Articles tagged with Cancer Patients
Researchers at VCU Massey Cancer Center have found a new biomarker related to the immune system that can predict breast cancer recurrence. The five-gene signature shows over 85% accuracy in predicting relapse-free survival.
A study published in the Journal of the National Cancer Institute found that patient reports of family cancer history are not highly accurate. The study revealed low to moderate accuracy rates for breast, colorectal, prostate, and lung cancer diagnoses, with higher accuracy rates for first-degree relatives
Researchers at Mayo Clinic have found a reliable method to detect pancreatic cancer through DNA testing of stool samples, with a marker detecting methylated genes in 70% of patients. This noninvasive test may lead to increased early detection and improved survival rates for those diagnosed with the disease.
Researchers identified previously undiscovered high-risk genetic features in T-cell acute lymphocytic leukemia (T-ALL) using zebrafish models. These genetic characteristics can predict which patients are more likely to experience aggressive forms of the disease that recur after treatment or do not respond to therapy.
A University of Alberta study found that submandibular gland transfer helps prevent radiation-induced dry mouth in cancer patients. The procedure improved speech but made swallowing more difficult, leading to nutritional issues and decreased quality of life.
Researchers at MD Anderson Cancer Center discovered WWP2's role in regulating PTEN, a tumor suppressor protein. WWP2 binding to PTEN leads to its degradation, allowing cancer cells to grow uncontrollably.
A study found that a pelvic MRI scan can identify local recurrence in prostate cancer patients with rising or persistently elevated PSA levels. About one-third of these patients have a low PSA level of less than 1, making it possible to treat them with higher doses and potentially increasing cure rates.
Pediatric cancer patients receive more accurate treatment delivery with proton radiography, reducing radiation exposure compared to standard diagnostic X-rays and cone beam CT. Proton imaging also enables real-time tumor tracking during treatment, benefiting children's sensitive growing bodies.
Low health literacy is a significant barrier to quality care for elderly cancer patients, but using simple and effective assessment tools can help. Nurses can assess patients' literacy levels and tailor communications to match their understanding, improving communication and health outcomes.
A team of surgeons from Mayo Clinic has found robotic surgery effective in treating larynx cancer, with patients able to resume normal eating and speaking after surgery. The study showed that robotic surgery was easier to perform than traditional approaches and resulted in clean, disease-free margins.
Researchers have developed a new technique that allows cancer-fighting cells to survive in patients' bloodstreams for over a year, without the need for toxic treatments. The study showed promising results, with one patient remaining cancer-free two years after treatment.
A new study found that Blacks are most willing to use up all personal financial resources to prolong life after lung or colorectal cancer diagnosis. Hispanic and Asian patients showed intermediate preferences. Factors influencing willingness include age, social support, and marital status.
A study found that black Americans are more willing to spend all their personal finances on cancer treatment to extend life, compared to whites. This discovery highlights the importance of understanding patients' financial decisions in delivering high-quality care.
Activation of CTNNB1 biomarker is associated with better survival rates among obese patients with colorectal cancer, while physical activity improves survival for those without CTNNB1 activation. The study suggests a possible interactive effect between tumor CTNNB1 signaling and energy balance status on tumor cell behavior.
Two studies published in JAMA describe the first clinical applications of whole-genome sequencing in patients with cancer, enabling targeted therapies based on genetic mutations. The technology is becoming increasingly affordable, with costs expected to drop below $10,000 within five years.
Two studies highlight the power of sequencing cancer patients' genomes, identifying novel genetic mutations that guide treatment. Researchers used genome sequencing to diagnose a patient with acute myeloid leukemia and breast cancer, changing her course from stem cell transplant to targeted chemotherapy.
A new study aims to improve the care of African Americans with cancer pain by providing a five-week program called Power Over Pain - Coaching or POP-C. The program addresses the challenges to pain care in this urban community and seeks to reduce suffering, distress, and burden among patients and caregivers.
A study found that late cancer diagnosis is a major factor in hospital cancer deaths in Northern Ireland, where over half of patients prefer to die at home. The study highlights the importance of early recognition of cancer symptoms and improving community services to support patients' wishes.
A Phase III study found that GOLFIG increased progression-free survival to 16.5 months, compared to 7.5 months with FOLFOX regimen. Researchers added gemcitabine and granulocyte-macrophage colony stimulating factor to boost immune system.
A worldwide trial is being conducted to assess the use of robotic-assisted keyhole surgery in removing bowel tumours. The study aims to evaluate whether this approach makes cancer less likely to come back and reduces complications for patients.
