Articles tagged with Cancer Patients
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Research found that specific DNA regions contribute to prostate cancer development and early death, with patients having two of these changes at high risk. The study identifies key genes PTEN and MYC as linked to prostate cancer lethality.
Researchers at Huntsman Cancer Institute developed a powerful technique to identify RNA cytosine methyltransferases (RMTs) targets in human RNA. The new method reveals previously unknown RMT targets for NSUN2, implicated in mental retardation and cancers.
Researchers found that intraventricular chemotherapy can palliate associated symptoms in patients with leptomeningeal carcinomatosis from non-small cell lung cancer. The study shows that 20 of 69 patients achieved normal ICP, and careful patient selection is recommended for successful treatment.
Scientists have developed a new chemical compound, WEHI-539, that inhibits BCL-XL protein in cancer cells. This could lead to the design of potential anti-cancer agents that restore cell death and improve treatment outcomes for patients with various types of cancer.
A new study suggests that tomosynthesis increases breast cancer detection rates by 11%, particularly benefiting women with dense breasts. The technology's improved performance in dense breast tissue was attributed to its ability to detect invasive and intraductal cancers more accurately.
Researchers at Columbia University developed a new computational model that uses gene signatures to predict breast cancer survival with high accuracy. The model, which won a crowd-sourced challenge, has the potential to improve diagnostic and prognostic products for multiple types of cancer.
A multicenter study found that 84% of lung cancer patients taking crizotinib have low testosterone levels, with 80% experiencing symptoms such as sexual dysfunction or depression. The study suggests that hormone replacement therapies may alleviate these symptoms and provide a new treatment option for affected patients.
A study of over 310,000 bowel cancer patients in six countries found that UK patients were more likely to be diagnosed at a later stage than others, resulting in lower survival rates. Improved diagnostic investigation and treatment are seen as key factors to increase UK survival rates.
Researchers at IRCM identified the DOCK1 protein as a key regulator of metastasis in breast cancer. The study found that eliminating DOCK1 in mice resulted in a significant decrease in lung metastases and tumor growth.
The study found that while the program was rarely used, those who participated reported gratitude for receiving a lethal prescription, regardless of use. The most common reasons for participation included loss of autonomy, inability to engage in enjoyable activities, and loss of dignity. SCCA's approach prioritizes palliative care and ...
A new class of tumor-fighting drugs using RNA interference has shown promising safety and efficacy in a clinical trial. The study found that the drug acts by silencing the PLK1 gene involved in tumor growth and can be safely administered in humans, with most patients tolerating it well and some showing therapeutic benefit.
A Mayo Clinic study found gene variations that can predict chemotherapy-induced peripheral neuropathy, a debilitating condition affecting 20-30% of cancer patients. The study implicates genes EPHA5, ARHGEF10, and PRX, enabling clinicians to individualize treatment and improve patient outcomes.
Researchers found that cosmic radiation impairs the ability of cells in the intestines of mice to eliminate oncogenic proteins, substantially increasing development of colorectal tumors. The study suggests that space travelers may be at increased risk of developing colorectal cancer due to prolonged exposure to cosmic radiation.
A new study by Fox Chase researchers finds that heterogeneity is prevalent even in early-stage ductal carcinoma in situ (DCIS) breast cancer, making it challenging for pathologists to accurately diagnose and treat the disease. The results suggest that a multiple-target approach may be necessary to effectively combat breast cancer.
Researchers have identified a set of misregulated genes common to tobacco-related cancers, which are associated with poor patient outcomes in lung and bladder cancers. These genes relate to the regulation of the cell cycle and could serve as a new prognostic tool to predict survival rates for patients with tobacco-related cancers.
The American Cancer Society has awarded 175 national research and training grants totaling $79,073,250. The grants will fund investigators at 93 institutions across the US, with a focus on esophageal cancer, retinoblastoma, childhood cancer, lung cancer, and breast cancer.
Researchers have discovered a new mechanism by which the human papilloma virus (HPV) causes head and neck cancer and designed a drug that blocks this mechanism. The findings could lead to a safer, more effective therapy for HPV-caused cancer, potentially reducing the need for high-dose chemotherapy.
Cleveland Clinic researchers find that patients with prior chest radiation are nearly twice as likely to die in the years following their heart surgery compared to similar patients who did not undergo radiation treatment. Radiation heart disease can cause coronary artery disease, valve disease, cardiomyopathy, and other cardiac problems.
A new study found that long-term use of arrhythmia medication amiodarone may significantly increase the risk of developing certain cancers. Men and individuals taking high cumulative daily doses were more likely to develop cancer, with a 46% increased risk compared to those taking low doses.
