Articles tagged with Cancer Patients
Researchers at University of Minnesota discovered a gene pattern in dogs that distinguishes between aggressive and less aggressive forms of bone cancer. The finding may lead to the development of laboratory tests to predict tumor behavior in humans, allowing for tailored therapy and potentially reducing side effects.
A study published in Cancer Research found that PTEN helps remove DNA damage caused by UVB radiation, a risk factor for non-melanoma skin cancer. Increasing PTEN activity through supplements or pharmaceuticals may prevent skin cancer.
Scientists have developed a novel protein called HER2-Affitoxin that targets HER2-positive cancer cells without interfering with the signaling pathway. The protein has shown promising results in killing tumor cells and is warranting clinical trials.
A nationally representative survey of 1,072 primary care physicians and 1,130 oncologists found significant barriers to effective communication and coordination of care following initial cancer treatment. Optimal cancer survivorship care includes surveillance for recurrence, managing late medical effects, and psychosocial support.
Researchers found two genetic variations linked to increased risk of second cancers in childhood Hodgkin's lymphoma patients treated with radiation. These markers appear to decrease activation of the PRDM1 gene, which can protect against cancer when exposed to radiation.
A new drug targeting the PI3K gene has shown significant shrinkage of tumors in two patients with advanced breast and cervical cancers. The drug, GDC-0941, is being tested in an early phase I study conducted by TGen and Virginia G. Piper Cancer Center.
Researchers shared findings on new treatments, predicting treatment outcomes, and patient quality of life issues. A phase II study of carfilzomib showed significant responses in patients with relapsed multiple myeloma.
A novel combined therapy has been developed to treat brain cancer patients with neoplastic meningitis, a devastating neurological complication. The treatment involves delivering chemotherapy directly to the brain's surfaces while draining excess spinal fluid to alleviate pressure and improve quality of life.
A study published in Cancer Research suggests that stem cell therapy can improve cognitive function in patients with brain cancer who experience radiation-induced learning and memory loss. The treatment involved human neural stem cell transplants, which led to significant improvements in cognitive function compared to control rats.
Researchers at the University of Texas at Austin are developing a novel 3D surface imaging technology to help cancer patients and children make informed decisions about reconstructive surgeries. The technology uses algorithms to analyze patient data and provide personalized simulations, aiming to improve cosmetic outcomes.
Researchers identified seven new DNA variants associated with increased prostate cancer risk, accounting for 25% of familial cancer risk. The study, conducted by an international consortium, used genome-wide association studies to identify genetic variants linked to the disease.
A recent study by UCLA found that nearly all patients with high-grade, non-invasive bladder cancer are not receiving comprehensive care recommended by the American Urology Association and National Comprehensive Cancer Network. This is critical as it can significantly minimize the likelihood of patient death from their cancer.
A new study reveals that nearly all high-grade noninvasive bladder cancer patients do not receive complete care as recommended by current guidelines. This suboptimal care has serious consequences, including increased risk of recurrence and progression to invasive tumors.
Research suggests that adding an inferior vena cava filter (IVCF) to the anticoagulant medication fondaparinux does not improve treatment outcomes for cancer patients with blood clots. In fact, median survival was shorter and VTE resolution rates were lower in patients who received both treatments.
A recent study found that celecoxib reduced the Ki-67 labeling index by 34% in former smokers, indicating a potential chemopreventive effect against lung cancer. The medication was also linked to a reduction in lung nodules, a precursor to cancer.
Researchers at John Theurer Cancer Center found that patients with more partner support experience less distress after stem cell transplants. The study suggests that social support plays a crucial role in improving patient outcomes and quality of life.
Researchers sequenced a patient's entire DNA and RNA to identify the origins of their metastatic adenocarcinoma of the lung, a mutation in the TP53 gene being found to halt tumor suppressor gene creation and result in tumor generation
The Max Cure Foundation and Samuel Waxman Cancer Research Foundation have partnered to fund research targeting the Ewing sarcoma family of tumors. Erwin G. Van Meir's proposal aims to reprogram ESFT cancer stem cells using a small molecule that induces cell death.
Researchers developed a novel analysis method to organize genomic cancer data, revealing previously unknown genetic connections and similarities among different types of cancers. The approach uses multiplicity to create three-dimensional models, potentially leading to trials of already approved drugs for additional cancers.
A study of 64,034 women found that those with heart problems, chronic lung disease, and diabetes had lower overall survival rates. Researchers conclude that managing both cancer and comorbidities is crucial for improving patient outcomes.
