Articles tagged with Cancer Patients
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Researchers found that FAK inhibitor Y15 effectively blocked colon cancer cell growth and viability in mice. The study showed promise for a new therapy by decreasing tumor growth and promoting apoptosis in mice treated with Y15.
A study published in the New England Journal of Medicine found that over half of patients with a specific type of lung cancer responded well to a new targeted treatment called crizotinib. The medication targets the gene driving the cancer and has been shown to improve patient outcomes, including reduced tumor growth and improved qualit...
A recent study by VCU Massey Cancer Center found that 21% of terminally ill cancer patients are eligible for genetic testing, yet none received it. This highlights the need for genetic services and patient education among dying cancer patients.
A new oral drug causes dramatic shrinkage of a rare, aggressive form of soft-tissue cancer driven by an abnormally activated protein. The findings highlight the value of personalized medicine gene-testing strategies to predict best drug treatment for individual cancers.
A new study found higher progression-free survival rates for HPV-positive head and neck cancer patients treated with cetuximab and intensity-modulated radiation therapy (IMRT). Patients showed a 100% one-year progression-free survival rate compared to 31% for those without HPV.
Researchers at MD Anderson Cancer Center identified a key signaling pathway that promotes osteosarcoma metastasis when blocked in mice. The study found significant decreases in lung metastases by targeting the Notch pathway and Hes1 gene.
A large randomized study found that preoperative radiation therapy significantly reduces the risk of local recurrence after 10 years for patients with rectal cancer. The treatment, combined with total mesorectal excision surgery, keeps colorectal cancer from returning in 50% of cases.
A randomized trial found that adding chemotherapy to radiation therapy for muscle invasive bladder cancer reduces the long-term risk of recurrence by 13 percentage points. The treatment also preserves bladder function, making it a viable alternative to radical surgery for patients with this form of the disease.
The updated guideline advises physicians to discuss individual risks and benefits of ESAs with cancer patients, recommending cautious use due to associated risks of thromboembolism and tumor progression. ESAs are still effective in reducing red blood cell transfusions, which can impact quality of life.
Parents of children with cancer reported feeling hurried and less well-informed about clinical trial protocols compared to adult patients. The study found that parents felt they had insufficient time to learn about the trials and asked fewer questions.
Researchers are conducting a phase II clinical trial using reovirus, a common virus that causes mild symptoms, to target and kill specific tumor cells with KRAS or EGFR mutations. The goal is to exploit the virus's ability to replicate in cancer cells while minimizing harm to healthy cells.
A new study from UT MD Anderson Cancer Center estimates a tenfold shortage of radiation oncologists over the next decade, driven by growing demand for radiation therapy. The researchers propose stop-gap measures to address the gap, including team-care models and increased residency training programs.
A study of post-menopausal women with hormone-sensitive breast cancers found that consuming high amounts of soy isoflavones lowered the risk of recurrence. The research, published in CMAJ, involved 524 women who were followed for five to six years.
Researchers found new mechanisms of protease activation, which helps spread cancer. The loss of protease inhibitors antiplasmin and antithrombin occur more in blood from cancer patients compared to healthy persons' blood.
A study found that removing 2mm around invasive breast cancer tumors reduces residual disease in 98% of patients, according to a research published in the International Journal of Clinical Practice. The study also showed that patients with non-invasive cancer have higher rates of residual disease.
Genomic Systems announces a major breakthrough in treating terminal cancer, citing research published in PNAS that shows an anti-PECAM-1 antibody is effective against three common fatal cancers in mice. The treatment targets normal endothelial cells rather than directly attacking cancer cells.
ASTRO recognizes Brian Hill as a cancer survivor who has given back to the community through his nonprofit, The Oral Cancer Foundation. He was diagnosed with Stage 4 metastatic tonsil cancer in 1997 but went on to donate $1,000 prize money to benefit the foundation.
The American Society for Radiation Oncology (ASTRO) partners with Mama's Kitchen to promote cancer survivorship and raise awareness on nutritional support for cancer patients. The partnership aims to provide essential nutrients to those affected by cancer, highlighting the importance of community care and volunteerism.
A significant proportion of patients with advanced cancer receive common cancer screenings, despite the limited benefit. Screening rates are higher among those with a recent history of screening and in those with higher socioeconomic status and married status.
A clinical trial is underway at Cincinnati Children's Hospital Medical Center to test a genetically reprogrammed herpes simplex virus (HSV1716) as a treatment for rare and aggressive forms of childhood cancer. The Phase I trial aims to assess the safety of the agent in young patients with solid tumors.