A recent study published by the American Association for Cancer Research found that consuming soy food did not increase the risk of cancer recurrence or death among breast cancer survivors. In fact, women who consumed more soy isoflavones had a reduced risk of mortality and cancer recurrence compared to those with lower intake levels.
A new study finds that vismodegib, a hedgehog pathway inhibitor, prevents the development of advanced basal cell carcinomas in patients with basal cell nevus syndrome. The treatment also shows promise for patients with an inherited predisposition to basal cell carcinoma.
A study found that receiving higher prescribed doses of opioids is associated with an increased risk of opioid overdose death, but receiving both as-needed and regularly scheduled doses is not. The study included data on over 154,000 patients who received opioid therapy for pain.
A study published at the AACR Annual Meeting found that women with ovarian cancer and BRCA2 mutations had improved survival rates compared to those with BRCA1 mutations or no mutations. The five-year survival rate for women with BRCA2 mutations was 61%, significantly higher than those without mutations (36%). Further research is needed...
Research reveals that people with AIDS have a significantly higher risk of developing stomach and esophageal malignancies, including a 6.9-fold increased incidence of stomach cancer and a 2.7-fold increased risk of esophageal cancer compared to the general population.
Researchers have developed a novel biomarker test that can detect proteins secreted from tumors caused by asbestos exposure with high accuracy. The test, which uses aptamer proteomics platform, showed an 80% sensitivity rate in detecting stage 1 or 2 malignant pleural mesothelioma, a type of aggressive and often fatal lung cancer.
Researchers found that breast cancer cells activate the unfolded protein response to evade anti-estrogen treatment, leading to increased resistance. Over-expression of XBP1 is a key driver of this process, suggesting a new target for restoring sensitivity to anti-estrogen therapies.
Researchers found that macrophage and T-cell levels can predict recurrence and survival in breast cancer. A new therapy targeting macrophages shows promising results in preclinical studies.
Researchers found a potential target for treating squamous cell lung cancer by identifying a DDR2 gene mutation that responds to dasatinib treatment. Approximately one in two thousand people in the US annually carry this mutation, and tumor cells with it showed significant response to dasatinib, indicating a new targeted therapy option.
Researchers discovered a single genetic variation associated with a 19% decrease in bladder cancer risk and longer telomeres, which guard against chromosomal damage. The finding provides new clues for understanding the causes of bladder cancer and developing therapies to reduce cancer risk.
A study found that improved quality of life and reduced stress response were associated with changes in telomere length in cancer patients. Psychological counseling had a potential impact on modulating telomere length, but the findings require further exploration.
Researchers at the BATTLE trial have identified two novel gene markers, including an EMT signature and LCN2, that predict response to EGFR inhibition in patients with wild-type EGFR. These biomarkers may help identify patients who can benefit from erlotinib treatment.
Researchers at UT MD Anderson Cancer Center developed two sets of gene expression profiles that predict response to erlotinib treatment for patients with no guiding indicators. The biomarkers, which cover 88% of patients without EGFR mutations, may have a broad impact on identifying patients who benefit from the drug.
Researchers testing a combination of GDC-0973 and GDC-0941, which inhibit the RAS/RAF/MEK and PI3K pathways, report encouraging safety data and early signs of anti-tumor activity. Patients with various types of cancer have shown decreases in tumor size, suggesting potential benefits for targeted therapy.
A new hedgehog pathway inhibitor, GDC-0449, demonstrated efficacy in preventing and treating basal cell cancer among patients with basal cell nevus syndrome. The drug reduced the development of new lesions and decreased tumor size, offering a promising treatment option for these patients.
A new pilot study aims to fill the research gap for young women with Triple Negative Breast Cancer, a rare and aggressive form of breast cancer that affects mostly African-American or Hispanic women. The two-year study will survey up to 60 women recently diagnosed with this type of breast cancer.
A study by UC Davis researchers found that frequent CT scans for testicular cancer surveillance are associated with a higher risk of secondary malignancies in older men. The study suggests that alternative imaging techniques, such as ultrasound and MRI, may be more suitable.
The molecular disease model for melanoma (MDMM) classifies the disease into molecular subtypes and provides treatment guidelines for each subtype. The MDMM is maintained online and updated continuously based on input from the melanoma community.
A new study found that certain women with early-stage breast cancer experience excessive worrying about cancer recurrence, affecting medical care and quality of life. The research identified factors associated with high levels of worry, including younger age, employment, pain, fatigue, and radiation treatment.
Dr. Arthur D. Levinson is recognized for his leadership and extraordinary achievements in cancer research, leading to targeted drugs and personalized healthcare. He was a key figure in developing cancer therapeutics, including Herceptin, Avastin, and Rituxan.
