Articles tagged with Cancer Patients
Researchers found a common genetic alteration in AML patients who died quickly from the disease. DNMT3A mutations were associated with poor survival rates, and patients with these mutations may benefit from aggressive treatment such as bone marrow transplantation.
A study found that physical activity reduces the risk of endometrial cancer, even among overweight women. Women exercising for 150 minutes per week had a 34% lower risk compared to inactive counterparts.
Duke University researchers identified a possible biomarker to measure breast cancer chemoprevention trial progress, allowing for smaller trials with fewer patients. This biomarker could indicate increased risk of breast cancer and be prevented by drugs targeting specific molecular signals.
A study published in Cancer Prevention Research found that gefitinib reduced pancreatic tumor incidence by 77% in mid-dose group and 100% in high-dose group. The compound also showed potential in preventing precursor lesions, with 67.6% of mice free of pancreatic intraepithelial neoplasms at 100 ppm dose.
Researchers found that allopurinol reduced levels of Ki67 biomarker in normal tissue but not in adenoma tissue. The study suggests allopurinol may have some activity against colon carcinogenesis, providing a potential background for a large trial to reduce adenoma recurrence.
A University of Michigan Health System study reveals that younger adult cancer patients experience more pain flares and emotional issues compared to older adults. Younger adults also reported smaller incomes and struggled more with paying healthcare bills, affecting their overall well-being.
Researchers have developed an algorithm to predict breast cancer patients with little risk of disease recurrence, potentially eliminating unnecessary chemotherapy. The tool uses gene expression signatures and achieves 87-100 percent accuracy in different patient groups.
A study by Georgetown Lombardi Comprehensive Cancer Center researchers found activation of pathways involved in cell death, inflammation, and systemic damage in smokers. The analysis revealed hallmarks of liver, heart, and kidney toxicity in healthy patients, paving the way for new blood tests to assess tobacco product harm.
A UNC research team has identified RGL2 as a critical protein in the KRAS signaling pathway, which could lead to the development of effective pancreatic cancer treatments. The team's findings suggest that blocking this pathway may hold promise for halting the growth of pancreatic tumors.
Dr. Edith P. Mitchell, a clinical professor at Thomas Jefferson University, has been named Physician of the Year by CancerCare for her expertise in treating gastrointestinal cancers. She is being recognized for her innovative research and teaching on new drug evaluations and chemotherapy strategies.
A phase I clinical trial at University of Texas M. D. Anderson Cancer Center found an antibody loaded with an anti-cancer agent produced complete or partial remissions in 38 percent of patients with relapsed or therapy-resistant Hodgkin lymphoma.
A recent study found that patients with MUTYH-associated polyposis have a statistically significant better survival rate than those with colorectal cancer from the general population. The five-year survival rate for MUTYH-associated polyposis was 78%, compared to 63% for control patients.
Researchers found that levels of a prostate-specific protein up to 18 months after salvage radiation therapy predict mortality and disease progression. Patients with rising PSA levels are at higher risk of spread and death, while those with stable levels may not require immediate hormonal therapy.
Researchers at Georgetown Lombardi Comprehensive Cancer Center found that robotic radiosurgery improved symptoms in patients with hilar lung tumors, reducing pain and improving breathing. However, the treatment did not show a significant impact on overall survival rates.
A study of 503 breast cancer survivors who underwent lumpectomy and radiation found that 30% rated their post-treatment breast appearance as 'fair' or 'poor'. The study highlights the need for additional patient education about potential cosmetic complications and encourages patients to take an active role in managing their health afte...
Stephen Barrager, a management science guru, survived acute multiple myeloma by applying engineering and management science principles. He developed the 'Cancer Quarterback' and 'Decision Coach' models to help patients navigate treatment options and communicate with doctors more effectively.
Researchers at Henry Ford Hospital found stereotactic body radiotherapy (SBRT) to be an effective treatment option for inoperable pancreatic cancer patients, slowing disease progression by almost six months. SBRT provides a highly targeted cancer radiation therapy with minimal side effects.
A new investigational DNA methylation test has been shown to detect precancerous adenomas and cancers with high accuracy, detecting 64% of polyps over 1cm and 85% of cancers. The test is simple, non-invasive, and can be done from home, making it a promising alternative to traditional screening methods.
A study found that only half of oncologists and haematologists agreed that sperm banking information is readily available to patients. Researchers are urging clinicians to discuss sperm banking with all male cancer patients to increase the opportunity for preservation.
