Articles tagged with Cancer Patients
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A worldwide trial is being conducted to assess the use of robotic-assisted keyhole surgery in removing bowel tumours. The study aims to evaluate whether this approach makes cancer less likely to come back and reduces complications for patients.
A recent study published by the American Association for Cancer Research found that consuming soy food did not increase the risk of cancer recurrence or death among breast cancer survivors. In fact, women who consumed more soy isoflavones had a reduced risk of mortality and cancer recurrence compared to those with lower intake levels.
A new study finds that vismodegib, a hedgehog pathway inhibitor, prevents the development of advanced basal cell carcinomas in patients with basal cell nevus syndrome. The treatment also shows promise for patients with an inherited predisposition to basal cell carcinoma.
A study found that receiving higher prescribed doses of opioids is associated with an increased risk of opioid overdose death, but receiving both as-needed and regularly scheduled doses is not. The study included data on over 154,000 patients who received opioid therapy for pain.
A study published at the AACR Annual Meeting found that women with ovarian cancer and BRCA2 mutations had improved survival rates compared to those with BRCA1 mutations or no mutations. The five-year survival rate for women with BRCA2 mutations was 61%, significantly higher than those without mutations (36%). Further research is needed...
Research reveals that people with AIDS have a significantly higher risk of developing stomach and esophageal malignancies, including a 6.9-fold increased incidence of stomach cancer and a 2.7-fold increased risk of esophageal cancer compared to the general population.
Researchers have developed a novel biomarker test that can detect proteins secreted from tumors caused by asbestos exposure with high accuracy. The test, which uses aptamer proteomics platform, showed an 80% sensitivity rate in detecting stage 1 or 2 malignant pleural mesothelioma, a type of aggressive and often fatal lung cancer.
Researchers found that breast cancer cells activate the unfolded protein response to evade anti-estrogen treatment, leading to increased resistance. Over-expression of XBP1 is a key driver of this process, suggesting a new target for restoring sensitivity to anti-estrogen therapies.
Researchers found that macrophage and T-cell levels can predict recurrence and survival in breast cancer. A new therapy targeting macrophages shows promising results in preclinical studies.
Researchers found a potential target for treating squamous cell lung cancer by identifying a DDR2 gene mutation that responds to dasatinib treatment. Approximately one in two thousand people in the US annually carry this mutation, and tumor cells with it showed significant response to dasatinib, indicating a new targeted therapy option.
Researchers discovered a single genetic variation associated with a 19% decrease in bladder cancer risk and longer telomeres, which guard against chromosomal damage. The finding provides new clues for understanding the causes of bladder cancer and developing therapies to reduce cancer risk.
A study found that improved quality of life and reduced stress response were associated with changes in telomere length in cancer patients. Psychological counseling had a potential impact on modulating telomere length, but the findings require further exploration.
Researchers at the BATTLE trial have identified two novel gene markers, including an EMT signature and LCN2, that predict response to EGFR inhibition in patients with wild-type EGFR. These biomarkers may help identify patients who can benefit from erlotinib treatment.
Researchers at UT MD Anderson Cancer Center developed two sets of gene expression profiles that predict response to erlotinib treatment for patients with no guiding indicators. The biomarkers, which cover 88% of patients without EGFR mutations, may have a broad impact on identifying patients who benefit from the drug.
Researchers testing a combination of GDC-0973 and GDC-0941, which inhibit the RAS/RAF/MEK and PI3K pathways, report encouraging safety data and early signs of anti-tumor activity. Patients with various types of cancer have shown decreases in tumor size, suggesting potential benefits for targeted therapy.
A new hedgehog pathway inhibitor, GDC-0449, demonstrated efficacy in preventing and treating basal cell cancer among patients with basal cell nevus syndrome. The drug reduced the development of new lesions and decreased tumor size, offering a promising treatment option for these patients.
A new pilot study aims to fill the research gap for young women with Triple Negative Breast Cancer, a rare and aggressive form of breast cancer that affects mostly African-American or Hispanic women. The two-year study will survey up to 60 women recently diagnosed with this type of breast cancer.
A study by UC Davis researchers found that frequent CT scans for testicular cancer surveillance are associated with a higher risk of secondary malignancies in older men. The study suggests that alternative imaging techniques, such as ultrasound and MRI, may be more suitable.
The molecular disease model for melanoma (MDMM) classifies the disease into molecular subtypes and provides treatment guidelines for each subtype. The MDMM is maintained online and updated continuously based on input from the melanoma community.
A new study found that certain women with early-stage breast cancer experience excessive worrying about cancer recurrence, affecting medical care and quality of life. The research identified factors associated with high levels of worry, including younger age, employment, pain, fatigue, and radiation treatment.
