Articles tagged with Cancer Patients
Depressive symptoms observed in cancer survivors between one and ten years after diagnosis increase the risk of premature death. Cancer survivors with depression are twice as likely to have died early compared to those without depression.
A new study from Fred Hutchinson Cancer Research Center found that cancer patients are more than two-and-a-half times more likely to declare bankruptcy than those without cancer. Younger cancer patients faced the highest bankruptcy rates, particularly in their early 20s and 30s.
A first prospective trial, CUSTOM, demonstrates that genetic analysis can assign cancer treatment for patients with three types of cancers. The study found that patients and doctors are interested in personalized medicine, but rare mutations remain a challenge.
A novel agent, (S)-YK-4-279, has been shown to halt the progression of Ewing sarcoma in rats and cause tumor regression. The agent works by blocking protein-protein interaction between cancer-causing proteins.
A new study by Penn Medicine found that most cancer doctors, patients, and the general public support cutting healthcare costs by refusing to pay for drugs without improving survival or quality of life. The survey also revealed that large numbers favored not paying for more expensive drugs when cheaper alternatives are equally effective.
A new study identifies microRNA-155 as a potential treatment target and prognostic marker for patients with cytogenetically normal acute myeloid leukemia. High levels of miR-155 expression are associated with poorer patient outcomes, including lower complete remission rates and shorter overall survival.
Researchers found that adolescents and young adults with cancer are at higher risk for social isolation due to lack of understanding from friends and family. The study suggests developing targeted support programs to address these social information needs, including online connections and communication tools.
Researchers found that the egg genome is reprogrammed to match sperm DNA with or without paternal contribution. The mother's genes undergo extensive changes to prepare for differentiation.
Researchers at Oregon Health & Science University have isolated a molecular mutation causing two rare forms of leukemia. The study suggests that patients with these conditions could be helped by existing FDA-approved drugs, paving the way for potential treatment breakthroughs.
This study assesses the effectiveness of the Liverpool Care Pathway on quality of end-of-life care for adult cancer patients. The LCP provides a structured programme to improve care dimensions, resulting in clinically significant improvements in respect, kindness, dignity, family emotional support, self-efficacy, and coordination of care.
Researchers at H. Lee Moffitt Cancer Center & Research Institute found that using a centralized warehouse of patient-donated biological data expedites participant accrual, reduces trial size, saves money, and speeds up test drugs through the drug development pipeline. The study used data from recent clinical trials conducted at Moffitt...
A new study found that Black women with breast cancer are three times more likely to delay treatment for over 90 days compared to white women. Low satisfaction with doctor communication is a significant reason for this delay, which increases the risk of mortality from the disease.
Researchers at UT Southwestern Medical Center found that a marker panel can predict which patients are more likely to experience cancer recurrence after bladder removal. The study identifies patients who could benefit from follow-up chemotherapy to improve treatment outcomes.
Researchers at Case Western Reserve University School of Medicine have identified a novel method to disrupt a common cancer pathway, suggesting a new treatment for breast, colon, melanoma and other cancers. The breakthrough was achieved by targeting a mutation in the PIK3CA gene.
Researchers have identified a link between HPV detection and improved survival rates in patients with oropharyngeal squamous cell carcinoma (OPSCC). A specific pattern of DNA modifications associated with HPV was found to be correlated with better outcomes in OPSCC patients.
Researchers found genetic mutations that could impact treatment plans and tumor classification for endometrial cancer patients. The study suggests reclassifying endometrial cancers into four categories based on copy number alterations and mutations.
Scientists at Weill Cornell Medicine have discovered two key proteins that work to block cancer's spread by generating a microenvironment that prevents cancer cells from settling and growing in distant organs. The study suggests that therapeutic proteins could offer a new treatment strategy for metastatic cancer.
A big data analysis identified 37 RNA molecules that may predict survival in breast cancer patients with the most common form of invasive ductal carcinoma. The study found a concise RNA signature associated with patient outcome, including early-stage tumors and those with clinical and molecular subclasses.
The region faces an alarming increase in cancer rates, with more than 1.7 million cases predicted to be diagnosed by 2030 and over 1 million deaths annually. Inadequate healthcare systems, lack of access to medical care, and inadequate health insurance exacerbate the issue.
Research found that specific DNA regions contribute to prostate cancer development and early death, with patients having two of these changes at high risk. The study identifies key genes PTEN and MYC as linked to prostate cancer lethality.
Researchers at Huntsman Cancer Institute developed a powerful technique to identify RNA cytosine methyltransferases (RMTs) targets in human RNA. The new method reveals previously unknown RMT targets for NSUN2, implicated in mental retardation and cancers.