Researchers found that FAK inhibitor Y15 effectively blocked colon cancer cell growth and viability in mice. The study showed promise for a new therapy by decreasing tumor growth and promoting apoptosis in mice treated with Y15.
A study published in the New England Journal of Medicine found that over half of patients with a specific type of lung cancer responded well to a new targeted treatment called crizotinib. The medication targets the gene driving the cancer and has been shown to improve patient outcomes, including reduced tumor growth and improved qualit...
A recent study by VCU Massey Cancer Center found that 21% of terminally ill cancer patients are eligible for genetic testing, yet none received it. This highlights the need for genetic services and patient education among dying cancer patients.
A new oral drug causes dramatic shrinkage of a rare, aggressive form of soft-tissue cancer driven by an abnormally activated protein. The findings highlight the value of personalized medicine gene-testing strategies to predict best drug treatment for individual cancers.
A new study found higher progression-free survival rates for HPV-positive head and neck cancer patients treated with cetuximab and intensity-modulated radiation therapy (IMRT). Patients showed a 100% one-year progression-free survival rate compared to 31% for those without HPV.
Researchers at MD Anderson Cancer Center identified a key signaling pathway that promotes osteosarcoma metastasis when blocked in mice. The study found significant decreases in lung metastases by targeting the Notch pathway and Hes1 gene.
A large randomized study found that preoperative radiation therapy significantly reduces the risk of local recurrence after 10 years for patients with rectal cancer. The treatment, combined with total mesorectal excision surgery, keeps colorectal cancer from returning in 50% of cases.
A randomized trial found that adding chemotherapy to radiation therapy for muscle invasive bladder cancer reduces the long-term risk of recurrence by 13 percentage points. The treatment also preserves bladder function, making it a viable alternative to radical surgery for patients with this form of the disease.
The updated guideline advises physicians to discuss individual risks and benefits of ESAs with cancer patients, recommending cautious use due to associated risks of thromboembolism and tumor progression. ESAs are still effective in reducing red blood cell transfusions, which can impact quality of life.
Parents of children with cancer reported feeling hurried and less well-informed about clinical trial protocols compared to adult patients. The study found that parents felt they had insufficient time to learn about the trials and asked fewer questions.
Researchers are conducting a phase II clinical trial using reovirus, a common virus that causes mild symptoms, to target and kill specific tumor cells with KRAS or EGFR mutations. The goal is to exploit the virus's ability to replicate in cancer cells while minimizing harm to healthy cells.
A new study from UT MD Anderson Cancer Center estimates a tenfold shortage of radiation oncologists over the next decade, driven by growing demand for radiation therapy. The researchers propose stop-gap measures to address the gap, including team-care models and increased residency training programs.
A study of post-menopausal women with hormone-sensitive breast cancers found that consuming high amounts of soy isoflavones lowered the risk of recurrence. The research, published in CMAJ, involved 524 women who were followed for five to six years.
Researchers found new mechanisms of protease activation, which helps spread cancer. The loss of protease inhibitors antiplasmin and antithrombin occur more in blood from cancer patients compared to healthy persons' blood.
A study found that removing 2mm around invasive breast cancer tumors reduces residual disease in 98% of patients, according to a research published in the International Journal of Clinical Practice. The study also showed that patients with non-invasive cancer have higher rates of residual disease.
Genomic Systems announces a major breakthrough in treating terminal cancer, citing research published in PNAS that shows an anti-PECAM-1 antibody is effective against three common fatal cancers in mice. The treatment targets normal endothelial cells rather than directly attacking cancer cells.
ASTRO recognizes Brian Hill as a cancer survivor who has given back to the community through his nonprofit, The Oral Cancer Foundation. He was diagnosed with Stage 4 metastatic tonsil cancer in 1997 but went on to donate $1,000 prize money to benefit the foundation.
The American Society for Radiation Oncology (ASTRO) partners with Mama's Kitchen to promote cancer survivorship and raise awareness on nutritional support for cancer patients. The partnership aims to provide essential nutrients to those affected by cancer, highlighting the importance of community care and volunteerism.
A significant proportion of patients with advanced cancer receive common cancer screenings, despite the limited benefit. Screening rates are higher among those with a recent history of screening and in those with higher socioeconomic status and married status.
A clinical trial is underway at Cincinnati Children's Hospital Medical Center to test a genetically reprogrammed herpes simplex virus (HSV1716) as a treatment for rare and aggressive forms of childhood cancer. The Phase I trial aims to assess the safety of the agent in young patients with solid tumors.
A study published in Cancer found that racial disparities in breast cancer care persist, even after accounting for patients' insurance and socioeconomic status. Black and Hispanic women are less likely to receive recommended treatments compared to white women.