A recent study published in International Journal of Cancer found that boosting the production of a specific microRNA, miR-34a, increases sensitivity of bladder cancer cells to chemotherapy. The study suggests that miR-34a may be used as a predictor of response to chemotherapy and a target for new drugs.
Researchers have discovered that complex changes in TP53 occur earlier than previously thought, setting the stage for additional abnormalities. This finding could help scientists determine which mutations lead to precancerous lesions and invasive carcinomas.
Patients treated with sunitinib and sorafenib showed an antibody response comparable to healthy participants, indicating the flu vaccine is safe and effective. This finding has broad implications for patient management beyond targeted therapy.
A new study from UT MD Anderson Cancer Center found that nearly half of women with advanced breast cancer in the US are not receiving life-saving post-mastectomy radiation therapy (PMRT), despite evidence-based guidelines outlining its benefits. The study suggests that better strategies, such as requiring compliance for accreditation a...
A new study found that despite publication of treatment guidelines, only 55% of older high-risk breast cancer patients received recommended radiation treatment after mastectomy. The lack of improvement in radiation use suggests guidelines may not be effectively improving care for breast cancer patients.
A holistic approach to treating cancer pain that addresses psychological, social, and spiritual needs can enhance treatment outcomes and ease suffering. Research suggests integrating palliative care from diagnosis can improve quality of life, reduce depression, and increase survival time for lung cancer patients.
A study found that men diagnosed with prostate cancer who are also smokers have an increased risk of dying from prostate cancer, as well as all-cause and cardiovascular disease mortality. Smoking cessation after diagnosis did not significantly impact mortality risks compared to never-smokers.
The foundation awarded Clinical Investigator Awards to nine early-career physician-scientists conducting patient-oriented cancer research at major centers. The recipients will receive $450,000 each over three years, while Continuation Grants will provide an additional two years of funding totaling $300,000.
A study published in Archives of Surgery found that most hospitals follow established practice guidelines for surgical treatment of cancer patients with Medicare. However, disparities in care exist, with patients receiving the right care at the right time not always guaranteed.
A large study published in the Journal of the National Cancer Institute found that patients with Barrett's esophagus have a lower risk of esophageal cancer than previously thought. Men and individuals aged 60-69 were found to be at higher risk, highlighting the importance of personalized risk scores.
A low-carbohydrate, high-protein diet has been shown to slow the growth of tumors and reduce the risk of cancer in mice. The study found that restricting carbohydrate intake can limit blood glucose and insulin, promoting tumor growth. A low-carb diet also boosted the immune system's ability to kill cancer cells and prevented obesity.
The new iGXT Platform combines genetically engineered mouse models with patient-derived tumor xenograft models for more accurate cancer drug testing. The partnership aims to improve treatment outcomes by identifying effective biomarkers and personalized therapy options.
Researchers recommend a national strategy for therapeutic cancer vaccines, focusing on cancers with poor treatment options. Vaccines targeting such cancers may offer better survival rates and fewer side effects than current treatments.
Researchers are using genomic research to identify new genes that give rise to osteosarcoma and develop personalized blood tests to monitor disease in patients. The goal is to improve treatment of this difficult disease through better diagnosis and monitoring.
A new study by Nancy Keating found that VHA care is at least as good as, and in some cases better than, Medicare-funded private sector care for men 65 years and older. The VHA's coordinated care approach, salaried doctors, and lack of financial incentives for overuse may contribute to its high quality.
Researchers developed a new alpha-emitter-based therapy that effectively targets and cures neuroendocrine tumors without harming healthy tissues. The treatment, called 213Bi-DOTATOC peptide receptor alpha-therapy, showed promising results in patients with liver metastases resistant to beta-particle peptide therapy.
Researchers found that Tai Chi improves cognitive functioning and psychological health in women who have undergone chemotherapy. The study suggests that Tai Chi could be a valuable addition to cancer treatment for mitigating cognitive decline.
Researchers developed a novel form of radioimmunotherapy that targets antigens associated with renal cell carcinoma. Patients receiving up to three doses show dramatic slowing of cancer growth and stabilization of their disease. The therapy, Lu-177-cG250, targets kidney tumors with high effectiveness for reducing cancer proliferation.
A recent study by Fred Hutchinson Cancer Center found that bankruptcy rates among cancer patients rise fourfold within five years of diagnosis. The risk is highest for lung, thyroid and leukemia/lymphoma cancer patients, who face significant financial stress due to income loss and treatment costs.
A Mayo Clinic study has found that a mutant gene thought to accelerate tumor growth actually inhibits the spread of malignant cells, showing promise for novel cancer therapies. The PAX8/PPARγ fusion protein functions as a tumor suppressor by upregulating anti-tumor agents.
