rates have led to the growth in survivor prevalence despite decreasing cancer incidence rates.
Researchers at H. Lee Moffitt Cancer Center & Research Institute found a multimedia psychoeducational intervention more effective in changing patients' perceptions and negative attitudes toward clinical trials than standard educational literature.
Researchers at University of Leeds and The Institute of Cancer Research have made breakthrough with a viral therapy that attacks cancer on two fronts. This 'hitch-hiking' virus can be injected into the bloodstream like standard chemotherapy agents, targeting cancer cells while leaving normal tissue alone.
A new immune approach to fighting some cancers has shown promise, with 20-25% of heavily pre-treated patients responding to BMS-936558. The treatment specifically blocks programmed cell death 1 (PD-1), a key immune checkpoint receptor.
A recent UCSF study found that radiation exposure from medical imaging doubled in integrated health care systems (HMOs) between 1996 and 2010, with significant variations between systems. The study, which analyzed millions of patient records, showed a dramatic increase in imaging rates and high radiation doses.
Researchers identified a molecular marker that quickly distinguishes between fast- and slow-progressing forms of chronic leukemia. The finding enables patients with aggressive disease to start treatment sooner.
A joint research project between Aarhus University and the Danish Cancer Society shows that mindfulness-based psychological therapy helps reduce anxiety and depression in cancer patients. Mindfulness teaches patients to be more conscious of life as it happens, reducing negative thoughts and worries.
A study using PET/CT imaging with F-18 FDG reveals that molecular imaging biomarkers can predict the effectiveness of radiochemotherapy for locally advanced rectal cancer. This improvement in treatment planning could lead to more effective and cost-efficient care.
A new molecular imaging method using PET/CT with Gallium-68 DOTATATE identifies hormonally active tissues, allowing clinicians to re-evaluate patient management. This technique changes treatment plans in over 35% of patients, saving them from unnecessary surgeries.
The Cleveland Clinic will participate in a six-institution MDS Clinical Research Consortium, supported by the Aplastic Anemia & MDS International Foundation. The five-year initiative aims to improve outcomes for patients with myelodysplastic syndrome through clinical trials and research.
A new antibody treatment has shown promising activity in patients with advanced kidney cancer, melanoma and lung cancer. Patients who received the treatment experienced a positive response without severe side effects.
Research shows that PET/CT imaging can change management plans for 34% of esophageal cancer patients, leading to improved survival rates. The technique provides powerful prognostic stratification and should be incorporated into routine clinical practice.
A computer-based algorithm can accurately predict seven-day heart failure mortality rates in emergency room patients. Researchers also found that childhood cancer survivors are at increased risk for gastrointestinal cancers starting as early as 5.5 years after diagnosis.
Patients with incomes under $50,000 were 27% less likely to participate than those earning more, with lower-income individuals expressing greater concerns about costs. The study highlights the need for better education and support for these patients.
Fox Chase researchers found that patients' socioeconomic status influences their treatment choices, with those having higher incomes opting for more effective but expensive treatments. This study highlights the need for policymakers to consider cost sensitivity in cancer care.
LDK378 shows encouraging activity in patients with ALK+ non-small cell lung cancer, including those who no longer respond to crizotinib. The compound is well-tolerated and its optimal dose is being further tested.
Researchers identified patterns in protein expression and found nearly 700 protein pairs implicated in networks of acute myeloid leukemia (AML) patients. The goal is to tailor therapy by targeting specific protein signaling pathways, which may lead to improved treatment outcomes.
A Penn study found that many patients with head and neck cancers experience significant late effects, but rarely report these issues to their doctors due to concerns about doctor's response. The researchers emphasize the need for improved survivorship care to encourage patients to seek help.
Studies found that regular exercise improved physical function in cancer survivors, but specific prescriptions remain unclear. Researchers also discovered that older cancer survivors engage less in physical activity due to functional declines, potentially affecting independence and survival.
The John Theurer Cancer Center will present research on multiple myeloma and leukemia, including combination therapies and salvage therapy for acute myeloid leukemia. The center's focus on bolstering its research program is part of its continued effort to provide comprehensive cancer care.