A study of 25 cancer survivors found that fertility concerns were inadequately addressed by doctors, with many feeling guilty about their sexual function. Fertility was crucial to these patients' sense of identity and body image, highlighting the need for healthcare professionals to address these issues.
Studies have found that patients with cancer who experience pain or depression also report a high rate of physical symptoms such as fatigue, dry mouth, and nausea. These somatic symptoms are associated with substantial functional impairment, disability, and healthcare use, even after controlling for medical and psychiatric comorbidity.
Researchers found that cancer patients across all stages exhibit a high burden of somatic symptoms, including fatigue, pain, and insomnia. These symptoms significantly impair daily functioning and overall well-being, highlighting the need for comprehensive symptom management strategies.
A recent study found that cancer patients taking targeted therapies have significantly decreased levels of sexual function and satisfaction. The researchers surveyed 51 patients and found that men's erectile function scores were just 53% of the maximum, while women's desire and arousal scores were also affected.
A Phase IIb/III trial shows afatinib benefits patients with lung adenocarcinoma whose cancer progressed after chemotherapy and erlotinib or gefitinib. Patients receiving afatinib experienced delayed disease progression and greater tumor shrinkage, but no significant difference in overall survival.
Researchers report a new surgical technique, balloon kyphoplasty, offers quick pain relief and improves quality of life for patients with vertebral compression fractures. The procedure, which involves inflation and injection of bone cement, shows sustained improvements in disability and mobility.
The American Society for Radiation Oncology (ASTRO) has partnered with the Emilio Nares Foundation to promote cancer survivorship. The foundation offers life-enhancing services, emotional, and spiritual support to children and their families battling cancer.
The European Oncology Nursing Society has launched a breakthrough cancer pain initiative to improve patient outcomes in palliative care. The survey aims to identify knowledge gaps and provide insights into best practices for managing breakthrough cancer pain among oncology nurses across Europe.
A vaccine that targets a genetic mutation driving aggressive glioblastoma improved patient survival, with median overall survival of 26 months compared to 15 months for control group. Limited side effects were reported.
Researchers developed a method to detect early signs of lung cancer by examining cheek cells using biophotonics technology. The test, called partial wave spectroscopic (PWS) microscopy, shows promise in prescreening patients at high risk for the disease.
Mayo Clinic researchers have identified five genes that relate directly to radiation response, which could lead to the development of novel therapies tailored to individual cancer patients. The findings may enhance treatment outcomes for roughly half of all cancer patients who undergo radiation therapy.
The John Theurer Cancer Center will present research on unique surgical techniques to treat bone cancers that preserve as much bone and soft tissue as possible. These techniques include endoprostheses, cryosurgery, and radiofrequency ablation, with the goal of reducing complications and improving patient outcomes.
A retrospective study found that African-American patients had a lower median overall survival rate due to factors such as age, stage, and type of treatment, rather than their race. Patients of other races, including Asian and Hispanic patients, had a better disease prognosis.
Data from a national survey reveals that nonwhite female cancer survivors receive significantly less social support than their white counterparts. The study suggests that this disparity may be linked to differences in engagement with moderate-intensity physical activity, which was found to be similar across racial groups.
A recent study found that patients without private health insurance had significantly poorer cancer survival rates compared to those with insurance. The study, which analyzed data from 178,891 patients, also found that African-American patients were twice as likely to die within four years of diagnosis.
A new study reveals that people with a history of cancer are 40% more likely to experience memory problems that interfere with daily functioning. The findings suggest that cancer itself is a key independent predictor of memory issues, going beyond previously recognized conditions like 'chemobrain'.
A new microRNA screening assay detected the majority of early-stage colorectal cancers with good specificity and sensitivity from a single plasma sample. The test has the potential to be safe, cheap, robust, accurate, and convenient for national screening programs.
A recent study by Mayo Clinic found that radical prostatectomy significantly improves survival rates for men with localized prostate cancer. The procedure has led to excellent overall survival rates, with only 3% of patients dying from prostate cancer.
A new microRNA panel test has been developed to further subclassify non-small cell lung cancer, allowing for more accurate diagnosis and treatment decisions. This test has shown high sensitivity and specificity in distinguishing between subtypes of lung cancer.
Researchers developed a novel, dual-platform technology to capture circulating tumor cells (CTCs) in breast cancer more efficiently than traditional methods. The On-Q-ity C5 chip captured 65% of human breast cancer cells compared to 45% with size-based and 16% with antibody affinity methods.