A phase 1 clinical trial found that a combination of sapacitabine and seliciclib showed anti-cancer activity in patients with incurable solid tumors and inherited BRCA mutations. The treatment demonstrated partial responses in four patients, stable disease for over a year in three others.
Researchers used advanced amplification technology to detect abnormal DNA in blood samples from patients with gastrointestinal stromal tumors (GIST). The new blood test found secondary resistance mutations in the KIT gene, which were missed by traditional tissue analysis.
Agios research shows that mutant IDH1 and IDH2 inhibitors can reverse cellular differentiation in patient-derived tumor samples, reducing the oncometabolite 2-HG levels. This provides promising preclinical support for targeted therapies against cancer-causing mutations.
Researchers identified biochemical changes in cancer cells that render them vulnerable to PARP inhibitors, which showed promise as a novel treatment strategy for cisplatin-resistant cancer. The study found that high levels of poly (ADP-ribose) polymerase 1 and elevated amounts of poly (ADP-ribosyl) were linked to resistance to cisplatin.
African Americans with HPV-positive throat cancer have better outcomes than those without HPV. The study found that HPV has a substantial impact on overall survival in this population. African Americans who are HPV-negative face poorer survival rates compared to Caucasians with or without HPV.
A survey by the IASLC found that 90% of physicians believe tobacco cessation is essential for lung cancer treatment, but only 39% provide assistance. The study highlights barriers to effective tobacco cessation support for cancer patients.
The number of cancer survivors in the US is projected to increase from 13.7 million in 2012 to 18 million by 2022, with two-thirds of those over age 65. The report highlights disparities in survival rates across different cancer subtypes.
A review of 21 National Comprehensive Cancer Network member institutions found that only four provided nutritional guidelines, while many linked to external sites with inconsistent information. The analysis highlights the need for evidence-based, standardized guidelines on dietary recommendations for cancer patients.
A nationwide study found that hospital infections in cancer patients increased by 2.7% per year over a 10-year period, while deaths linked to those infections decreased by 1.3% per year. Socio-demographic factors such as race and insurance status continued to be significant concerns.
Dr. Alfred Gilman, Nobel laureate and Regental Professor Emeritus at UT Southwestern Medical Center, has been elected an inaugural Fellow of the American Association for Cancer Research (AACR). His work on G proteins has propelled significant innovation in cancer research.
A UK study published in PLOS Medicine found that hospital deaths decreased by half between 2005 and 2010, while home and hospice deaths increased. The study attributed this shift to improved end-of-life care initiatives, particularly for single people, the elderly, and those with certain cancer types.
A new study has identified genetic alterations in the RGS pathway as key factors linked to bladder cancer risk, recurrence, disease progression, and patient survival. The research found that specific variants were associated with increased or decreased risks, providing potential molecular markers for screening and treatment.
The NHS has launched a new 46 gene test to predict cancer patients' responses to treatment, using the latest DNA sequencing technology. The test aims to reduce harm from side effects and save costs by getting patients on the right treatments straightaway.
Researchers developed a mathematical model to analyze lung cancer spread patterns, revealing that cancer cells move around the body in multiple directions. The study identified specific areas of the body as 'spreaders' and 'sponges,' which could guide physicians to targeted treatment options.
Researchers found that actin's monomeric form interacts with chromatin to regulate gene expression and genome stability. The discovery challenges the dogma that actin functions through polymerization, revealing a novel mechanism for nuclear actin.
The American College of Medical Genetics and Genomics (ACMG) has released recommendations on handling incidental genetic findings in clinical genome and exome sequencing. The guidelines prioritize the disclosure of disorders with preventative measures, treatments, and well-recognized genetic mutations.
A large multicentre study found that small kidney tumours can have an aggressive potential and should be treated. The study included 2197 patients with RCC of 4 cm or smaller and showed that the risk of nodal disease or distant metastasis increased significantly with rising tumour diameter.
Researchers are developing tiny sensory implants that can measure vital tumor factors, enabling doctors to target radiotherapy and chemotherapy for more effective treatment. The devices aim to personalize therapy based on individual patient responses, improving recovery chances.
A recent study published in BJU International found that smoking significantly increases the risk of developing serious urothelial carcinoma and dying from the disease, particularly in women. Smoking cessation is crucial to safeguard against deadly cancers of the bladder, ureters, and renal pelvis in females.
A new study found that one out of four colonoscopies paid for by Medicare is potentially inappropriate, based on current screening guidelines. The researchers suggest that older adults are less likely to benefit from early detection due to the slow progression of colon cancer.
A new protein Smad7 has been found to protect against and heal mouth sores commonly associated with cancer treatment. The protein was administered genetically or topically to mouse models, resulting in dramatic resistance to oral mucositis development.