Researchers found that intraventricular chemotherapy can palliate associated symptoms in patients with leptomeningeal carcinomatosis from non-small cell lung cancer. The study shows that 20 of 69 patients achieved normal ICP, and careful patient selection is recommended for successful treatment.
Scientists have developed a new chemical compound, WEHI-539, that inhibits BCL-XL protein in cancer cells. This could lead to the design of potential anti-cancer agents that restore cell death and improve treatment outcomes for patients with various types of cancer.
A new study suggests that tomosynthesis increases breast cancer detection rates by 11%, particularly benefiting women with dense breasts. The technology's improved performance in dense breast tissue was attributed to its ability to detect invasive and intraductal cancers more accurately.
Researchers at Columbia University developed a new computational model that uses gene signatures to predict breast cancer survival with high accuracy. The model, which won a crowd-sourced challenge, has the potential to improve diagnostic and prognostic products for multiple types of cancer.
A multicenter study found that 84% of lung cancer patients taking crizotinib have low testosterone levels, with 80% experiencing symptoms such as sexual dysfunction or depression. The study suggests that hormone replacement therapies may alleviate these symptoms and provide a new treatment option for affected patients.
A study of over 310,000 bowel cancer patients in six countries found that UK patients were more likely to be diagnosed at a later stage than others, resulting in lower survival rates. Improved diagnostic investigation and treatment are seen as key factors to increase UK survival rates.
Researchers at IRCM identified the DOCK1 protein as a key regulator of metastasis in breast cancer. The study found that eliminating DOCK1 in mice resulted in a significant decrease in lung metastases and tumor growth.
The study found that while the program was rarely used, those who participated reported gratitude for receiving a lethal prescription, regardless of use. The most common reasons for participation included loss of autonomy, inability to engage in enjoyable activities, and loss of dignity. SCCA's approach prioritizes palliative care and ...
A new class of tumor-fighting drugs using RNA interference has shown promising safety and efficacy in a clinical trial. The study found that the drug acts by silencing the PLK1 gene involved in tumor growth and can be safely administered in humans, with most patients tolerating it well and some showing therapeutic benefit.
A Mayo Clinic study found gene variations that can predict chemotherapy-induced peripheral neuropathy, a debilitating condition affecting 20-30% of cancer patients. The study implicates genes EPHA5, ARHGEF10, and PRX, enabling clinicians to individualize treatment and improve patient outcomes.
Researchers found that cosmic radiation impairs the ability of cells in the intestines of mice to eliminate oncogenic proteins, substantially increasing development of colorectal tumors. The study suggests that space travelers may be at increased risk of developing colorectal cancer due to prolonged exposure to cosmic radiation.
A new study by Fox Chase researchers finds that heterogeneity is prevalent even in early-stage ductal carcinoma in situ (DCIS) breast cancer, making it challenging for pathologists to accurately diagnose and treat the disease. The results suggest that a multiple-target approach may be necessary to effectively combat breast cancer.
Researchers have identified a set of misregulated genes common to tobacco-related cancers, which are associated with poor patient outcomes in lung and bladder cancers. These genes relate to the regulation of the cell cycle and could serve as a new prognostic tool to predict survival rates for patients with tobacco-related cancers.
The American Cancer Society has awarded 175 national research and training grants totaling $79,073,250. The grants will fund investigators at 93 institutions across the US, with a focus on esophageal cancer, retinoblastoma, childhood cancer, lung cancer, and breast cancer.
Researchers have discovered a new mechanism by which the human papilloma virus (HPV) causes head and neck cancer and designed a drug that blocks this mechanism. The findings could lead to a safer, more effective therapy for HPV-caused cancer, potentially reducing the need for high-dose chemotherapy.
Cleveland Clinic researchers find that patients with prior chest radiation are nearly twice as likely to die in the years following their heart surgery compared to similar patients who did not undergo radiation treatment. Radiation heart disease can cause coronary artery disease, valve disease, cardiomyopathy, and other cardiac problems.
A new study found that long-term use of arrhythmia medication amiodarone may significantly increase the risk of developing certain cancers. Men and individuals taking high cumulative daily doses were more likely to develop cancer, with a 46% increased risk compared to those taking low doses.
A phase 1 clinical trial found that a combination of sapacitabine and seliciclib showed anti-cancer activity in patients with incurable solid tumors and inherited BRCA mutations. The treatment demonstrated partial responses in four patients, stable disease for over a year in three others.
Researchers used advanced amplification technology to detect abnormal DNA in blood samples from patients with gastrointestinal stromal tumors (GIST). The new blood test found secondary resistance mutations in the KIT gene, which were missed by traditional tissue analysis.
