Articles tagged with Cancer Patients
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A new study published in CANCER found that many older lung cancer patients receive radiation therapy without extending their lifespan. Researchers analyzed data from the Surveillance, Epidemiology and End Results (SEER)-Medicare registry to determine if additional radiation therapy after surgery improves survival rates.
Researchers analyzed tumor specimens from 19 advanced stage carcinoma patients, discovering changes in biomarker expression that may impact therapy selection for women with recurrent ovarian cancer. The study highlights the importance of analyzing current tumor tissue to make informed treatment decisions.
A new clinical trial demonstrates the effectiveness of adaptive radiotherapy in treating head and neck cancer, requiring only one or two replans to maintain treatment quality. The study found that ART keeps radiation tightly fitted to a patient's body, offering individualized treatment with minimal burden.
A study by Concordia University and McGill University Health Centre found a strong link between muscle mass and strength in cancer patients with severe fatigue. The researchers suggest that specialized strength training programs could improve muscle mass and reduce fatigue, enhancing the quality of life for these patients.
The Australian Cancer Research Foundation has committed $2 million to two new cancer research laboratories at the Walter and Eliza Hall Institute. The new facilities will enable researchers to study the biology of epithelial cancers and develop new treatments for breast, ovarian, lung, and leukemia patients.
Researchers have developed a new approach to detect cancer cells in the bloodstream, allowing for real-time assessment and control of disease spread. The method could help predict response and resistance to therapies, enabling more effective treatment decisions.
A study published in Cancer Prevention Research found that soy isoflavone supplements did not decrease breast cancer cell proliferation. The results are consistent with previous studies on the effectiveness of dietary supplements in preventing cancer.
Different subgroups of non-small cell lung cancer exhibit distinct patterns of spread in the body, suggesting fundamentally different diseases. Targeted therapies have shown dramatic clinical responses in patients with ALK positive NSCLC, offering new hope for treatment.
Researchers developed a highly sensitive blood test for detecting and analyzing circulating tumor cells (CTCs) in cancer patients. The 'biopsy in a blood test' provides information comparable to surgical biopsies, enabling better monitoring, prediction, and understanding of cancer progression.
A new study published in Gastroenterology reveals that Barrett's esophagus patients who smoke are twice as likely to develop esophageal cancer. Tobacco smoking emerged as the strongest lifestyle risk factor for cancer progression in this patient group.
Researchers analyzed past studies on cancer-related pain reduction and found that psychosocial interventions can significantly improve cancer patients' pain severity. Skill-based interventions and educational approaches were most successful in reducing pain and its impact on daily life.
Smoking doubles the risk of developing oesophageal cancer in people with Barrett's Oesophagus. A 13-year study involving over 3000 patients found those who smoked tobacco were twice as likely to develop cancer.
Research team led by Edward T. H. Yeh discovers that SENP1 regulates SUMOylation of STAT5, essential for lymphoid development of T and B cells. Without SENP1, STAT5 cannot be activated or recycled, leading to severe defects in immune cell development.
A new study found that transplant patients with head and neck cancer are more likely to be non-smokers and non-drinkers, and less likely to survive past one year of diagnosis. The risk for developing head and neck cancer is small, but the study highlights the need for regular screenings and aggressive treatment.
A study by UC Davis researchers found that newer radiation therapy technology, intensity-modulated radiation therapy (IMRT), improves patients' quality of life for those with advanced head and neck cancers. IMRT was associated with fewer long-term side effects, leading to better quality of life.
A Danish health care fast track program has reduced the waiting time between a patient's initial meeting with a healthcare provider and their first treatment for head and neck cancer from 69 days in 2002 to 41 days in 2010. The program, implemented in 2008, prioritized cancer patients and implemented various reforms to curb wait times.
Researchers at Georgetown Lombardi Comprehensive Cancer Center are studying whether high-risk HPV-positive patients with head and neck cancer should receive more or less chemotherapy. Their research suggests intensifying therapy could increase cure rates, but additional studies are needed.
A 1993 Chevrolet Corvette 40th Anniversary coupe was sold at the Barrett-Jackson Scottsdale Auction, raising $120,000 for cancer research at TGen. The funds support research into colon and prostate cancer in memory of Russ and Brian Jackson.
Researchers have identified a new pathway that targets the root cause of glioblastoma resistance, paving the way for more effective treatments. By understanding how this complex signaling process works, scientists hope to develop novel therapies to improve patient outcomes and extend survival rates.
A new study found that many cancer patients continue to smoke after diagnosis, with 39% of lung cancer and 14% of colorectal cancer patients smoking at diagnosis. Factors such as insurance, emotional support, and education level can predict continued smoking in these patients.
