Articles tagged with Cancer Patients
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A study has identified a promising treatment approach for T-cell acute lymphoblastic leukemia (T-ALL), a highly aggressive childhood cancer. The dual PI3K gamma/delta inhibitor CAL-130 significantly prolonged survival in mouse models and prevented proliferation of human T-ALL cells, setting the stage for clinical trials.
Research suggests that individuals with polyglutamine (polyQ) diseases, including Huntington's disease, have a lower risk of developing cancer. This reduced cancer risk is thought to be due to the expansion of certain sequence repeats in specific genes, which impairs gene activity and leads to cell death.
A study published in Cancer found that frequent dental x-rays are linked to an increased risk of developing meningioma, the most commonly diagnosed primary brain tumor in the US. Patients who received bitewing exams or panorex exams on a yearly or more frequent basis were at higher risk of developing meningioma.
A study by Michigan Oncology Quality Consortium found that most practices followed guidelines for breast, colorectal, and lung cancers, but had gaps in managing symptoms and end-of-life care. To improve quality, the consortium initiated a project to provide palliative care delivery.
A new study finds that more than 60% of breast cancer survivors experience treatment-related complications even six years after their diagnosis. The study provides a comprehensive snapshot of the physical late effects of breast cancer treatment and outlines a model for monitoring and preventing these conditions.
A study reveals that cancer patients overwhelmingly prefer risky treatments with a chance of longer survival to safer options. This approach is driven by patients' desire for hope and limited remaining life expectancy, indicating a shift in how value should be defined from the patient's perspective.
A new study from Karolinska Institutet in Sweden found that cancer patients are at a significantly increased risk of suicide and cardiovascular death during the first week following a diagnosis. The risk decreases rapidly over time but is most pronounced for those with poor-prognosis cancers.
BIND Biosciences presents late-breaker clinical data for BIND-014, a targeted docetaxel Accurin, showing anti-tumor activity in six of 17 patients with advanced or metastatic solid tumor cancers. The study demonstrated partial response or stable disease with durable responses of up to six months.
A phase II clinical trial showed encouraging survival in patients with stage 3B/4 non-small cell lung cancer (NSCLC) treated with belagenpumatucel-L. The median survival rate was 14.5 months, and the five-year survival rate was 20%. Patients with stable disease had a longer median survival of 44 months.
A team of researchers at Georgetown University Medical Center has discovered an agent that prevents the spread of osteosarcoma cancer to the lungs in mice with the disease. The agent, an ezrin inhibitor, targets a protein vital to the spread of osteosarcoma and may potentially treat adults and children with bone tumors.
Researchers have found a promising combination of nab-paclitaxel and carboplatin to be effective in treating non-small cell lung cancer (NSCLC) patients who are ineligible for bevacizumab. The treatment resulted in an overall response rate of 41% and stable disease in 39% of patients.
A new study from Karolinska Institutet found that patients who suffered serious post-operative complications after esophageal cancer surgery had more symptoms of breathlessness, fatigue and eating problems, with impairments lasting for five years. Patients require long-term monitoring to identify and target any problems quickly.
Researchers developed a multimarker molecular stool test that is highly sensitive to early-stage cancers and precancerous adenomas. The test was unaffected by variables such as age, sex, race, alcohol consumption, tobacco use, body mass, and medication use.
A new phase III study comparing the efficacy of Bacillus Calmette Guérin strains Tice and Connaught for non-muscle invasive bladder cancer treatment found that Connaught significantly reduced cancer recurrence rates, with a five-year recurrence-free survival rate of 75% compared to 46% for Tice. The study has the potential to shift the...
Scientists have discovered a new paradigm for immunotherapy against cancer by priming antibodies and T cells with cancer stem cells. The study found that purified cancer stem cells strengthened the potency of antibodies and T cells that selectively targeted cancer stem cells.
A new study in animal models found that women with breast cancer who began eating soy as an adult may develop a tumor more resistant to treatment. The research suggests that stopping soy intake if diagnosed with breast cancer could be beneficial.
A Canadian Journal of Surgery study reveals that only 13 out of 14,000 cancer patients with bone metastases receive orthopedic care annually. This under-referral may contribute to poor outcomes and high mortality rates, emphasizing the need for timely surgical consultations.
Researchers found four proteins dysregulated by the PI3K/mTOR pathway associated with poor survival in hormone receptor-positive breast cancer. These findings suggest potential new prognostic factors and therapeutic targets for treatment.
Researchers at Fox Chase Cancer Center found that survivin levels were associated with longer disease-free survival and better response to chemotherapy in patients with pancreatic cancer. The study suggests that survivin could be a useful tool for identifying patients who may benefit from specific treatments.