Agios research shows that mutant IDH1 and IDH2 inhibitors can reverse cellular differentiation in patient-derived tumor samples, reducing the oncometabolite 2-HG levels. This provides promising preclinical support for targeted therapies against cancer-causing mutations.
Researchers identified biochemical changes in cancer cells that render them vulnerable to PARP inhibitors, which showed promise as a novel treatment strategy for cisplatin-resistant cancer. The study found that high levels of poly (ADP-ribose) polymerase 1 and elevated amounts of poly (ADP-ribosyl) were linked to resistance to cisplatin.
African Americans with HPV-positive throat cancer have better outcomes than those without HPV. The study found that HPV has a substantial impact on overall survival in this population. African Americans who are HPV-negative face poorer survival rates compared to Caucasians with or without HPV.
A survey by the IASLC found that 90% of physicians believe tobacco cessation is essential for lung cancer treatment, but only 39% provide assistance. The study highlights barriers to effective tobacco cessation support for cancer patients.
The number of cancer survivors in the US is projected to increase from 13.7 million in 2012 to 18 million by 2022, with two-thirds of those over age 65. The report highlights disparities in survival rates across different cancer subtypes.
A review of 21 National Comprehensive Cancer Network member institutions found that only four provided nutritional guidelines, while many linked to external sites with inconsistent information. The analysis highlights the need for evidence-based, standardized guidelines on dietary recommendations for cancer patients.
A nationwide study found that hospital infections in cancer patients increased by 2.7% per year over a 10-year period, while deaths linked to those infections decreased by 1.3% per year. Socio-demographic factors such as race and insurance status continued to be significant concerns.
Dr. Alfred Gilman, Nobel laureate and Regental Professor Emeritus at UT Southwestern Medical Center, has been elected an inaugural Fellow of the American Association for Cancer Research (AACR). His work on G proteins has propelled significant innovation in cancer research.
A UK study published in PLOS Medicine found that hospital deaths decreased by half between 2005 and 2010, while home and hospice deaths increased. The study attributed this shift to improved end-of-life care initiatives, particularly for single people, the elderly, and those with certain cancer types.
A new study has identified genetic alterations in the RGS pathway as key factors linked to bladder cancer risk, recurrence, disease progression, and patient survival. The research found that specific variants were associated with increased or decreased risks, providing potential molecular markers for screening and treatment.
The NHS has launched a new 46 gene test to predict cancer patients' responses to treatment, using the latest DNA sequencing technology. The test aims to reduce harm from side effects and save costs by getting patients on the right treatments straightaway.
Researchers developed a mathematical model to analyze lung cancer spread patterns, revealing that cancer cells move around the body in multiple directions. The study identified specific areas of the body as 'spreaders' and 'sponges,' which could guide physicians to targeted treatment options.
Researchers found that actin's monomeric form interacts with chromatin to regulate gene expression and genome stability. The discovery challenges the dogma that actin functions through polymerization, revealing a novel mechanism for nuclear actin.
The American College of Medical Genetics and Genomics (ACMG) has released recommendations on handling incidental genetic findings in clinical genome and exome sequencing. The guidelines prioritize the disclosure of disorders with preventative measures, treatments, and well-recognized genetic mutations.
A large multicentre study found that small kidney tumours can have an aggressive potential and should be treated. The study included 2197 patients with RCC of 4 cm or smaller and showed that the risk of nodal disease or distant metastasis increased significantly with rising tumour diameter.
Researchers are developing tiny sensory implants that can measure vital tumor factors, enabling doctors to target radiotherapy and chemotherapy for more effective treatment. The devices aim to personalize therapy based on individual patient responses, improving recovery chances.
A recent study published in BJU International found that smoking significantly increases the risk of developing serious urothelial carcinoma and dying from the disease, particularly in women. Smoking cessation is crucial to safeguard against deadly cancers of the bladder, ureters, and renal pelvis in females.
A new study found that one out of four colonoscopies paid for by Medicare is potentially inappropriate, based on current screening guidelines. The researchers suggest that older adults are less likely to benefit from early detection due to the slow progression of colon cancer.
A new protein Smad7 has been found to protect against and heal mouth sores commonly associated with cancer treatment. The protein was administered genetically or topically to mouse models, resulting in dramatic resistance to oral mucositis development.
A study published in the Journal of the National Cancer Institute found that Medicare spending for advanced cancer patients does not correlate with survival rates. Despite significant regional differences in spending, researchers discovered a strong link between higher spending and more frequent hospital visits.