Researchers found that prostaglandin E2 accelerates colorectal cancer development by silencing tumor-suppressing genes and increasing DNA methylation. Combining anti-inflammatory and demethylating agents reduced tumors by up to 93% in mice with colorectal cancer.
Researchers at IMIM have discovered a new mechanism of resistance to colon cancer treatment, where a mutation in the EGFR oncogene causes resistance to drug cetuximab. The finding has significant clinical implications and opens up possibilities for using alternative treatments like panitumumab.
A recent study found that adding oxaliplatin to adjuvant chemotherapy for stage III colon cancer patients in the general population improved overall survival rates. The research also showed that this combination therapy was effective across various practice settings, including older and minority patients with comorbid conditions.
A study by Virginia Commonwealth University found that patients receive only 46% of guideline-recommended preventive services during routine annual visits. The most common services delivered were screenings for colorectal cancer, hypertension, and breast cancer.
Scientists have documented how ALK positive advanced non-small cell lung cancer becomes resistant to crizotinib, a previously effective treatment. Researchers now aim to develop combination therapies to tackle this resistance and improve patient outcomes.
Researchers have identified a novel connection between two RNA-binding proteins, Musashi1 and HuR, which plays a significant role in glioblastoma development. The study suggests that disruptions to these regulatory processes can contribute to tumor formation.
Researchers at Stanford University have used a computer algorithm to find markers that predict how deadly bladder cancer will be, offering faster and more accurate analysis of cancer risk. The test can be performed by someone with little training and may help identify patients with the most aggressive subtype before it becomes invasive.
A leading cancer researcher highlights high levels of doctor-patient trust and confidence within the NHS. Closer clinical relationships between physicians and patients are crucial for coping with treatment and diagnosis. However, cost-cutting measures risk eroding this trust if not carefully implemented.
Researchers found that patients with 'matted' lymph nodes had a 69% survival rate over three years, compared to 94% for those without matted nodes. The study's results may help doctors identify patients at higher risk and reduce standard treatment side effects.
Researchers reassessed symptom indices to detect ovarian cancer early on, finding similar results to previous reports and a limited benefit in advancing diagnosis. The study highlights the challenges of detecting ovarian cancer early due to its biology, screening limitations, and clinical characteristics.
Dr. Sandra Van Schaeybroeck's research aims to identify ways to increase survival from bowel cancer by developing new treatment strategies and understanding drug resistance. The £688,000 Cancer Research UK Clinical Scientist Fellowship renewal will support her work for another three years.
In a preclinical study, ganetespib slowed the growth of cancer cells from non-small cell lung tumors with a KRAS gene mutation. The drug was more active when combined with traditional lung cancer treatments and other targeted therapies, indicating its potential effectiveness in treating patients with KRAS-mutant NSCLC.
TGen researchers identify multiple novel mutations and pathway changes in never-smoker lung cancer patients, diverging from those found in smokers. These findings hold promise for developing therapeutic targets in this patient population.
A preclinical study found that a combination of estrogen-targeting drugs significantly reduced tobacco carcinogen-induced lung tumors in mice. The treatment, which blocks estrogen production and its effects on the body, showed maximum antitumor effects in both healthy and precancerous cells.
Researchers identified potential gene mutations and pathway alterations that could lead to lung cancer in never-smokers. They found that these patients' tumors lacked common genes associated with lung cancer, making them ideal cases for discovering new mutations that may drive the disease.
Researchers developed a sensitive test to analyze circulating tumor cells in blood, enabling clinicians to track cancer progress and treatments. The method uses high-throughput mass spectrometry analysis, allowing for the detection of genetic mutations present in small numbers of malignant cells.
Most patients who survive oesophageal cancer surgery recover an average quality of life, but one in six experience significant deterioration. Hospitals must improve identification and follow-up for these patients to prevent persistently low quality of life.
A new downloadable tool from the University of Colorado Cancer Center guides cancer survivors through a personalized exercise plan, helping them set goals and track progress. The program aims to overcome common challenges faced by cancer patients, including fatigue and self-doubt.
Women with breast cancer who take anti-estrogen supplements may be decreasing their risk for melanoma. Risk for melanoma was 60 percent higher among patients who did not receive anti-estrogen therapy compared to those who received it.
Researchers discovered an agent, PEDF, that suppresses brain metastatic activity and shields the brain from tumor-induced damage. This finding represents a significant step forward in managing brain metastases, a major challenge in cancer treatment.