A combination of cixutumumab and temsirolimus shrank tumors in some patients with treatment-resistant Ewing's sarcoma or desmoplastic small-round-cell tumors, with two achieving complete responses. The study suggests that managing side effects is vital to maintaining the therapy and slowing disease progression.
Researchers identified pazopanib as a clinically meaningful treatment for refractory urothelial cancer. The study found that increases in interleukin-8 levels after treatment predicted a lack of tumor response, with 10% of patients experiencing long-term cure.
A new breast cancer susceptibility gene, XRCC2, has been discovered by researchers at the University of Utah Health. The study found that mutations in this gene increase breast cancer risk, providing a new target for chemotherapy and improving diagnostic accuracy.
David A. Solomon, a Georgetown University Medical Center student, has been recognized for his groundbreaking work in cancer research. His research focuses on identifying new cancer genes and developing targeted therapies, with notable findings including the identification of CDKN2C and PTPRD as tumor suppressor genes.
A new study from the University of Leicester found that patient information leaflets for cancer trials are often poorly written, leading to confusion among patients. The research suggests that a standardized approach to writing these leaflets could improve patient understanding and trust in the decision-making process.
Researchers found low LDL cholesterol in patients with no history of cholesterol-lowering drugs existed before cancer diagnosis, suggesting an underlying mechanism. The study's lead investigator noted that the relationship between low LDL-C and cancer exists for many years prior to diagnosis, highlighting the need for further examination.
Researchers discovered a DNA damage marker, telomeric allelic imbalance (tAI), that predicts sensitivity to platinum-based chemotherapy in patients with triple-negative breast cancer. The study found an inverse relationship between tAI and BRCA1 expression levels.
A 15-year follow-up of over 1000 DCIS patients found that radiotherapy reduced local recurrence risk by 50%, while improving survival for invasive recurrence cases. The study suggests a continuous protective effect of RT on DCIS recurrence in the long term.
A study found that wide negative margins are associated with a lower risk of local recurrence in women with ductal carcinoma in situ treated with breast-conserving surgery. Researchers recommend considering radiotherapy as the top priority to complement targeting wider free margins.
A University at Buffalo study found that parents of pediatric cancer patients distrust online sources of health information and fear what they might encounter. Despite the accessibility of online medical information, caregivers preferred to receive information from trusted healthcare providers rather than the internet.
A new method detects cancer-causing chromosomal translocations quickly and accurately, allowing for potential single-array testing for every known cancer-causing translocation simultaneously. The technique combines microarray technology with a novel antibody to detect the presence of the translocation.
Fox Chase Cancer Center is leading efforts to establish national standards for survivorship care, citing the need for comprehensive plans and guidelines. The Center's own survivorship care plan will be tailored to each patient, summarizing therapy and making recommendations based on their specific case.
Researchers sequenced DNA from cancer cells in patients with myelodysplastic syndromes who later developed leukemia, finding that the disease is an early form of cancer. The study suggests that targeted cancer drugs should be aimed at mutations that develop early in the disease.
Researchers have identified genetic abnormalities that help doctors predict patient prognoses and guide treatment decisions for AML. The study shows that nearly two-thirds of patients can be categorized into clear prognostic groups, leading to improved treatment outcomes.
Researchers identified a gene mutation associated with chronic neuroblastoma that typically affects adolescents and young adults. The discovery provides clues about the genetic basis of treatment outcome and age at diagnosis.
The study reported a significant increase in five-year and 10-year survival rates for children with acute lymphoblastic leukemia, rising to 90.4% and 83.9%, respectively. Advances in treatment, including new drugs and supportive care, contributed to the improved outcomes.
Researchers identified ways to reduce costs of molecular profiling and targeted therapies, enabling more patients to benefit from personalized treatments. The methods include recommending testing only for high-risk patients and merging tests to lower combined prices.
A study found that over 80% of radiation oncologists discuss fertility risks with patients of childbearing age, but many receive inadequate education. The role of radiation oncologists in communicating fertility preservation options is crucial for improving quality of life and care for young cancer patients.
Scientists at German Cancer Research Center have discovered that histone proteins actively open access to genetic information by detaching short DNA segments. This mechanism allows genes to be read and may be disrupted in cancer cells.
Researchers report a rare phenomenon where localized radiation therapy leads to disappearance of metastatic tumors, suggesting an immune system-activating effect. The combination of ipilimumab and radiation may offer a promising approach for treating advanced melanoma.
Therapeutic cancer vaccines are being evaluated in clinical trials with immune checkpoint inhibitors and small-molecule targeted therapies to overcome immunosuppressive entities. Patients with fewer chemotherapeutic regimens respond better to vaccines, indicating a shift towards combination therapies.