Research at the University of Texas MD Anderson Cancer Center found that customizing targeted therapies based on a patient's specific gene mutations can lead to higher response rates, survival, and failure-free survival compared to non-matched patients. This approach has shown promise in treating solid tumors with gene aberrations.
A clinical trial published in the New England Journal of Medicine reveals that a vaccine combined with Interleukin-2 improves response rate and progression-free survival for patients with advanced melanoma. The vaccine stimulates the immune system to recognize and attack tumor cells, resulting in increased survival rates.
Researchers are conducting a clinical trial called MANTICORE to detect and treat cardiovascular disease in breast cancer patients before treatment begins. The study aims to use special blood tests and imaging scans to identify potential cardiac risk factors.
Researchers have discovered that protein kinase C inhibitors can block kidney damage caused by the cancer drug cisplatin. This finding suggests using these inhibitors as an adjunct therapy to reduce toxicity and improve treatment outcomes.
Scientists have identified a drug combination that shows a survival advantage in advanced lung cancer patients who no longer respond to existing therapies. The combination of bexarotene and erlotinib broadens the reach to include patients resistant due to ras mutations, offering new hope for those with limited treatment options.
The study found that the vaccine improved response rates by 16% and progression-free survival by 2.2 months in patients compared to those without the vaccine. The researchers aim to broaden their approach using mixtures of peptides and other immune-stimulatory agents.
A study by University of Pennsylvania researchers found that even with private health insurance, newly diagnosed cancer patients often struggle to schedule an appointment with an oncologist. The authors suggest that patient navigator programs and staff training could help improve access to care.
A University of Michigan Health System study shows surgery mortality dropped substantially for eight different high-risk surgeries performed on 3.2 million Medicare patients from 1999 to 2008. High-volume hospitals and their expertise drove a significant decline in deaths, particularly in pancreatectomy and cystectomy.
The Society of Gynecologic Oncology has released guidelines for surveillance of gynecologic cancer recurrence in women who have had a complete response to primary cancer therapy. The recommendations focus on clinical effectiveness and cost-effectiveness, advising against routine cytologic procedures or imaging unless necessary.
A recent Korean survey found that most cancer patients, family members, oncologists, and the general public are receptive to ending futile life-sustaining treatments for terminally ill patients. This positive attitude towards withdrawing such treatments is attributed to patient autonomy and hastening the dying process.
A recent study published by the European Alliance of Associations for Rheumatology (EULAR) found that arthritis patients treated with anti-tumour necrosis factor agents do not have an overall increased cancer risk. The nine-year follow-up study showed no significant difference in cancer risk among patients with rheumatoid arthritis, ps...
A randomized, controlled trial found that patient navigators can significantly improve CRC screening rates among low-income, black, and non-English-speaking patients. The study suggests that focusing on these populations with patient navigation may be an effective approach to reducing screening disparities.
A phase II study by the University of Texas M. D. Anderson Cancer Center found that an antibody-guided chemotherapy drug eradicated or greatly reduced ALL cells in 61% of patients with resistant or recurrent disease. This makes it a potential most active single-agent therapy for ALL.
A recent study found that granting patients full access to their medical records increases their satisfaction without causing anxiety. The research, published in the Cancer journal, suggests that providing accurate information through medical records can complement verbal communication with physicians and improve patient outcomes.
A study led by the University of California, San Francisco found that childhood cancer survivors have a significantly higher risk of developing gastrointestinal complications later in life. Over 40% of cancer survivors reported experiencing some type of GI complication within 20 years after treatment.
A new study from MD Anderson Cancer Center found that yoga improved physical functioning, general health, and reduced cortisol levels in women with breast cancer. Yoga also helped patients find meaning in their cancer experience and report positive life changes after treatment.
A new treatment combination of a PARP inhibitor with chemotherapy offered significant benefit in patients with metastatic colon cancer who had exhausted all standard therapies. The study found that the treatment controlled cancer growth for nearly six months in 23% of patients, with two experiencing a partial response.
New studies released by ASCO highlight advances in cervical cancer screening, ovarian cancer detection, and prostate cancer risk prediction. The studies also explore genetic biomarkers for chemotherapy-induced neuropathy and potential treatments for relapsed ovarian cancer.
A blood test counting circulating tumor cells is a reliable indicator of disease progression in patients with metastatic breast cancer. The test's predictive value remains consistent regardless of treatment type or sites of disease involvement.
A new study links obstructive sleep apnea (OSA) to increased tumor growth and aggressiveness in melanoma cancer cells in mice. Recurrent hypoxia, a hallmark of OSA, enhances tumor proliferation and necrosis.