Researchers have discovered a technique to keep normal cells and tumor cells taken from an individual cancer patient alive in the laboratory. This breakthrough could revolutionize personalized cancer medicine and regenerative medicine, enabling oncologists to find the right therapies for patients.
Researchers at Ohio State University have discovered a hereditary cancer syndrome that increases risk for uveal melanoma, lung cancer, brain cancer, and possibly other types of cancer due to mutations in the BAP1 gene. The study identifies six families with this syndrome, which can be screened for using a clinical test.
Scientists at Lawson Research Institute are testing stereotactic ablative radiotherapy (SABR) to treat cancers that spread beyond the original tumor, offering new hope for survival. The COMET Trial aims to assess SABR's impact on patient survival, side effects, and quality of life.
Researchers developed two new QCancer algorithms to predict patients most likely to have pancreatic and bowel cancer, improving early diagnosis and treatment options. The calculators were successful in predicting 62% of pancreatic cancers and 70% of bowel cancers diagnosed over the following two years.
A study published in Medical Care explores ways to empower patients and transform cancer care systems to improve quality. Researchers propose new approaches, including accountable care and personal health records, to address racial disparities and wasteful overuse.
A new prognostic model developed by researchers at the University of Texas M. D. Anderson Cancer Center has identified three risk groups for patients with treatment-related myelodysplastic syndrome, each with different survival prospects. The model incorporates multiple factors, including age, cytogenetics, and serum hemoglobin levels,...
A new test developed by QUT PhD student Helen McCosker can predict the likelihood of breast cancer growth, dormancy, or spread to other organs. The test analyzes tissue surrounding cancer cells and offers personalized treatment plans for patients.
A study published in JAMA Network found that patients with myotonic muscular dystrophy are at an increased risk of developing certain types of cancer, including endometrial, brain, ovarian, and colon cancer. The study analyzed data from over 1,600 patients and found a significant excess of these cancers compared to the general population.
Research found that people with myotonic muscular dystrophy are at higher risk for developing four specific types of cancer. Additionally, there may be an increased risk for other cancers such as eye, thyroid, pancreas, and female reproductive organs. Patients should prioritize cancer screening, particularly colon cancer screening.
Researchers found that tumors with high microRNA-200c levels are more likely to spread and those with lower levels may benefit from focused local treatment. This discovery could help identify patients who can benefit from aggressive, targeted radiation therapy and move them away from whole-body treatments.
A Phase II clinical trial of 75 AML patients treated with vorinostat and chemotherapy resulted in an 85% remission rate. Higher-risk patients showed a complete response rate of 100%, while those with -5/-7 cytogenetic alterations fared less well. The Phase III trial will compare this combination to standard-of-care frontline therapies.
Researchers sequenced DNA from two sisters with follicular lymphoma and found identical BCL2/IGH rearrangements. The study identified 15 mutations that were present in both lymphomas, indicating a donor-recipient transmission of cancer-causing genetic material.
A University of Rochester Medical Center study found that nearly 78% of cancer-related blood clots occur in outpatients during chemotherapy treatment. The study's findings suggest a shift towards outpatient care and the need for education and compliance to prevent blood clots.
A Phase I/II clinical trial for patients with relapsed or resistant chronic lymphocytic leukemia (CLL) showed impressive potential for PCI-32765, a B cell receptor inhibitor, achieving durable remissions and minimal toxicity. The study demonstrated six-month progression-free survival of 90-92%.
Researchers found that loss of the retinoblastoma tumor suppressor gene (RB) in triple negative breast cancer patients is linked to improved survival rates. This discovery could lead to personalized treatment approaches for these patients.
Studies using echocardiography revealed early signs of myocardial damage and impaired ventricular relaxation in cancer patients treated with trastuzumab. ACE inhibitors and statins were found to deliver cardio protective effects, reducing oxidative stress and inflammation.
A follow-up study by Moffitt Cancer Center researchers found that patients who received chemotherapy for breast cancer may experience prolonged fatigue years after treatment. This contradicts prior research and has important implications for patient education and fatigue monitoring during follow-up.
Researchers observed oxidative changes in living organisms for the first time, revealing that many assumptions about oxidative stress and aging are incorrect. Antioxidants did not reduce oxidant levels, but rather increased production in energy plants.
The American Society of Clinical Oncology (ASCO) has released its annual report on progress against cancer, showcasing the most significant developments in cancer research and policy. The report highlights advances in personalized treatment approaches, early detection, and new drug approvals for various cancers.
A tiny genetic variation in the KRAS oncogene can predict ovarian cancer outcomes and response to treatment, with women carrying the variant being three times more resistant to standard chemotherapy. The biomarker also increases the risk of poor outcomes in other types of cancer.