Dr. Arthur D. Levinson is recognized for his leadership and extraordinary achievements in cancer research, leading to targeted drugs and personalized healthcare. He was a key figure in developing cancer therapeutics, including Herceptin, Avastin, and Rituxan.
Pier Paolo Pandolfi has made significant contributions to cancer research, particularly in the area of leukemia treatment. His work on mouse models and chromosomal translocations has led to the development of novel therapeutic strategies, making APL a curable disease.
Dr. Yosef Shiloh is recognized for his groundbreaking work on ataxia-telangiectasia (A-T), a rare disease caused by a defect in the cellular response to DNA damage. His identification of the ATM gene has revolutionized the field, leading to significant advances in our understanding of DNA damage response and repair.
Researchers from McGill University found that cancer coverage has increased in Canadian newspapers over the past 20 years, with a greater emphasis on positivity and hope. However, the study also identified a gap in coverage of palliative care and psychological aspects of cancer.
Researchers sequenced a mouse cancer genome to find mutations driving human cancer. They identified genetic changes in three genes, including a mutation that also occurs in human patients with leukemia.
A large prospective study of black and white smokers found that mentholated cigarettes are associated with a lower lung cancer incidence and fewer lung cancer deaths than regular cigarettes. The researchers also found that menthol smokers reported smoking fewer cigarettes per day, but had similar quit rates as non-menthol smokers.
A study of over 3,000 patients found robot-assisted prostate surgery to be safe, with a low major complication rate and no disease recurrence after five years for nearly 87 percent of patients. The study analyzed surgical outcomes from 2005 to 2009 and addressed the lack of standardized reporting in previous literature.
The University of Texas MD Anderson Cancer Center is conducting a Phase III randomized clinical trial to examine whether acupuncture can prevent xerostomia, a debilitating side effect of radiation treatment for head and neck cancer. The study aims to determine if true acupuncture effectively prevents radiation-induced xerostomia and im...
Patients with CML taking imatinib in remission after two years have a mortality rate similar to the general population. Despite side effects, survival rates remain high even after eight years of treatment.
Dr. Von Hoff's research and clinical work advance personalized cancer treatment by analyzing patients' DNA sequences to determine the best course of treatment. His work has improved patient outcomes and paved the way for individualized healthcare based on genetic factors.
A single gene defect in the BRAF gene has been linked to pilocytic astrocytoma, a common brain tumor in children. Treatment with kinase inhibitors has shown promise in slowing down growth, paving the way for further research into targeted therapies.
The article discusses the need for targeted care in adolescents and young adults with cancer, who require collaboration between pediatric and medical oncologists. Research has shown that AYA cancer patients often deal with ongoing developmental and psychosocial issues, making it essential to address these challenges.
Researchers found that tumors with defects in DNA repair systems are less likely to recur post-surgery, reducing the need for chemotherapy. The study suggests testing for defective DNA mismatch repair and KRAS gene mutations to guide treatment strategies.
A new study published in Journal of Clinical Oncology found that adding targeted therapy bevacizumab to treatment for advanced ovarian cancer patients is not cost-effective. The researchers analyzed a clinical trial and found that the additional survival benefit was offset by high costs.
The Society of Surgical Oncology is presenting the James Ewing Layman's Award to Kimberly Duchossois for her leadership and vision in improving cancer care. Her family's dedication began after her mother died from cancer, leading them to create and endow the American Cancer Society Patient Navigation Services.
A study by Mayo Clinic and TGen found that patients are willing to undergo many tests for advanced experimental treatment in clinical trials. Patients were most willing to undergo non-invasive tests such as urine, blood, and imaging studies, but less willing to undergo invasive procedures like skin biopsies and MRIs.
A University of Louisville professor is developing a statistical model that can help determine what prolongs cancer-free survival. The new multi-state model analyzes how diseases progress from one stage to another, allowing for broad inspection of patient patterns and data collection.
A new patented therapy has been developed by WSU researcher Dr. Karli Rosner, which uses genetic constructs to target cancer cells and induce apoptosis, eliminating the need for external medications. The treatment shows promise in treating various types of cancers, including melanoma, prostate, lung, and breast cancers.
A new analysis found that fish oil supplementation can help combat cancer-related malnutrition, allowing patients to maintain their weight and muscle mass during chemotherapy. The study suggests that fish oil's omega-3 fatty acids may interfere with pathways altered in advanced cancer.
A long-term study confirms trastuzumab's benefit for women with early-stage HER2-positive breast cancer, showing a significant reduction in disease-free survival and no increase in mortality risk. The treatment also improves outcomes in patients who cross over to trastuzumab therapy.