A study published in the Journal of the National Cancer Institute found that Medicare spending for advanced cancer patients does not correlate with survival rates. Despite significant regional differences in spending, researchers discovered a strong link between higher spending and more frequent hospital visits.
A new study defines 'sudden exhaustion syndrome' as a distinct condition affecting cancer patients undergoing treatment, characterized by intense and prolonged fatigue. The research aims to enhance recognition and management of this often-overlooked symptom among oncology professionals.
A study published in Health Psychology found that endometrial cancer survivors who had higher daily self-efficacy tended to exercise longer and more intensively. This is significant because exercise is a crucial aspect of cancer survivorship, particularly for those who are overweight or obese.
UT MD Anderson scientists found that a common substance in cancer vaccines facilitates a buildup of T cells at the vaccination site, summoning more T cells and causing lesions. Switching to saline adjuvant reversed the effect, allowing T cells to target tumors. A new clinical trial is expected to test this concept.
Patients with advanced head and neck cancers have higher survival rates when treated at high-volume hospitals and dedicated cancer centers. Despite this, the proportion of patients who received multimodality therapy was similar between low- and high-volume hospitals.
Researchers found that patients with metastatic gastric cancer who underwent both surgery and radiation had better survival rates than those receiving one or no treatment. Radiation therapy also showed promise in reducing symptoms such as pain, obstruction, and bleeding from gastric tumors.
Women with Lynch Syndrome have a 50-60% lifetime risk of developing colorectal cancer, but an 11% risk of breast cancer, 11% risk of kidney cancer, and 9% risk of bladder cancer. This study expands the spectrum of cancers associated with Lynch Syndrome.
A recent study by Ohio State University researchers has identified specific small molecules in the blood that can accurately measure damage to the body after ionizing radiation exposure. The findings suggest that these microRNA markers could help doctors identify individuals at risk for acute radiation syndrome and plan personalized ra...
A study by Rutgers University behavioral neuroscientist Tracey Shors found that prolonged chemotherapy decreases the development of new brain cells, disrupting ongoing brain rhythms necessary for learning. This can lead to cognitive problems such as short-term memory loss and disordered thinking in cancer patients.
A recent study by Professor Hermann Brenner and colleagues found that smoking cessation in older adults significantly reduces the risk of heart attacks and strokes. Within five years of quitting, smokers experience a reduction of over 40% in cardiovascular disease risk compared to non-smokers.
A growing health threat across low-income and middle-income countries, childhood cancer claims over 100,000 lives of children under 15 annually. Poor treatment access, lack of awareness, and limited healthcare infrastructure hinder effective care, emphasizing the need for investment in healthcare systems and capacity.
A six-session program addressing cognitive, physical, emotional, social and spiritual well-being significantly improved patients' quality-of-life measures. Despite the benefits for cancer patients, caregivers showed no improvement in quality-of-life measures during treatment.
Researchers at St. Michael's Hospital have developed a shorter version of the Patient-Generated Subjective Global Assessment (PG-SGA) tool to screen cancer patients for malnutrition. The abPG-SGA tool was found to be effective in identifying malnourished patients and improving patient outcomes.
A study published in Blood found that certain chemotherapies increase a patient's risk of developing therapy-related acute myeloid leukemia (tAML), a rare but frequently fatal condition. The risk varies by type of cancer and year of diagnosis, with some patients facing higher risks more than 10 years after their initial diagnosis.
Researchers discover pairing Avastin with dasatinib can stop lethal spread of aggressive brain cancer glioblastoma multiforme. The combination reduces tumor growth and blocks further spread by inhibiting protein migration.
A study published in Journal of Pediatric Oncology Nursing found that discomfort with tube feeding is the main reason families prefer IV nutrition. Tube feeding is associated with better gut function and lower infection rates, but perceived discomfort leads to a preference for IV feeding.
Researchers found that selumetinib increased iodine uptake in tumors resistant to radioiodine therapy, allowing some patients to undergo treatment. The study shows promise for RAS-mutant disease and paves the way for a larger clinical trial.
A phase II clinical trial shows that selumetinib, a targeted therapy, can halt growth or shrink tumors in 15% of patients with recurrent low-grade ovarian cancer. The two-year overall survival rate is 55%, and the median overall survival has not been reached due to high patient survival rates.
Researchers warn that molecularly targeted therapies may stunt growth, delay puberty, or increase the risk of diabetes in children. The lack of long-term data on these treatments raises concerns about their use in pediatric patients. Experts recommend using these drugs only in clinical trials to monitor side effects.
A new study published in Radiology found that CT scans are associated with a significantly lower risk of death than radiation-induced cancer in young adults. The study analyzed imaging records of patients 18 to 35 years old who underwent chest or abdominopelvic CT exams between 2003 and 2007.