A study published in the Journal of Clinical Oncology found that childhood cancer survivors experience increased anxiety, depression, and depressive symptoms due to persistent hair loss and disfigurement. The study's findings highlight the long-term impact of childhood cancer treatment on quality of life.
A study by Duke University Medical Center found that breast cancer patients have significantly impaired cardio-pulmonary function that can persist for years after treatment. Higher cardio fitness levels were linked to longer median survival among women with advanced breast cancer, suggesting exercise may be a useful intervention.
The University of Kentucky Markey Cancer Center will conduct research on myelodysplastic syndrome, a deadly blood disorder often caused by chemotherapy or radiation treatments. The goal is to determine biomarkers for the disease and tailor cancer treatments to reduce the risk of developing MDS.
A study by the University of Wisconsin found an association between sleep disordered breathing and increased cancer mortality. The researchers analyzed data from 1,522 subjects and found that those with mild, moderate, or severe SDB had a higher risk of cancer mortality compared to those without SDB.
A study presented at Heart Failure Congress 2012 found that statin therapy prevents cancer and reduces death from all causes in heart transplant recipients. Cancer is the leading cause of death late after heart transplantation, with skin cancer being particularly common.
A new study published in the American Journal of Respiratory and Critical Care Medicine found a significant association between sleep-disordered breathing (SDB) and increased risk of cancer mortality. Patients with severe SDB had a nearly five times higher incidence of cancer deaths compared to those without the disorder.
A systematic review found that low-dose computerized tomography (LDCT) screening can reduce lung cancer mortality rates among high-risk individuals. The study analyzed 8 randomized controlled trials and 13 cohort studies, with the National Lung Screening Trial demonstrating a significant benefit. However, potential harms of LDCT screen...
A nurse practitioner-driven consultation improved cancer patients' emotional health and quality of life, with a significant improvement in those who received the intervention. The study suggests that incorporating palliative care discussions into oncology practices can lead to better patient outcomes.
A modified version of Google's PageRank algorithm is used to rank proteins by their genetic relevance to pancreatic cancer progression. Seven proteins were found that can help assess tumor aggressiveness and guide treatment decisions.
Researchers from the University of Southampton have developed a groundbreaking study to investigate the experiences and needs of people after primary treatment of colorectal cancer. The CREW study aims to inform healthcare providers about what helps or hinders rapid and effective recovery, with over 1,000 patients recruited.
Dabrafenib, a BRAF inhibitor, demonstrates substantial tumor shrinkage in patients with brain metastases from melanoma. The study also reveals potential for the treatment to prolong survival beyond 12 months.
A phase I clinical trial combining temsirolimus and capecitabine demonstrates promising evidence of disease control in advanced malignancies. The study shows that the combination can be given safely to patients, with a positive survival trend observed.
Researchers from Mount Sinai presented several landmark studies on late-stage cancer treatment trends, a promising multiple myeloma vaccine, and predictive models of soft tissue sarcomas, prostate, and bladder cancer. The studies aimed to identify factors associated with lack of treatment and explore new treatments for various cancers.
Robert F. Ozols, a leading expert in ovarian cancer research, will be honored with the American Society of Clinical Oncology's 2012 Distinguished Achievement Award. He made significant contributions to advancing chemotherapy research and overcoming drug resistance.
Researchers at Memorial Sloan Kettering Cancer Center have identified three genetic targets in approximately 50% of patients with squamous cell carcinomas. This breakthrough enables personalized treatment for a previously untreatable type of lung cancer.
A new treatment regimen, accelerated MVAC, has been shown to provide comparable benefits to standard chemotherapy without the same toxicity. This accelerated schedule of six weeks has improved response rates and tolerability for patients with muscle-invasive bladder cancer.
The American Society of Clinical Oncology (ASCO) has released five new studies at its upcoming annual meeting, including those on precision medicine and cancer's genetic weak spots. These studies demonstrate improvements in treatment for aggressive cancers and provide valuable tools to lessen the side effects of cancer treatment.
A recent study found that 54% of patients with stage two and three rectal cancer did not receive treatment consistent with guidelines. The study, published in Clinical Oncology, also showed significant regional variation in treatment patterns across Alberta.
A Phase III clinical trial found lenalidomide treatment decreased the risk of progressive myeloma or death in stem cell transplant patients, with a 63 percent reduction in disease progression risk. The study's results support the use of lenalidomide maintenance therapy after stem cell transplantation to improve patient outcomes.