Researchers developed a new approach using billions of clones of patients' own tumor-fighting cells combined with chemotherapy, showing promise in treating advanced melanoma. The treatment resulted in long-term remission and temporary non-progression of disease in some patients.
A recent study published in Mayo Clinic Proceedings found that robotic surgery offers a less invasive alternative to traditional treatments for oropharyngeal cancer, resulting in high survival rates and improved patient quality of life. The treatment preserved patients' ability to swallow and maintained excellent speech performance.
A combination therapy of dendritic cell implants and radiotherapy was found to be effective in inducing tumor-specific immune responses in 52.9% of trial patients with high-risk soft tissue sarcomas. The treatment resulted in dramatic increases in immune T cells in the tumors, leading to significant clinical benefits.
The new drug Vemurafenib doubles the median survival time of metastatic melanoma patients with a specific genetic mutation, from 6 months to 15.9 months. In responding patients, the drug stops cancer progression for an additional 6.7 months.
Researchers found that palliative care staff use multifaceted approaches to provide physical, psychological, social, spiritual, and existential care. These caregiving activities can improve the quality of death for both patients and their families.
Researchers have found that combining gemcitabine with nab-paclitaxel increases intratumoral gemcitabine levels by reducing the primary metabolizing enzyme, cytidine deaminase. This combination may lead to improved patient outcomes and better administration of therapeutic treatments.
Research at Yale University reveals that prostate cancer treatment is often not necessary for older men with short life expectancy. The study found that cancer treatment became more common among men with moderate-risk tumors and shorter life expectancies, despite being unlikely to benefit from it.
A study published in the Journal of Clinical Oncology found that women who underwent chemotherapy with the CMF regimen between 1976 and 1995 scored slightly lower on cognitive tests compared to those without a history of cancer. The differences were subtle but statistically significant, affecting word learning, memory, and information ...
A new study found that patients with chronic myeloid leukemia (CML) who have not responded to interferon treatments experience significant long-term benefits when switching to imatinib. Up to 93% of patients survive at least eight years, compared to only three to six years prior to imatinib.
A new study published in Radiology found that computed tomography (CT) colonography, also known as virtual colonoscopy, is an effective screening tool for colorectal cancer in adults over 65. The study analyzed data from 477 patients over 65 and found high diagnostic accuracy rates comparable to those for younger patients.
A survey of over 41,000 patients with various cancers found that women, young people, and ethnic minorities experience delayed recognition due to symptom characteristics. GPs are less likely to consider cancer in younger patients and those from different ethnic groups, leading to longer consultation times.
A new study has found that cancer patients with breast, melanoma, testicular, and endometrial cancers are more likely to be referred to a specialist after just one or two consultations. In contrast, patients with less common cancers such as multiple myeloma, pancreatic, stomach, and ovarian cancer require three or more visits before re...
A recent analysis of data from the National CT Colonography Trial confirms the efficacy of CT colonography as a front-line colorectal cancer screening tool for seniors. The study found that CT colonography accurately detects polyps and precancerous lesions in people aged 65 and older, comparable to standard colonoscopy.
Researchers evaluated a teaching program for breaking bad news to patients, finding that medical students reported improved comfort in addressing difficult topics. The program involved videotaped sessions with standardized patients and post-interview discussions, which were found to be highly beneficial.
Researchers say anti-clotting effect of heparin is well established but its impact on cancer patients remains unclear. The SAVE-ONCO study found semuloparin reduced thromboembolism incidence but had no significant effect on major bleeding and death.
Researchers found a powerful cause-and-effect relationship between elevated platelets and ovarian cancer progression. Tumors stimulate platelet production, which strengthens the disease, reducing survival rates in patients with thrombocytosis.
Malnourished cancer patients who received oral nutritional support showed improvements in aspects of quality of life, including emotional functioning and loss of appetite. However, the interventions had no impact on mortality rates or consistent effects on weight gain.
A study found that injectable Low Molecular Weight Heparin (LMWH) treatment increased clot prevention rates compared to warfarin-based therapy in advanced cancer patients. Despite being recommended by guidelines, LMWH use is low due to patient preference for oral warfarin.
Researchers found that certain drugs can activate hepatitis B viruses in liver cells, increasing viral replication. This activation is linked to the stress protein p38, which can lead to complications in transplant patients.
A study published in PLOS ONE found that fetal exposure to radiation increases the risk of developing testicular cancer in male mice. The research suggests that DNA-damaging agents, such as radiation, may be responsible for the increasing incidence of testicular cancer in young Caucasian men.