Pier Paolo Pandolfi has made significant contributions to cancer research, particularly in the area of leukemia treatment. His work on mouse models and chromosomal translocations has led to the development of novel therapeutic strategies, making APL a curable disease.
Dr. Yosef Shiloh is recognized for his groundbreaking work on ataxia-telangiectasia (A-T), a rare disease caused by a defect in the cellular response to DNA damage. His identification of the ATM gene has revolutionized the field, leading to significant advances in our understanding of DNA damage response and repair.
Researchers from McGill University found that cancer coverage has increased in Canadian newspapers over the past 20 years, with a greater emphasis on positivity and hope. However, the study also identified a gap in coverage of palliative care and psychological aspects of cancer.
Researchers sequenced a mouse cancer genome to find mutations driving human cancer. They identified genetic changes in three genes, including a mutation that also occurs in human patients with leukemia.
A large prospective study of black and white smokers found that mentholated cigarettes are associated with a lower lung cancer incidence and fewer lung cancer deaths than regular cigarettes. The researchers also found that menthol smokers reported smoking fewer cigarettes per day, but had similar quit rates as non-menthol smokers.
A study of over 3,000 patients found robot-assisted prostate surgery to be safe, with a low major complication rate and no disease recurrence after five years for nearly 87 percent of patients. The study analyzed surgical outcomes from 2005 to 2009 and addressed the lack of standardized reporting in previous literature.
The University of Texas MD Anderson Cancer Center is conducting a Phase III randomized clinical trial to examine whether acupuncture can prevent xerostomia, a debilitating side effect of radiation treatment for head and neck cancer. The study aims to determine if true acupuncture effectively prevents radiation-induced xerostomia and im...
Patients with CML taking imatinib in remission after two years have a mortality rate similar to the general population. Despite side effects, survival rates remain high even after eight years of treatment.
Dr. Von Hoff's research and clinical work advance personalized cancer treatment by analyzing patients' DNA sequences to determine the best course of treatment. His work has improved patient outcomes and paved the way for individualized healthcare based on genetic factors.
A single gene defect in the BRAF gene has been linked to pilocytic astrocytoma, a common brain tumor in children. Treatment with kinase inhibitors has shown promise in slowing down growth, paving the way for further research into targeted therapies.
The article discusses the need for targeted care in adolescents and young adults with cancer, who require collaboration between pediatric and medical oncologists. Research has shown that AYA cancer patients often deal with ongoing developmental and psychosocial issues, making it essential to address these challenges.
Researchers found that tumors with defects in DNA repair systems are less likely to recur post-surgery, reducing the need for chemotherapy. The study suggests testing for defective DNA mismatch repair and KRAS gene mutations to guide treatment strategies.
A new study published in Journal of Clinical Oncology found that adding targeted therapy bevacizumab to treatment for advanced ovarian cancer patients is not cost-effective. The researchers analyzed a clinical trial and found that the additional survival benefit was offset by high costs.
The Society of Surgical Oncology is presenting the James Ewing Layman's Award to Kimberly Duchossois for her leadership and vision in improving cancer care. Her family's dedication began after her mother died from cancer, leading them to create and endow the American Cancer Society Patient Navigation Services.
A study by Mayo Clinic and TGen found that patients are willing to undergo many tests for advanced experimental treatment in clinical trials. Patients were most willing to undergo non-invasive tests such as urine, blood, and imaging studies, but less willing to undergo invasive procedures like skin biopsies and MRIs.
A University of Louisville professor is developing a statistical model that can help determine what prolongs cancer-free survival. The new multi-state model analyzes how diseases progress from one stage to another, allowing for broad inspection of patient patterns and data collection.
A new patented therapy has been developed by WSU researcher Dr. Karli Rosner, which uses genetic constructs to target cancer cells and induce apoptosis, eliminating the need for external medications. The treatment shows promise in treating various types of cancers, including melanoma, prostate, lung, and breast cancers.
A new analysis found that fish oil supplementation can help combat cancer-related malnutrition, allowing patients to maintain their weight and muscle mass during chemotherapy. The study suggests that fish oil's omega-3 fatty acids may interfere with pathways altered in advanced cancer.
A long-term study confirms trastuzumab's benefit for women with early-stage HER2-positive breast cancer, showing a significant reduction in disease-free survival and no increase in mortality risk. The treatment also improves outcomes in patients who cross over to trastuzumab therapy.
A study found that dialysis patients receive high doses of radiation, increasing their cancer risk. The researchers recommend tracking radiation exposure to develop alternative strategies and justify CT scans.