Researchers have created a highly sensitive biosensor that can detect biomolecules without the need for a reference electrode, enabling miniaturization and low-cost applications. The device has potential applications in personalized medicine and early cancer diagnosis.
Researchers developed a genetic test to predict ocular melanoma tumor spread, classifying tumors with over 97% accuracy. The test identified two classes of tumors: those unlikely to spread (class 1) and those more likely to develop metastatic cancer (class 2).
Patients with HPV-positive throat cancer have significantly better control of the tumour, disease-specific survival, and overall survival when treated with radiotherapy alone compared to HPV-negative patients. HPV-positive light or non-smokers have even more favourable outcomes.
Researchers at the University of Pittsburgh Cancer Institute have identified a molecule activated by a virus that can selectively kill tumor cells in animal studies. A new drug candidate, YM155, has shown promising results in killing MCC cells and suppressing tumor growth.
A new study launched by University of Leicester is exploring whether tablets containing curcumin can enhance the effectiveness of chemotherapy for advanced bowel cancer. The trial aims to recruit 40 patients and investigate the safety and efficacy of adding curcumin to standard treatment.
A new study found that women with benign breast biopsies do not require close surveillance at six or twelve months, and may not need follow-up care at all. The study suggests an annual mammogram could replace the need for follow-up examinations.
Two UC Davis faculty members, Frederic Chedin and Noriko Satake, received Individual Biomedical Research Awards to explore novel approaches to understanding autoimmune diseases. Paula Goines, a postdoctoral researcher, will also receive funding for her work on autism research using nerve cells grown from adult stem cells.
The University of California, Santa Cruz, has established the Cancer Genomics Hub to manage and analyze large-scale cancer genomic data. This hub will support research programs like The Cancer Genome Atlas and enable personalized cancer care by connecting specific genomic changes with clinical outcomes.
A study published in Cancer Research found that weight loss of at least 5% reduced markers of inflammation in postmenopausal women. This reduction was observed even when exercise alone was not sufficient to decrease inflammation markers.
A recent analysis of 23,359 patients found that young CT scan recipients are more likely to die from their underlying disease than develop radiation-induced cancer. The study revealed a significantly lower risk of cancer induced by CT scans compared to the risk of dying from the disease.
Researchers found that most African-American breast cancer survivors were satisfied with their treatment but lacked access to critical information about treatment options, support services, and clinical trials. Only 62% of women received information about support services, while nearly half said they wanted such services.
Researchers at St. Jude Children's Research Hospital found no significant difference in survival rates between African-American and white children treated for virtually all cancers during a 15-year period. The study suggests equal access to comprehensive treatment translates into equally good outcomes, closing the racial survival gap.
Researchers at Moffitt Cancer Center are developing 'designer lymph nodes' that use gene-modified cells to produce a pre-planned immunologic response for cancer patients. These innovative nodes aim to rebuild and augment the immune system, overcoming dysfunction caused by tumors or treatments.
Researchers at Harvard's Wyss Institute have developed a microfluidic device that can capture and culture rare circulating tumor cells from blood, providing insights into patient-specific drug sensitivity and cancer progression. The technology has the potential to become a valuable tool for cancer diagnosis and personalized treatment.
A new analysis found that Hispanic lung cancer patients have a 15% lower risk of dying compared to white patients, with black patients slightly more likely to die. The study also identified higher frequencies of less serious lung cancer types in Hispanics, which may be linked to genetic or environmental factors.
A new University of Michigan study found that patients with early-stage kidney cancer who underwent partial nephrectomy had better survival rates than those who received radical nephrectomy. The study analyzed data from 7,138 Medicare beneficiaries and showed that younger or medically compromised patients benefited most from the less i...
A study published in Journal of Virology identifies apoptosis, the programmed death of a host cell, as the trigger for high-level viral replication of Kaposi's sarcoma-associated herpesvirus (KSHV). This discovery suggests that KSHV can sense and respond to changes in its host cells, granting it an evolutionary advantage.
A new study found that communication problems between patients and their care providers are more prevalent than traditional medical errors, leading to significant harms. Patients often take positive steps to address issues, but some become more hesitant to seek care.