A study found that dialysis patients receive high doses of radiation, increasing their cancer risk. The researchers recommend tracking radiation exposure to develop alternative strategies and justify CT scans.
Researchers have developed a new DNA microarray technology that can measure the unique genetic changes in breast cancer patients. This technology has the potential to identify new biomarkers for various types of cancer and serve as a universal cancer biomarker.
A new study found that the active ingredient in cannabis can help cancer patients regain their appetites and sense of taste. The study showed that THC-treated patients reported an increased appreciation of food, better quality of sleep, and relaxation compared to those receiving placebo.
A blood test can accurately detect biomolecular markers of bladder cancer risk linked to environmental exposures like cigarette smoke and industrial pollutants. The test measures methylation patterns in immune system cells, which are associated with an increased likelihood of disease.
A study found that women with melanoma report higher levels of both positive and negative impacts of cancer, including increased worries about UV radiation. Women also adjust their sun behavior more often and experience difficulties in getting life insurance as a result of their diagnosis.
The American Cancer Society has received a Presidential Citation Award from the American Academy of Hospice and Palliative Medicine for its efforts in promoting palliative care for patients with cancer. The organization has funded over $7 million in research grants to improve quality of life for patients, survivors, and their families.
The commentary highlights knowledge gaps in current guidelines for cancer survivors, emphasizing the need for longer-term research to address chronic health conditions. Nutrition interventions are seen as crucial in preventing cancer recurrence and managing comorbidities.
A new balloon kyphoplasty procedure provides rapid pain relief, increased mobility, and reduced need for painkillers compared to standard non-surgical care. Cancer patients with spinal fractures experience improved spinal function, quality of life, and pain during the study period.
A small proportion of adult cancer patients participate in clinical trials due to low physician referrals. Medical and radiation oncologists were more likely to refer patients, as well as those in larger practices and academic appointments.
Scientists at Queen's University Belfast have discovered the role of an enzyme that causes life-threatening damage to the heart when cancer patients receive chemotherapy, restricting treatment doses. New drugs targeting this enzyme could reduce heart damage and increase survival rates.
A new study found a link between low-dose ionizing radiation exposure from cardiac imaging and therapeutic procedures and an increased risk of incident cancer. Patients who underwent more procedures were more likely to develop cancer, particularly in the abdomen and chest areas.
Researchers propose cancer cells employ ancient genetic pathways, a 'toolkit' from 1 billion years ago, to evade control and develop resistance. This concept offers new hope for personalized medicine and potentially reveals clues about life's history.
A new FDA-approved drug, Sodium Fluoride F18, has been approved for use in bone scans, providing a safer alternative to the radioactive tracer Technetium-99m. The drug offers improved images using PET imaging, enabling better and earlier detection of bone metastases in cancer patients.
A recent study by Beth Israel Deaconess Medical Center researchers found that nonprofit hospice agencies disproportionately care for patients with diagnoses associated with less skilled care and longer lengths of stay. This may lead to financial obstacles in providing appropriate care for the neediest patients.
Research suggests that high levels of circulating DNA, specifically human telomerase reverse transcriptase (hTERT), can indicate a faster progression of lung cancer and lower overall survival. Patients with lower hTERT levels had improved time to progression and higher overall survival rates compared to those with higher levels.
Yosef Shiloh, a renowned expert in ataxia-telangiectasia (A-T) research, has been awarded the 51st Annual AACR G.H.A. Clowes Memorial Award for his groundbreaking work on cellular DNA damage response and A-T. His discoveries have significantly advanced our understanding of this rare genomic instability syndrome.
A novel form of personalized therapy using genetically engineered anti-tumor immune cells shows promising results in treating metastatic melanoma and synovial cell sarcoma. The technique, called adoptive immunotherapy, resulted in response rates of 45% and 67% in malignant melanoma and synovial cell sarcoma patients, respectively.
A study from Henry Ford Hospital found that photodynamic therapy can preserve vocal cord function in patients with early-stage laryngeal cancer. The treatment, which uses a powerful laser and light-activated drug, showed consistent trends toward normal vocal cord vibration over several weeks and months.
Researchers identified a gene signature that can accurately assess which breast cancer patients are at risk of relapse. The test has the potential to identify low-risk patients who may not require aggressive treatments, balancing risks against benefits.
A new gene test can identify which bladder cancer patients may have cancer spread in their lymph nodes, allowing doctors to determine the best course of treatment. The test analyzes 20 genes on tumor biopsies and has shown promising results in a large sample of patients.