A study published in Cancer found that racial disparities in breast cancer care persist, even after accounting for patients' insurance and socioeconomic status. Black and Hispanic women are less likely to receive recommended treatments compared to white women.
A study of 25 cancer survivors found that fertility concerns were inadequately addressed by doctors, with many feeling guilty about their sexual function. Fertility was crucial to these patients' sense of identity and body image, highlighting the need for healthcare professionals to address these issues.
Studies have found that patients with cancer who experience pain or depression also report a high rate of physical symptoms such as fatigue, dry mouth, and nausea. These somatic symptoms are associated with substantial functional impairment, disability, and healthcare use, even after controlling for medical and psychiatric comorbidity.
Researchers found that cancer patients across all stages exhibit a high burden of somatic symptoms, including fatigue, pain, and insomnia. These symptoms significantly impair daily functioning and overall well-being, highlighting the need for comprehensive symptom management strategies.
A recent study found that cancer patients taking targeted therapies have significantly decreased levels of sexual function and satisfaction. The researchers surveyed 51 patients and found that men's erectile function scores were just 53% of the maximum, while women's desire and arousal scores were also affected.
A Phase IIb/III trial shows afatinib benefits patients with lung adenocarcinoma whose cancer progressed after chemotherapy and erlotinib or gefitinib. Patients receiving afatinib experienced delayed disease progression and greater tumor shrinkage, but no significant difference in overall survival.
Researchers report a new surgical technique, balloon kyphoplasty, offers quick pain relief and improves quality of life for patients with vertebral compression fractures. The procedure, which involves inflation and injection of bone cement, shows sustained improvements in disability and mobility.
The American Society for Radiation Oncology (ASTRO) has partnered with the Emilio Nares Foundation to promote cancer survivorship. The foundation offers life-enhancing services, emotional, and spiritual support to children and their families battling cancer.
The European Oncology Nursing Society has launched a breakthrough cancer pain initiative to improve patient outcomes in palliative care. The survey aims to identify knowledge gaps and provide insights into best practices for managing breakthrough cancer pain among oncology nurses across Europe.
A vaccine that targets a genetic mutation driving aggressive glioblastoma improved patient survival, with median overall survival of 26 months compared to 15 months for control group. Limited side effects were reported.
Researchers developed a method to detect early signs of lung cancer by examining cheek cells using biophotonics technology. The test, called partial wave spectroscopic (PWS) microscopy, shows promise in prescreening patients at high risk for the disease.
Mayo Clinic researchers have identified five genes that relate directly to radiation response, which could lead to the development of novel therapies tailored to individual cancer patients. The findings may enhance treatment outcomes for roughly half of all cancer patients who undergo radiation therapy.
The John Theurer Cancer Center will present research on unique surgical techniques to treat bone cancers that preserve as much bone and soft tissue as possible. These techniques include endoprostheses, cryosurgery, and radiofrequency ablation, with the goal of reducing complications and improving patient outcomes.
A retrospective study found that African-American patients had a lower median overall survival rate due to factors such as age, stage, and type of treatment, rather than their race. Patients of other races, including Asian and Hispanic patients, had a better disease prognosis.
Data from a national survey reveals that nonwhite female cancer survivors receive significantly less social support than their white counterparts. The study suggests that this disparity may be linked to differences in engagement with moderate-intensity physical activity, which was found to be similar across racial groups.
A recent study found that patients without private health insurance had significantly poorer cancer survival rates compared to those with insurance. The study, which analyzed data from 178,891 patients, also found that African-American patients were twice as likely to die within four years of diagnosis.
A new study reveals that people with a history of cancer are 40% more likely to experience memory problems that interfere with daily functioning. The findings suggest that cancer itself is a key independent predictor of memory issues, going beyond previously recognized conditions like 'chemobrain'.
A new microRNA screening assay detected the majority of early-stage colorectal cancers with good specificity and sensitivity from a single plasma sample. The test has the potential to be safe, cheap, robust, accurate, and convenient for national screening programs.
A recent study by Mayo Clinic found that radical prostatectomy significantly improves survival rates for men with localized prostate cancer. The procedure has led to excellent overall survival rates, with only 3% of patients dying from prostate cancer.
A new microRNA panel test has been developed to further subclassify non-small cell lung cancer, allowing for more accurate diagnosis and treatment decisions. This test has shown high sensitivity and specificity in distinguishing between subtypes of lung cancer.
Researchers developed a novel, dual-platform technology to capture circulating tumor cells (CTCs) in breast cancer more efficiently than traditional methods. The On-Q-ity C5 chip captured 65% of human breast cancer cells compared to 45% with size-based and 16% with antibody affinity methods.
A novel nanoscale protein measurement technology, NIA, can be used in clinical trials to learn how drugs work and tailor therapy for each patient. The test distinguishes tumor cells from normal cells using protein profiles in the RAS and MAP kinase pathways.
Researchers have found a gene associated with aggressive skin cancer, INPP5A, which could predict its onset and track its progression. The study suggests that targeting this gene may provide new ways to prevent and treat cutaneous squamous cell carcinoma.
Researchers found that African-American patients with non-small cell lung cancer have similar rates of EGFR mutations, making targeted therapies like erlotinib a viable option. This discovery challenges previous assumptions about racial disparities in lung cancer treatment.
Research published in Annals of Oncology suggests that intrauterine devices releasing progestin hormone levonorgestrel combined with GnRH injections can halt and reverse cancer growth in women aged 40 or younger. The treatment has shown promise in treating specific types of endometrial cancer, preserving fertility for young women.
Scientists at the University of Leicester are pioneering the use of turmeric extract to target chemo-resistant cancer cells. The research aims to improve chemotherapy effectiveness and prevent disease recurrence.
Researchers found that circulating tumor cells (CTCs) can provide real-time information on patient's current disease state through biomarker assessments. The technology has potential for non-invasive detection and analysis of cancer biomarkers.
A recent clinical study has shown that patient-specific vaccines can sometimes induce durable complete regression of progressing soft-tissue melanoma metastases. The vaccine was found to be effective in one particular patient who remained in complete remission for over two years, more than four years after her initial diagnosis.
Researchers found that surgery provides high survival rates of 92% for patients with aggressive prostate cancer, outperforming radiation therapy alone in terms of cancer-specific and overall survival. The study suggests that limiting hormone therapy may avoid adverse health consequences for these patients.
A new analysis reveals that male partners of women with breast cancer are at a significantly higher risk of developing severe mood disorders requiring hospitalization. The study found a 39% increased risk of being hospitalized with an affective disorder among men whose partners had breast cancer, compared to those without.
A new study published in the Journal of the National Cancer Institute found that breast cancer survivors with physical limitations are more likely to die from other diseases due to poorer health. Regular physical activity can reduce the risk of breast cancer recurrence and improve survival rates.
This special issue examines the ways cancer treatment affects cardiovascular function and overall survival, highlighting key challenges and potential strategies for minimizing collateral damage. Key findings include the need for cardiac outcomes data and evidence-based practice guidelines to mitigate heart-related complications.
Cells rapidly repair and maintain their structure when exposed to stress, thanks to a newly discovered protein called zyxin. This protein plays a crucial role in maintaining the cell's internal framework, or cytoskeleton, which is essential for cell function.
The American College of Physicians has announced that current stool DNA tests are not effective or cost-effective for colorectal cancer screening. Additionally, researchers have found that using proton pump inhibitors and clopidogrel together does not increase risk for adverse cardiovascular outcomes after a first heart attack. In anot...
Scientists at Huntsman Cancer Institute link loss of Apc to DNA demethylase, a system that erases DNA methylation. This system stalls normal intestinal cell development, leading to stem cell-like cells. Inhibition of the demethylase restores normal development and provides new opportunities for colon cancer treatment.
A study by Dana-Farber Cancer Institute found that cancer patients who die in hospitals or ICUs have worse quality of life, compared to those dying at home with hospice services. Caregivers of patients who died in ICUs are also at higher risk for developing PTSD and prolonged grief disorder.
Women with secondary breast cancer face inadequate support due to lack of knowledge, experience and staff numbers among healthcare professionals. Better training, resources, and services are needed to address this complex condition.
A novel JAK inhibitor has shown significant and lasting benefits for patients with myelofibrosis, a debilitating bone marrow disorder. The treatment produces substantial reductions in enlarged spleens, pain, fatigue, and improved quality of life.
This special edition of The Hastings Center Report examines the promise and pitfalls of personalized medicine, from direct-to-consumer genetic testing to hospice care. Key findings include the need for thousands of human biospecimens for genetic studies, as well as debates over individual mandates in healthcare reform.
A new risk prediction model for venous thromboembolism (VTE) in cancer patients has been developed, incorporating two new biomarkers. The model improves the classification of patients into different risk categories, with a significant increase in accurate predictions of VTE development.